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Journal Articles

Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities

Liang Xu, Ye Chen, Yulun Huang, Edwin Sandanaraj, John S. Yu, Ruby Yu-Tong Lin, Pushkar Dakle, Xin-Yu Ke, Yuk Kien Chong, Lynnette Koh, Anand Mayakonda, Kassoum Nacro, Jeffrey Hill, Mo-Li Huang, Sigal Gery, See Wee Lim, Zhengyun Huang, Ying Xu, Jianxiang Chen, Longchuan Bai, Shaomeng Wang, Hiroaki Wakimoto, Tseng Tsai Yeo, Beng Ti Ang, Markus Müschen, Carol Tang, Tuan Zea Tan, Phillip H. Koeffler
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2123.
https://doi.org/10.1158/1538-7445.AM2021-2123
Published: 01 July 2021
View article titled, Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities
Journal Articles

Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury

Yi Hu, Chun Yang, Tania Amorim, Mohsin Maqbool, Jenny Lin, Chen Li, Chuanfeng Fang, Li Xue, Ariel Kwart, Hua Fang, Mei Yin, Allison J. Janocha, Daisuke Tsuchimoto, Yusaku Nakabeppu, Xiaofeng Jiang, Alex Mejia-Garcia, Faiz Anwer, Jack Khouri, Xin Qi, Qing Y. Zheng, Jennifer S. Yu, Shan Yan, Thomas LaFramboise, Kenneth C. Anderson, Leal C. Herlitz, Nikhil C. Munshi, Jianhong Lin, Jianjun Zhao
Journal: Cancer Research
Cancer Res (2021) 81 (3): 713–723.
https://doi.org/10.1158/0008-5472.CAN-20-1010
Published: 01 February 2021
View article titled, Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury
Open the PDF for Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury in another window
Includes: Supplementary data
Journal Articles

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K. Mandal, Timothy McAfoos, Meredith A. Miller, Robert A. Mullinax, Michael Peoples, Vandhana Ramamoorthy, Sahil Seth, Nakia D. Spencer, Erika Suzuki, Christopher C. Williams, Simon S. Yu, Andy M. Zuniga, Giulio F. Draetta, Joseph R. Marszalek, Timothy P. Heffernan, Nancy E. Kohl, Philip Jones
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (21): 4840–4853.
https://doi.org/10.1158/0008-5472.CAN-20-1634
Published: 03 November 2020
View article titled, Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Open the PDF for Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib in another window
Includes: Supplementary data
Journal Articles

Abstract 5357: Total abdominal ultra-rapid FLASH irradiation enhances the efficacy of PD-1 inhibition in preclinical models of ovarian cancer

Stephanie Chow, Joshua T. Eggold, Karen Levy, Jinghui Wang, Rakesh Manjappa, Dylan Y. Breitkreutz, Amy S. Yu, Karl Bush, Oliver Dorigo, Billy W. Loo, Erinn B. Rankin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5357.
https://doi.org/10.1158/1538-7445.AM2020-5357
Published: 15 August 2020
View article titled, Abstract 5357: Total abdominal ultra-rapid FLASH irradiation enhances the efficacy of PD-1 inhibition in preclinical models of ovarian cancer
Journal Articles

Abstract 5351: FLASH irradiation enhances the therapeutic index of abdominal radiotherapy in mice

Suchitra Natarajan, Karen Levy, Jinghui Wang, Stephanie Chow, Joshua Eggold, Phoebe Loo, Rakesh Manjappa, Frederick M. Lartey, Emil Schüler, Lawrie Skinner, Marjan Rafat, Ryan Ko, Anna Kim, Duaa Al Rawi, Rie von Eyben, Oliver Dorigo, Kerriann M. Casey, Edward E. Graves, Karl Bush, Amy S. Yu, Albert C. Koong, Peter G. Maxim, Billy W. Loo, Erinn B. Rankin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5351.
https://doi.org/10.1158/1538-7445.AM2020-5351
Published: 15 August 2020
View article titled, Abstract 5351: FLASH irradiation enhances the therapeutic index of abdominal radiotherapy in mice
Journal Articles

Abstract 3452: hnRNPUL1 regulation by ATR in DNA damage response

Hui Zhang, PamelaSara E. Head, Duc M. Duong, Nicholas T. Seyfried, David S. Yu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3452.
https://doi.org/10.1158/1538-7445.AM2019-3452
Published: 01 July 2019
View article titled, Abstract 3452: hnRNPUL1 regulation by ATR in DNA damage response
Journal Articles

Abstract 1751: The role of SIRT2 in BRCA1 regulation

Elizabeth Minten, Hui Zhang, Chunyang Li, PamelaSara Head, David S. Yu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1751.
https://doi.org/10.1158/1538-7445.AM2019-1751
Published: 01 July 2019
View article titled, Abstract 1751: The role of SIRT2 in BRCA1 regulation
Journal Articles

Abstract 2561: DNA-PKCS deacetylation by SIRT2 promotes DNA double-strand break repair by non-homologous end joining

PamelaSara E. Head, Nagaraju P. Ganji, Shi-Ya Wang, Duc Duong, Hui Zhang, Waaqo Daddacha, Shuyi Li, Nicholas T. Seyfried, David M. Smalley, Ya Wang, Xingming Deng, William S. Dynan, Bassel El-Rayes, Anthony J. Davis, David S. Yu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2561.
https://doi.org/10.1158/1538-7445.AM2019-2561
Published: 01 July 2019
View article titled, Abstract 2561: DNA-PKCS deacetylation by SIRT2 promotes DNA double-strand break repair by non-homologous end joining
Journal Articles

Abstract 3277: IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme

Faika Mseeh, Matthew M. Hamilton, Joseph R. Marszalek, Norma E. Rogers, Connor A. Parker, Simon S. Yu, Zhen Liu, Naphtali J. Reyna, Timothy McAfoos, Brett W. Virgin-Downey, Paul G. Leonard, Jason B. Cross, Ningping Feng, Angela L. Harris, Andy M. Zuniga, Keith Mikule, Martin Tremblay, Yongying Jiang, Mikhila Mahendra, Jihai Pang, Qi Wu, Quanyun Xu, Timothy P. Heffernan, Philip Jones, Richard T. Lewis
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3277.
https://doi.org/10.1158/1538-7445.AM2019-3277
Published: 01 July 2019
View article titled, Abstract 3277: IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme
Journal Articles

Abstract P6-17-03: 24 months results from a double-blind, randomized phase III trial comparing the efficacy and safety of neoadjuvant then adjuvant trastuzumab and its biosimilar candidate CT-P6 in HER2 positive early breast cancer (EBC)

FJ Esteva, S Lee, S Yu, M Kim, N Kim, J Stebbing
Journal: Cancer Research
Cancer Res (2019) 79 (4_Supplement): P6-17-03.
https://doi.org/10.1158/1538-7445.SABCS18-P6-17-03
Published: 15 February 2019
View article titled, Abstract P6-17-03: 24 months results from a double-blind, randomized phase III trial comparing the efficacy and safety of neoadjuvant then adjuvant trastuzumab and its biosimilar candidate CT-P6 in HER2 positive early breast cancer (EBC)
Journal Articles

Abstract PD3-08: A randomized phase II trial of pyrotinib plus capecitabine versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer previously treated with taxanes, anthracyclines and/or trastuzumab

B Xu, F Ma, Q Ouyang, W Li, Z Jiang, Z Tong, Y Liu, H Li, S Yu, J Feng, S Wang, X Hu, X Zhu, J Zou
Journal: Cancer Research
Cancer Res (2018) 78 (4_Supplement): PD3-08.
https://doi.org/10.1158/1538-7445.SABCS17-PD3-08
Published: 15 February 2018
View article titled, Abstract PD3-08: A randomized phase II trial of pyrotinib plus capecitabine versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer previously treated with taxanes, anthracyclines and/or trastuzumab
Journal Articles

Abstract 3892: Delineating the role of ZEB1 loss in the chemo and radioresistance of glioma stem cells

Mecca Madany, Lincoln Edwards, John S. Yu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3892.
https://doi.org/10.1158/1538-7445.AM2017-3892
Published: 01 July 2017
View article titled, Abstract 3892: Delineating the role of ZEB1 loss in the chemo and radioresistance of glioma stem cells
Journal Articles

Abstract P2-09-10: A new oral SERD AZD9496 for treatment of hormone dependent postmenopausal breast cancer

GJ Sabnis, A Kazi, A Schech, S Yu, O Golubeva, H Weir, A Brodie
Journal: Cancer Research
Cancer Res (2017) 77 (4_Supplement): P2-09-10.
https://doi.org/10.1158/1538-7445.SABCS16-P2-09-10
Published: 15 February 2017
View article titled, Abstract P2-09-10: A new oral SERD AZD9496 for treatment of hormone dependent postmenopausal breast cancer
Journal Articles

Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling

Jianghong Man, Jocelyn D. Shoemake, Tuopu Ma, Anthony E. Rizzo, Andrew R. Godley, Qiulian Wu, Alireza M. Mohammadi, Shideng Bao, Jeremy N. Rich, Jennifer S. Yu
Journal: Cancer Research
Cancer Res (2015) 75 (8): 1760–1769.
https://doi.org/10.1158/0008-5472.CAN-14-3621
Published: 14 April 2015
View article titled, Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling
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Includes: Supplementary data
Journal Articles

CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer

Lauren E. Colbert, Aleksandra V. Petrova, Sarah B. Fisher, Brooke G. Pantazides, Matthew Z. Madden, Claire W. Hardy, Matthew D. Warren, Yunfeng Pan, Ganji P. Nagaraju, Elaine A. Liu, Burcu Saka, William A. Hall, Joseph W. Shelton, Khanjan Gandhi, Rini Pauly, Jeanne Kowalski, David A. Kooby, Bassel F. El-Rayes, Charles A. Staley, III, N. Volkan Adsay, Walter J. Curran, Jr, Jerome C. Landry, Shishir K. Maithel, David S. Yu
Journal: Cancer Research
Cancer Res (2014) 74 (10): 2677–2687.
https://doi.org/10.1158/0008-5472.CAN-13-1996
Published: 14 May 2014
View article titled, CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Abstract A33: A loss of function genetic screen identifies determinants of gemcitabine sensitivity in pancreatic cancer.

Claire W. Hardy, Brooke G. Pantazides, Khanjan Gandhi, Jerome C. Landry, Joseph W. Shelton, Shishir K. Maithel, Bassel El-Rayes, Jeanne Kowalski, David S. Yu
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A33.
https://doi.org/10.1158/1538-7445.PANCA2012-A33
Published: 03 April 2014
View article titled, Abstract A33: A loss of function genetic screen identifies determinants of gemcitabine sensitivity in pancreatic cancer.
Journal Articles

Abstract P6-06-42: Impact of molecular subtype on overall survival according to age in Korean women

A Lee, J Woo, C Yun, SY Min, Y Kim, S Yu, W Lim, N-S Paik, B-I Moon
Journal: Cancer Research
Cancer Res (2013) 73 (24_Supplement): P6-06-42.
https://doi.org/10.1158/0008-5472.SABCS13-P6-06-42
Published: 15 December 2013
View article titled, Abstract P6-06-42: Impact of molecular subtype on overall survival according to age in Korean women
Journal Articles

Abstract LB-168: A pilot clinical trial of chromodomain-helicase-DNA-binding protein 7 (CHD7) expression as a prognostic and predictive biomarker in patients with early-stage pancreatic adenocarcinoma.

Lauren E. Colbert, William A. Hall, Claire W. Hardy, Sarah B. Fisher, David S. Yu, Shishir K. Maithel, Bassel El-Rayes, Burcu Saka, N Volkan Adsay, Aleksandra Petrova, Brooke Pantazides, Jeanne Kowalski, Khanjan Gandhi, David Kooby, Charles Staley, Jerome C. Landry
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-168.
https://doi.org/10.1158/1538-7445.AM2013-LB-168
Published: 15 April 2013
View article titled, Abstract LB-168: A pilot clinical trial of chromodomain-helicase-DNA-binding protein 7 (CHD7) expression as a prognostic and predictive biomarker in patients with early-stage pancreatic adenocarcinoma.
Journal Articles

Abstract 1767: A synthetic lethal screen identifies determinants of gemcitabine sensitivity in pancreatic cancer.

Matthew D. Warren, Claire W. Hardy, Brooke G. Pantazides, Khanjan Gandhi, Jerome C. Landry, Joseph W. Shelton, Shishir K. Maithel, Bassel El-Rayes, Jeanne Kowalski, David S. Yu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1767.
https://doi.org/10.1158/1538-7445.AM2013-1767
Published: 15 April 2013
View article titled, Abstract 1767: A synthetic lethal screen identifies determinants of gemcitabine sensitivity in pancreatic cancer.
Journal Articles

Abstract 3981: Reprogramming tumor associated macrophages toward an anti-tumor phenotype by targeting the NF-κB pathway using novel targeted nanotherapeutics.

Ryan A. Ortega, Whitney Barham, Bharat Kumar, Shann S. Yu, Fiona Yull, Todd D. Giorgio
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3981.
https://doi.org/10.1158/1538-7445.AM2013-3981
Published: 15 April 2013
View article titled, Abstract 3981: Reprogramming tumor associated macrophages toward an anti-tumor phenotype by targeting the NF-κB pathway using novel targeted nanotherapeutics.