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Journal Articles

Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo

Shinji Takeuchi, Akiko Takahashi, Noriko Motoi, Shin Yoshimoto, Tomoko Tajima, Kimi Yamakoshi, Atsushi Hirao, Shigeru Yanagi, Kiyoko Fukami, Yuichi Ishikawa, Saburo Sone, Eiji Hara, Naoko Ohtani
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9381–9390.
https://doi.org/10.1158/0008-5472.CAN-10-0801
Published: 14 November 2010
View articletitled, Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo
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Includes: Supplementary data
Journal Articles

Abstract 626: Therapeutic effect of HGF inhibitors against HGF-induced EGFR-TKI resistance in lung cancer harboring EGFR mutations

Seiji Yano, Wei Wang, Qi Li, Ivan S. Donev, Shinji Takeuchi, Tadaaki Yamada, Kunio Matsumoto, Yasuhiko Nishioka, Saburo Sone
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 626.
https://doi.org/10.1158/1538-7445.AM10-626
Published: 15 April 2010
View articletitled, Abstract 626: Therapeutic effect of HGF inhibitors against HGF-induced EGFR-TKI resistance in lung cancer harboring EGFR mutations
Journal Articles

Abstract 629: Hepatocyte growth factor induces resistance to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer

Tadaaki Yamada, Kunio Matsumoto, Ivan Shterev Donev, Yoshitaka Sekido, Yasuhiko Nishioka, Saburo Sone, Seiji Yano
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 629.
https://doi.org/10.1158/1538-7445.AM10-629
Published: 15 April 2010
View articletitled, Abstract 629: Hepatocyte growth factor induces resistance to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer
Journal Articles

Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor–Activating Mutations

Seiji Yano, Wei Wang, Qi Li, Kunio Matsumoto, Haruko Sakurama, Takahiro Nakamura, Hirokazu Ogino, Soji Kakiuchi, Masaki Hanibuchi, Yasuhiko Nishioka, Hisanori Uehara, Tetsuya Mitsudomi, Yasushi Yatabe, Toshikazu Nakamura, Saburo Sone
Journal: Cancer Research
Cancer Res (2008) 68 (22): 9479–9487.
https://doi.org/10.1158/0008-5472.CAN-08-1643
Published: 14 November 2008
View articletitled, Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor–Activating Mutations
Open the PDF for Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor–Activating Mutations in another window
Includes: Supplementary data
Journal Articles

Role and regulatory mechanism of Endothelin-1 in osteoblastic bone metastasis produced by a human lung adenocarcinoma cell line

Kenji Ikuta, Shinsaku Ohtsuka, Seiji Yano, Soji Kakiuchi, Hirokazu Ogino, Hisanori Uehara, Takashi Takahashi, Saburo Sone
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 475.
Published: 01 May 2007
View articletitled, Role and regulatory mechanism of Endothelin-1 in osteoblastic bone metastasis produced by a human lung adenocarcinoma cell line
Journal Articles

Vandetanib (ZD6474), an orally available inhibitor of VEGFR-2 and EGFR tyrosine kinase activity, may be a novel therapeutic agent against malignant pleural mesothelioma

Hirokazu Ogino, Seiji Yano, Soji Kakiuchi, Tadaaki Yamada, Kenji Ikuta, Saburo Sone
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2123.
Published: 01 May 2007
View articletitled, Vandetanib (ZD6474), an orally available inhibitor of VEGFR-2 and EGFR tyrosine kinase activity, may be a novel therapeutic agent against malignant pleural mesothelioma
Journal Articles

The Neuromedin U-Growth Hormone Secretagogue Receptor 1b/Neurotensin Receptor 1 Oncogenic Signaling Pathway as a Therapeutic Target for Lung Cancer

Koji Takahashi, Chiyuki Furukawa, Atsushi Takano, Nobuhisa Ishikawa, Tatsuya Kato, Satoshi Hayama, Chie Suzuki, Wataru Yasui, Kouki Inai, Saburo Sone, Tomoo Ito, Hitoshi Nishimura, Eiju Tsuchiya, Yusuke Nakamura, Yataro Daigo
Journal: Cancer Research
Cancer Res (2006) 66 (19): 9408–9419.
https://doi.org/10.1158/0008-5472.CAN-06-1349
Published: 03 October 2006
View articletitled, The Neuromedin U-Growth Hormone Secretagogue Receptor 1b/Neurotensin Receptor 1 Oncogenic Signaling Pathway as a Therapeutic Target for Lung Cancer
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Includes: Supplementary data
Journal Articles

Plakophilin 3 Oncogene as Prognostic Marker and Therapeutic Target for Lung Cancer

Chiyuki Furukawa, Yataro Daigo, Nobuhisa Ishikawa, Tatsuya Kato, Tomoo Ito, Eiju Tsuchiya, Saburo Sone, Yusuke Nakamura
Journal: Cancer Research
Cancer Res (2005) 65 (16): 7102–7110.
https://doi.org/10.1158/0008-5472.CAN-04-1877
Published: 15 August 2005
View articletitled, Plakophilin 3 Oncogene as Prognostic Marker and Therapeutic Target for Lung Cancer
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Journal Articles

Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells SBC-5 through an anti-osteoclastic activity

Hiroaki Muguruma, Seiji Yano, Emiko Nakataki, Hideki Tomimoto, Takafumi Todoroki, Soji Kakiuchi, Makoto Kawatani, Hiroyuki Osada, Saburo Sone
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1385.
Published: 01 May 2005
View articletitled, Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells SBC-5 through an anti-osteoclastic activity
Journal Articles

Establishment of orthotopically implanted malignant mesothelioma model which represents intrathoracic tumors and bloody pleural effusions

Seiji Yano, Emiko Nakataki, Hiroaki Muguruma, Hideki Tomimoto, Soji Kakiuchi, Saburo Sone
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 245.
Published: 01 May 2005
View articletitled, Establishment of orthotopically implanted malignant mesothelioma model which represents intrathoracic tumors and bloody pleural effusions
Journal Articles

Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839) and its application to the development of diagnostic test

Yataro Daigo, Nobuhisa Ishikawa, Soji Kakiuchi, Tatsuhiko Tsunoda, Seiji Yano, Kazuhiko Nakagawa, Takashi Tsuruo, Nobuoki Kohno, Masahiro Fukuoka, Saburo Sone, Yusuke Nakamura
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1251.
Published: 01 May 2005
View articletitled, Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839) and its application to the development of diagnostic test
Journal Articles

Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal Preparation

Masato Okamoto, Sachiko Furuichi, Yasuhiko Nishioka, Tetsuya Oshikawa, Tomoyuki Tano, Sharif Uddin Ahmed, Kiyoshi Takeda, Shizuo Akira, Yoshiki Ryoma, Yoichiro Moriya, Motoo Saito, Saburo Sone, Mitsunobu Sato
Journal: Cancer Research
Cancer Res (2004) 64 (15): 5461–5470.
https://doi.org/10.1158/0008-5472.CAN-03-4005
Published: 02 August 2004
View articletitled, Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal Preparation
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Journal Articles

Organ Heterogeneity of Host-derived Matrix Metalloproteinase Expression and Its Involvement in Multiple-Organ Metastasis by Lung Cancer Cell Lines

Minoru Shiraga, Seiji Yano, Akihiko Yamamoto, Hirohisa Ogawa, Hisatsugu Goto, Toyokazu Miki, Keisuke Miki, Helong Zhang, Saburo Sone
Journal: Cancer Research
Cancer Res (2002) 62 (20): 5967–5973.
Published: 15 October 2002
View articletitled, Organ Heterogeneity of Host-derived Matrix Metalloproteinase Expression and Its Involvement in Multiple-Organ Metastasis by Lung Cancer Cell Lines
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Journal Articles

Activity of a New Vascular Targeting Agent, ZD6126, in Pulmonary Metastases by Human Lung Adenocarcinoma in Nude Mice

Hisatsugu Goto, Seiji Yano, Helong Zhang, Yuka Matsumori, Hirohisa Ogawa, David C. Blakey, Saburo Sone
Journal: Cancer Research
Cancer Res (2002) 62 (13): 3711–3715.
Published: 01 July 2002
View articletitled, Activity of a New Vascular Targeting Agent, ZD6126, in Pulmonary Metastases by Human Lung Adenocarcinoma in Nude Mice
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Journal Articles

Interferon γ-dependent Induction of Thymidine Phosphorylase/Platelet-derived Endothelial Growth Factor through γ-Activated Sequence-like Element in Human Macrophages

Hisatsugu Goto, Kimitoshi Kohno, Saburo Sone, Shin-ichi Akiyama, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research
Cancer Res (2001) 61 (2): 469–473.
Published: 01 January 2001
View articletitled, Interferon γ-dependent Induction of Thymidine Phosphorylase/Platelet-derived Endothelial Growth Factor through γ-Activated Sequence-like Element in Human Macrophages
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Journal Articles

Nuclear Factor-κB-dependent Expression of Metastasis Suppressor KAI1/CD82 Gene in Lung Cancer Cell Lines Expressing Mutant p53

Tsutomu Shinohara, Toyokazu Miki, Naoki Nishimura, Hiroshi Nokihara, Hirofumi Hamada, Naofumi Mukaida, Saburo Sone
Journal: Cancer Research
Cancer Res (2001) 61 (2): 673–678.
Published: 01 January 2001
View articletitled, Nuclear Factor-κB-dependent Expression of Metastasis Suppressor KAI1/CD82 Gene in Lung Cancer Cell Lines Expressing Mutant p53
Open the PDF for Nuclear Factor-κB-dependent Expression of Metastasis Suppressor KAI1/CD82 Gene in Lung Cancer Cell Lines Expressing Mutant p53 in another window
Journal Articles

Natural Killer Cell-dependent Suppression of Systemic Spread of Human Lung Adenocarcinoma Cells by Monocyte Chemoattractant Protein-1 Gene Transfection in Severe Combined Immunodeficient Mice

Hiroshi Nokihara, Hiroaki Yanagawa, Yasuhiko Nishioka, Seiji Yano, Naofumi Mukaida, Kouji Matsushima, Saburo Sone
Journal: Cancer Research
Cancer Res (2000) 60 (24): 7002–7007.
Published: 01 December 2000
View articletitled, Natural Killer Cell-dependent Suppression of Systemic Spread of Human Lung Adenocarcinoma Cells by Monocyte Chemoattractant Protein-1 Gene Transfection in Severe Combined Immunodeficient Mice
Open the PDF for Natural Killer Cell-dependent Suppression of Systemic Spread of Human Lung Adenocarcinoma Cells by Monocyte Chemoattractant Protein-1 Gene Transfection in Severe Combined Immunodeficient Mice in another window
Journal Articles

Apoptosis Induction of Human Lung Cancer Cell Line in Multicellular Heterospheroids with Humanized Antiganglioside GM2 Monoclonal Antibody

Kazuyasu Nakamura, Masaki Hanibuchi, Seiji Yano, Yuko Tanaka, Ikuko Fujino, Miho Inoue, Toshiaki Takezawa, Kenya Shitara, Saburo Sone, Nobuo Hanai
Journal: Cancer Research
Cancer Res (1999) 59 (20): 5323–5330.
Published: 01 October 1999
View articletitled, Apoptosis Induction of Human Lung Cancer Cell Line in Multicellular Heterospheroids with Humanized Antiganglioside GM2 Monoclonal Antibody
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Journal Articles

Macrophage Colony-stimulating Factor Gene Transduction into Human Lung Cancer Cells Differentially Regulates Metastasis Formations in Various Organ Microenvironments of Natural Killer Cell-depleted SCID Mice

Seiji Yano, Yasuhiko Nishioka, Hiroshi Nokihara, Saburo Sone
Journal: Cancer Research
Cancer Res (1997) 57 (4): 784–790.
Published: 01 February 1997
View articletitled, Macrophage Colony-stimulating Factor Gene Transduction into Human Lung Cancer Cells Differentially Regulates Metastasis Formations in Various Organ Microenvironments of Natural Killer Cell-depleted SCID Mice
Open the PDF for Macrophage Colony-stimulating Factor Gene Transduction into Human Lung Cancer Cells Differentially Regulates Metastasis Formations in Various Organ Microenvironments of Natural Killer Cell-depleted SCID Mice in another window
Journal Articles

Prevention of Adenocarcinoma Colon 26-induced Cachexia by Interleukin 10 Gene Transfer

Fujio Fujiki, Naofumi Mukaida, Kunitaka Hirose, Hiroshi Ishida, Akihisa Harada, Shinsuke Ohno, Horst Bluethmann, Masanobu Kawakami, Mariko Akiyama, Saburo Sone, Kouji Matsushima
Journal: Cancer Research
Cancer Res (1997) 57 (1): 94–99.
Published: 01 January 1997
View articletitled, Prevention of Adenocarcinoma Colon 26-induced Cachexia by Interleukin 10 Gene Transfer
Open the PDF for Prevention of Adenocarcinoma Colon 26-induced Cachexia by Interleukin 10 Gene Transfer in another window