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Rolf A. Brekken
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Journal Articles

SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Open Access
Gilbert Z. Murimwa, Natalie E. Williams, Dina Alzhanova, Amir Mohammadi, Jill M. Westcott, Francisca Beato, Ruifan Dai, Luis Nivelo, Francesca Rossi, Henry K. Fleming, Alexandra F. Tassielli, Zeynep Yazgan, Jason E. Toombs, Jason B. Fleming, Aatur D. Singhi, Cecilia G. Ethun, Huocong Huang, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-1970
Published: 29 May 2025
View articletitled, SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition
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Includes: Supplementary data
Journal Articles

AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Free
Mauricio Marquez-Palencia, Luis Reza Herrera, Pravat Kumar Parida, Suvranil Ghosh, Kangsan Kim, Nikitha M. Das, Paula I. Gonzalez-Ericsson, Melinda E. Sanders, Bret C. Mobley, Sebastian Diegeler, Todd A. Aguilera, Yan Peng, Cheryl M. Lewis, Carlos L. Arteaga, Ariella B. Hanker, Angelique W. Whitehurst, James B. Lorens, Rolf A. Brekken, Anthony J. Davis, Srinivas Malladi
Journal: Cancer Research
Cancer Res (2024) 84 (5): 675–687.
https://doi.org/10.1158/0008-5472.CAN-23-1459
Published: 04 March 2024
View articletitled, AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer
Open the PDF for AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3641: Loss of Smad4 induces SPP1 secretion and immunosuppressive myeloid cell formation in pancreatic ductal adenocarcinoma

Free
Gilbert Z. Murimwa, Francesca Rossi, Henry K. Fleming, Zeynep Yazgan, Dina Alzhanova, Huocong Huang, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3641.
https://doi.org/10.1158/1538-7445.AM2023-3641
Published: 04 April 2023
View articletitled, Abstract 3641: Loss of Smad4 induces SPP1 secretion and immunosuppressive myeloid cell formation in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1545: Targeting anticancer agents to the tumor microenvironment with cathepsin B cleavable drug-linker conjugates of phosphatidylserine-binding proteins

Free
Yuling Deng, Jacob W. Ford, Jenny M. VanNatta, Casey J. Maguire, Deboprosad Mondal, Natalie Z. Phinney, Rolf A. Brekken, Kevin G. Pinney, Mary Lynn Trawick
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1545.
https://doi.org/10.1158/1538-7445.AM2023-1545
Published: 04 April 2023
View articletitled, Abstract 1545: Targeting anticancer agents to the tumor microenvironment with cathepsin B cleavable drug-linker conjugates of phosphatidylserine-binding proteins
Journal Articles

Abstract C078: Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Free
Huocong Huang, Zhaoning Wang, Yuqing Zhang, Rachana N. Pradhan, Debolina Ganguly, Raghav Chandra, Gilbert Murimwa, Steven Wright, Xiaowu Gu, Ravikanth Maddipati, Sören Müller, Shannon J. Turley, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C078.
https://doi.org/10.1158/1538-7445.PANCA22-C078
Published: 15 November 2022
View articletitled, Abstract C078: Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Journal Articles

Abstract 3144: Pleiotrophin drives a pro-metastatic immune niche within breast tumor microenvironment

Free
Debolina Ganguly, Tuong V. Ngo, Morgan Coleman, Noah Sorrelle, Adrian Dominguez, Jason Toombs, Marcel Schmidt, Fa V. Mora, David G. Ortega, Anton Wellstein, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3144.
https://doi.org/10.1158/1538-7445.AM2022-3144
Published: 15 June 2022
View articletitled, Abstract 3144: Pleiotrophin drives a pro-metastatic immune niche within breast tumor microenvironment
Journal Articles

Are TEMs Canceled? Questioning the Functional Relevance of Tie2-Expressing Macrophages

Available to Purchase
Yuqing Zhang, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1172–1173.
https://doi.org/10.1158/0008-5472.CAN-22-0330
Published: 01 April 2022
View articletitled, Are TEMs Canceled? Questioning the Functional Relevance of Tie2-Expressing Macrophages
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Journal Articles

Abstract LT010: Pleiotrophin drives pro-metastatic immune niche within breast tumor microenvironment

Free
Debolina Ganguly, Noah Sorrelle, Adrian Dominguez, Jason Toombs, Marcel Schmidt, Fa Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): LT010.
https://doi.org/10.1158/1538-7445.TME21-LT010
Published: 01 March 2021
View articletitled, Abstract LT010: Pleiotrophin drives pro-metastatic immune niche within breast tumor microenvironment
Journal Articles

ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion

Available to Purchase
Jill M. Westcott, Sharon Camacho, Apsra Nasir, Molly E. Huysman, Raneen Rahhal, Tuyen T. Dang, Anna T. Riegel, Rolf A. Brekken, Gray W. Pearson
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3933–3944.
https://doi.org/10.1158/0008-5472.CAN-20-0014
Published: 15 September 2020
View articletitled, ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion
Open the PDF for ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion in another window
Includes: Multimedia, Supplementary data
Journal Articles

Loss of BAP1 Leads to More YAPing in Pancreatic Cancer

Available to Purchase
Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2020) 80 (8): 1624–1625.
https://doi.org/10.1158/0008-5472.CAN-20-0592
Published: 15 April 2020
View articletitled, Loss of BAP1 Leads to More YAPing in Pancreatic Cancer
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Journal Articles

Abstract 1790: Investigation of oncogenic G-protein coupled receptor signaling pathways in Kras dependent pancreatic cancer cell lines

Free
Ozhan Ocal, Raymond MacDonald, Rolf A. Brekken, Thomas Wilkie
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1790.
https://doi.org/10.1158/1538-7445.AM2019-1790
Published: 01 July 2019
View articletitled, Abstract 1790: Investigation of oncogenic G-protein coupled receptor signaling pathways in Kras dependent pancreatic cancer cell lines
Journal Articles

Abstract CT087: Concentration-dependent early anti-vascular and anti-tumor effects of itraconazole in non-small cell lung cancer (NSCLC)

Free
David E. Gerber, Farjana J. Fattah, Rolf A. Brekken, Rachael Skelton, Jessica Saltarski, Chul Ahn, Kemp H. Kernstine, Chyndhri Padmanabhan, Vaidehi Chemburkar, Sahba Kasiri, Rajareddy Kallem, Indhumathy Subramaniyan, Qing Yuan, Quyen N. Do, Yin Xi, Ivan Pedrosa, William C. Putnam, James Kim
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT087.
https://doi.org/10.1158/1538-7445.AM2019-CT087
Published: 01 July 2019
View articletitled, Abstract CT087: Concentration-dependent early anti-vascular and anti-tumor effects of itraconazole in non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 1037: Axl is critical for pancreatic cancer progression and metastasis

Free
Wenting Du, Huocong Huang, Jason Toombs, Zhaoning Wang, Abdel Hosein, Natalie Burton, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1037.
https://doi.org/10.1158/1538-7445.AM2019-1037
Published: 01 July 2019
View articletitled, Abstract 1037: Axl is critical for pancreatic cancer progression and metastasis
Journal Articles

The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer

Free
Huocong Huang, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2019) 79 (2): 328–330.
https://doi.org/10.1158/0008-5472.CAN-18-3751
Published: 15 January 2019
View articletitled, The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer
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Journal Articles

Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

Free
Kjersti Davidsen, Katarzyna Wnuk-Lipinska, Wenting Du, Magnus Blø, Agnete Engelsen, Stephane Terry, Stacey D´mello, Maria Lie, Jing Kang, Linn Hodneland, Sebastien Bougnaud, Kristina Aguilera, Oddbjørn Straume, Salem Chouaib, Rolf A. Brekken, Gro Gausdal, James B. Lorens
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3774.
https://doi.org/10.1158/1538-7445.AM2018-3774
Published: 01 July 2018
View articletitled, Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy
Journal Articles

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Free
Kathleen F. Ludwig, Wenting Du, Noah B. Sorrelle, Katarzyna Wnuk-Lipinska, Mary Topalovski, Jason E. Toombs, Victoria H. Cruz, Shinichi Yabuuchi, N.V. Rajeshkumar, Anirban Maitra, James B. Lorens, Rolf A. Brekken
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (1): 246–255.
https://doi.org/10.1158/0008-5472.CAN-17-1973
Published: 02 January 2018
View articletitled, Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer
Open the PDF for Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1985: Tbk1 loss in pancreatic cancer leads to changes in epithelial plasticity

Free
Victoria Haley Burton, Rolf A. Brekken, Melissa Gross, Alberto Bremauntz
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1985.
https://doi.org/10.1158/1538-7445.AM2017-1985
Published: 01 July 2017
View articletitled, Abstract 1985: Tbk1 loss in pancreatic cancer leads to changes in epithelial plasticity
Journal Articles

Abstract LB-216: Stroma-induced up-regulation of discoidin domain receptor 1 enhances peritoneal metastasis of gastric carcinomas

Free
Hyejin Jin, In-Hye Ham, Hye Jung Oh, Dakeun Lee, Sang-Uk Han, Rolf A. Brekken, Hoon Hur
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-216.
https://doi.org/10.1158/1538-7445.AM2017-LB-216
Published: 01 July 2017
View articletitled, Abstract LB-216: Stroma-induced up-regulation of discoidin domain receptor 1 enhances peritoneal metastasis of gastric carcinomas
Journal Articles

Abstract 22: Investigating the functional contribution of TANK binding kinase 1 to inflammation induced disease progression

Free
Victoria H. Burton, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 22.
https://doi.org/10.1158/1538-7445.AM2016-22
Published: 15 July 2016
View articletitled, Abstract 22: Investigating the functional contribution of TANK binding kinase 1 to inflammation induced disease progression
Journal Articles

Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

Free
Gro Gausdal, Kjersti Davidsen, Katarzyna Wnuk-Lipinska, Kathleen Wiertel, Jing Kang, Agnete Engelsen, Sébastien Bougnaud, Monica Hellesøy, Magnus Blø, Lavina Ahmed, Linn Hodneland, Sergej Kiprijanov, Oddbjørn Straume, Rolf A. Brekken, James B. Lorens
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 566.
https://doi.org/10.1158/1538-7445.AM2016-566
Published: 15 July 2016
View articletitled, Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy