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Journal Articles

Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer

Daniel Westaby, Juan M. Jimenez-Vacas, Ines Figueiredo, Claire Pettinger, Bora Gurel, Denisa Bogdan, Jan Rekowski, Lorenzo Buroni, Antje Neeb, Ruth Riisnaes, Mateus Crespo, Susana Miranda, Ana Ferreira, Daniel Nava Rodrigues, George Seed, Claudia Bertan, Maria de los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Rafael Grochot, Khobe Chandran, Andreas Varkaris, Steven P. Balk, Wei Yuan, Suzanne Carreira, Peter S. Nelson, Michael Haffner, Eva Corey, Johann de Bono, Adam Sharp
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B020.
https://doi.org/10.1158/1538-7445.PRCA2023-B020
Published: 02 June 2023
View article titled, Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer
Journal Articles

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

Marta J. Llorca-Cardenosa, Lauren I. Aronson, Dragomir B. Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T. Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros Roumeliotis, Jyoti Choudhary, Stephen J. Pettitt, Johann de Bono, Andres Cervantes, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Irene Y. Chong
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3962–3973.
https://doi.org/10.1158/0008-5472.CAN-21-4339
Published: 02 November 2022
View article titled, SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Open the PDF for SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract 2807: HER3 is an actionable target in advanced prostate cancer

Susana Miranda, Veronica Gil, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, SU2C/PCF International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2807.
https://doi.org/10.1158/1538-7445.AM2022-2807
Published: 15 June 2022
View article titled, Abstract 2807: HER3 is an actionable target in advanced prostate cancer
Journal Articles

JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

Alec Paschalis, Jonathan Welti, Antje J. Neeb, Wei Yuan, Ines Figueiredo, Rita Pereira, Ana Ferreira, Ruth Riisnaes, Daniel Nava Rodrigues, Juan M. Jiménez-Vacas, Soojin Kim, Takuma Uo, Patrizio Di Micco, Anthony Tumber, Md. Saiful Islam, Marc A. Moesser, Martine Abboud, Akane Kawamura, Bora Gurel, Rossitza Christova, Veronica S. Gil, Lorenzo Buroni, Mateus Crespo, Susana Miranda, Maryou B. Lambros, Suzanne Carreira, Nina Tunariu, Andrea Alimonti, Bissan Al-Lazikani, Christopher J. Schofield, Stephen R. Plymate, Adam Sharp, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1087–1100.
https://doi.org/10.1158/0008-5472.CAN-20-1807
Published: 15 February 2022
View article titled, JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer
Open the PDF for JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

HER3 Is an Actionable Target in Advanced Prostate Cancer

Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, PCF/SU2C International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6207–6218.
https://doi.org/10.1158/0008-5472.CAN-21-3360
Published: 15 December 2021
View article titled, HER3 Is an Actionable Target in Advanced Prostate Cancer
Open the PDF for HER3 Is an Actionable Target in Advanced Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract CT161: A homologous recombination repair (HRR) functional assay to stratify patients with metastatic prostate cancer for PARP inhibitor treatment in the TOPARP-B clinical trial

Sara Arce-Gallego, Alba Llop-Guevara, Suzanne Carreira, Nuria Porta, Roberta Fasani, Diletta Bianchini, George Seed, Pasquale Rescigno, Alec Paschalis, Claudia Bertan, Chloe Baker, Jane Goodall, Susana Miranda, Ruth Riisnaes, Ines Figueiredo, Ana Ferreira, Rita Pereira, Bora Gurel, Daniel Nava Rodrigues, Wei Yuan, Jan Rekowski, Emma Hall, Violeta Serra, Johann S. de Bono, Joaquin Mateo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT161.
https://doi.org/10.1158/1538-7445.AM2021-CT161
Published: 01 July 2021
View article titled, Abstract CT161: A homologous recombination repair (HRR) functional assay to stratify patients with metastatic prostate cancer for PARP inhibitor treatment in the TOPARP-B clinical trial
Journal Articles

Abstract LB035: B7-H3 as a therapeutic target in prostate cancer

Christina Guo, Ines Figueiredo, Bora Gurel, Matues Crespo, Jan Rekowski, Suzanne Carreira, Antje Neeb, Adam Sharp, Maria D. Fenor de la Maza, Pasquale Rescigno, Khobe Chandran, Ana Ferreira, Ruth Riisnaes, Susana Miranda, Rita Pereira, Veronica Gil, George Seed, Claudia Bertan, Chloe Baker, Wei Yuan, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB035.
https://doi.org/10.1158/1538-7445.AM2021-LB035
Published: 01 July 2021
View article titled, Abstract LB035: B7-H3 as a therapeutic target in prostate cancer
Journal Articles

Abstract CT120: Results of the glioblastoma multiforme (GBM) cohort of phase 1 trial Ice-CAP (NCT03673787): Preliminary evidence of antitumour activity of Ipatasertib (Ipa) and Atezolizumab (A) in patients (pts) with PTEN loss

Crescens Tiu, Andrea Biondo, Liam C. Welsh, Timothy L. Jones, Anna Zachariou, Toby Prout, Alison J. Turner, Robert Daly, Igor Vivanco, Christina Yap, Ben Jenkins, Mateus Crespo, Ruth Riisnaes, Suzanne Carreira, Bora Gurel, Nina Tunariu, Anna Minchom, Udai Banerji, Johann S. de Bono, Juanita S. Lopez
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT120.
https://doi.org/10.1158/1538-7445.AM2021-CT120
Published: 01 July 2021
View article titled, Abstract CT120: Results of the glioblastoma multiforme (GBM) cohort of phase 1 trial Ice-CAP (NCT03673787): Preliminary evidence of antitumour activity of Ipatasertib (Ipa) and Atezolizumab (A) in patients (pts) with PTEN loss
Journal Articles

Abstract LB-075: CDK12-mutated lethal prostate cancers: How hot are these tumors

Bora Gurel, Pasquale Rescigno, Wei Yuan, Rita Pereira, Mateus Crespo, Mattia Rediti, Ines Figueiredo, Maialen Barrero, Diletta Bianchini, Maria D. Fenor de la Maza, Khobe Chandran, Juliet Carmichael, Alec Paschalis, Adam Sharp, George Seed, Ruth Riisnaes, Claudia Bertan, Suzanne Carreira, Johann S. De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-075.
https://doi.org/10.1158/1538-7445.AM2020-LB-075
Published: 15 August 2020
View article titled, Abstract LB-075: CDK12-mutated lethal prostate cancers: How hot are these tumors
Journal Articles

Abstract CT143: Phase I study of the combination of a RAF-MEK inhibitor CH5126766 and FAK inhibitor defactinib in an intermittent dosing schedule with expansions in KRAS mutant cancers

Rajiv Shinde, Angelika Terbuch, Martin Little, Reece Caldwell, Roopa Kurup, Ruth Riisnaes, Mateus Crespo, Ruth Ruddle, Bora Gurel, Adam Stewart, Jenny King, Mona Parmar, Alison Turner, Florence Raynaud, Muneeb Mahmud, Christina Yap, Jonathan A. Pachter, Gordon B. Mills, Anna Minchom, Juanita Lopez, Susana N. Banerjee, Johann S. de Bono, Matthew Krebs, Udai Banerji
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT143.
https://doi.org/10.1158/1538-7445.AM2020-CT143
Published: 15 August 2020
View article titled, Abstract CT143: Phase I study of the combination of a RAF-MEK inhibitor CH5126766 and FAK inhibitor defactinib in an intermittent dosing schedule with expansions in <em>KRAS</em> mutant cancers
Journal Articles

Abstract CT129: HyPeR: A phase 1, dose escalation and expansion trial of guadecitabine (SGI-110), a second-generation hypomethylating agent in combination with pembrolizumab (MK3475) in patients with refractory solid tumors

Dionysis Papadatos-Pastos, Abhijit Pal, Melek Akay, Malaka Ameratunga, Sanjena Mithra, Joo-Ern Ang, Sofia Levva, Reece Caldwell, Ruth Riisnaes, Mateus Crespo, Wei Yuan, George Seed, Bora Gurel, Ines Figueiredo, Rita Pereira, Susana Miranda, Anna Ferreira, Suzanne Carreira, Claudia Bertan, Chloe Baker, Ricardo Morilla, Robert Brown, Nahal Masrour, Toby Prout, Anna Zachariou, Alison Turner, Mona Parmar, Mark Van de Velde, Ben Jenkins, Christina Yap, Nina Tunariu, Udai Banerji, Juanita Lopez, Anna Minchom, Johann De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT129.
https://doi.org/10.1158/1538-7445.AM2020-CT129
Published: 15 August 2020
View article titled, Abstract CT129: HyPeR: A phase 1, dose escalation and expansion trial of guadecitabine (SGI-110), a second-generation hypomethylating agent in combination with pembrolizumab (MK3475) in patients with refractory solid tumors
Journal Articles

Abstract CT140: Proof-of-concept evidence of immune modulation by blockade of the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway in the phase I dose escalation study of Ipatasertib (Ipa) in combination with atezolizumab (A) in patients (pts) with advanced solid tumors (Ice-CAP)

Juanita S. Lopez, Andrea Biondo, Crescens Tiu, Mariana Scaranti, Malaka Ameratunga, Anna Zachariou, Alison Turner, Nina Tunariu, Toby Prout, Mona Parmar, Hannah Badham, Karen Swales, Wei Yuan, Ricardo Morilla, Mateus Crespo, Rob Daly, Ines Figueiredo, Bora Gurel, Rita Pereira, Ruth Riisnaes, Igor Vivanco, Anna Minchom, Ben Jenkins, Christina Yap, Udai Banerji, Johann De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT140.
https://doi.org/10.1158/1538-7445.AM2020-CT140
Published: 15 August 2020
View article titled, Abstract CT140: Proof-of-concept evidence of immune modulation by blockade of the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway in the phase I dose escalation study of Ipatasertib (Ipa) in combination with atezolizumab (A) in patients (pts) with advanced solid tumors (Ice-CAP)
Journal Articles

Abstract 4679: Mismatch repair defects in lethal prostate cancer

Pasquale Rescigno, Daniel Nava Rodrigues, Wei Yuan, Suzanne Carreira, Maryou Lambros, George Seed, Ruth Riisnaes, Susana Miranda, David Dolling, Matthew Clarke, Mateus Crespo, Claudia Bertan, Gunther Boysen, Joaquin Mateo, Ana Ferreira, Adam Sharp, Ines Figueiredo, Semini Sumanasuriya, Mariane Sousa Fontes, Diletta Bianchini, Zafeiris Zafeiriou, Johann Sebastian de Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4679.
https://doi.org/10.1158/1538-7445.AM2017-4679
Published: 01 July 2017
View article titled, Abstract 4679: Mismatch repair defects in lethal prostate cancer
Journal Articles

Abstract LB-044: Copy number estimation from targeted amplicon-based next-generation sequencing of castration-resistant prostate cancer biopsies: analytic validation and clinical qualification for a iPARP clinical trial

George Seed, Wei Yuan, Joaquin Mateo, Suzanne Carreira, Maryou Lambros, Gunther Boysen, Roberta Ferraldeschi, Susana Miranda, Ines Figueiredo, Ruth Riisnaes, Mateus Crespo, Daniel Nava Rodrigues, Eric Talevich, Dan Robinson, Priya Kunju, Yi-mi Wu, Robert Lonigro, Shahneen Sandhu, Arul Chinnayan, Johann De Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-044.
https://doi.org/10.1158/1538-7445.AM2017-LB-044
Published: 01 July 2017
View article titled, Abstract LB-044: Copy number estimation from targeted amplicon-based next-generation sequencing of castration-resistant prostate cancer biopsies: analytic validation and clinical qualification for a iPARP clinical trial
Journal Articles

Abstract 4965: Analytic validation and clinical qualification of a novel immunohistochemical assay for AR-V7 protein expression in metastatic prostate cancer

Daniel Nava Rodrigues, Jon Welti, Adam Sharp, Shihua Sun, Ruth Riisnaes, Ines Figueiredo, Zafeiris Zafeiriou, Pasquale Rescigno, Johann S. de Bono, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4965.
https://doi.org/10.1158/1538-7445.AM2016-4965
Published: 15 July 2016
View article titled, Abstract 4965: Analytic validation and clinical qualification of a novel immunohistochemical assay for AR-V7 protein expression in metastatic prostate cancer
Journal Articles

Abstract 4976: Monitoring CHD1 during prostate cancer progression

Gunther Boysen, Daniel Nava Rodrigues, Joaquin Mateo, Rossitza Christova, Ruth Riisnaes, Mateus Crespo, Theresa MacDonald, Susana Miranda, Ines Figueiredo, Veronica Gil, Sara Aziz, Adam Sharp, Niven Mehra, Pasquale Rescigno, Juan M. Mosquera, Christopher E. Barbieri, Mark A. Rubin, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4976.
https://doi.org/10.1158/1538-7445.AM2016-4976
Published: 15 July 2016
View article titled, Abstract 4976: Monitoring CHD1 during prostate cancer progression
Journal Articles

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells

Roberta Ferraldeschi, Jonathan Welti, Marissa V. Powers, Wei Yuan, Tomoko Smyth, George Seed, Ruth Riisnaes, Somaieh Hedayat, Hannah Wang, Mateus Crespo, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Suzanne Carreira, John F. Lyons, Swee Sharp, Stephen R. Plymate, Gerhardt Attard, Nicola Wallis, Paul Workman, Johann S. de Bono
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (9): 2731–2742.
https://doi.org/10.1158/0008-5472.CAN-15-2186
Published: 01 May 2016
View article titled, Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells
Open the PDF for Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells in another window
Journal Articles

Abstract 4819: Evaluation of PTEN status in circulating tumor cells (CTCs) and matched tumor tissue from castrate-resistant prostate cancer (CRPC) patients

Elizabeth Punnoose, Eric Tucker, Edith Szafer-Glusman, Jin Zhu, Dena Marrinucci, Jessica Louw, Florence Lee, Mikel Kitchen, Natalee Bales, Lukas Amler, Hartmut Koeppen, Premal Patel, Yibing Yan, Ruth Riisnaes, Gerhardt Attard, Johann de Bono
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4819.
https://doi.org/10.1158/1538-7445.AM2014-4819
Published: 01 October 2014
View article titled, Abstract 4819: Evaluation of PTEN status in circulating tumor cells (CTCs) and matched tumor tissue from castrate-resistant prostate cancer (CRPC) patients
Journal Articles

Abstract 2433: In vitro and in vivo antitumor activity of the next generation HSP90 inhibitor, AT13387, in both hormone-sensitive and castration-resistant prostate cancer models.

Roberta Ferraldeschi, Somaieh Hedayat, Tomoko Smyth, Nicola Wallis, John Lyons, Ruth Riisnaes, Mateus Crespo, Daniel Nava Rodrigues, Susana Miranda, Swee Sharp, Gerhardt Attard, Suzanne Eccles, Paul Workman, Johann de Bono
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2433.
https://doi.org/10.1158/1538-7445.AM2013-2433
Published: 15 April 2013
View article titled, Abstract 2433: <em>In vitro</em> and <em>in vivo</em> antitumor activity of the next generation HSP90 inhibitor, AT13387, in both hormone-sensitive and castration-resistant prostate cancer models.
Journal Articles

Abstract 3072: Prospective study of genetic mutations in matched tumor and plasma specimens in advanced cancer patients referred to phase I trials

Geraldine Perkins, Juliet Dukes, Lorna Pope, Jeremy Clark, Timothy Anthony Yap, Ruth Riisnaes, Amy Cassidy, Katie Ann Denholm, Stan Kaye, Johann Sebastian De Bono
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3072.
https://doi.org/10.1158/1538-7445.AM2011-3072
Published: 15 April 2011
View article titled, Abstract 3072: Prospective study of genetic mutations in matched tumor and plasma specimens in advanced cancer patients referred to phase I trials