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Abstract 1017: RICTOR/mTOR signaling regulates novel immune checkpoints in non-small cell lung cancer (NSCLC)

Mariam Alexander, Ni Fan, Xiaoxin Ren, Jeffrey Ross, Hao Wang, Feng Wang, Balazs Halmos, Roman Perez-Soler, Xingxing Zang, Haiying Cheng

Cancer Res (2020) 80 (16_Supplement): 1017.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1017

Published: 15 August 2020

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Journal Articles

Abstract 4907: A novel functional analysis of MET exon 14 skipping mutation in regulation of tumor cell invasion and metastasis

Feng Wang, Yang Liu, Elaine Shum, Mariam Alexander, Deyou Zheng, Roman Perez-Soler, Haiying Cheng, Balazs Halmos

Cancer Res (2020) 80 (16_Supplement): 4907.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4907

Published: 15 August 2020

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Journal Articles

Abstract 4748: RICTOR signaling modulates the activity of EGFR tyrosine kinase inhibitors (TKI) in EGFR-mutated non-small cell lung cancer (NSCLC)

Ni Fan, Yiyu Zou, Balazs Halmos, Roman Perez-Soler, Haiying Cheng

Cancer Res (2019) 79 (13_Supplement): 4748.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4748

Published: 01 July 2019

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Journal Articles

Abstract 2740: MET exon 14 skipping mutation promotes metastasis via activation of the PI3K/Akt-Rac1 pathway in non-small cell lung cancer

Feng Wang, Elaine Shum, Roman Perez-Soler, Haiying Cheng, Balazs Halmos

Cancer Res (2019) 79 (13_Supplement): 2740.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2740

Published: 01 July 2019

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Journal Articles

Abstract 905: RICTOR modulation regulates cisplatin sensitivity in lung cancer

Haiying Cheng, Ni Fan, Alain Borczu, Huijie Liu, Aditi Singh, Feng Wang, Balazs Halmos, Roman Perez-Soler

Cancer Res (2018) 78 (13_Supplement): 905.

DOI: https://doi.org/10.1158/1538-7445.AM2018-905

Published: 01 July 2018

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Journal Articles

Abstract 1217: Blockade of Aurora kinase A synergizes with platinum and radiation in non-small cell lung cancer cells

Huijie Liu, Dongwei Zhang, Alain Borczuk, Vincent Chau, Roman Perez-Soler, Balazs Halmos, Haiying Cheng

Cancer Res (2017) 77 (13_Supplement): 1217.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1217

Published: 01 July 2017

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Journal Articles

Abstract 518: Synergistic effects of dual inhibition of YAP1 and TAZ in non-small cell lung cancer cells

Elaine Shum, Huijie Liu, Liang Zhu, Roman Perez-Soler, Balazs Halmos, Haiying Cheng

Cancer Res (2017) 77 (13_Supplement): 518.

DOI: https://doi.org/10.1158/1538-7445.AM2017-518

Published: 01 July 2017

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Journal Articles

Abstract 3306: Inhibition of ribosomal protein S6 (rpS6) phosphorylation and cell proliferation by a novel chloroquine analog in lung cancer cells

Juan Sironi, Evelyn Aranda, Lars Nordstroem, Roman Perez Soler, Edward L. Schwartz

Cancer Res (2017) 77 (13_Supplement): 3306.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3306

Published: 01 July 2017

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Journal Articles

Abstract 1012: Discovery and synthesis of novel autophagy inhibitors with anti-proliferative activity in lung and pancreatic cancer cells

Juan Sironi, Lars Ulrik Nordstroem, Evelyn Aranda, Marina Shcherba, Roman Perez-Soler, Peng Wu, Edward L. Schwartz

Cancer Res (2015) 75 (15_Supplement): 1012.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1012

Published: 01 August 2015

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Journal Articles

Abstract 589: DNA demethylating agent and histone deacetylation inhibitor synergistically induce paired box 5 gene expression in non-small cell lung cancer cell lines

Yuanxin Liang, Roman Perez-Soler, Yiyu Zou

Cancer Res (2014) 74 (19_Supplement): 589.

DOI: https://doi.org/10.1158/1538-7445.AM2014-589

Published: 01 October 2014

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Journal Articles

Abstract 683: Toxicity of aerosolized azacytidine (Vidaza) in mice.

Xuan Qiu, Rani Sellers, Yuanxin Liang, Bilal Piperdi, Roman Perez-Soler, Yiyu Zou

Cancer Res (2013) 73 (8_Supplement): 683.

DOI: https://doi.org/10.1158/1538-7445.AM2013-683

Published: 15 April 2013

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Abstract 2033: Identification of a novel genetic abnormality, the amplification of rictor (rapamycin-insensitive companion of mTOR), in a patient with non-small cell lung cancer.

Haiying Cheng, Bilal Piperdi, Edward L. Schwartz, Changcheng Zhu, Zhenfeng Zhang, Balazs Halmos, Vincent Miller, Roman Perez-Soler

Cancer Res (2013) 73 (8_Supplement): 2033.

DOI: https://doi.org/10.1158/1538-7445.AM2013-2033

Published: 15 April 2013

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Abstract 2044: Down-regulation of YAP sensitizes lung cancer cells to platinum and ionizing radiation.

Haiying Cheng, Zhenfeng Zhang, Ruth Rodriguez-Barrueco, Jiyang Yu, Jose M. Silva, Simon Cheng, Roman Perez-Soler, Balazs Halmos

Cancer Res (2013) 73 (8_Supplement): 2044.

DOI: https://doi.org/10.1158/1538-7445.AM2013-2044

Published: 15 April 2013

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Journal Articles

Abstract 4075: Aerosol azacytidine inhibits the orthotopic lung cancer in mice by its demethylation function but not cytotoxic effect

Xuan Qiu, Roman Perez-Soler, Yiyu Zou

Cancer Res (2012) 72 (8_Supplement): 4075.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4075

Published: 15 April 2012

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Journal Articles

Abstract 850: Activation of autophagy by erlotinib protects NSCLC cells with wild-type EGFR from erlotinib cytotoxicity

Edward L. Schwartz, Yi-He Ling, Yiyu Zou, Bilal Piperdi, Roman Perez-Soler

Cancer Res (2012) 72 (8_Supplement): 850.

DOI: https://doi.org/10.1158/1538-7445.AM2012-850

Published: 15 April 2012

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Journal Articles

Abstract 5040: Dysregulation of the mTOR/AKT pathway in serum tumor DNA correlates with primary and acquired resistances to erlotinib in advanced NSCLC patients

Sonal J. Desai, Yi-He Ling, Ryan Davis, Clifford G. Tepper, David R. Gandara, Roman Perez-Soler, Tianhong Li

Cancer Res (2011) 71 (8_Supplement): 5040.

DOI: https://doi.org/10.1158/1538-7445.AM2011-5040

Published: 15 April 2011

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Journal Articles

Abstract 1253: Combination of chloroquine to inhibitors of the HER family receptors leads to synergistic growth inhibition of breast cancer cell lines

Apurva N. Shah, Yi-He Ling, Roman Perez-Soler

Cancer Res (2010) 70 (8_Supplement): 1253.

DOI: https://doi.org/10.1158/1538-7445.AM10-1253

Published: 15 April 2010

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Journal Articles

Abstract 3472: Inhaled carcinogen induced lung cancer in mice

Yiyu Zou, Xuan Qiu, Roman Perez-Soler

Cancer Res (2010) 70 (8_Supplement): 3472.

DOI: https://doi.org/10.1158/1538-7445.AM10-3472

Published: 15 April 2010

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Journal Articles

Abstract #2656: Irvalec (PM02734) induces caspase-independent autophagic cell death in human non-small cell lung cancer cell lines through the inhibition of akt/mtor signaling pathways and activation of dath asociated potein kinase

Yi-He Ling, Miguel Aracil, Yiyu Zou, José Jimeno, Román Pérez-Soler

Cancer Res (2009) 69 (9_Supplement): 2656.

Published: 01 May 2009

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Journal Articles

Abstract #5466: Antitumor activity of Irvalec (PM02734) against lung cancer xenografts

Yiyu Zou, Huanhuan Chen, Yihe Ling, Miguel Aracil, Roman Perez-Soler

Cancer Res (2009) 69 (9_Supplement): 5466.

Published: 01 May 2009

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NARROW

Abstract 1017: RICTOR/mTOR signaling regulates novel immune checkpoints in non-small cell lung cancer (NSCLC)

Abstract 4907: A novel functional analysis of MET exon 14 skipping mutation in regulation of tumor cell invasion and metastasis

Abstract 4748: RICTOR signaling modulates the activity of EGFR tyrosine kinase inhibitors (TKI) in EGFR-mutated non-small cell lung cancer (NSCLC)

Abstract 2740: MET exon 14 skipping mutation promotes metastasis via activation of the PI3K/Akt-Rac1 pathway in non-small cell lung cancer

Abstract 905: RICTOR modulation regulates cisplatin sensitivity in lung cancer

Abstract 1217: Blockade of Aurora kinase A synergizes with platinum and radiation in non-small cell lung cancer cells

Abstract 518: Synergistic effects of dual inhibition of YAP1 and TAZ in non-small cell lung cancer cells

Abstract 3306: Inhibition of ribosomal protein S6 (rpS6) phosphorylation and cell proliferation by a novel chloroquine analog in lung cancer cells

Abstract 1012: Discovery and synthesis of novel autophagy inhibitors with anti-proliferative activity in lung and pancreatic cancer cells

Abstract 589: DNA demethylating agent and histone deacetylation inhibitor synergistically induce paired box 5 gene expression in non-small cell lung cancer cell lines

Abstract 683: Toxicity of aerosolized azacytidine (Vidaza) in mice.

Abstract 2033: Identification of a novel genetic abnormality, the amplification of rictor (rapamycin-insensitive companion of mTOR), in a patient with non-small cell lung cancer.

Abstract 2044: Down-regulation of YAP sensitizes lung cancer cells to platinum and ionizing radiation.

Abstract 4075: Aerosol azacytidine inhibits the orthotopic lung cancer in mice by its demethylation function but not cytotoxic effect

Abstract 850: Activation of autophagy by erlotinib protects NSCLC cells with wild-type EGFR from erlotinib cytotoxicity

Abstract 5040: Dysregulation of the mTOR/AKT pathway in serum tumor DNA correlates with primary and acquired resistances to erlotinib in advanced NSCLC patients

Abstract 1253: Combination of chloroquine to inhibitors of the HER family receptors leads to synergistic growth inhibition of breast cancer cell lines

Abstract 3472: Inhaled carcinogen induced lung cancer in mice

Abstract #2656: Irvalec (PM02734) induces caspase-independent autophagic cell death in human non-small cell lung cancer cell lines through the inhibition of akt/mtor signaling pathways and activation of dath asociated potein kinase

Abstract #5466: Antitumor activity of Irvalec (PM02734) against lung cancer xenografts

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