1-20 of 24
Sagar Lonial
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 2825: Stromal cell derived IL6 inhibits the extrinsic apoptotic pathway in multiple myeloma cell lines

James C. Ackley, Samuel McCachren, Sagar Lonial, Damien J. Green, Stanley R. Riddell, Geoffrey R. Hill, Madhav V. Dhodapkar, Lawrence H. Boise
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2825.
https://doi.org/10.1158/1538-7445.AM2022-2825
Published: 15 June 2022
View articletitled, Abstract 2825: Stromal cell derived IL6 inhibits the extrinsic apoptotic pathway in multiple myeloma cell lines
Journal Articles

Abstract CT186: Pharmacokinetic (PK) profile of a novel IKZF1/3 degrader, CFT7455, enables significant potency advantage over other IKZF1/3 degraders in models of multiple myeloma (MM) and the results of the initial treatment cohort from a first-in-human (FIH) phase 1/2 study of CFT7455 in MM

Sagar Lonial, Shambavi Richard, Jeffrey V Matous, Andrew J. Yee, Urvi Shah, Neha Mehta-Shah, Thomas Martin, Eli Muchtar, Sikander Ailawadhi, Paul G. Richardson, Manisha Bhutani, Samantha Perino, Jason Kirby, Roman V. Agafonov, Prasoon Chaturvedi, Bradley Class, Matthew Schnaderbeck, Michael R. Palmer, Cathleen Gorman, Oliver Schoenborn-Kellenberger, Amanda Hoerres, Stewart L. Fisher, Roy M. Pollock, Adam Crystal, Michelle Mahler, Jesus Bardeja
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT186.
https://doi.org/10.1158/1538-7445.AM2022-CT186
Published: 15 June 2022
View articletitled, Abstract CT186: Pharmacokinetic (PK) profile of a novel IKZF1/3 degrader, CFT7455, enables significant potency advantage over other IKZF1/3 degraders in models of multiple myeloma (MM) and the results of the initial treatment cohort from a first-in-human (FIH) phase 1/2 study of CFT7455 in MM
Journal Articles

Abstract 839: Whole genome DNA methylation analysis of multiple myeloma identifies pervasive hypomethylation and biomarkers of survival

Benjamin G. Barwick, Doris R. Powell, Daniel Penaherrera, Sheri Skerget, Jonathan J. Keats, Daniel Auclair, Sagar Lonial, Lawrence H. Boise, Paula M. Vertino
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 839.
https://doi.org/10.1158/1538-7445.AM2019-839
Published: 01 July 2019
View articletitled, Abstract 839: Whole genome DNA methylation analysis of multiple myeloma identifies pervasive hypomethylation and biomarkers of survival
Journal Articles

Abstract 4913: Differences in presentation and survival outcomes for African American patients with newly diagnosed multiple myeloma

Nisha Joseph, Vikas A. Gupta, Craig Hofmeister, Charise Gleason, Leonard T. Heffner, Kafuman L. Jonathan, Lawrence H. Boise, Madhav D. Dhodapkar, Sagar Lonial, Ajay K. Nooka
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4913.
https://doi.org/10.1158/1538-7445.AM2019-4913
Published: 01 July 2019
View articletitled, Abstract 4913: Differences in presentation and survival outcomes for African American patients with newly diagnosed multiple myeloma
Journal Articles

Abstract 2715: Deciphering a metabolic basis for single-agent venetoclax efficacy in t(11;14) multiple myeloma

Richa Bajpai, Abhinav Achreja, Changyong Wei, Arusha Siddiqa, Shannon M. Matulis, Vikas Gupta, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Hsiao-Rong Chen, Jeanne Kowalski, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2715.
https://doi.org/10.1158/1538-7445.AM2019-2715
Published: 01 July 2019
View articletitled, Abstract 2715: Deciphering a metabolic basis for single-agent venetoclax efficacy in t(11;14) multiple myeloma
Journal Articles

Abstract 2921: Co-inhibition of BET and proteasome enhances ER stress and Bim-dependent apoptosis with augmented cancer therapeutic efficacy

Guoqing Qian, Weilong Yao, Williams D. Hall, Mala Shanmugam, Sagar Lonial, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2921.
https://doi.org/10.1158/1538-7445.AM2018-2921
Published: 01 July 2018
View articletitled, Abstract 2921: Co-inhibition of BET and proteasome enhances ER stress and Bim-dependent apoptosis with augmented cancer therapeutic efficacy
Journal Articles

Abstract 319: Syntenin regulates multiple myeloma cell survival

Tyler Moser-Katz, Catherine M. Gavile, Benjamin G. Barwick, Sagar Lonial, Lawrence H. Boise
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 319.
https://doi.org/10.1158/1538-7445.AM2018-319
Published: 01 July 2018
View articletitled, Abstract 319: Syntenin regulates multiple myeloma cell survival
Journal Articles

Abstract 223: A meta-analysis of genome-wide association studies of multiple myeloma among African Americans

Zhaohui Du, Chi Song, Kristin Rand, Niels Weinhold, David Van Den Berg, Amie Hwang, Xin Sheng, Victor Hom, Sikander Ailawadhi, Ajay K. Nooka, Seema Singhal, Karen Pawlish, Edward S. Peters, Cathryn Bock, Ann Mohrbacher, Alexander Stram, Sonja I. Berndt, William Blot, John David Carpten, Antoinette Stroup, Andrew Olshan, Wei Zhang, African Ancestry Breast & Prostate Consortium, Stephen Chanock, Jayesh Mehta, Graham A. Colditz, Jeffrey Wolf, Thomas G. Martin, Michael Tomasson, Mark A. Fiala, Howard Terebelo, Nalini Janakiraman, Laurence Kolonel, Loic LeMarchand, Elad Ziv, Daniel Stram, Ravi Vij, Leon Bernal-Mizrachi, Gareth J. Morgan, Jeffrey A. Zonder, Carol Ann Huff, Sagar Lonial, Robert Z. Orlowski, David V. Conti, Christopher A. Haiman, Wendy Cozen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 223.
https://doi.org/10.1158/1538-7445.AM2018-223
Published: 01 July 2018
View articletitled, Abstract 223: A meta-analysis of genome-wide association studies of multiple myeloma among African Americans
Journal Articles

Abstract 4629: Multiple myeloma susceptibility loci examined in African and European ancestry populations

Kristin A. Rand, Chi Song, Eric Dean, Daniel Serie, Karen Curtin, Dennis Hazelett, Amie E. Hwang, Xin Sheng, Alex Stram, David J. Van Den Berg, Carol Ann Huff, Leon Bernal-Mizrachi, Michael H. Tomasson, Sikander Ailawadhi, Anneclaire De Roos, Seema Singhal, Karen Pawlish, Edward Peters, Catherine Bock, David V. Conti, Graham Colditz, Todd Zimmerman, Scott Huntsman, John Graff, African Ancestry Prostate Cancer GWAS Consortium, African Ancestry Breast Cancer GWAS Consortium, Stephen J. Chanock, Michael Lieber, Jayesh Mehta, Eric A. Klein, Nalini Janakiraman, Richard K. Severson, Angela R. Brooks-Wilson, Vincent Rajkumar, Elizabeth E. Brown, Laurence Kolonel, Susan Slager, Brian E. Henderson, Graham G. Giles, John J. Spinelli, Brian Chiu, Kenneth C. Anderson, Jeffrey Zonder, Robert Z. Orlowski, Sagar Lonial, Nicola Camp, Celine Vachon, Elad Ziv, Dan O. Stram, Christopher A. Haiman, Wendy Cozen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4629.
https://doi.org/10.1158/1538-7445.AM2015-4629
Published: 01 August 2015
View articletitled, Abstract 4629: Multiple myeloma susceptibility loci examined in African and European ancestry populations
Journal Articles

Abstract 3852: Obesity is associated with clinical characteristics in African American multiple myeloma patients

Amie E. Hwang, Sikander Ailwadhi, Carol Ann Huff, Leon Bernal-Mizrachi, Christopher A. Haiman, Edward Peters, Seema Singhal, Karen Pawlish, Cathryn Bock, Todd Zimmerman, David J. Van Den Berg, David V. Conti, Brenda B. Birmann, Jayesh Mehta, John J. Graff, Daniel O. Stram, Niquelle Brown, Yang Yu, Moosa Azadian, Laurence Kolonel, Brian E. Henderson, Ann Mohrbacher, Graham Colditz, Brian-C Chiu, Michael Tomasson, Jeffrey Zonder, Robert Z. Orlowski, Sagar Lonial, Wendy Cozen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3852.
https://doi.org/10.1158/1538-7445.AM2014-3852
Published: 01 October 2014
View articletitled, Abstract 3852: Obesity is associated with clinical characteristics in African American multiple myeloma patients
Journal Articles

Abstract 4561: The MMRF CoMMpassSM Study: A prospective, longitudinal, multicenter observational study in newly diagnosed multiple myeloma patients to assess the relationship between patient outcomes, treatment regimens and molecular profiles

Carolyn J. Hoban, Pamela Kidd, Scott Jewell, Thomas Monroe, Sok Khoo, Dan Rohrer, Joan Levy, Beverly Harrison, Sagar Lonial, Jonathan Keats, Walter Capone, Kathy Giuisti, John Carpten, Louise Perkins
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4561.
https://doi.org/10.1158/1538-7445.AM2012-4561
Published: 15 April 2012
View articletitled, Abstract 4561: The MMRF CoMMpassSM Study: A prospective, longitudinal, multicenter observational study in newly diagnosed multiple myeloma patients to assess the relationship between patient outcomes, treatment regimens and molecular profiles
Journal Articles

Abstract 4782: The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through JNK-dependent downregulation of c-FLIP in head and neck cancer cells

Liqun Zhao, Ping Yue, Sagar Lonial, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4782.
https://doi.org/10.1158/1538-7445.AM2011-4782
Published: 15 April 2011
View articletitled, Abstract 4782: The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through JNK-dependent downregulation of c-FLIP in head and neck cancer cells
Journal Articles

Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth

Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus Boggon, Fadlo Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, Jing Chen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 34.
https://doi.org/10.1158/1538-7445.AM10-34
Published: 15 April 2010
View articletitled, Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth
Journal Articles

Abstract LB-291: Translational studies of the dual mTOR-PI3K inhibitor SF1126

Jingdong Su, Xiaodong Peng, Ebenezer David, Christopher Flowers, Sagar Lonial, Joseph Garlich
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-291.
https://doi.org/10.1158/1538-7445.AM10-LB-291
Published: 15 April 2010
View articletitled, Abstract LB-291: Translational studies of the dual mTOR-PI3K inhibitor SF1126
Journal Articles

Abstract 1635: Combination of the HDAC inhibitor romidepsin with the MEK inhibitor U0126 results in synergistic plasma cell apoptosis

Yanyan Gu, Jonathan Kaufman, Lawrence H. Boise, Sagar Lonial
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1635.
https://doi.org/10.1158/1538-7445.AM10-1635
Published: 15 April 2010
View articletitled, Abstract 1635: Combination of the HDAC inhibitor romidepsin with the MEK inhibitor U0126 results in synergistic plasma cell apoptosis
Journal Articles

Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy

Lei Fu, Young-Ae Kim, Xuerong Wang, Xiaoyun Wu, Ping Yue, Sagar Lonial, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8967–8976.
https://doi.org/10.1158/0008-5472.CAN-09-2190
Published: 30 November 2009
View articletitled, Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy
Open the PDF for Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy in another window
Includes: Supplementary data
Journal Articles

Abstract #4546: The HDAC inhibitor panobinostat (LBH589) induces transient thrombocytopenia in mice, with minimal effects on bone marrow megakaryocyte populations

Cynthia Giver, Edmund Waller, Sagar Lonial
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4546.
Published: 01 May 2009
View articletitled, Abstract #4546: The HDAC inhibitor panobinostat (LBH589) induces transient thrombocytopenia in mice, with minimal effects on bone marrow megakaryocyte populations
Journal Articles

EGF stimulates RSK2 activation through activation of the MEK/ERK pathway and Src-dependent tyrosine phosphorylation of RSK2 at Y529

Sumin Kang, Shaozhong Dong, Ailan Guo, Hong Ruan, Sagar Lonial, Hanna Khoury, Ting-Lei Gu, Jing Chen
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3486.
Published: 01 May 2008
View articletitled, EGF stimulates RSK2 activation through activation of the MEK/ERK pathway and Src-dependent tyrosine phosphorylation of RSK2 at Y529
Journal Articles

SNS-032, a potent and selective CDK2, 7 and 9 inhibitor, demonstrates preclinical activity in human multiple myeloma

Suzanne Trudel, Michael Sebag, Zhi Hua Li, Chang-Xin Shi, P Bergsagel, Marta Chesi, Lori Hazlehurst, Constantine Mitsiades, Sagar Lonial, Rachael Hawtin, Judith Fox, Pietro Taverna, A Stewart, MMRC Validation Team
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4972.
Published: 01 May 2008
View articletitled, SNS-032, a potent and selective CDK2, 7 and 9 inhibitor, demonstrates preclinical activity in human multiple myeloma
Journal Articles

The Farnesyltransferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells

Yuanzheng Qiu, Xiangguo Liu, Wei Zou, Ping Yue, Sagar Lonial, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2007) 67 (10): 4973–4980.
https://doi.org/10.1158/0008-5472.CAN-06-4044
Published: 17 May 2007
View articletitled, The Farnesyltransferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells
Open the PDF for The Farnesyltransferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells in another window