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Rona Yaeger
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Journal Articles

Abstract CT002: Circulating tumor DNA status to direct adjuvant immunotherapy for mismatch repair deficient tumors

Free
Yelena Yuriy Janjigian, Michael B. Foote, Melissa Lumish, Marinela Capanu, Joanne Chou, Julio Garcia-Aguilar, Martin Weiser, Jason Konner, Vivian Strong, Elizabeth Jewell, Jennifer Mueller, Steven Maron, Ping Gu, Rona Yaeger, Sree Chalasani, Andrea Cercek, Jia Li, Maliha Nusrat, Ryan Sugarman, David Jones, Daniela Molena, David Solit, Brian Loomis, Marc Ladanyi, Michael Berger, Luis A. Diaz
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT002.
https://doi.org/10.1158/1538-7445.AM2025-CT002
Published: 22 May 2025
View articletitled, Abstract CT002: Circulating tumor DNA status to direct adjuvant immunotherapy for mismatch repair deficient tumors
Journal Articles

Abstract CT019: Preliminary safety and antitumor activity of zoldonrasib (RMC-9805), an oral, RAS(ON) G12D-selective, tri-complex inhibitor in patients with KRAS G12D non-small cell lung cancer (NSCLC) from a phase 1 study in advanced solid tumors

Free
Kathryn C. Arbour, Tanvetyanon Tawee, Rona Yaeger, Aparna R. Parikh, Paul Oberstein, Kyriakos P. Papadopoulos, John Strickler, Alexander Spira, John Powderly, Minal Barve, Judy Wang, Jia Luo, Nilofer Saba Hazad, Alexander Starodub, Patricia LoRusso, Avantika Elgin, Michelle Yang, Walter Yu, Mark McCleland, Satwant Lally, Sophia Sohoni, David S. Hong
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT019.
https://doi.org/10.1158/1538-7445.AM2025-CT019
Published: 22 May 2025
View articletitled, Abstract CT019: Preliminary safety and antitumor activity of zoldonrasib (RMC-9805), an oral, RAS(ON) G12D-selective, tri-complex inhibitor in patients with KRAS G12D non-small cell lung cancer (NSCLC) from a phase 1 study in advanced solid tumors
Journal Articles

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

Open Access
Sunyana Gadal, Jacob A. Boyer, Simon F. Roy, Noah A. Outmezguine, Malvika Sharma, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Afsar Barlas, Qing Chang, Priya Pancholi, Neilawattie Merna Timaul, Michael Overholtzer, Rona Yaeger, Katia Manova-Todorova, Elisa de Stanchina, Marcus W. Bosenberg, Neal Rosen
Journal: Cancer Research
Cancer Res (2025) 85 (9): 1611–1627.
https://doi.org/10.1158/0008-5472.CAN-24-2220
Published: 02 May 2025
View articletitled, Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
Open the PDF for Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract CT247: FORTE: A phase 2 master protocol assessing plixorafenib for BRAF-altered cancers

Free
Karisa C. Schreck, Macarena I. de la Fuente, Jessica Rine, Irina Kline, Stacie Peacock Shepherd, Jordi Rodon, Rona Yaeger, Eric Sherman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT247.
https://doi.org/10.1158/1538-7445.AM2025-CT247
Published: 25 April 2025
View articletitled, Abstract CT247: FORTE: A phase 2 master protocol assessing plixorafenib for BRAF-altered cancers
Journal Articles

Abstract 5508: Direct inhibition of RAS reveals the features of oncogenic signaling in RAS-mutant cancers

Free
Santiago Garcia Borrego, Michelangelo Marasco, Dinesh Kumar, Tessa Seale, Riccardo Mezzadra, Giulia Maddalena, Kylie Belanger, Soren Cole, Bryan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa de Stanchina, Scott Lowe, Richard Burkhart, Jackie Zimmerman, Rona Yaeger, Scott Kopetz, Neal Rosen, Sandra Misale
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5508.
https://doi.org/10.1158/1538-7445.AM2025-5508
Published: 21 April 2025
View articletitled, Abstract 5508: Direct inhibition of RAS reveals the features of oncogenic signaling in RAS-mutant cancers
Journal Articles

Abstract 3391: Clonality and allelic imbalance of driver genes in a large retrospective cohort of colorectal cancer patients

Free
Henry Walch, Paolo Manca, Jierui Xu, Christopher Fong, Justin Jee, Karl Pichotta, Adam Price, Allison L. Richards, Mark Donoghue, Jinru Shia, Efsevia Vakiani, Neil H. Segal, Andrea Cercek, Nikolaus Schultz, Francisco Sanchez-Vega, Walid K. Chatila, Rona Yaeger
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3391.
https://doi.org/10.1158/1538-7445.AM2025-3391
Published: 21 April 2025
View articletitled, Abstract 3391: Clonality and allelic imbalance of driver genes in a large retrospective cohort of colorectal cancer patients
Journal Articles

Abstract 1240: Genomic characterization of changes in the molecular profile of locally advanced rectal cancer treated with neoadjuvant therapy

Free
Sharafudeen D. Abubakar, Christina I. Lee, Farheen Shah, Chin-Tung Chen, Paolo Manca, Henry Walch, Walid K. Chatila, Rona Yaeger, Julio Garcia-Aguilar, Francisco Sanchez-Vega
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1240.
https://doi.org/10.1158/1538-7445.AM2025-1240
Published: 21 April 2025
View articletitled, Abstract 1240: Genomic characterization of changes in the molecular profile of locally advanced rectal cancer treated with neoadjuvant therapy
Journal Articles

Abstract 3386: Clinicogenomic comparison of patients with liver-avid/lung-adverse and lung-avid/liver-adverse patterns of metastases highlights commonalities across cancer types

Free
John Nguyen, Walid K. Chatila, Paolo Manca, Henry Walch, Subhiksha Nandakumar, Pedram Razavi, Eileen M. O'Reilly, Yelena Y. Janjigian, Rona Yaeger, Karuna Ganesh, Michael F. Berger, Nikolaus Schultz, Francisco Sanchez-Vega
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3386.
https://doi.org/10.1158/1538-7445.AM2025-3386
Published: 21 April 2025
View articletitled, Abstract 3386: Clinicogenomic comparison of patients with liver-avid/lung-adverse and lung-avid/liver-adverse patterns of metastases highlights commonalities across cancer types
Journal Articles

Abstract 1152: The landscape of copy number variations following WGD in 5,980 colorectal cancers

Free
Jierui Xu, Henry Walch, Paolo Manca, Maria Perry, Christopher Fong, Justin Jee, Karl Pichotta, Efsevia Vakiani, Neil H. Segal, Adam Price, Allison L. Richards, Chai Bandlamudi, Mark Donoghue, Andrea Cercek, Rona Yaeger, Nikolaus Schultz, Walid K. Chatila
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1152.
https://doi.org/10.1158/1538-7445.AM2025-1152
Published: 21 April 2025
View articletitled, Abstract 1152: The landscape of copy number variations following WGD in 5,980 colorectal cancers
Journal Articles

Abstract 3248: Circulating tumor DNA analysis of patients with BRAF-mutated advanced unresectable solid tumors treated with plixorafenib (FORE8394/PLX8394) in phase 1/2a study

Free
Rona Yaeger, Eric J. Sherman, Macarena de la Fuente, Frank Q. Tsai, Nicholas Butowski, Carl E. Allen, Natraj R. Ammakkanavar, Philip Lammers, Jessica C. Jang, Michael Paz, Sam Wang, Stacie Peacock Shepherd, Ping Jiang, Jordi Rodon
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3248.
https://doi.org/10.1158/1538-7445.AM2025-3248
Published: 21 April 2025
View articletitled, Abstract 3248: Circulating tumor DNA analysis of patients with BRAF-mutated advanced unresectable solid tumors treated with plixorafenib (FORE8394/PLX8394) in phase 1/2a study
Journal Articles

Abstract 7108: Leveraging race-informed biological models for disparities research in colorectal cancer

Free
Xiang Han, Stefanie Gerstberger, Kathleen Luckett, Francesco Cambuli, Jaeyop Lee, Andres Rettig, Ahmed Mahmoud, Jonathan Bermeo, Asha Saxena, T.Peter Kingham, William Jarnagin, Philip Paty, Martin Weiser, Michael D’Angelica, Rona Yaeger, Julio Garcia-Aguilar, Francisco Sanchez-Vega, Karuna Ganesh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7108.
https://doi.org/10.1158/1538-7445.AM2025-7108
Published: 21 April 2025
View articletitled, Abstract 7108: Leveraging race-informed biological models for disparities research in colorectal cancer
Journal Articles

Abstract 6387: Oral and selective ribonucleotide reductase (RNR) inhibitor, BBI-825, suppresses acquired resistance to mutant-specific, pan, and multi-RAS targeting inhibitors

Free
Joshua Lange, Salvador Garcia, Evan Holmes, AnneMarie Pferdekamper, Ben Norman, Auzon Steffy, Joshua Plum, Nicholas Catalano, Cory DuPai, HuiYong Zhao, Elisa de Stanchina, Claire Kuelbs, Austin Christofferson, Ardalan Ardeshiri, Edison Tse, Frederick Derheimer, Joan Chen, Debbie Liao, Ryan Hansen, Rona Yaeger, Sudhir Chowdhry, Christian Hassig
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6387.
https://doi.org/10.1158/1538-7445.AM2025-6387
Published: 21 April 2025
View articletitled, Abstract 6387: Oral and selective ribonucleotide reductase (RNR) inhibitor, BBI-825, suppresses acquired resistance to mutant-specific, pan, and multi-RAS targeting inhibitors
Journal Articles

Abstract 2856: Pks+ E. coli trigger intestinal stem cell plasticity and early onset colorectal cancer

Free
Stefanie Gerstberger, Melissa Lumish, Saskia Hartner, Farheen Shah, Seongmin Choi, Krystal Lum, Christopher Cowley, Anisha Luthra, Qingwen Jiang, Hyung Jun Woo, Ahmed Mahmoud, Henry Walch, Asha Saxena, Tavis J. Reed, Andrea Cercek, Rona Yaeger, Ileana Cristea, Andrew McPherson, Francisco Sanchez-Vega, Karuna Ganesh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2856.
https://doi.org/10.1158/1538-7445.AM2025-2856
Published: 21 April 2025
View articletitled, Abstract 2856: Pks+ E. coli trigger intestinal stem cell plasticity and early onset colorectal cancer
Journal Articles

Abstract 7105: Analyses of real-world clinico-genomic and demographic data highlight the multifactorial causes of poor colorectal cancer outcomes in patients of African ancestry

Free
Sharafudeen D. Abubakar, Henry Walch, Christina I. Lee, Chin-Tung Chen, Kanika Arora, Farheen Shah, Tejiri Agbamu, Michele Waters, Christopher Fong, Justin Jee, Michael F. Berger, Karuna Ganesh, Debyani Chakravarty, Walid K. Chatila, Nikolaus Schultz, Rona Yaeger, Julio Garcia-Aguilar, Francisco Sanchez-Vega
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7105.
https://doi.org/10.1158/1538-7445.AM2025-7105
Published: 21 April 2025
View articletitled, Abstract 7105: Analyses of real-world clinico-genomic and demographic data highlight the multifactorial causes of poor colorectal cancer outcomes in patients of African ancestry
Journal Articles

Abstract 3880: Functional dissection of the highly plastic basal cell state in pancreatic cancer

Free
Anupriya Singhal, Hannah Styers, Jonathan Rub, Kate Ryan, Jung Yun Kim, Zeynep C. Tarcan, Jill Hallin, Olca Basturk, Rona Yaeger, James G. Christensen, Yan Yan, Elisa de Stanchina, Tuomas Tammela
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3880.
https://doi.org/10.1158/1538-7445.AM2025-3880
Published: 21 April 2025
View articletitled, Abstract 3880: Functional dissection of the highly plastic basal cell state in pancreatic cancer
Journal Articles

Abstract C077: Functional Dissection of the Highly Plastic Basal Cell State in Pancreatic Cancer

Free
Anupriya Singhal, Hannah C. Styers, Jonathan Rub, Zhuxuan Li, Zeynep Tarcan, Jill Hallin, Olca Basturk, Rona Yaeger, James G. Christensen, Doron Betel, Yan Yan, Elisa de Stanchina, Tuomas Tammela
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C077.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C077
Published: 15 September 2024
View articletitled, Abstract C077: Functional Dissection of the Highly Plastic Basal Cell State in Pancreatic Cancer
Journal Articles

Abstract CT178: Phase 1 trial of PF-07799933 (ARRY-440), a next-generation BRAF inhibitor, for BRAF-mutant cancers

Free
Rona Yaeger, Meredith McKean, Rizwan Haq, Joseph T. Beck, Matthew H. Taylor, Jonathan Cohen, Daniel Bowles, Shirish M. Gadgeel, Catalin Mihalcioiu, Kyriakos P. Papadopoulos, Eli L. Diamond, Keren B. Sturtz, Gang Feng, Stefanie K. Drescher, Micaela B. Reddy, Bhaswati Sengupta, Arnab K. Maity, Suzy A. Brown, Anurag Singh, Eric N. Brown, Brian R. Baer, Jim Wong, Tung-Chung Mou, Wen I. Wu, Dean Kahn, Sunyana Gadal, Neal Rosen, John J. Gaudino, Patrice A. Lee, Dylan P. Hartley, Stephen Michael Rothenberg
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT178.
https://doi.org/10.1158/1538-7445.AM2024-CT178
Published: 05 April 2024
View articletitled, Abstract CT178: Phase 1 trial of PF-07799933 (ARRY-440), a next-generation BRAF inhibitor, for BRAF-mutant cancers
Journal Articles

Abstract 6623: Ala59 mutants of KRAS cooperate with Nf1 loss to enhance colon tumorigenesis

Free
Christian William Johnson, Elizabeth M. Terrell, Josh Cook, Bing Shui, Eve O'Donoghue, Shannon Hull, Moon Hee Yang, Shikha Sheth, Rona Yaeger, Scott Kopetz, Deborah K. Morrison, Kevin Haigis
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6623.
https://doi.org/10.1158/1538-7445.AM2024-6623
Published: 22 March 2024
View articletitled, Abstract 6623: Ala59 mutants of KRAS cooperate with Nf1 loss to enhance colon tumorigenesis
Journal Articles

Abstract 3779: Genomic and clinical characterization of metastatic patterns using real-word data from a large cohort of colorectal cancer patients

Free
Paolo Manca, Ayush V. Kris, Henry Walch, Christopher Fong, Justin Jee, Karl Pichotta, Nikolaus Schultz, Walid K. Chatila, Rona Yaeger, Francisco Sanchez-Vega
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3779.
https://doi.org/10.1158/1538-7445.AM2024-3779
Published: 22 March 2024
View articletitled, Abstract 3779: Genomic and clinical characterization of metastatic patterns using real-word data from a large cohort of colorectal cancer patients
Journal Articles

Abstract 2796: Colibactin mutation signatures are associated with younger age of onset in colorectal cancer

Free
Stefanie Gerstberger, Melissa Lumish, Saskia Hartner, Farheen Shah, Seongmin Choi, Anisha Luthra, Qingwen Jiang, Hyung Jun Woo, Ahmed Mahmoud, Henry Walch, Simran Asawa, Mark Donoghue, Andrea Cercek, Rona Yaeger, Andrew McPherson, Francisco Sanchez-Vega, Karuna Ganesh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2796.
https://doi.org/10.1158/1538-7445.AM2024-2796
Published: 22 March 2024
View articletitled, Abstract 2796: Colibactin mutation signatures are associated with younger age of onset in colorectal cancer