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Roger E. McLendon
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Journal Articles

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation

Landon J. Hansen, Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, Carlee Hemphill, Austin B. Carpenter, Patrick Healy, Ryan C. Ruger, Chin-Pu J. Chen, Paula K. Greer, Fangping Zhao, Ivan Spasojevic, Carole Grenier, Zhiqing Huang, Susan K. Murphy, Roger E. McLendon, Henry S. Friedman, Allan H. Friedman, James E. Herndon, II, John H. Sampson, Stephen T. Keir, Darell D. Bigner, Hai Yan, Yiping He
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3383–3394.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-1010
Published: 01 July 2019
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Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities

Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner, Hai Yan
Journal: Cancer Research
Cancer Res (2018) 78 (1): 36–50.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-1352
Published: 02 January 2018
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Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Elizabeth A. Reap, Carter M. Suryadevara, Kristen A. Batich, Luis Sanchez-Perez, Gary E. Archer, Robert J. Schmittling, Pamela K. Norberg, James E. Herndon, II, Patrick Healy, Kendra L. Congdon, Patrick C. Gedeon, Olivia C. Campbell, Adam M. Swartz, Katherine A. Riccione, John S. Yi, Mohammed K. Hossain-Ibrahim, Anirudh Saraswathula, Smita K. Nair, Anastasie M. Dunn-Pirio, Taylor M. Broome, Kent J. Weinhold, Annick Desjardins, Gordana Vlahovic, Roger E. McLendon, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, Peter E. Fecci, Duane A. Mitchell, John H. Sampson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (1): 256–264.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-0469
Published: 02 January 2018
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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation

Rui Yang, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, Bill H. Diplas, Matthew S. Waitkus, Paula K. Greer, Huishan Zhu, Roger E. McLendon, Darell D. Bigner, Yiping He, Hai Yan
Journal: Cancer Research
Cancer Res (2017) 77 (22): 6097–6108.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-1018
Published: 14 November 2017
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A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

Christopher G. Hubert, Maricruz Rivera, Lisa C. Spangler, Qiulian Wu, Stephen C. Mack, Briana C. Prager, Marta Couce, Roger E. McLendon, Andrew E. Sloan, Jeremy N. Rich
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2465–2477.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-2402
Published: 14 April 2016
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Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma

Christopher J. Pirozzi, Catherine Y. Wang, Austin B. Carpenter, Huishan Zhu, Paula K. Greer, Roger E. McLendon, Darell D. Bigner, Yiping He, Hai Yan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 63.
DOI: https://doi.org/10.1158/1538-7445.AM2014-63
Published: 01 October 2014
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Abstract LB-82: MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation

Changcun Guo, Lee H. Chen, Yafen Huang, Chun-chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, Xuhui Bao, Paula K. Greer, Roger E. McLendon, Hai Yan, Stephen T. Keir, Darell D. Bigner, Yiping He
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-82.
DOI: https://doi.org/10.1158/1538-7445.AM2014-LB-82
Published: 01 October 2014
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Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

Genglin Jin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B. Ahmed Rasheed, Rui Yang, Giselle Y. Lopez, Yiping He, Roger E. McLendon, Darell D. Bigner, Hai Yan
Journal: Cancer Research
Cancer Res (2013) 73 (2): 496–501.
DOI: https://doi.org/10.1158/0008-5472.CAN-12-2852
Published: 16 January 2013
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Abstract 3318: Molecular targeting of brain tumor stem cells

Christine E. Eyler, Michael T. Forrester, Jennifer M. MacSwords, Qiulian Wu, Katherine M. LaFiura, Justin D. Lathia, Andrew E. Sloan, Jeongwu Lee, Roger E. McLendon, Anita B. Hjelmeland, Jeremy N. Rich
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3318.
DOI: https://doi.org/10.1158/1538-7445.AM10-3318
Published: 15 April 2010
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Abstract 233: OTX2 copy number gain is a driver event in Shh-independent medulloblastomas

Matthew Wortham, David C. Adamson, Qun Shi, Paul A. Northcott, Chunhui Di, Christopher G. Duncan, Jianjun Li, Roger E. McLendon, Darell D. Bigner, Michael D. Taylor, Hai Yan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 233.
DOI: https://doi.org/10.1158/1538-7445.AM10-233
Published: 15 April 2010
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Journal Articles

OTX2 Is Critical for the Maintenance and Progression of Shh-Independent Medulloblastomas

David C. Adamson, Qun Shi, Matthew Wortham, Paul A. Northcott, Chunhui Di, Christopher G. Duncan, Jianjun Li, Roger E. McLendon, Darell D. Bigner, Michael D. Taylor, Hai Yan
Journal: Cancer Research
Cancer Res (2010) 70 (1): 181–191.
DOI: https://doi.org/10.1158/0008-5472.CAN-09-2331
Published: 04 January 2010
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Glioblastoma Proto-oncogene SEC61γ Is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress

Zheming Lu, Lei Zhou, Patrick Killela, Ahmed B. Rasheed, Chunhui Di, William E. Poe, Roger E. McLendon, Darell D. Bigner, Christopher Nicchitta, Hai Yan
Journal: Cancer Research
Cancer Res (2009) 69 (23): 9105–9111.
DOI: https://doi.org/10.1158/0008-5472.CAN-09-2775
Published: 30 November 2009
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Journal Articles

Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth

Shideng Bao, Qiulian Wu, Zhizhong Li, Sith Sathornsumetee, Hui Wang, Roger E. McLendon, Anita B. Hjelmeland, Jeremy N. Rich
Journal: Cancer Research
Cancer Res (2008) 68 (15): 6043–6048.
DOI: https://doi.org/10.1158/0008-5472.CAN-08-1079
Published: 01 August 2008
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AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma

Sith Sathornsumetee, Anita B. Hjelmeland, Stephen T. Keir, Roger E. McLendon, David Batt, Timothy Ramsey, Naeem Yusuff, B.K. Ahmed Rasheed, Mark W. Kieran, Andrea Laforme, Darell D. Bigner, Henry S. Friedman, Jeremy N. Rich
Journal: Cancer Research
Cancer Res (2006) 66 (17): 8722–8730.
DOI: https://doi.org/10.1158/0008-5472.CAN-06-0284
Published: 01 September 2006
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Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor

Shideng Bao, Qiulian Wu, Sith Sathornsumetee, Yueling Hao, Zhizhong Li, Anita B. Hjelmeland, Qing Shi, Roger E. McLendon, Darell D. Bigner, Jeremy N. Rich
Journal: Cancer Research
Cancer Res (2006) 66 (16): 7843–7848.
DOI: https://doi.org/10.1158/0008-5472.CAN-06-1010
Published: 15 August 2006
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Journal Articles

Prognostic significance of OTX2 in medulloblastoma

D. Cory Adamson, Chunhui Di, Qun Shi, Roger E. McLendon, Darell D. Bigner, Hai Yan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 606.
Published: 15 April 2006
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O6-alkylguanine-DNA alkyltransferase (AGT) and microsatellite instability (MSI) analyses in malignant glioma

Jill A. Maxwell, Stewart P. Johnson, Roger E. McLendon, Francis Ali-Osman, Jennifer A. Quinn, Allan H. Friedman, James E. Herndon, Katja Bierau, Joseph Bigley, Darell D. Bigner, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1054.
Published: 15 April 2006
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Journal Articles

Characterizing oligodendroglioma rearrangements using whole genome hrCGH arrays

Nicole V. Johnson, Jessica J. Connelly, Josh Virigadamo, Roger E. McLendon, Jeffrey M. Vance, Darell D. Bigner, Simon G. Gregory
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 36.
Published: 15 April 2006
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Journal Articles

Gene Expression Profiling and Genetic Markers in Glioblastoma Survival

Jeremy N. Rich, Christopher Hans, Beatrix Jones, Edwin S. Iversen, Roger E. McLendon, B.K. Ahmed Rasheed, Adrian Dobra, Holly K. Dressman, Darell D. Bigner, Joseph R. Nevins, Mike West
Journal: Cancer Research
Cancer Res (2005) 65 (10): 4051–4058.
DOI: https://doi.org/10.1158/0008-5472.CAN-04-3936
Published: 16 May 2005
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Genetic analysis of LOH of chromosome 1p, 19q and PIK3CA mutations in oligodendrogliomas

D. Cory Adamson, Daniel K. Broderick, Chunhui Di, Timothy J. Parrett, Yardena R. Samuels, Jordan M. Cummins, Roger E. McLendon, Daniel W. Fults, Victor E. Velculescu, Rasheed Ahmed, Darell D. Bigner, Hai Yan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 659–660.
Published: 01 May 2005
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