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Journal Articles

Abstract P5-17-04: Combined PI3K and NOS inhibition enhances efficacy of taxane-based chemotherapy in metaplastic breast cancer

Tejaswini P Reddy, Bijan Mahboubi, Roberto R. Rosato, Liliana Guzman-Rojas, Wei Qian, Jianying Zhou, Baek Kim, Stacy Moulder, Helen Piwnica-Worms, Jenny C. Chang

Cancer Res (2022) 82 (4_Supplement): P5-17-04.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-17-04

Published: 15 February 2022

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Journal Articles

Abstract PD3-01: Inducible nitric oxide synthase activates PI3K/Akt signaling via PTEN S-nitrosylation in triple-negative breast cancer

Tejaswini P. Reddy, Liliana Guzman-Rojas, Roberto R. Rosato, Wei Qian, Hong Zhao, Jenny C. Chang

Cancer Res (2022) 82 (4_Supplement): PD3-01.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD3-01

Published: 15 February 2022

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Journal Articles

Abstract PS11-17: Combination PI3K and NOS targeted therapy for metaplastic breast cancer

Tejaswini Parlapalle Reddy, Roberto R Rosato, Liliana Guzman, Wei Qian, Jianying Zhou, Hongbin Wang, Helen Piwnica-Worms, Stacy Moulder, Jenny C Chang

Cancer Res (2021) 81 (4_Supplement): PS11-17.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS11-17

Published: 15 February 2021

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Journal Articles

Abstract PS13-28: Pre-treating TNBC with docetaxel and il-12 enhances anti-PD1 efficacy

Ann Cassany Anselme, Wei Qian, Jianying Zhou, Roberto R. Rosato, Jenny C. Chang

Cancer Res (2021) 81 (4_Supplement): PS13-28.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS13-28

Published: 15 February 2021

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Journal Articles

Abstract PS17-30: Trps1 disrupts angiogenesis in triple negative breast cancer by down regulating genes involved in angiogenesis pathways

Liliana Guzman, Jessica Bronstad, Roberto Rangel, Roberto R Rosato, Wei Qian, Jianying Zhou, Jenny C Chang

Cancer Res (2021) 81 (4_Supplement): PS17-30.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS17-30

Published: 15 February 2021

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Journal Articles

Abstract 2261: Understanding the mechanism underlying resistance to immunotherapy in TNBC

Ann C. Anselme, Wei Qian, Anthony Kozielski, Roberto R. Rosato, Jenny C. Chang

Cancer Res (2019) 79 (13_Supplement): 2261.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2261

Published: 01 July 2019

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Journal Articles

Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts

Roberto R. Rosato, Don S. Choi, Wei Qian, Wen Chen, Johan Lantto, Ivan D. Horak, Michael Kragh, Jenny C. Chang

Cancer Res (2019) 79 (13_Supplement): 357.

DOI: https://doi.org/10.1158/1538-7445.AM2019-357

Published: 01 July 2019

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Journal Articles

Abstract 2035: Knockdown of TGFβ-activated ATF4 inhibits triple negative breast cancer metastases independently of cellular stress

Jenny C. Chang, Alberto Ramirez, Maria P. Molina, Francisca E. Cara, Wei Qian, Wen Chen, Anthony J. Kozielski, Roberto R. Rosato, Juan A. Marchal, Jose A. Lorente, Pedro Sanchez-Rovira, Sergio Granados-Principal

Cancer Res (2018) 78 (13_Supplement): 2035.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2035

Published: 01 July 2018

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Journal Articles

Abstract LB-196: Evaluation of anti PD-1 plus nitric oxide synthase inhibition combination therapy in 12 triple-negative breast cancer patient-derived xenografts using a human-derived immune system model

Daniel Davila-Gonzalez, Roberto R. Rosato, Wei Qian, Antony J. Kozielski, Wen Chen, Dong S. Choi, Bhuvanesh Dave, Dinko Kranjac, Joe E. Ensor, Jenny C. Chang

Cancer Res (2017) 77 (13_Supplement): LB-196.

DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-196

Published: 01 July 2017

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Journal Articles

Abstract 2552: Addition of repositioned-drug dexamethasone improves anti-leukemia synergy between HDAC inhibitors and nucleoside analogs

Hong Zhao, Jaime Mejia, Adriana E. Rosato, Swaminathan P. Iyer, Jenny C. Chang, Roberto R. Rosato

Cancer Res (2015) 75 (15_Supplement): 2552.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2552

Published: 01 August 2015

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Journal Articles

Abstract 2960: Flavopiridol-mediated multiple modulatory effects synergistically increase sensitivity to TRAIL-induced cell death in human leukemia cells.

Swaminathan P. Iyer, Jaime Mejia, Adriana E. Rosato, Steven Grant, Roberto R. Rosato

Cancer Res (2013) 73 (8_Supplement): 2960.

DOI: https://doi.org/10.1158/1538-7445.AM2013-2960

Published: 15 April 2013

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Journal Articles

Abstract 3652: HDAC inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-dependent DNA Damage-related pathway

Roberto R. Rosato, Sarah S. Kolla, Stefanie K. Hock, Jorge A. Almenara, Peter Atadja, Paul Dent, Steve Grant

Cancer Res (2010) 70 (8_Supplement): 3652.

DOI: https://doi.org/10.1158/1538-7445.AM10-3652

Published: 15 April 2010

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Journal Articles

The Multikinase Inhibitor Sorafenib Potentiates TRAIL Lethality in Human Leukemia Cells in Association with Mcl-1 and cFLIP_L Down-regulation

Roberto R. Rosato, Jorge A. Almenara, Stefanie Coe, Steven Grant

Cancer Res (2007) 67 (19): 9490–9500.

DOI: https://doi.org/10.1158/0008-5472.CAN-07-0598

Published: 01 October 2007

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Includes: Supplementary data

Journal Articles

Synergistic interactions between the HDAC inhibitor NVP-LAQ824 and the nucleoside analog fludarabine in human leukemia cells involve ROS generation and modulation of the NF-kB and JNK pathways

Roberto R. Rosato, Sonia C. Maggio, Jorge A. Almenara, Stefanie Coe, Mohamed Rahmani, Yun Dai, Peter Atadja, Steven Grant

Cancer Res (2006) 66 (8_Supplement): 1095.

Published: 15 April 2006

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Journal Articles

Potentiation of LAQ824-mediated lethality by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells proceeds through an XIAP- and reactive oxygen species (ROS)-dependent mechanism

Roberto R. Rosato, Jorge A. Almenara, Sonia C. Maggio, Peter Atadja, Paul Dent, Steven Grant

Cancer Res (2005) 65 (9_Supplement): 1259.

Published: 01 May 2005

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Journal Articles

The histone deacetylase inhibitor Ms-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells

Sonia C. Maggio, Roberto R. Rosato, Lora Kramer, Yun Dai, Mohamed Rahmani, David S. Paik, Ann C. Czarnik, Shawn G. Payne, Sarah Spiegel, Steven Grant

Cancer Res (2004) 64 (7_Supplement): 459.

Published: 01 April 2004

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Journal Articles

Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol

Roberto R. Rosato, Jorge A. Almenara, Chunrong Yu, Steven Grant

Cancer Res (2004) 64 (7_Supplement): 1006.

Published: 01 April 2004

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Journal Articles

The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

Sonia C. Maggio, Roberto R. Rosato, Lora B. Kramer, Yun Dai, Mohamed Rahmani, David S. Paik, Ann C. Czarnik, Shawn G. Payne, Sarah Spiegel, Steven Grant

Cancer Res (2004) 64 (7): 2590–2600.

DOI: https://doi.org/10.1158/0008-5472.CAN-03-2631

Published: 01 April 2004

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Journal Articles

The Histone Deacetylase Inhibitor MS-275 Promotes Differentiation or Apoptosis in Human Leukemia Cells through a Process Regulated by Generation of Reactive Oxygen Species and Induction of p21^{CIP1/WAF1 1}

Roberto R. Rosato, Jorge A. Almenara, Steven Grant

Cancer Res (2003) 63 (13): 3637–3645.

Published: 01 July 2003

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NARROW

Abstract P5-17-04: Combined PI3K and NOS inhibition enhances efficacy of taxane-based chemotherapy in metaplastic breast cancer

Abstract PD3-01: Inducible nitric oxide synthase activates PI3K/Akt signaling via PTEN S-nitrosylation in triple-negative breast cancer

Abstract PS11-17: Combination PI3K and NOS targeted therapy for metaplastic breast cancer

Abstract PS13-28: Pre-treating TNBC with docetaxel and il-12 enhances anti-PD1 efficacy

Abstract PS17-30: Trps1 disrupts angiogenesis in triple negative breast cancer by down regulating genes involved in angiogenesis pathways

Abstract 2261: Understanding the mechanism underlying resistance to immunotherapy in TNBC

Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts

Abstract 2035: Knockdown of TGFβ-activated ATF4 inhibits triple negative breast cancer metastases independently of cellular stress

Abstract LB-196: Evaluation of anti PD-1 plus nitric oxide synthase inhibition combination therapy in 12 triple-negative breast cancer patient-derived xenografts using a human-derived immune system model

Abstract 2552: Addition of repositioned-drug dexamethasone improves anti-leukemia synergy between HDAC inhibitors and nucleoside analogs

Abstract 2960: Flavopiridol-mediated multiple modulatory effects synergistically increase sensitivity to TRAIL-induced cell death in human leukemia cells.

Abstract 3652: HDAC inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-dependent DNA Damage-related pathway

The Multikinase Inhibitor Sorafenib Potentiates TRAIL Lethality in Human Leukemia Cells in Association with Mcl-1 and cFLIP_L Down-regulation

Synergistic interactions between the HDAC inhibitor NVP-LAQ824 and the nucleoside analog fludarabine in human leukemia cells involve ROS generation and modulation of the NF-kB and JNK pathways

Potentiation of LAQ824-mediated lethality by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells proceeds through an XIAP- and reactive oxygen species (ROS)-dependent mechanism

The histone deacetylase inhibitor Ms-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells

Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol

The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

The Histone Deacetylase Inhibitor MS-275 Promotes Differentiation or Apoptosis in Human Leukemia Cells through a Process Regulated by Generation of Reactive Oxygen Species and Induction of p21^{CIP1/WAF1 1}

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