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Journal Articles

Abstract 4388: Tumor-associated RhoA mutants interact with effectors in both GDP- and GTP-bound states

Yuan Lin, Theresa A. Ramelot, Simge Senyuz, Attila Gursoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng

Cancer Res (2024) 84 (6_Supplement): 4388.

https://doi.org/10.1158/1538-7445.AM2024-4388

Published: 22 March 2024

View articletitled, Abstract 4388: Tumor-associated RhoA mutants interact with effectors in both GDP- and GTP-bound states

Journal Articles

Abstract 873: The mechanisms of SHP2 activation in cancer and neurodevelopmental disorder

Yonglan Liu, Mingzhen Zhang, Wengang Zhang, Hyunbum Jang, Ruth Nussinov

Cancer Res (2023) 83 (7_Supplement): 873.

https://doi.org/10.1158/1538-7445.AM2023-873

Published: 04 April 2023

View articletitled, Abstract 873: The mechanisms of SHP2 activation in cancer and neurodevelopmental disorder

Journal Articles

Abstract 872: Deciphering the activation mechanism of CDK4/cyclin-D complex that differs from the CDK2/cyclin-E complex

Wengang Zhang, Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov

Cancer Res (2023) 83 (7_Supplement): 872.

https://doi.org/10.1158/1538-7445.AM2023-872

Published: 04 April 2023

View articletitled, Abstract 872: Deciphering the activation mechanism of CDK4/cyclin-D complex that differs from the CDK2/cyclin-E complex

Journal Articles

Abstract 3845: Structural mechanisms of how PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

Hyunbum Jang, Jiaye Chen, Lilia M. Iakoucheva, Ruth Nussinov

Cancer Res (2023) 83 (7_Supplement): 3845.

https://doi.org/10.1158/1538-7445.AM2023-3845

Published: 04 April 2023

View articletitled, Abstract 3845: Structural mechanisms of how PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

Journal Articles

Abstract 2085: Structural principles of kinase-selectivity drug design

Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov

Cancer Res (2023) 83 (7_Supplement): 2085.

https://doi.org/10.1158/1538-7445.AM2023-2085

Published: 04 April 2023

View articletitled, Abstract 2085: Structural principles of kinase-selectivity drug design

Journal Articles

A New View of Activating Mutations in Cancer

Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang

Cancer Res (2022) 82 (22): 4114–4123.

https://doi.org/10.1158/0008-5472.CAN-22-2125

Published: 15 November 2022

View articletitled, A New View of Activating Mutations in Cancer

Journal Articles

Abstract 148: New conformational details help in clarifying Raf activation by dimerization

Mingzhen Zhang, Ryan Maloney, Hyunbum Jang, Ruth Nussinov

Cancer Res (2022) 82 (12_Supplement): 148.

https://doi.org/10.1158/1538-7445.AM2022-148

Published: 15 June 2022

View articletitled, Abstract 148: New conformational details help in clarifying Raf activation by dimerization

Journal Articles

Abstract 2919: The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia

Yonglan Liu, Hyunbum Jang, Mingzhen Zhang, Chung-Jung Tsai, Ryan Maloney, Ruth Nussinov

Cancer Res (2022) 82 (12_Supplement): 2919.

https://doi.org/10.1158/1538-7445.AM2022-2919

Published: 15 June 2022

View articletitled, Abstract 2919: The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia

Journal Articles

Abstract 2918: Comprehensive survey of KRas4B membrane interaction and orientation

Hyunbum Jang, Mingzhen Zhang, Vadim Gaponenko, Ruth Nussinov

Cancer Res (2022) 82 (12_Supplement): 2918.

https://doi.org/10.1158/1538-7445.AM2022-2918

Published: 15 June 2022

View articletitled, Abstract 2918: Comprehensive survey of KRas4B membrane interaction and orientation

Journal Articles

Abstract 2270: Membrane organization of KRas4B with regulatory domain of Raf-1

Hyunbum Jang, Mingzhen Zhang, Ruth Nussinov

Cancer Res (2021) 81 (13_Supplement): 2270.

https://doi.org/10.1158/1538-7445.AM2021-2270

Published: 01 July 2021

View articletitled, Abstract 2270: Membrane organization of KRas4B with regulatory domain of Raf-1

Journal Articles

Abstract 2302: The mechanism of activation of monomeric B-Raf V600E

Ryan C. Maloney, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov

Cancer Res (2021) 81 (13_Supplement): 2302.

https://doi.org/10.1158/1538-7445.AM2021-2302

Published: 01 July 2021

View articletitled, Abstract 2302: The mechanism of activation of monomeric B-Raf V600E

Journal Articles

Abstract 2301: Atomic-level insights into PI3K activation

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov

Cancer Res (2021) 81 (13_Supplement): 2301.

https://doi.org/10.1158/1538-7445.AM2021-2301

Published: 01 July 2021

View articletitled, Abstract 2301: Atomic-level insights into PI3K activation

Journal Articles

Survivin Expression Is Differentially Regulated by a Selective Cross-talk between RBM38 and miRNAs let-7b or miR-203a

Christopher A. Lucchesi, Jin Zhang, Buyong Ma, Ruth Nussinov, Xinbin Chen

Cancer Res (2021) 81 (7): 1827–1839.

https://doi.org/10.1158/0008-5472.CAN-20-3157

Published: 01 April 2021

View articletitled, Survivin Expression Is Differentially Regulated by a Selective Cross-talk between RBM38 and miRNAs let-7b or miR-203a

Includes: Supplementary data

Journal Articles

PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov

Cancer Res (2021) 81 (2): 237–247.

https://doi.org/10.1158/0008-5472.CAN-20-0911

Published: 15 January 2021

View articletitled, PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective

Journal Articles

Abstract 3397: The mechanism of PI3K activation at the atomic level

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov

Cancer Res (2019) 79 (13_Supplement): 3397.

https://doi.org/10.1158/1538-7445.AM2019-3397

Published: 01 July 2019

View articletitled, Abstract 3397: The mechanism of PI3K activation at the atomic level

Journal Articles

Abstract 5145: A new discovering motif on SOS1 PR domain clues Grb2-SOS1 association

Tsung-Jen Liao, Hyunbum Jang, Ruth Nussinov, David Fushman

Cancer Res (2019) 79 (13_Supplement): 5145.

https://doi.org/10.1158/1538-7445.AM2019-5145

Published: 01 July 2019

View articletitled, Abstract 5145: A new discovering motif on SOS1 PR domain clues Grb2-SOS1 association

Journal Articles

Abstract 2763: Raf-1 cysteine-rich domain (CRD) promotes active KRas4B membrane orientation facilitating dimerization through the allosteric lobe interface

Hyunbum Jang, Ruth Nussinov

Cancer Res (2019) 79 (13_Supplement): 2763.

https://doi.org/10.1158/1538-7445.AM2019-2763

Published: 01 July 2019

View articletitled, Abstract 2763: Raf-1 cysteine-rich domain (CRD) promotes active KRas4B membrane orientation facilitating dimerization through the allosteric lobe interface

Journal Articles

Abstract 678: Raf-1 cysteine-rich domain (CRD) supports active orientations of KRas4B/Raf-1 at the membrane

Hyunbum Jang, Ruth Nussinov

Cancer Res (2018) 78 (13_Supplement): 678.

https://doi.org/10.1158/1538-7445.AM2018-678

Published: 01 July 2018

View articletitled, Abstract 678: Raf-1 cysteine-rich domain (CRD) supports active orientations of KRas4B/Raf-1 at the membrane

Journal Articles

Abstract 682: The mechanism of PI3Kα activation by SH2 release

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov

Cancer Res (2018) 78 (13_Supplement): 682.

https://doi.org/10.1158/1538-7445.AM2018-682

Published: 01 July 2018

View articletitled, Abstract 682: The mechanism of PI3Kα activation by SH2 release

Journal Articles

Abstract 683: SOS1 allosterically linked conformational changes modulate KRas4B activation

Tsung-Jen Liao, Hyunbum Jang, David Fushman, Ruth Nussinov

Cancer Res (2018) 78 (13_Supplement): 683.

https://doi.org/10.1158/1538-7445.AM2018-683

Published: 01 July 2018

View articletitled, Abstract 683: SOS1 allosterically linked conformational changes modulate KRas4B activation

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Abstract 4388: Tumor-associated RhoA mutants interact with effectors in both GDP- and GTP-bound states

Abstract 873: The mechanisms of SHP2 activation in cancer and neurodevelopmental disorder

Abstract 872: Deciphering the activation mechanism of CDK4/cyclin-D complex that differs from the CDK2/cyclin-E complex

Abstract 3845: Structural mechanisms of how PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

Abstract 2085: Structural principles of kinase-selectivity drug design

A New View of Activating Mutations in Cancer

Abstract 148: New conformational details help in clarifying Raf activation by dimerization

Abstract 2919: The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia

Abstract 2918: Comprehensive survey of KRas4B membrane interaction and orientation

Abstract 2270: Membrane organization of KRas4B with regulatory domain of Raf-1

Abstract 2302: The mechanism of activation of monomeric B-Raf V600E

Abstract 2301: Atomic-level insights into PI3K activation

Survivin Expression Is Differentially Regulated by a Selective Cross-talk between RBM38 and miRNAs let-7b or miR-203a

PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective

Abstract 3397: The mechanism of PI3K activation at the atomic level

Abstract 5145: A new discovering motif on SOS1 PR domain clues Grb2-SOS1 association

Abstract 2763: Raf-1 cysteine-rich domain (CRD) promotes active KRas4B membrane orientation facilitating dimerization through the allosteric lobe interface

Abstract 678: Raf-1 cysteine-rich domain (CRD) supports active orientations of KRas4B/Raf-1 at the membrane

Abstract 682: The mechanism of PI3Kα activation by SH2 release

Abstract 683: SOS1 allosterically linked conformational changes modulate KRas4B activation

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