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Rolf Larsson
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Journal Articles

Abstract 1859: Inhibition of proteasome deubiquitinase activity prevents cytoprotective aggresome formation in cancer cells

Ellin-Kristina Hillert, Slavica Brjnic, Magdalena Mazurkiewicz, Rolf Larsson, Mårten Fryknäs, Lisa Swanton, Stephen High, Stig Linder, Padraig B. D'Arcy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1859.
https://doi.org/10.1158/1538-7445.AM2018-1859
Published: 01 July 2018
View article titled, Abstract 1859: Inhibition of proteasome deubiquitinase activity prevents cytoprotective aggresome formation in cancer cells
Journal Articles

Abstract 4175: Targeting of a mesenchymal profile in order to sensitize multitherapy resistant glioblastoma clones

Mia Niklasson, Malin Jarvius, Caroline Haglund, Efthymia Chantzi, Tobias Bergström, Frida Nyberg, Annika Hermansson, Mårten Fryknäs, Mats Gustafsson, Bo Segerman, Rolf Larsson, Bengt Westermark, Anna Segerman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4175.
https://doi.org/10.1158/1538-7445.AM2017-4175
Published: 01 July 2017
View article titled, Abstract 4175: Targeting of a mesenchymal profile in order to sensitize multitherapy resistant glioblastoma clones
Journal Articles

Abstract 4990: High-throughput drug combination screening in tumor spheroids identifies context-dependent synthetic lethalities

Wojciech Senkowski, Madiha Nazir, Malin Jarvius, Jenny Rubin, Johan Lengqvist, Mats G. Gustafsson, Peter Nygren, Kim Kultima, Rolf Larsson, Mårten Fryknäs
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4990.
https://doi.org/10.1158/1538-7445.AM2017-4990
Published: 01 July 2017
View article titled, Abstract 4990: High-throughput drug combination screening in tumor spheroids identifies context-dependent synthetic lethalities
Journal Articles

Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype

Smitha Sreedharan, Naga Prathyusha Maturi, Yuan Xie, Anders Sundström, Malin Jarvius, Sylwia Libard, Irina Alafuzoff, Holger Weishaupt, Mårten Fryknäs, Rolf Larsson, Fredrik J. Swartling, Lene Uhrbom
Journal: Cancer Research
Cancer Res (2017) 77 (3): 802–812.
https://doi.org/10.1158/0008-5472.CAN-16-2482
Published: 31 January 2017
View article titled, Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype
Open the PDF for Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype in another window
Includes: Supplementary data
Journal Articles

Abstract 213: Mitochondrial inhibitors and statins: a lethal combination for metabolically stressed cancer cells

Wojciech Senkowski, Malin Jarvius, Kim Kultima, Jenny Rubin, Mats Gustafsson, Peter Nygren, Rolf Larsson, Mårten Fryknäs.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 213.
https://doi.org/10.1158/1538-7445.AM2016-213
Published: 15 July 2016
View article titled, Abstract 213: Mitochondrial inhibitors and statins: a lethal combination for metabolically stressed cancer cells
Journal Articles

Abstract 2415: GBM exhibits phenotypic microheterogeneity and harbors pre-existing multi- resistant clones with a mesenchymal transition signature

Anna Segerman, Maria Niklasson, Caroline Haglund, Tobias Bergstrom, Malin Jarvius, Yuan Xie, Demet Caglayan Simov, Annika Hermansson, Marianne Kastemar, Zeinab Naimaie-Ali, Malin Berglund, Ann Westermark, Magnus Sundstrom, Goran Hesselager, Lene Uhrbom, Mats Gustafsson, Rolf Larsson, Marten Fryknas, Bo Segerman, Bengt Westermark
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2415.
https://doi.org/10.1158/1538-7445.AM2016-2415
Published: 15 July 2016
View article titled, Abstract 2415: GBM exhibits phenotypic microheterogeneity and harbors pre-existing multi- resistant clones with a mesenchymal transition signature
Journal Articles

Abstract 323: Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Wojciech Senkowski, Xiaonan Zhang, Peter Nygren, Maria Hägg Olofsson, Mats Gustafsson, Stig Linder, Rolf Larsson, Mårten Fryknäs
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 323.
https://doi.org/10.1158/1538-7445.AM2015-323
Published: 01 August 2015
View article titled, Abstract 323: Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics
Journal Articles

Abstract 1736: The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Magdalena Mazurkiewicz, Slavica Brnjic, Mårten Fryknäs, Chao Sun, Xiaonan Zhang, Rolf Larsson, Pádraig D'Arcy, Stig Linder
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1736.
https://doi.org/10.1158/1538-7445.AM2015-1736
Published: 01 August 2015
View article titled, Abstract 1736: The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress
Journal Articles

Abstract 3781: A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Wojciech Senkowski, Xiaonan Zhang, Maria Hägg Olofsson, Stig Linder, Rolf Larsson, Mårten Fryknäs
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3781.
https://doi.org/10.1158/1538-7445.AM2014-3781
Published: 01 October 2014
View article titled, Abstract 3781: A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning
Journal Articles

Abstract 3999: Spontaneous time-dependent accumulation of interferon-regulatory factor 9 induces chemo-resistance in colon carcinoma cells independently of STAT1 signaling.

Iryna Kolosenko, Mårten Fryknäs, Hanif Rassoolzadeh, Paola Pellegrini, Slavica Brnjic, Per Johnsson, Giuseppe Di Lernia, Dan Grander, Rolf Larsson, Katja Pokrovskaja, Stig Linder, Angelo De Milito De Milito
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3999.
https://doi.org/10.1158/1538-7445.AM2013-3999
Published: 15 April 2013
View article titled, Abstract 3999: Spontaneous time-dependent accumulation of interferon-regulatory factor 9 induces chemo-resistance in colon carcinoma cells independently of STAT1 signaling.
Journal Articles

Abstract 2941: Inhibition of proteasome deubiquitinating activity as a novel cancer therapy

Pádraig D'Arcy1, Slavica Brnjic1, Maria H. Olofsson, Marten Fryknas, Rolf Larsson, Stig T. Linder
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2941.
https://doi.org/10.1158/1538-7445.AM2012-2941
Published: 15 April 2012
View article titled, Abstract 2941: Inhibition of proteasome deubiquitinating activity as a novel cancer therapy
Journal Articles

Abstract 4725: Inhibition of the Hedgehog signaling pathway - a new target in treatment for children with neuroblastoma

Malin Wickstrom, Cecilia Dyberg, Takashi Shimokawa, Ninib Baryawno, Jelena Milosevic, Ole M. Fuskevag, Rolf Larsson, Peter G. Zaphiropoulos, Per Kogner, John I. Johnsen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4725.
https://doi.org/10.1158/1538-7445.AM2012-4725
Published: 15 April 2012
View article titled, Abstract 4725: Inhibition of the Hedgehog signaling pathway - a new target in treatment for children with neuroblastoma
Journal Articles

Abstract #1951: Identification of drugs for treatment of solid tumors by spheroid screening

Slavica Brnjic, Walid Fayad, Maria Berndtsson, Maria Hägg Olofsson, Mårten Fryknäs, Rolf Larsson, Stig Linder
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1951.
Published: 01 May 2009
View article titled, Abstract #1951: Identification of drugs for treatment of solid tumors by spheroid screening
Journal Articles

Resistance marker analysis in several human cancer cell lines with acquired resistance against different cytostatics using SELDI mass spectrometry.

Lukas Orre, Sumeer Dhar, Rolf Lewensohn, Rolf Larsson, Janne Lehtiö
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 822.
Published: 01 April 2004
View article titled, Resistance marker analysis in several human cancer cell lines with acquired resistance against different cytostatics using SELDI mass spectrometry.
Journal Articles

Action of a Novel Anticancer Agent, CHS 828, on Mouse Fibroblasts: Increased Sensitivity of Cells Lacking Poly (ADP-Ribose) Polymerase-1

Henrik Lövborg, Jacek Wojciechowski, Rolf Larsson, Józefa Węsierska-Gądek
Journal: Cancer Research
Cancer Res (2002) 62 (15): 4206–4211.
Published: 01 August 2002
View article titled, Action of a Novel Anticancer Agent, CHS 828, on Mouse Fibroblasts: <subtitle>Increased Sensitivity of Cells Lacking Poly (ADP-Ribose) Polymerase-1</subtitle>
Open the PDF for Action of a Novel Anticancer Agent, CHS 828, on Mouse Fibroblasts: <subtitle>Increased Sensitivity of Cells Lacking Poly (ADP-Ribose) Polymerase-1</subtitle> in another window
Journal Articles

CHS 828, a Novel Pyridyl Cyanoguanidine with Potent Antitumor Activity in Vitro and in Vivo

Pernille-Julia Vig Hjarnaa, Elin Jonsson, Scilla Latini, Sumeer Dhar, Rolf Larsson, Erik Bramm, Torsten Skov, Lise Binderup
Journal: Cancer Research
Cancer Res (1999) 59 (22): 5751–5757.
Published: 01 November 1999
View article titled, CHS 828, a Novel Pyridyl Cyanoguanidine with Potent Antitumor Activity <em>in Vitro</em> and <em>in Vivo</em>
Open the PDF for CHS 828, a Novel Pyridyl Cyanoguanidine with Potent Antitumor Activity <em>in Vitro</em> and <em>in Vivo</em> in another window