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Journal Articles

Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML

Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil Maclean, Marcela Gronda, Vincent Rondeau, Brandon D. Brown, Courtney L. Jones, Hong Chang, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Brian Raught, Vito Spadavecchio, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2024-1646
Published: 22 March 2024
View article titled, Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML
Journal Articles

Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells

Matthew Tcheng, Marcela Gronda, Rose Hurren, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Mark D. Minden, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5898.
https://doi.org/10.1158/1538-7445.AM2024-5898
Published: 22 March 2024
View article titled, Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells
Journal Articles

Abstract 7053: Serine phosphorylation marks proteins for degradation by the mitochondrial matrix protease, ClpXP

Yue Feng, Monica M. Goncalves, Yulia Jitkova, Alexander Keszei, Chaitra Sarathy, Vincent Trudel, Jonathan St-Germain, Matthew Tcheng, Yongran Yan, Rose Hurren, Matthew Schultz, Brian Raught, Andrei Yudin, Mohammad Mazhab-Jafari, Siavash Vahidi, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7053.
https://doi.org/10.1158/1538-7445.AM2024-7053
Published: 22 March 2024
View article titled, Abstract 7053: Serine phosphorylation marks proteins for degradation by the mitochondrial matrix protease, ClpXP
Journal Articles

Abstract 4833: Inhibiting the mitochondrial RNA degradosome complex SUV3 and PNPase increases dsRNA in the cytoplasm, triggers a viral mimicry response and kills AML cells and progenitors

Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiao Ming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron Schimmer
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4833.
https://doi.org/10.1158/1538-7445.AM2023-4833
Published: 04 April 2023
View article titled, Abstract 4833: Inhibiting the mitochondrial RNA degradosome complex SUV3 and PNPase increases dsRNA in the cytoplasm, triggers a viral mimicry response and kills AML cells and progenitors
Journal Articles

Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability

Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D. Brown, Brian Raught, Andrea Arruda, Hong Chang, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadavecchio, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 333.
https://doi.org/10.1158/1538-7445.AM2023-333
Published: 04 April 2023
View article titled, Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability
Journal Articles

Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness

Geethu Emily Thomas, Grace Egan, Laura Gracia Prat, Aaron Botham, Veronique Voisin, Elias Orouji, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Neil Maclean, Rose Hurren, Marcela Gronda, Xiaoming Wang, Dilshad H. Khan, Rashim P. Singh, Andrea Arruda, Mark Minden, Gary D. Bader, John E. Dick, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3099.
https://doi.org/10.1158/1538-7445.AM2021-3099
Published: 01 July 2021
View article titled, Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness
Journal Articles

Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML

Grace Egan, G.E. Thomas, Parasvi Patel, Veronique Voisin, Rose Hurren, Neil MacLean, Razq Hakem, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3098.
https://doi.org/10.1158/1538-7445.AM2021-3098
Published: 01 July 2021
View article titled, Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML
Journal Articles

Abstract 3784: The metabolic enzyme Hexokinase 2 localizes to the nucleus and regulates stemness in AML through a kinase independent mechanism

Grace Egan, Geethu E. Thomas, Parasvi S. Patel, Jordan Chin, Aaron Botham, Rose Hurren, Neil MacLean, Razq Hakem, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3784.
https://doi.org/10.1158/1538-7445.AM2020-3784
Published: 15 August 2020
View article titled, Abstract 3784: The metabolic enzyme Hexokinase 2 localizes to the nucleus and regulates stemness in AML through a kinase independent mechanism
Journal Articles

Abstract 6321: BEND3 modulates sensitivity to the UBA1 inhibitor TAK-243 by regulating expression of the multidrug transporter BCRP

Samir H. Barghout, Ahmed Aman, Zachary Blatman, Karen Arevalo, Geethu Thomas, Neil MacLean, Xiaoming Wang, Rose Hurren, Troy Ketela, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6321.
https://doi.org/10.1158/1538-7445.AM2020-6321
Published: 15 August 2020
View article titled, Abstract 6321: BEND3 modulates sensitivity to the UBA1 inhibitor TAK-243 by regulating expression of the multidrug transporter BCRP
Journal Articles

Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Jo Ishizawa, Sarah F. Zarabi, R Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, John Man Chun Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2720.
https://doi.org/10.1158/1538-7445.AM2019-2720
Published: 01 July 2019
View article titled, Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
Journal Articles

Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)

Mingjing Xu, Ayesh Seneviratne, Val A. Fajardo, Geethu E. Thomas, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, David Sharon, Ahmed Aman, Rima Al-awar, Steven Chan, Mark D. Minden, Paul LeBlanc, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3003.
https://doi.org/10.1158/1538-7445.AM2019-3003
Published: 01 July 2019
View article titled, Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)
Journal Articles

Abstract 4529: Mapping the protein interactome of mitochondrial intermembrane space proteases identifies a novel function for HTRA2

Aaron D. Botham, Etienne Coyaud, Sanjit Nirmalanandhan, Marcela Gronda, Rose Hurren, Neil Maclean, Jonathan St. Germain, Sara Mirali, Estelle Laurent, Brian Raught, Aaron Schimmer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4529.
https://doi.org/10.1158/1538-7445.AM2019-4529
Published: 01 July 2019
View article titled, Abstract 4529: Mapping the protein interactome of mitochondrial intermembrane space proteases identifies a novel function for HTRA2
Journal Articles

Abstract 210: Targeting the mitochondrial DNA polymerase gamma with 2’3’-dideoxycytidine as a novel therapeutic strategy for acute myeloid leukemia

Sanduni Liyanage, Rose Hurren, Xiaoming Wang, Neil Maclean, Rebecca Laposa, Aaron Schimmer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 210.
https://doi.org/10.1158/1538-7445.AM2016-210
Published: 15 July 2016
View article titled, Abstract 210: Targeting the mitochondrial DNA polymerase gamma with 2’3’-dideoxycytidine as a novel therapeutic strategy for acute myeloid leukemia
Journal Articles

Abstract 3039: Targeting mitochondrial DNA polymerase gamma (POLG) as a novel therapeutic strategy for acute myeloid leukemia (AML)

Sanduni Liyanage, Rose Hurren, Rebecca Laposa, Aaron Schimmer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3039.
https://doi.org/10.1158/1538-7445.AM2015-3039
Published: 01 August 2015
View article titled, Abstract 3039: Targeting mitochondrial DNA polymerase gamma (POLG) as a novel therapeutic strategy for acute myeloid leukemia (AML)
Journal Articles

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Eric A. Lee, Leonard Angka, Sarah-Grace Rota, Thomas Hanlon, Andrew Mitchell, Rose Hurren, Xiao Ming Wang, Marcela Gronda, Ezel Boyaci, Barbara Bojko, Mark Minden, Shrivani Sriskanthadevan, Alessandro Datti, Jeffery L. Wrana, Andrea Edginton, Janusz Pawliszyn, Jamie W. Joseph, Joe Quadrilatero, Aaron D. Schimmer, Paul A. Spagnuolo
Journal: Cancer Research
Cancer Res (2015) 75 (12): 2478–2488.
https://doi.org/10.1158/0008-5472.CAN-14-2676
Published: 14 June 2015
View article titled, Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death
Open the PDF for Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death in another window
Includes: Supplementary data
Journal Articles

Abstract 4317: Inhibiting the mitochondrial DNA polymerase gamma (POLG) with 2′,3′-dideoxycytidine reduces oxidative phosphorylation and increases apoptosis in acute myeloid leukemia (AML) cells

Sanduni Liyanage, Rose Hurren, Rebecca Laposa, Aaron Schimmer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4317.
https://doi.org/10.1158/1538-7445.AM2014-4317
Published: 01 October 2014
View article titled, Abstract 4317: Inhibiting the mitochondrial DNA polymerase gamma (POLG) with 2′,3′-dideoxycytidine reduces oxidative phosphorylation and increases apoptosis in acute myeloid leukemia (AML) cells
Journal Articles

Abstract 1123: AML cells have low reserve capacity in their respiratory chain complexes leading to increased sensitivity to palmitate-induced cell death

Shrivani Sriskanthadevan, Marko Skrtic, Bozhena Jhas, Yulia Jitkova, Rose Hurren, Marcela Gronda, Xiaoming Wang, Mahadeo A. Sukhai, Mark Minden, Aaron Schimmer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1123.
https://doi.org/10.1158/1538-7445.AM2012-1123
Published: 15 April 2012
View article titled, Abstract 1123: AML cells have low reserve capacity in their respiratory chain complexes leading to increased sensitivity to palmitate-induced cell death
Journal Articles

Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

Siyuan Song, Tania Christova, Stephen Perusini, Solmaz Alizadeh, Ren-Yue Bao, Bryan W. Miller, Rose Hurren, Yulia Jitkova, Marcela Gronda, Methvin Isaac, Babu Joseph, Ratheesh Subramaniam, Ahmed Aman, Anh Chau, Donna E. Hogge, Scott J. Weir, James Kasper, Aaron D. Schimmer, Rima Al-awar, Jeff L. Wrana, Liliana Attisano
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7628–7639.
https://doi.org/10.1158/0008-5472.CAN-11-2745
Published: 15 December 2011
View article titled, Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers
Open the PDF for Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells

Reza Beheshti Zavareh, Rose Hurren, Marcela Gronda, Mahadeo A. Sukhai, Craig D. Simpson, Xiaoming Wang, Neil A. MacLean, Troy Ketela, Jason Moffat, David R. Rose, Harry Schachter, James W. Dennis, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1484.
https://doi.org/10.1158/1538-7445.AM2011-1484
Published: 15 April 2011
View article titled, Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells
Journal Articles

Abstract 5448: The tricyclic anti-depressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases

Xinliang Mao, Wenjie Wang, Biyin Cao, Zhihua Li, Rose Hurren, Suzanne Trudel, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5448.
https://doi.org/10.1158/1538-7445.AM10-5448
Published: 15 April 2010
View article titled, Abstract 5448: The tricyclic anti-depressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases