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Journal Articles

Abstract 518: The CDK2/9 inhibitor fadraciclib is active in Richter transformation and lymphoma cell lines by targeting both cell survival and proliferation

Rong Chen, Yuling Chen, Ping Xiong, William Plunkett
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 518.
https://doi.org/10.1158/1538-7445.AM2024-518
Published: 22 March 2024
View article titled, Abstract 518: The CDK2/9 inhibitor fadraciclib is active in Richter transformation and lymphoma cell lines by targeting both cell survival and proliferation
Journal Articles

Abstract 2551: Harness the power of real-world-data for oncology target and biomarker research: A case study by applying clinic-genomics data for 2,659 lung cancer patients and beyond

Si Wu, Weilong Zhao, Christy Choi, Mona Cai, Peter Ansell, Alexander Liede, Rong Chen, Xi Zhao, Josue Samayoa
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2551.
https://doi.org/10.1158/1538-7445.AM2024-2551
Published: 22 March 2024
View article titled, Abstract 2551: Harness the power of real-world-data for oncology target and biomarker research: A case study by applying clinic-genomics data for 2,659 lung cancer patients and beyond
Journal Articles

Abstract CT026: A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced myeloid malignancies

Courtney D. DiNardo, Pau Montesinos, Lina Benajiba, Ana Triguero, Christian Recher, Andre C. Schuh, Maël Heiblig, Ashish Bajel, Arnaud Pigneux, Juan M. Alonso-Domiguez, Amir T. Fathi, Carolyn Grove, Hsin-An Hou, Michael Heuser, Sarit Assouline, Shaun Fleming, Dong-Yeop Shin, Kendra Sweet, Olatoyosi Odenike, Jessica Altman, Melissa Gaik Ming Ooi, Lao Zhentang, Nobert Vey, Joshua Zeidner, Amandeep Salhotra, Eunice Wang, Gary Schiller, Kimmo Porkka, Tsila Zuckerman, Violaine Havelange, Brian A. Jonas, Sujaatha Narayanan, Jun Ho Jang, Je-Hwan Lee, Anna M. Szpurka, Dana Heirich, Hsiao Rong Chen, Violet Hanft, Junjie Zhao, Ivelina Gueorguieva, Yin Zhang, Eytan M. Stein
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT026.
https://doi.org/10.1158/1538-7445.AM2023-CT026
Published: 14 April 2023
View article titled, Abstract CT026: A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced myeloid malignancies
Journal Articles

Abstract 2526: The Bcl-2 family proteins in CLL: Effects by the cytogenetics, microenvironments and therapy

Rong Chen, Ping Xiong, Chaomei Liu, Yuling Chen, Yingjun Jiang, Varsha Gandhi, Nitin Jain, William Wierda, William Plunkett
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2526.
https://doi.org/10.1158/1538-7445.AM2023-2526
Published: 04 April 2023
View article titled, Abstract 2526: The Bcl-2 family proteins in CLL: Effects by the cytogenetics, microenvironments and therapy
Journal Articles

Abstract P1-04-09: Correlating Predicted Adjuvant Therapy Benefit and Risk of Recurrence between Breast Cancer Index (BCI) and 21-gene Oncotype DX Recurrence Score (RS)

Rima Patel, Nicole Casasanta, Zhiqiang Li, Melanie Kier, Julia Blanter, Sophie Sohval, Malin Hovstadius, Catherine Wu, Marc Fink, Xiang Zhou, Brittney Zimmerman, Krystal Cascetta, Rong Chen, William Oh, Amy Tiersten
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P1-04-09.
https://doi.org/10.1158/1538-7445.SABCS22-P1-04-09
Published: 01 March 2023
View article titled, Abstract P1-04-09: Correlating Predicted Adjuvant Therapy Benefit and Risk of Recurrence between Breast Cancer Index (BCI) and 21-gene Oncotype DX Recurrence Score (RS)
Journal Articles

Abstract P5-18-11: Impact of supportive therapies on tolerance of aromatase inhibitors in patients with early-stage, hormone-positive breast cancer

Melanie W Kier, Zhiqiang Li, Brittney S Zimmerman, Rima Patel, Yunchen Yang, Mark Y Fink, Jason D Wells, Xiang Zhou, Scott Newman, Rong Chen, Eric Schadt, William Oh, Amy Tiersten
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-18-11.
https://doi.org/10.1158/1538-7445.SABCS21-P5-18-11
Published: 15 February 2022
View article titled, Abstract P5-18-11: Impact of supportive therapies on tolerance of aromatase inhibitors in patients with early-stage, hormone-positive breast cancer
Journal Articles

Abstract P1-17-06: Impact of body mass index on the efficacy of aromatase inhibitors in patients with metastatic breast cancer

Rima Patel, Zhiqiang Li, Brittney S. Zimmerman, Marc Y. Fink, Jason D. Wells, Xiang Zhou, Kristin L. Ayers, Arielle Redfern, Scott Newman, Rong Chen, William K. Oh, Amy Tiersten
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-17-06.
https://doi.org/10.1158/1538-7445.SABCS21-P1-17-06
Published: 15 February 2022
View article titled, Abstract P1-17-06: Impact of body mass index on the efficacy of aromatase inhibitors in patients with metastatic breast cancer
Journal Articles

Abstract P3-09-15: Value-added clinical tumor/normal whole exome and whole transcriptome sequencing versus a DNA and RNA tumor only gene panel for managing breast cancer

Kimberly S. Cole, Zhiqiang Li, Amy Tiersten, Wanying Zhang, Hussam Al-Kateb, Feras M. Hantash, Michael R. Rossi, Scott Newman, Xiang Zhou, Eric E. Schadt, Rong Chen, William K. Oh, Marc Y. Fink
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-15.
https://doi.org/10.1158/1538-7445.SABCS21-P3-09-15
Published: 15 February 2022
View article titled, Abstract P3-09-15: Value-added clinical tumor/normal whole exome and whole transcriptome sequencing versus a DNA and RNA tumor only gene panel for managing breast cancer
Journal Articles

Abstract 868: Heritable cancer mutations in multiple myeloma

Santiago Thibaud, Aaron Etra, Ryan Subaran, Zachry Soens, Scott Newman, Rong Chen, Ajai Chari, Hearn J. Cho, Sundar Jagannath, Deepu Madduri, David T. Melnekoff, Shambavi Richard, Joshua Richter, Larysa Sanchez, Alessandro Lagana, Samir Parekh, Kenan Onel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 868.
https://doi.org/10.1158/1538-7445.AM2021-868
Published: 01 July 2021
View article titled, Abstract 868: Heritable cancer mutations in multiple myeloma
Journal Articles

MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1

Huai-Chia Chuang, Chih-Chi Chang, Chiao-Fang Teng, Chia-Hsin Hsueh, Li-Li Chiu, Pu-Ming Hsu, Ming-Ching Lee, Chung-Ping Hsu, Yi-Rong Chen, Yi-Chung Liu, Ping-Chiang Lyu, Tse-Hua Tan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (19): 4978–4993.
https://doi.org/10.1158/0008-5472.CAN-19-1402
Published: 01 October 2019
View article titled, MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1
Open the PDF for MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1 in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1854: Novel pateamine analogs to target the translation initiation factor eIF4A in chronic lymphocytic leukemia

Rong Chen, Mingzhao Zhu, Rajan R. Chaudhari, Omar Robles, Yuling Chen, Wesley Skillern, Qun Qin, William Wierda, Shuxing Zhang, Kenneth G. Hull, Daniel Romo, William Plunkett
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1854.
https://doi.org/10.1158/1538-7445.AM2019-1854
Published: 01 July 2019
View article titled, Abstract 1854: Novel pateamine analogs to target the translation initiation factor eIF4A in chronic lymphocytic leukemia
Journal Articles

Abstract 2715: Deciphering a metabolic basis for single-agent venetoclax efficacy in t(11;14) multiple myeloma

Richa Bajpai, Abhinav Achreja, Changyong Wei, Arusha Siddiqa, Shannon M. Matulis, Vikas Gupta, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Hsiao-Rong Chen, Jeanne Kowalski, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2715.
https://doi.org/10.1158/1538-7445.AM2019-2715
Published: 01 July 2019
View article titled, Abstract 2715: Deciphering a metabolic basis for single-agent venetoclax efficacy in t(11;14) multiple myeloma
Journal Articles

Abstract 247: Identification of the GABAA receptor in melanoma brain metastases patient tumors and demonstration that it is a viable drug target using benzodiazepine-derivatives

Milota Kaluzova, Tahseen Nasti, Hiao-Rong Chen, Lindsey Lowder, Robert Press, Havi Rosen, Manali Rupji, Laura Kallay, Rikesh Patel, Andre Burnham, Maxwell Xu, Alexandra Ross, Havva Keskin, Erin Connelly, Benjamin Izar, Cory Adamson, Jeffrey Olson, Jing Su, Walter Curran, Ragini Kudchadkar, Matthew Schniederjan, Stewart Neill, David Lawson, Michael Chan, Jeanne Kowalski, Mohammad Khan, Daniel Pomeranz Krummel, Soma Sengupta
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 247.
https://doi.org/10.1158/1538-7445.AM2019-247
Published: 01 July 2019
View article titled, Abstract 247: Identification of the GABA<sub>A</sub> receptor in melanoma brain metastases patient tumors and demonstration that it is a viable drug target using benzodiazepine-derivatives
Journal Articles

Abstract 3905: Strategic combination of the cyclin-dependent kinase inhibitor CYC065 with venetoclax to target anti-apoptotic proteins in chronic lymphocytic leukemia

Rong Chen, Yuling Chen, Sheelagh Frame, David Blake, William G. Wierda, Daniella Zheleva, William Plunkett
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3905.
https://doi.org/10.1158/1538-7445.AM2018-3905
Published: 01 July 2018
View article titled, Abstract 3905: Strategic combination of the cyclin-dependent kinase inhibitor CYC065 with venetoclax to target anti-apoptotic proteins in chronic lymphocytic leukemia
Journal Articles

Abstract B21: Novel pateamine A analogs to target pro-survival proteins in chronic lymphocytic leukemia

Rong Chen, Mingzhao Zhu, Yuling Chen, Wesley Skillern, Qun Qin, William G. Wierda, Kenneth G. Hull, Daniel Romo, William Plunkett
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): B21.
https://doi.org/10.1158/1538-7445.Transcontrol16-B21
Published: 14 March 2017
View article titled, Abstract B21: Novel pateamine A analogs to target pro-survival proteins in chronic lymphocytic leukemia
Journal Articles

Abstract B02: Oncogene MCT-1 deregulates oxidative metabolism and promotes tumor metastasis via YY1 signaling network

Hong-Yu Tseng, Yen-An Chen, Yi-Rong Chen, Hsin-Ling Hsu
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): B02.
https://doi.org/10.1158/1538-7445.TME16-B02
Published: 28 July 2016
View article titled, Abstract B02: Oncogene MCT-1 deregulates oxidative metabolism and promotes tumor metastasis via YY1 signaling network
Journal Articles

Abstract 4495: Development and clinical application of an integrative genomic approach to personalized cancer therapy

Rong Chen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4495.
https://doi.org/10.1158/1538-7445.AM2016-4495
Published: 15 July 2016
View article titled, Abstract 4495: Development and clinical application of an integrative genomic approach to personalized cancer therapy
Journal Articles

Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf–DAPK Complex by Raf Inhibitor Combination Therapy

Yi-Ta Tsai, Mei-Jen Chuang, Shou-Hung Tang, Sheng-Tang Wu, Yu-Chi Chen, Guang-Huan Sun, Pei-Wen Hsiao, Shih-Ming Huang, Hwei-Jen Lee, Cheng-Ping Yu, Jar-Yi Ho, Hui-Kuan Lin, Ming-Rong Chen, Chung-Chih Lin, Sun-Yran Chang, Victor C. Lin, Dah-Shyong Yu, Tai-Lung Cha
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (17): 3568–3582.
https://doi.org/10.1158/0008-5472.CAN-14-3264
Published: 31 August 2015
View article titled, Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf–DAPK Complex by Raf Inhibitor Combination Therapy
Open the PDF for Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf–DAPK Complex by Raf Inhibitor Combination Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 63: Alview (ALignment VIEWer): A software tool to visualize next generation sequencing (NGS) data

Daoud Meerzaman, Richard Finney, Qing-Rong Chen, Cu Nguyen, Chih Hao Hsu, Barbra Dunn
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 63.
https://doi.org/10.1158/1538-7445.AM2015-63
Published: 01 August 2015
View article titled, Abstract 63: Alview (ALignment VIEWer): A software tool to visualize next generation sequencing (NGS) data
Journal Articles

Abstract 1765: Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia

Rong Chen, Mingzhao Zhu, Yuling Chen, Wesley Skillern, William G. Wierda, Ken Hull, Daniel Romo, William Plunkett
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1765.
https://doi.org/10.1158/1538-7445.AM2015-1765
Published: 01 August 2015
View article titled, Abstract 1765: Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia