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Abstract 3144: Pleiotrophin drives a pro-metastatic immune niche within breast tumor microenvironment

Debolina Ganguly, Tuong V. Ngo, Morgan Coleman, Noah Sorrelle, Adrian Dominguez, Jason Toombs, Marcel Schmidt, Fa V. Mora, David G. Ortega, Anton Wellstein, Rolf A. Brekken

Cancer Res (2022) 82 (12_Supplement): 3144.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3144

Published: 15 June 2022

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Journal Articles

Are TEMs Canceled? Questioning the Functional Relevance of Tie2-Expressing Macrophages

Yuqing Zhang, Rolf A. Brekken

Cancer Res (2022) 82 (7): 1172–1173.

DOI: https://doi.org/10.1158/0008-5472.CAN-22-0330

Published: 01 April 2022

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Journal Articles

Abstract LT010: Pleiotrophin drives pro-metastatic immune niche within breast tumor microenvironment

Debolina Ganguly, Noah Sorrelle, Adrian Dominguez, Jason Toombs, Marcel Schmidt, Fa Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A. Brekken

Cancer Res (2021) 81 (5_Supplement): LT010.

DOI: https://doi.org/10.1158/1538-7445.TME21-LT010

Published: 01 March 2021

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Journal Articles

ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion

Jill M. Westcott, Sharon Camacho, Apsra Nasir, Molly E. Huysman, Raneen Rahhal, Tuyen T. Dang, Anna T. Riegel, Rolf A. Brekken, Gray W. Pearson

Cancer Res (2020) 80 (18): 3933–3944.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-0014

Published: 15 September 2020

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Includes: Multimedia, Supplementary data

Journal Articles

Loss of BAP1 Leads to More YAPing in Pancreatic Cancer

Rolf A. Brekken

Cancer Res (2020) 80 (8): 1624–1625.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-0592

Published: 15 April 2020

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Journal Articles

Abstract 1790: Investigation of oncogenic G-protein coupled receptor signaling pathways in Kras dependent pancreatic cancer cell lines

Ozhan Ocal, Raymond MacDonald, Rolf A. Brekken, Thomas Wilkie

Cancer Res (2019) 79 (13_Supplement): 1790.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1790

Published: 01 July 2019

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Journal Articles

Abstract CT087: Concentration-dependent early anti-vascular and anti-tumor effects of itraconazole in non-small cell lung cancer (NSCLC)

David E. Gerber, Farjana J. Fattah, Rolf A. Brekken, Rachael Skelton, Jessica Saltarski, Chul Ahn, Kemp H. Kernstine, Chyndhri Padmanabhan, Vaidehi Chemburkar, Sahba Kasiri, Rajareddy Kallem, Indhumathy Subramaniyan, Qing Yuan, Quyen N. Do, Yin Xi, Ivan Pedrosa, William C. Putnam, James Kim

Cancer Res (2019) 79 (13_Supplement): CT087.

DOI: https://doi.org/10.1158/1538-7445.AM2019-CT087

Published: 01 July 2019

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Journal Articles

Abstract 1037: Axl is critical for pancreatic cancer progression and metastasis

Wenting Du, Huocong Huang, Jason Toombs, Zhaoning Wang, Abdel Hosein, Natalie Burton, Rolf A. Brekken

Cancer Res (2019) 79 (13_Supplement): 1037.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1037

Published: 01 July 2019

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Journal Articles

The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer

Huocong Huang, Rolf A. Brekken

Cancer Res (2019) 79 (2): 328–330.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-3751

Published: 15 January 2019

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Journal Articles

Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

Kjersti Davidsen, Katarzyna Wnuk-Lipinska, Wenting Du, Magnus Blø, Agnete Engelsen, Stephane Terry, Stacey D´mello, Maria Lie, Jing Kang, Linn Hodneland, Sebastien Bougnaud, Kristina Aguilera, Oddbjørn Straume, Salem Chouaib, Rolf A. Brekken, Gro Gausdal, James B. Lorens

Cancer Res (2018) 78 (13_Supplement): 3774.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3774

Published: 01 July 2018

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Journal Articles

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Kathleen F. Ludwig, Wenting Du, Noah B. Sorrelle, Katarzyna Wnuk-Lipinska, Mary Topalovski, Jason E. Toombs, Victoria H. Cruz, Shinichi Yabuuchi, N.V. Rajeshkumar, Anirban Maitra, James B. Lorens, Rolf A. Brekken

Cancer Res (2018) 78 (1): 246–255.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-1973

Published: 02 January 2018

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Includes: Supplementary data

Journal Articles

Abstract LB-216: Stroma-induced up-regulation of discoidin domain receptor 1 enhances peritoneal metastasis of gastric carcinomas

Hyejin Jin, In-Hye Ham, Hye Jung Oh, Dakeun Lee, Sang-Uk Han, Rolf A. Brekken, Hoon Hur

Cancer Res (2017) 77 (13_Supplement): LB-216.

DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-216

Published: 01 July 2017

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Journal Articles

Abstract 1985: Tbk1 loss in pancreatic cancer leads to changes in epithelial plasticity

Victoria Haley Burton, Rolf A. Brekken, Melissa Gross, Alberto Bremauntz

Cancer Res (2017) 77 (13_Supplement): 1985.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1985

Published: 01 July 2017

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Journal Articles

Abstract 22: Investigating the functional contribution of TANK binding kinase 1 to inflammation induced disease progression

Victoria H. Burton, Rolf A. Brekken

Cancer Res (2016) 76 (14_Supplement): 22.

DOI: https://doi.org/10.1158/1538-7445.AM2016-22

Published: 15 July 2016

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Journal Articles

Abstract LB-318: SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A-targeted therapies in non-small cell lung cancers (NSCLCs)

Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Adi F. Gazdar, Michael G. Roth

Cancer Res (2016) 76 (14_Supplement): LB-318.

DOI: https://doi.org/10.1158/1538-7445.AM2016-LB-318

Published: 15 July 2016

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Journal Articles

Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

Gro Gausdal, Kjersti Davidsen, Katarzyna Wnuk-Lipinska, Kathleen Wiertel, Jing Kang, Agnete Engelsen, Sébastien Bougnaud, Monica Hellesøy, Magnus Blø, Lavina Ahmed, Linn Hodneland, Sergej Kiprijanov, Oddbjørn Straume, Rolf A. Brekken, James B. Lorens

Cancer Res (2016) 76 (14_Supplement): 566.

DOI: https://doi.org/10.1158/1538-7445.AM2016-566

Published: 15 July 2016

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Journal Articles

Abstract 5182: A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics using the tumor marker Rgs16::GFP

Ozhan Ocal, Victor Pashkov, Rahul K. Kollipara, James B. Lorens, Galvin H. Swift, Rolf A. Brekken, Thomas M. Wilkie

Cancer Res (2016) 76 (14_Supplement): 5182.

DOI: https://doi.org/10.1158/1538-7445.AM2016-5182

Published: 15 July 2016

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Journal Articles

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer

Miao Wang, Mary Topalovski, Jason E. Toombs, Christopher M. Wright, Zachary R. Moore, David A. Boothman, Hiromi Yanagisawa, Huamin Wang, Agnieszka Witkiewicz, Diego H. Castrillon, Rolf A. Brekken

Cancer Res (2015) 75 (23): 5058–5069.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-0744

Published: 30 November 2015

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Includes: Supplementary data

Journal Articles

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Amanda Kirane, Kathleen F. Ludwig, Noah Sorrelle, Gry Haaland, Tone Sandal, Renate Ranaweera, Jason E. Toombs, Miao Wang, Sean P. Dineen, David Micklem, Michael T. Dellinger, James B. Lorens, Rolf A. Brekken

Cancer Res (2015) 75 (18): 3699–3705.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-2887-T

Published: 14 September 2015

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Includes: Supplementary data

Journal Articles

Abstract LB-130: Reporter genes for a rapid in vivo screen of PDA therapeutics are required for energy homeostasis in pancreatic cancer-associated malnutrition

Ozhan Ocal, Yalda Zolghadri, Galvin H. Swift, Rolf A. Brekken, Thomas M. Wilkie

Cancer Res (2015) 75 (15_Supplement): LB-130.

DOI: https://doi.org/10.1158/1538-7445.AM2015-LB-130

Published: 01 August 2015

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NARROW

Abstract 3144: Pleiotrophin drives a pro-metastatic immune niche within breast tumor microenvironment

Are TEMs Canceled? Questioning the Functional Relevance of Tie2-Expressing Macrophages

Abstract LT010: Pleiotrophin drives pro-metastatic immune niche within breast tumor microenvironment

ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion

Loss of BAP1 Leads to More YAPing in Pancreatic Cancer

Abstract 1790: Investigation of oncogenic G-protein coupled receptor signaling pathways in Kras dependent pancreatic cancer cell lines

Abstract CT087: Concentration-dependent early anti-vascular and anti-tumor effects of itraconazole in non-small cell lung cancer (NSCLC)

Abstract 1037: Axl is critical for pancreatic cancer progression and metastasis

The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer

Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Abstract LB-216: Stroma-induced up-regulation of discoidin domain receptor 1 enhances peritoneal metastasis of gastric carcinomas

Abstract 1985: Tbk1 loss in pancreatic cancer leads to changes in epithelial plasticity

Abstract 22: Investigating the functional contribution of TANK binding kinase 1 to inflammation induced disease progression

Abstract LB-318: SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A-targeted therapies in non-small cell lung cancers (NSCLCs)

Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

Abstract 5182: A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics using the tumor marker Rgs16::GFP

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Abstract LB-130: Reporter genes for a rapid in vivo screen of PDA therapeutics are required for energy homeostasis in pancreatic cancer-associated malnutrition

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