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Roel G. Verhaak
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Journal Articles

Abstract 2668: Spatial-temporal diversity of extrachromosomal DNA shapes urothelial carcinoma evolution and tumor-immune microenvironment

Free
Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Jens Luebeck, Huiying Tao, Yanfen Zhu, Xiaolong Sui, Yue Li, Shiqi Jiang, Qingqing Gao, Elias Rodriguez Fos, Gino Prasad, Yuanmei Wang, Run Zhou, Zhe Xu, Xiaoguang Pan, Linlin Chen, Xiang Xi, Huajing Teng, Chaoyang Sun, Tianyu Qin, Wei Dong, Yongwei Li, Xun Lan, Xuesong Li, Lin Lin, Lars Bolund, Huanming Yang, Roel G. Verhaak, Bishoy M. Faltas, Jacob B. Hansen, Sihan Wu, Paul S. Mischel, Anton G. Henssen, Vineet Bafna, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2668.
https://doi.org/10.1158/1538-7445.AM2025-2668
Published: 21 April 2025
View articletitled, Abstract 2668: Spatial-temporal diversity of extrachromosomal DNA shapes urothelial carcinoma evolution and tumor-immune microenvironment
Journal Articles

Abstract 3755: AmpliconSuite enables discovery of extrachromosomal DNA in tumor genomes

Free
Jens Luebeck, Edwin Huang, Ted Liefeld, Forrest Kim, Ivy T. Wong, Bhargavi Dameracharla, Gino Prasad, Rohil Ahuja, Daniel Schreyer, Kaiyuan Zhu, Rishaan Kenkre, Tushar Agashe, Devika Torvi, Soyeon Kim, Hoon Kim, Peter Bailey, Roel G. Verhaak, Viraj Deshpande, Michael Reich, Paul S. Mischel, Jill Mesirov, Vineet Bafna
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3755.
https://doi.org/10.1158/1538-7445.AM2025-3755
Published: 21 April 2025
View articletitled, Abstract 3755: AmpliconSuite enables discovery of extrachromosomal DNA in tumor genomes
Journal Articles

Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Free
Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Morgan Oneka, Roel G. Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel Wahl, Sunita Shankar, Todd Hollon, Oren Sagher, Jason Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C. deCarvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB013.
https://doi.org/10.1158/1538-7445.AM2022-LB013
Published: 15 June 2022
View articletitled, Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma
Journal Articles

Abstract 2168: Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

Free
Frederick S. Varn, Kevin C. Johnson, Jan Martinek, Jason T. Huse, MacLean P. Nasrallah, Pieter Wesseling, Lee A. Cooper, Tathiane M. Malta, Taylor E. Wade, Thais S. Sabedot, Daniel J. Brat, Peter V. Gould, Adelheid Wöehrer, Kenneth Aldape, Azzam Ismail, Floris P. Barthel, Hoon Kim, Emre Kocakavuk, Nazia Ahmed, Kieron White, Santhosh Sivajothi, Indrani Datta, Jill S. Barnholtz-Sloan, Spyridon Bakas, Fulvio D'Angelo, Hui K. Gan, Luciano Garofano, Mustafa Khasraw, Simona Migliozzi, D. Ryan Ormond, Sun Ha Paek, Erwin G. Van Meir, Annemiek M. Walenkamp, Colin Watts, Michael Weller, Tobias Weiss, Karolina Palucka, Lucy F. Stead, Laila M. Poisson, Houtan Noushmehr, Antonio Iavarone, Roel G. Verhaak, The GLASS Consortium
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2168.
https://doi.org/10.1158/1538-7445.AM2022-2168
Published: 15 June 2022
View articletitled, Abstract 2168: Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment
Journal Articles

Abstract 5786: Mitochondrial genome evolution in gliomas under therapy

Free
Taylor E. Wade, Frederick S. Varn, Kevin C. Johnson, Roel G. Verhaak
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5786.
https://doi.org/10.1158/1538-7445.AM2022-5786
Published: 15 June 2022
View articletitled, Abstract 5786: Mitochondrial genome evolution in gliomas under therapy
Journal Articles

Abstract 2084: Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response

Free
Kevin C. Johnson, Kevin J. Anderson, Elise T. Courtois, Amit D. Gujar, Floris P. Barthel, Frederick S. Varn, Diane Luo, Martine Seignon, Eunhee Yi, Hoon Kim, Marcos R. Estecio, Ming Tang, Nicholas E. Navin, Rahul Maurya, Chew Yee Ngan, Niels Verburg, Philip C. De Witt Hamer, Ketan Bulsara, Michael L. Samuels, Sunit Das, Paul Robson, Roel G. Verhaak
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2084.
https://doi.org/10.1158/1538-7445.AM2021-2084
Published: 01 July 2021
View articletitled, Abstract 2084: Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response
Journal Articles

Abstract 2068: Radiotherapy is associated with a deletion signature that contributes to poor cancer patient outcomes

Free
Emre Kocakavuk, Kevin J. Anderson, Kevin C. Johnson, Frederick S. Varn, Samirkumar B. Amin, Erik P. Sulman, Floris P. Barthel, Roel G. Verhaak
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2068.
https://doi.org/10.1158/1538-7445.AM2021-2068
Published: 01 July 2021
View articletitled, Abstract 2068: Radiotherapy is associated with a deletion signature that contributes to poor cancer patient outcomes
Journal Articles

Abstract 3147: Stereotactic image-guided epigenome profiling reveals a neural stem cell evolutionary origin of diffuse gliomas

Free
Floris P. Barthel, Niels Verburg, Russell Rockne, Roelant Eijgelaar, Kevin Anderson, Domenique Müller, Sergio Branciamore, Kevin C. Johnson, Pieter Wesseling, Philip C. de Witt Hamer, Roel G. Verhaak
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3147.
https://doi.org/10.1158/1538-7445.AM2021-3147
Published: 01 July 2021
View articletitled, Abstract 3147: Stereotactic image-guided epigenome profiling reveals a neural stem cell evolutionary origin of diffuse gliomas
Journal Articles

Abstract 4698: Development of a CRISPR-Cas9D10A targetable, high-complexity, single-cell barcoding approach for capture of treatment resistant subclones from heterogeneous cancers

Free
Ze-yan Zhang, Ravesanker Ezhilarasan, Yingwen Ding, Qianghu Wang, Jie Yang, Lihong Long, Roel G. Verhaak, Erik P. Sulman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4698.
https://doi.org/10.1158/1538-7445.AM2019-4698
Published: 01 July 2019
View articletitled, Abstract 4698: Development of a CRISPR-Cas9D10A targetable, high-complexity, single-cell barcoding approach for capture of treatment resistant subclones from heterogeneous cancers
Journal Articles

Abstract 3491: Heterogeneous extrachromosomal amplification of mutant PDGFRA is associated with an aggressive phenotype in glioblastoma

Free
Artem D. Berezovsky, Andrea D. Transou, Susan M. Irtenkauf, Laura A. Hasselbach, Julie Koeman, Hoon Kim, Roel G. Verhaak, Tom Mikkelsen, Laila M. Poisson, Ana C. deCarvalho
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3491.
https://doi.org/10.1158/1538-7445.AM2018-3491
Published: 01 July 2018
View articletitled, Abstract 3491: Heterogeneous extrachromosomal amplification of mutant PDGFRA is associated with an aggressive phenotype in glioblastoma
Journal Articles

Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587

Free
Javier Figueroa, Lynette M. Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J. Bean, George A. Calin, Juan Fueyo, Edgar T. Walters, Raghu Kalluri, Roel G. Verhaak, Frederick F. Lang
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5808–5819.
https://doi.org/10.1158/0008-5472.CAN-16-2524
Published: 31 October 2017
View articletitled, Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587
Open the PDF for Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587 in another window
Includes: Supplementary data
Journal Articles

Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer

Free
Hengyu Lu, Nicole Villafane, Turgut Dogruluk, Caitlin L. Grzeskowiak, Kathleen Kong, Yiu Huen Tsang, Oksana Zagorodna, Angeliki Pantazi, Lixing Yang, Nicholas J. Neill, Young Won Kim, Chad J. Creighton, Roel G. Verhaak, Gordon B. Mills, Peter J. Park, Raju Kucherlapati, Kenneth L. Scott
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3502–3512.
https://doi.org/10.1158/0008-5472.CAN-16-2745
Published: 02 July 2017
View articletitled, Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer
Open the PDF for Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3468: Comprehensive analysis of telomere length and telomere maintenance mechanisms across 31 human cancer types

Free
Floris P. Barthel, Siyuan Zheng, Roel G. Verhaak
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3468.
https://doi.org/10.1158/1538-7445.AM2017-3468
Published: 01 July 2017
View articletitled, Abstract 3468: Comprehensive analysis of telomere length and telomere maintenance mechanisms across 31 human cancer types
Journal Articles

Abstract 1720: MSK1 mediates PI3K inhibition resistance by induction of β-catenin phosphorylation in glioblastoma

Free
Shaofang Wu, Jun Fu, Siyuan Zheng, Roel G. Verhaak, W. K Yung, Dimpy Koul
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1720.
https://doi.org/10.1158/1538-7445.AM2014-1720
Published: 01 October 2014
View articletitled, Abstract 1720: MSK1 mediates PI3K inhibition resistance by induction of β-catenin phosphorylation in glioblastoma
Journal Articles

Abstract 4170: Oncogenic activation of LMO2 by EGFR signaling regulates STAT3 phosphorylation and transcriptional activity in human glioma

Free
Jun Fu, Dimpy Koul, Shaofang Wu, Siyuan Zheng, Roel G. Verhaak, W.K Yung
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4170.
https://doi.org/10.1158/1538-7445.AM2014-4170
Published: 01 October 2014
View articletitled, Abstract 4170: Oncogenic activation of LMO2 by EGFR signaling regulates STAT3 phosphorylation and transcriptional activity in human glioma
Journal Articles

Abstract 3127: Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.

Free
Hideo Watanabe, Joshua M. Francis, Michele S. Woo, Banafsheh Etemad, Wenchu Lin, Daniel F. Fries, Shouyong Peng, Eric L. Snyder, Purushothama Rao Tata, Anna C. Schinzel, Jeonghee Cho, Peter S. Hammerman, Roel G. Verhaak, William C. Hahn, Jayaraj Rajagopal, Tyler Jacks, Matthew Meyerson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3127.
https://doi.org/10.1158/1538-7445.AM2013-3127
Published: 15 April 2013
View articletitled, Abstract 3127: Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.