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S. John Weroha
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Journal Articles

Abstract 4739: Development of a prognostic ovarian cancer gene signature based on glucocorticoid receptor transcriptional activity

Free
Ananth V. Panchamukhi, Lei Huang, Eleanore P. Gray, Yuanhang Liu, Manisha Taya, Jennifer T. Veneris, Xiaonan Hou, S John Weroha, Balázs Győrffy, Gini F. Fleming, Chen Wang, Suzanne D. Conzen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4739.
https://doi.org/10.1158/1538-7445.AM2025-4739
Published: 21 April 2025
View articletitled, Abstract 4739: Development of a prognostic ovarian cancer gene signature based on glucocorticoid receptor transcriptional activity
Journal Articles

Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C

Open Access
Chunling Hu, Anil Belur Nagaraj, Hermela Shimelis, Gemma Montalban, Kun Y. Lee, Huaizhi Huang, Carolyn A. Lumby, Jie Na, Lisa R. Susswein, Maegan E. Roberts, Megan L. Marshall, Susan Hiraki, Holly LaDuca, Elizabeth Chao, Amal Yussuf, Tina Pesaran, Susan L. Neuhausen, Christopher A. Haiman, Peter Kraft, Sara Lindstrom, Julie R. Palmer, Lauren R. Teras, Celine M. Vachon, Song Yao, Irene Ong, Katherine L. Nathanson, Jeffrey N. Weitzel, Nicholas Boddicker, Rohan Gnanaolivu, Eric C. Polley, Georges Mer, Gaofeng Cui, Rachid Karam, Marcy E. Richardson, Susan M. Domchek, Siddhartha Yadav, Kathleen S. Hruska, Jill Dolinsky, S. John Weroha, Steven N. Hart, Jacques Simard, Jean Yves Masson, Yuan-Ping Pang, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2023) 83 (15): 2557–2571.
https://doi.org/10.1158/0008-5472.CAN-22-2319
Published: 01 August 2023
View articletitled, Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C
Open the PDF for Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C in another window
Includes: Supplementary data
Journal Articles

Abstract 5495: Combination therapy with poly (ADP-ribose) polymerase inhibitor in endometrial cancer

Free
Conway Xu, Xiaonan Hou, Erik Jessen, Chen Wang, S. John Weroha
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5495.
https://doi.org/10.1158/1538-7445.AM2023-5495
Published: 04 April 2023
View articletitled, Abstract 5495: Combination therapy with poly (ADP-ribose) polymerase inhibitor in endometrial cancer
Journal Articles

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin

Open Access
Gwo Yaw Ho, Elizabeth L. Kyran, Justin Bedo, Matthew J. Wakefield, Darren P. Ennis, Hasan B. Mirza, Cassandra J. Vandenberg, Elizabeth Lieschke, Andrew Farrell, Anthony Hadla, Ratana Lim, Genevieve Dall, James E. Vince, Ngee Kiat Chua, Olga Kondrashova, Rosanna Upstill-Goddard, Ulla-Maja Bailey, Suzanne Dowson, Patricia Roxburgh, Rosalind M. Glasspool, Gareth Bryson, Andrew V. Biankin, for the Scottish Genomes Partnership, Susanna L. Cooke, Gayanie Ratnayake, Orla McNally, Nadia Traficante, for the Australian Ovarian Cancer Study12,13, Anna DeFazio, S. John Weroha, David D. Bowtell, Iain A. McNeish, Anthony T. Papenfuss, Clare L. Scott, Holly E. Barker
Journal: Cancer Research
Cancer Res (2022) 82 (23): 4457–4473.
https://doi.org/10.1158/0008-5472.CAN-21-4012
Published: 02 December 2022
View articletitled, Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Open the PDF for Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin in another window
Includes: Supplementary data
Journal Articles

Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer

Open Access
Upasana Ray, Deok-Beom Jung, Ling Jin, Yinan Xiao, Subramanyam Dasari, Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Julie K. Staub, Debarshi Roy, Bhaskar Roy, S. John Weroha, Xiaonan Hou, James W. Purcell, Jamie N. Bakkum-Gamez, Scott H. Kaufmann, Nagarajan Kannan, Anirban K. Mitra, Viji Shridhar
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1038–1054.
https://doi.org/10.1158/0008-5472.CAN-21-0622
Published: 15 March 2022
View articletitled, Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma

Open Access
Arun Kanakkanthara, Xiaonan Hou, Thomas L. Ekstrom, Valentina Zanfagnin, Amelia M. Huehls, Rebecca L. Kelly, Husheng Ding, Melissa C. Larson, George Vasmatzis, Ann L. Oberg, Scott H. Kaufmann, Aaron S. Mansfield, S. John Weroha, Larry M. Karnitz
Journal: Cancer Research
Cancer Res (2022) 82 (2): 307–319.
https://doi.org/10.1158/0008-5472.CAN-21-0732
Published: 15 January 2022
View articletitled, Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma
Open the PDF for Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma in another window
Includes: Supplementary data
Journal Articles

Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma

Free
Ksenija Nesic, Olga Kondrashova, Rachel M. Hurley, Cordelia D. McGehee, Cassandra J. Vandenberg, Gwo-Yaw Ho, Elizabeth Lieschke, Genevieve Dall, Nirashaa Bound, Kristy Shield-Artin, Marc Radke, Ashan Musafer, Zi Qing Chai, Mohammad Reza Eftekhariyan Ghamsari, Maria I. Harrell, Damien Kee, Inger Olesen, Orla McNally, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D.L. Bowtell, Elizabeth M. Swisher, S. John Weroha, Katia Nones, Nicola Waddell, Scott H. Kaufmann, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4709–4722.
https://doi.org/10.1158/0008-5472.CAN-21-0774
Published: 15 September 2021
View articletitled, Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma
Open the PDF for Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1426: Multiomic analysis identifies CPT1A and fatty acid oxidation as a potential therapeutic target in platinum-refractory high grade serous ovarian cancer

Free
Hong Wang, Dongqing Hugang, Shrabanti Chowdhury, Sara Savage, Richard Ivey, Jacob Kennedy, Jeffrey Whiteaker, Chenwei Lin, Xiaonan Hou, Catherine Huntoon, Uliana Voytovich, Zahra Shire, Qing Yu, Steven Gygi, Andrew Hoofnagle, Zachary Herbert, Anna Calinawan, Larry Karnitz, S. John Weroha, Scott Kaufmann, Bing Zhang, Pei Wang, Michael Birrer, Amanda Paulovich
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1426.
https://doi.org/10.1158/1538-7445.AM2021-1426
Published: 01 July 2021
View articletitled, Abstract 1426: Multiomic analysis identifies CPT1A and fatty acid oxidation as a potential therapeutic target in platinum-refractory high grade serous ovarian cancer
Journal Articles

Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

Available to Purchase
Ki Hyun Yoo, Jason J. Tang, Mohammad Abdur Rashid, Chang Hoon Cho, Ana Corujo-Ramirez, Jonghoon Choi, Mun Gyeong Bae, Danielle Brogren, John R. Hawse, Xiaonan Hou, S. John Weroha, Alfredo Oliveros, Lindsey A. Kirkeby, Joseph A. Baur, Mi-Hyeon Jang
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3727–3737.
https://doi.org/10.1158/0008-5472.CAN-20-3290
Published: 01 July 2021
View articletitled, Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments
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Includes: Supplementary data
Journal Articles

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma

Available to Purchase
Zhiwei Dong, Kok Siong Yeo, Gonzalo Lopez, Cheng Zhang, Erin N. Dankert Eggum, Jo Lynne Rokita, Choong Yong Ung, Taylor M. Levee, Zuag Paj Her, Cassie J. Howe, Xiaonan Hou, Janine H. van Ree, Shuai Li, Shuning He, Ting Tao, Karen Fritchie, Jorge Torres-Mora, Julia S. Lehman, Alexander Meves, Gina L. Razidlo, Komal S. Rathi, S. John Weroha, A. Thomas Look, Jan M. van Deursen, Hu Li, Jennifer J. Westendorf, John M. Maris, Shizhen Zhu
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2995–3007.
https://doi.org/10.1158/0008-5472.CAN-20-1890
Published: 01 June 2021
View articletitled, GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma
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Includes: Supplementary data
Journal Articles

BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents

Available to Purchase
Arun Kanakkanthara, Kiran Kurmi, Thomas L. Ekstrom, Xiaonan Hou, Emma R. Purfeerst, Ethan P. Heinzen, Cristina Correia, Catherine J. Huntoon, Daniel O'Brien, Andrea E. Wahner Hendrickson, Sean C. Dowdy, Hu Li, Ann L. Oberg, Taro Hitosugi, Scott H. Kaufmann, S. John Weroha, Larry M. Karnitz
Journal: Cancer Research
Cancer Res (2019) 79 (23): 5920–5929.
https://doi.org/10.1158/0008-5472.CAN-19-1405
Published: 02 December 2019
View articletitled, BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents
Open the PDF for BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents in another window
Includes: Supplementary data
Journal Articles

Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance

Free
Rachel M. Hurley, Ksenija Nesic, Cordelia McGehee, Olga Kondrashova, Maria I. Harrell, Paula A. Schneider, Xiaonan Hou, Cristina Correia, Karen S. Flatten, Giada V. Zapparoli, Alexander Dobrovic, Kevin K. Lin, Thomas C. Harding, Andrea E. Wahner Hendrickson, Elizabeth M. Swisher, Matthew Wakefield, S. John Weroha, Clare L. Scott, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5885.
https://doi.org/10.1158/1538-7445.AM2018-5885
Published: 01 July 2018
View articletitled, Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance
Journal Articles

Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion

Free
Yinhui Yang, Alexandra M. Blee, Dejie Wang, Jian An, Yunqian Pan, Yuqian Yan, Tao Ma, Yundong He, Joseph Dugdale, Xiaonan Hou, Jun Zhang, S. John Weroha, Wei-Guo Zhu, Y. Alan Wang, Ronald A. DePinho, Wanhai Xu, Haojie Huang
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (23): 6524–6537.
https://doi.org/10.1158/0008-5472.CAN-17-0686
Published: 30 November 2017
View articletitled, Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion
Open the PDF for Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion in another window
Includes: Supplementary data
Journal Articles

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Free
Terrence F. Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A. Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A. Wiser, Patrick Dunn, Dale A. Begley, Debra M. Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H. Brush, Annette T. Byrne, Carlos Caldas, Amanda L. Christie, Dominic A. Clark, Heidi Dowst, Jonathan R. Dry, James H. Doroshow, Olivier Duchamp, Yvonne A. Evrard, Stephane Ferretti, Kristopher K. Frese, Neal C. Goodwin, Danielle Greenawalt, Melissa A. Haendel, Els Hermans, Peter J. Houghton, Jos Jonkers, Kristel Kemper, Tin O. Khor, Michael T. Lewis, K.C. Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B. Neuhauser, James M. Olson, Daniel S. Peeper, Oscar M. Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J. Wechsler-Reya, David M. Weinstock, Alana Welm, S. John Weroha, Frédéric Amant, Stefan M. Pfister, Marcel Kool, Helen Parkinson, Atul J. Butte, Carol J. Bult
Journal: Cancer Research
Cancer Res (2017) 77 (21): e62–e66.
https://doi.org/10.1158/0008-5472.CAN-17-0582
Published: 01 November 2017
View articletitled, PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
Open the PDF for PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 3274: Development of a clinically relevant in vivo model of ovarian cancer tumorgrafts in immunodeficient mice

Free
Sergio Enderica Gonzalez, S. John Weroha, Marc Becker, Sean Harrington, Xiaonan Hou, Paul Haluska
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3274.
https://doi.org/10.1158/1538-7445.AM2012-3274
Published: 15 April 2012
View articletitled, Abstract 3274: Development of a clinically relevant in vivo model of ovarian cancer tumorgrafts in immunodeficient mice
Journal Articles

Overexpression of cyclin D1, D3, E1, and associated cdk2/4 kinases in premalignant stages and primary breast tumors induced solely by estrogen in female ACI rats

Free
S. John Weroha, Jonathan J. Li, Sara A. Li
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 493.
Published: 01 May 2005
View articletitled, Overexpression of cyclin D1, D3, E1, and associated cdk2/4 kinases in premalignant stages and primary breast tumors induced solely by estrogen in female ACI rats
Journal Articles

Estrogen mediates Aurora A kinase overexpression, centrosome amplification, chromosomal instability, and oncogenesis in female ACI rat mammary glands

Free
Jonathan J. Li, S. John Weroha, Wilma L. Lingle, Jeffrey L. Salisbury, Sara A. Li
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 2.
Published: 01 April 2004
View articletitled, Estrogen mediates Aurora A kinase overexpression, centrosome amplification, chromosomal instability, and oncogenesis in female ACI rat mammary glands