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Journal Articles

Abstract CT088: Clinical validation of a novel blood-based protein multi-analyte test for early detection of pancreatic ductal adenocarcinoma (PDAC) in a large, independent high-risk patient population

Bryson Katona, Norma Alonzo Palma, Aimee Lucas, Rosalie Sears, Salvatore Paiella, George Zogopoulos, Eli M. Grindedal, Raymond Wadlow, Erkut Borazanci, Daniel A. Sussman, Ora Gordon, Natasha Kureshi, Lisa Ford, Thomas King, Randall Brand, Diane Simeone
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT088.
https://doi.org/10.1158/1538-7445.AM2025-CT088
Published: 25 April 2025
View articletitled, Abstract CT088: Clinical validation of a novel blood-based protein multi-analyte test for early detection of pancreatic ductal adenocarcinoma (PDAC) in a large, independent high-risk patient population
Journal Articles

Abstract 1438: HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity

Sita Kugel, Stephanie Dobersch, Naomi Yamamoto, Aidan Schutter, Sarah M. Cavender, Tess M. Robertson, Gun Ho Jang, Annie N. Samraj, Ben Doron, Lisa A. Poole, Martine Roudier, Cindy L. Wladyka, Isabel English, Guillermo Barreto, Rosalie Sears, Srivatsan Raghavan, Faiyaz Notta, Robert N. Eisenman, Andrew C. Hsieh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1438.
https://doi.org/10.1158/1538-7445.AM2025-1438
Published: 21 April 2025
View articletitled, Abstract 1438: HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
Journal Articles

Abstract C078: Chromatin accessibility profiling of human pancreatic tumors reveals epigenetic features of malignant and stromal cell subtypes

Kevin MacPherson-Hawthorne, Jason M. Link, Patrick Worth, Brett Sheppard, Andrew Fields, Colin Daniel, Andrew Nishida, Carl Pelz, Trent Waugh, Ethan Agritelle, John Muschler, Andrew Adey, Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C078.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C078
Published: 15 September 2024
View articletitled, Abstract C078: Chromatin accessibility profiling of human pancreatic tumors reveals epigenetic features of malignant and stromal cell subtypes
Journal Articles

Abstract C029: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS/MEK signaling

Motoyuki Tsuda, Colin Daniel, Xiaoyan Wang, Carl Peltz, Hayley Zimmny, Alexander Smith, John Muschler, Xi Li, Tugba Yildiran Ozmen, Furkan Ozmen, Dove Keith, Christopher Corless, Koei Chin, Jonathan Brody, Charles Lopez, Gordon Mills, Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C029.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C029
Published: 15 September 2024
View articletitled, Abstract C029: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS/MEK signaling
Journal Articles

Abstract 1586: Unraveling the importance of pancreatic cancer extracellular signaling to endothelial cells within the tumor microenvironment

Jennifer M. Finan, Yifei Guo, Alexandra Q. Bartlett, Kevin MacPherson, Valerie Calvert, Madeline D. Hedberg, Emanuel Petricoin, Rosalie Sears, Jonathan R. Brody
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1586.
https://doi.org/10.1158/1538-7445.AM2024-1586
Published: 22 March 2024
View articletitled, Abstract 1586: Unraveling the importance of pancreatic cancer extracellular signaling to endothelial cells within the tumor microenvironment
Journal Articles

Abstract 2499: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS signaling

Motoyuki Tsuda, Colin Daniel, Xiaoyan Wang, Carl Pelz, Hayley Zimny, Alexander Smith, John Muschler, Xi Li, Tugba Yildiran Ozmen, Furkan Ozmen, Dove Keith, Christopher Corless, Koei Chin, Jonathan Brody, Charles Lopez, Gordon Mills, Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2499.
https://doi.org/10.1158/1538-7445.AM2024-2499
Published: 22 March 2024
View articletitled, Abstract 2499: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS signaling
Journal Articles

Abstract B003: Advancing biomarker discovery using a novel window of opportunity (WOO) trial for pancreatic ductal adenocarcinoma: Trial updates

Charles D. Lopez, Adel Kardosh, Emerson Chen, Guillame Pegna, Alexander Guimaraes, Bryan Foster, Brian Brinkerhoff, Shaun M. Goodyear, Erin Taber, Brindha Rajagopalan, Johnson Vo, Kiara Siex, Brett Johnson, Danielle Galipeau, Dove Keith, Brett Sheppard, Brody Jonathan, Rosalie Sears, Gordon Mills
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B003.
https://doi.org/10.1158/1538-7445.PANCA2023-B003
Published: 16 January 2024
View articletitled, Abstract B003: Advancing biomarker discovery using a novel window of opportunity (WOO) trial for pancreatic ductal adenocarcinoma: Trial updates
Journal Articles

Abstract C080: Decoding the MYC-PDAC nexus: Unveiling the impact of PP2A-C subunit methylation on tumor onset and advancement

Vidhi Shah, Alexander Smith, Gabriel Cohn, Motoyuki Tsuda, Goutham Narla, Jonathan Brody, Brett Sheppard, Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C080.
https://doi.org/10.1158/1538-7445.PANCA2023-C080
Published: 16 January 2024
View articletitled, Abstract C080: Decoding the MYC-PDAC nexus: Unveiling the impact of PP2A-C subunit methylation on tumor onset and advancement
Journal Articles

Abstract A100: KRAS inhibition targets and depends on pro-oncogenic HuR in PDAC cells

Hen Halamish, Michaela Bush, Alexander Smith, Rosalie Sears, Jonathan Brody
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A100.
https://doi.org/10.1158/1538-7445.PANCA2023-A100
Published: 16 January 2024
View articletitled, Abstract A100: KRAS inhibition targets and depends on pro-oncogenic HuR in PDAC cells
Journal Articles

Abstract C102: Investigating rapid metastatic recurrence of pancreatic cancer after resection in a novel, immune-competent, Myc-dependent murine model

Jackie L. Phipps, Isabel English, Jennifer Chu, Gustavo Salgado Garza, Jason Link, Ellen Langer, Motoyuki Tsuda, Kevin MacPherson, Carl Pelz, Jonathan Brody, Brett Sheppard, Rosalie Sears, Patrick Worth
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C102.
https://doi.org/10.1158/1538-7445.PANCA2023-C102
Published: 16 January 2024
View articletitled, Abstract C102: Investigating rapid metastatic recurrence of pancreatic cancer after resection in a novel, immune-competent, Myc-dependent murine model
Journal Articles

Abstract A037: Unraveling the importance of pancreatic cancer extracellular signaling to endothelial cells within the tumor microenvironment

Jennifer M. Finan, Yifei Guo, Kevin MacPherson, Valerie Calvert, Carl Pelz, Emanuel F. Petricoin, Julie A. Saugstad, Rosalie Sears, Jonathan R. Brody
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A037.
https://doi.org/10.1158/1538-7445.PANCA2023-A037
Published: 16 January 2024
View articletitled, Abstract A037: Unraveling the importance of pancreatic cancer extracellular signaling to endothelial cells within the tumor microenvironment
Journal Articles

Abstract A118: Chromatin accessibility profiling of human pancreatic tumors reveals epigenetic features of malignancy and rapid recurrence

Kevin MacPherson, Jason M. Link, Patrick Worth, Brett Sheppard, Andrew Fields, Colin Daniel, Andrew Nishida, Carl Pelz, Trent Waugh, Ethan Agritelle, John Muschler, Andrew Adey, Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A118.
https://doi.org/10.1158/1538-7445.PANCA2023-A118
Published: 16 January 2024
View articletitled, Abstract A118: Chromatin accessibility profiling of human pancreatic tumors reveals epigenetic features of malignancy and rapid recurrence
Journal Articles

Abstract PR03: Addressing disparities in the Native American population in Oregon: The development of multi-disciplinary frameworks to study pancreatic ductal adenocarcinoma in Native American communities

Jared Delaney, Grace McCarthy, Jackie Shannon, Rosalie Sears, Brett Sheppard, Jonathan Brody, Claymore Kills First
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): PR03.
https://doi.org/10.1158/1538-7445.PANCA2023-PR03
Published: 16 January 2024
View articletitled, Abstract PR03: Addressing disparities in the Native American population in Oregon: The development of multi-disciplinary frameworks to study pancreatic ductal adenocarcinoma in Native American communities
Journal Articles

Abstract A011: Proteomic expression using exosomes in intraductal papillary mucinous neoplasms (IPMN) patients to inform risk stratification

Harmeet Dhani, Roberta V. Alexander, Juan Pablo Hinestrosa, Jesus Izaguirre-Carbonell, Dove Keith, Paul R. Billings, Gregory Cote', Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A011.
https://doi.org/10.1158/1538-7445.PANCA2023-A011
Published: 16 January 2024
View articletitled, Abstract A011: Proteomic expression using exosomes in intraductal papillary mucinous neoplasms (IPMN) patients to inform risk stratification
Journal Articles

Abstract 6515: Pancreatic ductal adenocarcinoma (PDAC) early detection

Juan P. Hinestrosa, Harmeet Dhani, Gregor Schroeder, Jean M. Lewis, Heath I. Balcer, Razelle Kurzrock, Dove Keith, Rosalie Sears, Paul Billings
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6515.
https://doi.org/10.1158/1538-7445.AM2023-6515
Published: 04 April 2023
View articletitled, Abstract 6515: Pancreatic ductal adenocarcinoma (PDAC) early detection
Journal Articles

Abstract PR010: Multiplex imaging reveals features of organotropism in pancreatic ductal adenocarcinoma

Jennifer Eng, Jason Link, Carl Pelz, Rosalie Sears
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): PR010.
https://doi.org/10.1158/1538-7445.METASTASIS22-PR010
Published: 15 January 2023
View articletitled, Abstract PR010: Multiplex imaging reveals features of organotropism in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 825: Evasion of apoptosis in MYC dependent T-ALL through epigenetic control

Gabrielle Dewson, Benedict Anchang, Rosalie Sears, Daniel F. Liefwalker
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 825.
https://doi.org/10.1158/1538-7445.AM2022-825
Published: 15 June 2022
View articletitled, Abstract 825: Evasion of apoptosis in MYC dependent T-ALL through epigenetic control
Journal Articles

Abstract A34: Suppression of dystroglycan function is a hallmark of acinar-to-ductal metaplasia and favors the development of neoplasias and PDAC

Ge Huang, Christian Lanciault, Rosalie Sears, John Muschler
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A34.
https://doi.org/10.1158/1538-7445.PANCA19-A34
Published: 13 December 2019
View articletitled, Abstract A34: Suppression of dystroglycan function is a hallmark of acinar-to-ductal metaplasia and favors the development of neoplasias and PDAC
Journal Articles

Abstract I16: KRAS and environmental signals regulate MYC to drive lineage plasticity, pancreas cancer progression, and therapeutic resistance

Ellen Langer, Yulong Su, Meghan Joly, Brittany Allen-Petersen, Amy Farrell, Patrick Worth, Dan Liefwalker, Jason Link, Brett Sheppard, Rosalie Sears
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): I16.
https://doi.org/10.1158/1538-7445.PANCA19-I16
Published: 13 December 2019
View articletitled, Abstract I16: KRAS and environmental signals regulate MYC to drive lineage plasticity, pancreas cancer progression, and therapeutic resistance
Journal Articles

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Kimberly McClinch, Rita A. Avelar, David Callejas, Sudeh Izadmehr, Danica Wiredja, Abbey Perl, Jaya Sangodkar, David B. Kastrinsky, Daniela Schlatzer, Maxwell Cooper, Janna Kiselar, Agnes Stachnik, Shen Yao, Divya Hoon, Daniel McQuaid, Nilesh Zaware, Yixuan Gong, David L. Brautigan, Stephen R. Plymate, Cynthia C.T. Sprenger, William K. Oh, Alice C. Levine, Alexander Kirschenbaum, John P. Sfakianos, Rosalie Sears, Analisa DiFeo, Yiannis Ioannou, Michael Ohlmeyer, Goutham Narla, Matthew D. Galsky
Journal: Cancer Research
Cancer Res (2018) 78 (8): 2065–2080.
https://doi.org/10.1158/0008-5472.CAN-17-0123
Published: 12 April 2018
View articletitled, Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
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Includes: Supplementary data