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Rossana Trotta
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Journal Articles

Abstract 3338: Concurrent treatment with Pim kinase inhibitor enhances efficacy of FLT3 inhibitors in AML with FLT3-ITD through GSK-3βactivation and GSK-3β-mediated enhanced proteasomal degradation of c-Myc and Mcl-1

Jonelle Lee, Mario Scarpa, Aditi Chatterjee, Mooath Mustafa Ali, Prerna Singh, Shivani Kapoor, Rossana Trotta, Maria Baer
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3338.
https://doi.org/10.1158/1538-7445.AM2022-3338
Published: 15 June 2022
View article titled, Abstract 3338: Concurrent treatment with Pim kinase inhibitor enhances efficacy of FLT3 inhibitors in AML with FLT3-ITD through GSK-3βactivation and GSK-3β-mediated enhanced proteasomal degradation of c-Myc and Mcl-1
Journal Articles

Abstract 4736: Bone marrow microenvironment-induced miR-300 expression impairs natural killer cell proliferation and antitumor activity

Rossana Trotta, Giovannino Silvestri, Lorenzo Stramucci, Martin Guimond, Guido Marcucci, Xiaoxuan Fan, Maria R. Baer, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4736.
https://doi.org/10.1158/1538-7445.AM2018-4736
Published: 01 July 2018
View article titled, Abstract 4736: Bone marrow microenvironment-induced miR-300 expression impairs natural killer cell proliferation and antitumor activity
Journal Articles

Abstract 1134: The tumor suppressor activity of miR-300 is detrimental for leukemia development but required for leukemia stem cell maintenance

Giovannino Silvestri, Lorenzo Stramucci, Justin Ellis, Jason Harb, Paolo Neviani, Bin Zhang, Klara Srutova, Gabriel Pineda, Catriona Jamieson, Bruno Calabretta, Fabio Stagno, Paolo Vigneri, Georgios Nteliopoulos, Philippa May, Alistar Reid, Ramiro Garzon, Denis-Claude Roy, Martin Guimond, Peter Hokland, Michael Deininger, Garrett Fitzgerald, Chris Harman, Francesco Dazzi, Dragana Milojkovic, Jane Apperley, Guido Marcucci, Jianfei Qi, Katerina Machova-Polakova, Xiaoxuan Fan, Maria Baer, Rossana Trotta, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1134.
https://doi.org/10.1158/1538-7445.AM2018-1134
Published: 01 July 2018
View article titled, Abstract 1134: The tumor suppressor activity of miR-300 is detrimental for leukemia development but required for leukemia stem cell maintenance
Journal Articles

Abstract 951: Role of the MSC-derived exosomal and endogenous JAK2-SET/PP2A-β-catenin-modulator miR-300 in leukemic stem/progenitor proliferation and survival in CML

Rossana Trotta, Giovannino Silvestri, Lorenzo Stramucci, Justin J. Ellis, Justine Yu, Jason J. Harb, Paolo Neviani, Guido Marcucci, Klara Srutova, Polakova K. Machova, Denis-Claude Roy, Peter Hokland, Michael Deininger, Ravi Bhatia, Carlo Gambacorti-Passerini, Dragana Milojkovic, Alistair Reid, Jane Apperley, Ferenc Livak, Jianfei Qi, Maria R. Baer, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 951.
https://doi.org/10.1158/1538-7445.AM2016-951
Published: 15 July 2016
View article titled, Abstract 951: Role of the MSC-derived exosomal and endogenous JAK2-SET/PP2A-β-catenin-modulator miR-300 in leukemic stem/progenitor proliferation and survival in CML
Journal Articles

Abstract #4154: CD94 defines distinct NK1.1 mouse and CD56dim human n atural killer cell subsets

Jianhua Yu, Min Wei, Hsiaoyin Mao, Tiffany Hughes, Rossana Trotta, Il-kyoo Park, Takeki Mitsui, Christine Hwang, Shujun Liu, David Jarjoura, Don Benson, Michael Caligiuri
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4154.
Published: 01 May 2009
View article titled, Abstract #4154: CD94 defines distinct NK1.1 mouse and CD56<sup>dim</sup> human n atural killer cell subsets
Journal Articles

FTY720, a new and alternative strategy for treating blast crisis CML and Ph1 ALL patients

Paolo Neviani, Ramasamy Santhanam, Joshua Oaks, Anna Eiring, Mario Notari, Bradley Blaser, Shujun Liu, Rossana Trotta, Natarajan Muthusamy, Carlo Gambacorti-Passerini, Brian Druker, Jorge Cortes, Guido Marcucci, Ching-Shih Chen, Denis Roy, Michael Caligiuri, Clara Bloomfield, John Byrd, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1638.
Published: 01 May 2007
View article titled, FTY720, a new and alternative strategy for treating blast crisis CML and Ph<sup>1 </sup>ALL patients
Journal Articles

The homeobox transcription factor, HLX, is a negative regulator of interferon gamma production in natural killer cells

Brian Becknell, Tiffany Hughes, Aharon G. Freud, Bradley W. Blaser, Jianhua Yu, Rossana Trotta, Hsiaoyin C. Mao, Marie L. Caligiuri de Jesús, Mohamad Alghothani, Michael D. Bates, Michael A. Caligiuri
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 28–29.
Published: 15 April 2006
View article titled, The homeobox transcription factor, HLX, is a negative regulator of interferon gamma production in natural killer cells
Journal Articles

Mechanism of synergistic proliferation in response to IL-2/15 and c-kit ligand involves both structural and functional cooperation: Insights into lymphohematopoietic stem cell expansion

Don M. Benson, Jr., Roger Briesewitz, M. Brian Becknell, Rossana Trotta, Michael A. Caligiuri
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1133.
Published: 15 April 2006
View article titled, Mechanism of synergistic proliferation in response to IL-2/15 and c-kit ligand involves both structural and functional cooperation: Insights into lymphohematopoietic stem cell expansion
Journal Articles

Src Homology 2–Containing Inositol 5′-Phosphatase 1 Negatively Regulates IFN-γ Production by Natural Killer Cells Stimulated with Antibody-Coated Tumor Cells and Interleukin-12

Robin Parihar, Rossana Trotta, Julie M. Roda, Amy K. Ferketich, Susheela Tridandapani, Michael A. Caligiuri, William E. Carson, III
Journal: Cancer Research
Cancer Res (2005) 65 (19): 9099–9107.
https://doi.org/10.1158/0008-5472.CAN-04-4424
Published: 03 October 2005
View article titled, Src Homology 2–Containing Inositol 5′-Phosphatase 1 Negatively Regulates IFN-γ Production by Natural Killer Cells Stimulated with Antibody-Coated Tumor Cells and Interleukin-12
Open the PDF for Src Homology 2–Containing Inositol 5′-Phosphatase 1 Negatively Regulates IFN-γ Production by Natural Killer Cells Stimulated with Antibody-Coated Tumor Cells and Interleukin-12 in another window
Journal Articles

Human natural killer cell IFN-gamma production: Inhibition by TGF-beta involves SMAD-mediated downregulation of T-BET expression

Jianhua Yu, Brian Becknell, Rossana Trotta, Shujun Liu, Min Wei, Darshna Bhatt, Michael Jaung, Tiffany Hughes, Guido Marcucci, Michael A. Caligiuri
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 570.
Published: 01 May 2005
View article titled, Human natural killer cell IFN-gamma production: Inhibition by TGF-beta involves SMAD-mediated downregulation of T-BET expression
Journal Articles

Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine co-stimulation

Rossana Trotta, Robin Parihar, Janhua Yu, Brian Becknell, Jeffrey Allard, II, Jing Wen, Wei Ding, Hsiaoyin Mao, Susheela Tridandapani, William E. Carson, Michael A. Caligiuri
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 571.
Published: 01 May 2005
View article titled, Differential expression of SHIP1 in CD56<sup>bright</sup> and CD56<sup>dim</sup> NK cells provides a molecular basis for distinct functional responses to monokine co-stimulation
Journal Articles

Activation of PP2A: A novel mechanism for a potential targeted therapy of blast crisis and imatinib-resistant chronic myelogenous leukemia

Paolo Neviani, Ramasamy Santhanam, Rossana Trotta, Mario Notari, Ashwin Uttam, Bradley W. Blaser, Shujun Liu, Denis C. Roy, Michael A. Caligiuri, Clara D. Bloomfield, Guido Marcucci, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 358.
Published: 01 May 2005
View article titled, Activation of PP2A: A novel mechanism for a potential targeted therapy of blast crisis and imatinib-resistant chronic myelogenous leukemia
Journal Articles

IL-12 potently augments cytokine secretion by FcR-stimulated NK cells via enhanced activation of Syk protein tyrosine kinase, STAT4, and the p44/42 MAP kinase

Robin Parihar, Rossana Trotta, Susheela Tridandapani, Julie M. Roda, William E. Carson, III
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1083.
Published: 01 April 2004
View article titled, IL-12 potently augments cytokine secretion by FcR-stimulated NK cells via enhanced activation of Syk protein tyrosine kinase, STAT4, and the p44/42 MAP kinase
Journal Articles

Activation of Mitochondrial Raf-1 Is Involved in the Antiapoptotic Effects of Akt

Miroslaw Majewski, Malgorzata Nieborowska-Skorska, Paolo Salomoni, Artur Slupianek, Krzysztof Reiss, Rossana Trotta, Bruno Calabretta, Tomasz Skorski
Journal: Cancer Research
Cancer Res (1999) 59 (12): 2815–2819.
Published: 15 June 1999
View article titled, Activation of Mitochondrial Raf-1 Is Involved in the Antiapoptotic Effects of Akt
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