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Ronald A. DePinho
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Journal Articles

Abstract 5100: Mediator subunit Med4 enforces metastatic dormancy in breast cancer

Seong-Yeon Bae, Hsiang-Hsi Ling, Yi Chen, Hong Chen, Dhiraj Kumar, Jiankang Zhang, Aaron Viny, Ronald A. DePinho, Filippo G. Giancotti
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5100.
https://doi.org/10.1158/1538-7445.AM2025-5100
Published: 21 April 2025
View articletitled, Abstract 5100: Mediator subunit Med4 enforces metastatic dormancy in breast cancer
Journal Articles

Abstract 3921: Development of a KRAS-G12C-driven pancreatic cancer mouse model

Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Phuoc T. Nguyen, Xiaofei Wang, Zecheng Yang, Dean N. Pan, Jangho Park, Yiming Cai, Andrea Viale, Huamin Wang, Dan Zhao, Ronald A. DePinho, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3921.
https://doi.org/10.1158/1538-7445.AM2025-3921
Published: 21 April 2025
View articletitled, Abstract 3921: Development of a KRAS-G12C-driven pancreatic cancer mouse model
Journal Articles

Abstract A072: Decoding human kinome specificities through a computational data-driven approach and unveiling kinase activity in pancreatic ductal adenocarcinoma

Li Cai, Jared L Johnson, Chen Peng, Tomer M Yaron, Lewis C Cantley, Ronald A DePinho
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A072.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A072
Published: 15 September 2024
View articletitled, Abstract A072: Decoding human kinome specificities through a computational data-driven approach and unveiling kinase activity in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors

Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Phuoc T. Nguyen, Xiaofei Wang, Zecheng Yang, Abdelrahman Yousef, Dean Pan, Yanqing Jin, Madelaine S. Theady, Jangho Park, Yiming Cai, Mitsunobu Takeda, Matthew Vasquez, Yong Zhou, Hong Zhao, Andrea Viale, Huamin Wang, Dan Zhao, Ronald A. DePinho, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6532.
https://doi.org/10.1158/1538-7445.AM2024-6532
Published: 22 March 2024
View articletitled, Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors
Journal Articles

Abstract IA20: Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer

Jincheng Han, Jiaqian Xu, Yonghong Liu, Shaoheng Liang, Kyle A. LaBella, Deepavali Chakravarti, Denise J. Spring, Yan Xia, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): IA20.
https://doi.org/10.1158/1538-7445.PANCA2023-IA20
Published: 16 January 2024
View articletitled, Abstract IA20: Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
Journal Articles

Abstract A087: Loss of KDM5A supports KRAS-driven pancreatic cancer

Jasper Chen, Jincheng Han, Ronald A. DePinho, Cullen M. Taniguchi
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A087.
https://doi.org/10.1158/1538-7445.PANCA2023-A087
Published: 16 January 2024
View articletitled, Abstract A087: Loss of KDM5A supports KRAS-driven pancreatic cancer
Journal Articles

Abstract B082: Extinction of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8+ T cells

Valerie S. LeBleu, Krishnan K. Mahadevan, Elena V. Ramirez, Yang Chen, Bingrui Li, Amari M. Sockwell, Mihai Gagea, Hikaru Sugimoto, Desiree Tampe, Michael Zeisberg, Haoqiang Ying, Abhinav K. Jain, Ronald A. DePinho, Aniban Maitra, Kathleen M. McAndrews, Raghu Kalluri
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B082.
https://doi.org/10.1158/1538-7445.PANCA2023-B082
Published: 16 January 2024
View articletitled, Abstract B082: Extinction of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8+ T cells
Journal Articles

Abstract C096: Targeting Syndecan1 to overcome acquired resistant to KRAS inhibitor in gastrointestinal cancer

Mitsunobu Takeda, Alexey Sorokin, Madelaine Theardy, Oluwadara Coker, Scott Kopetz, Haoqiang Ying, Giulio Draetta, Ronald A. DePinho, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C096.
https://doi.org/10.1158/1538-7445.PANCA2023-C096
Published: 16 January 2024
View articletitled, Abstract C096: Targeting Syndecan1 to overcome acquired resistant to KRAS inhibitor in gastrointestinal cancer
Journal Articles

Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer

Benny Johnson, Cara Haymaker, Van K. Morris, Arvind Dasari, Victoria Serpas Higbie, John Paul Shen, Christine Parseghian, Maria Pia Morelli, Ryan Huey, Michael S. Lee, Jason Willis, Kanwal P. Raghav, Ying Yuan, John Zebala, Ronald A. DePinho, Scott Kopetz, Michael Overman
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT118.
https://doi.org/10.1158/1538-7445.AM2023-CT118
Published: 14 April 2023
View articletitled, Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer
Journal Articles

Abstract 4757: Loss of KDM5A supports KRAS-driven pancreatic cancer

Jasper R. Chen, Jincheng Han, Cullen M. Taniguchi, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4757.
https://doi.org/10.1158/1538-7445.AM2023-4757
Published: 04 April 2023
View articletitled, Abstract 4757: Loss of KDM5A supports KRAS-driven pancreatic cancer
Journal Articles

Abstract 3515: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer

Jiexi Li, Zhengdao Lan, Wenting Liao, Jielin Liu, Shan Jiang, Hong Seok Shim, Max Slotnik, Kyle A. LaBella, Wen-Hao Hsu, Xiaoying Shang, Denise Spring, Y Alan Wang, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3515.
https://doi.org/10.1158/1538-7445.AM2023-3515
Published: 04 April 2023
View articletitled, Abstract 3515: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer
Journal Articles

Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC

Rumi Lee, Jiexi Li, Jun Li, Chang-Jiun Wu, Shan Jiang, Wen-Hao Hsu, Deepavali Chakravarti, Peiwen Chen, Kyle A. LaBella, Jing Li, Denise J. Spring, Di Zhao, Y. Alan Wang, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): IA014.
https://doi.org/10.1158/1538-7445.CRC22-IA014
Published: 01 December 2022
View articletitled, Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC
Journal Articles

Abstract PR011: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer

Jiexi Li, Zhengdao Lan, Wenting Liao, James W. Horner, Jielin Liu, Shan Jiang, Hong S. Shim, Max Slotnik, Kyle A. LaBella, Wen-Hao Hsu, Denise J. Spring, Y. Alan Wang, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): PR011.
https://doi.org/10.1158/1538-7445.CRC22-PR011
Published: 01 December 2022
View articletitled, Abstract PR011: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer
Journal Articles

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Shawn M. Davidson, Daniel R. Schmidt, Julia E. Heyman, James P. O'Brien, Amy C. Liu, William J. Israelsen, Talya L. Dayton, Raghav Sehgal, Roderick T. Bronson, Elizaveta Freinkman, Howard H. Mak, Giuseppe Nicolò Fanelli, Scott Malstrom, Gary Bellinger, Arkaitz Carracedo, Pier Paolo Pandolfi, Kevin D. Courtney, Abhishek Jha, Ronald A. DePinho, James W. Horner, Craig J. Thomas, Lewis C. Cantley, Massimo Loda, Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2403–2416.
https://doi.org/10.1158/0008-5472.CAN-21-2352
Published: 05 July 2022
View articletitled, Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
Open the PDF for Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract IA01: Modeling and understanding tumor biologic mechanisms

Adam Boutin, Peiwen Chen, Prasenjit Dey, Pingping Hou, Wen-Ting Liao, Xin Lu, Haoqiang Ying, Di Zhao, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): IA01.
https://doi.org/10.1158/1538-7445.CAMODELS2020-IA01
Published: 02 June 2020
View articletitled, Abstract IA01: Modeling and understanding tumor biologic mechanisms
Journal Articles

Abstract A09: CD4 T cells mediated protumorigenic pathway in pancreatic cancer

Prasenjit Dey, Jun Li, Jianhua Zhang, Huamin Wang, Wen-Ting Liao, Vincent P Bernard, Giannicola Genovese, Anirban Maitra, Anders Strom, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A09.
https://doi.org/10.1158/1538-7445.PANCA19-A09
Published: 13 December 2019
View articletitled, Abstract A09: CD4 T cells mediated protumorigenic pathway in pancreatic cancer
Journal Articles

An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer

Xin Lu, Xiaolu Pan, Chang-Jiun Wu, Di Zhao, Shan Feng, Yong Zang, Rumi Lee, Sunada Khadka, Samirkumar B. Amin, Eun-Jung Jin, Xiaoying Shang, Pingna Deng, Yanting Luo, William R. Morgenlander, Jacqueline Weinrich, Xuemin Lu, Shan Jiang, Qing Chang, Nora M. Navone, Patricia Troncoso, Ronald A. DePinho, Y. Alan Wang
Journal: Cancer Research
Cancer Res (2018) 78 (14): 3823–3833.
https://doi.org/10.1158/0008-5472.CAN-17-3564
Published: 15 July 2018
View articletitled, An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer
Open the PDF for An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer in another window
Journal Articles

Abstract 117: Lysyl oxidase secreted by PTEN-deficient glioblastoma cells recruits macrophages and promotes malignant growth

Peiwen Chen, Alan Y. Wang, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 117.
https://doi.org/10.1158/1538-7445.AM2018-117
Published: 01 July 2018
View articletitled, Abstract 117: Lysyl oxidase secreted by PTEN-deficient glioblastoma cells recruits macrophages and promotes malignant growth
Journal Articles

Abstract 2831: Collateral lethality: A new target for personalized oncology

Yu-Hsi Lin, Naima Hammoudi, Nikunj Satani, Jeffrey Ackroyd, Sunada Khadka, Dimitra Georgiou, Joe Marszalek, Yuting Sun, Marina Protopopova, Maria E. Di Francesco, Barbara Czako, Alan Y. Wang, Ronald A. DePinho, Florian L. Muller
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2831.
https://doi.org/10.1158/1538-7445.AM2018-2831
Published: 01 July 2018
View articletitled, Abstract 2831: Collateral lethality: A new target for personalized oncology
Journal Articles

Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion

Yinhui Yang, Alexandra M. Blee, Dejie Wang, Jian An, Yunqian Pan, Yuqian Yan, Tao Ma, Yundong He, Joseph Dugdale, Xiaonan Hou, Jun Zhang, S. John Weroha, Wei-Guo Zhu, Y. Alan Wang, Ronald A. DePinho, Wanhai Xu, Haojie Huang
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (23): 6524–6537.
https://doi.org/10.1158/0008-5472.CAN-17-0686
Published: 30 November 2017
View articletitled, Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion
Open the PDF for Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion in another window
Includes: Supplementary data