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Roberto R. Rosato
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Journal Articles

Abstract 1606: Unraveling the microbiome-iNOS connection in obesity-driven triple-negative breast cancer

Free
Ivonne Uzair, Ann C. Anselme, Wei Qian, Jianying Zhou, Adriana E. Rosato, Roberto R. Rosato, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1606.
https://doi.org/10.1158/1538-7445.AM2025-1606
Published: 21 April 2025
View articletitled, Abstract 1606: Unraveling the microbiome-iNOS connection in obesity-driven triple-negative breast cancer
Journal Articles

Abstract 2709: Leukosome-based siRNA strategy for targeting ribosomal protein L39 (RPL39) in metaplastic breast cancer

Free
Maria Florencia Chervo, Chiara Mancino, Federica Giordano, Tejaswini P. Reddy, Wei Qian, Jianying Zhou, Liliana Guzman-Rojas, Roberto R. Rosato, Francesca Taraballi, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2709.
https://doi.org/10.1158/1538-7445.AM2023-2709
Published: 04 April 2023
View articletitled, Abstract 2709: Leukosome-based siRNA strategy for targeting ribosomal protein L39 (RPL39) in metaplastic breast cancer
Journal Articles

Abstract P5-17-04: Combined PI3K and NOS inhibition enhances efficacy of taxane-based chemotherapy in metaplastic breast cancer

Free
Tejaswini P Reddy, Bijan Mahboubi, Roberto R. Rosato, Liliana Guzman-Rojas, Wei Qian, Jianying Zhou, Baek Kim, Stacy Moulder, Helen Piwnica-Worms, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-17-04.
https://doi.org/10.1158/1538-7445.SABCS21-P5-17-04
Published: 15 February 2022
View articletitled, Abstract P5-17-04: Combined PI3K and NOS inhibition enhances efficacy of taxane-based chemotherapy in metaplastic breast cancer
Journal Articles

Abstract PD3-01: Inducible nitric oxide synthase activates PI3K/Akt signaling via PTEN S-nitrosylation in triple-negative breast cancer

Free
Tejaswini P. Reddy, Liliana Guzman-Rojas, Roberto R. Rosato, Wei Qian, Hong Zhao, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD3-01.
https://doi.org/10.1158/1538-7445.SABCS21-PD3-01
Published: 15 February 2022
View articletitled, Abstract PD3-01: Inducible nitric oxide synthase activates PI3K/Akt signaling via PTEN S-nitrosylation in triple-negative breast cancer
Journal Articles

Abstract PS13-28: Pre-treating TNBC with docetaxel and il-12 enhances anti-PD1 efficacy

Free
Ann Cassany Anselme, Wei Qian, Jianying Zhou, Roberto R. Rosato, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS13-28.
https://doi.org/10.1158/1538-7445.SABCS20-PS13-28
Published: 15 February 2021
View articletitled, Abstract PS13-28: Pre-treating TNBC with docetaxel and il-12 enhances anti-PD1 efficacy
Journal Articles

Abstract PS17-30: Trps1 disrupts angiogenesis in triple negative breast cancer by down regulating genes involved in angiogenesis pathways

Free
Liliana Guzman, Jessica Bronstad, Roberto Rangel, Roberto R Rosato, Wei Qian, Jianying Zhou, Jenny C Chang
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS17-30.
https://doi.org/10.1158/1538-7445.SABCS20-PS17-30
Published: 15 February 2021
View articletitled, Abstract PS17-30: Trps1 disrupts angiogenesis in triple negative breast cancer by down regulating genes involved in angiogenesis pathways
Journal Articles

Abstract PS11-17: Combination PI3K and NOS targeted therapy for metaplastic breast cancer

Free
Tejaswini Parlapalle Reddy, Roberto R Rosato, Liliana Guzman, Wei Qian, Jianying Zhou, Hongbin Wang, Helen Piwnica-Worms, Stacy Moulder, Jenny C Chang
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS11-17.
https://doi.org/10.1158/1538-7445.SABCS20-PS11-17
Published: 15 February 2021
View articletitled, Abstract PS11-17: Combination PI3K and NOS targeted therapy for metaplastic breast cancer
Journal Articles

Abstract 2261: Understanding the mechanism underlying resistance to immunotherapy in TNBC

Free
Ann C. Anselme, Wei Qian, Anthony Kozielski, Roberto R. Rosato, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2261.
https://doi.org/10.1158/1538-7445.AM2019-2261
Published: 01 July 2019
View articletitled, Abstract 2261: Understanding the mechanism underlying resistance to immunotherapy in TNBC
Journal Articles

Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts

Free
Roberto R. Rosato, Don S. Choi, Wei Qian, Wen Chen, Johan Lantto, Ivan D. Horak, Michael Kragh, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 357.
https://doi.org/10.1158/1538-7445.AM2019-357
Published: 01 July 2019
View articletitled, Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts
Journal Articles

Abstract 2035: Knockdown of TGFβ-activated ATF4 inhibits triple negative breast cancer metastases independently of cellular stress

Free
Jenny C. Chang, Alberto Ramirez, Maria P. Molina, Francisca E. Cara, Wei Qian, Wen Chen, Anthony J. Kozielski, Roberto R. Rosato, Juan A. Marchal, Jose A. Lorente, Pedro Sanchez-Rovira, Sergio Granados-Principal
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2035.
https://doi.org/10.1158/1538-7445.AM2018-2035
Published: 01 July 2018
View articletitled, Abstract 2035: Knockdown of TGFβ-activated ATF4 inhibits triple negative breast cancer metastases independently of cellular stress
Journal Articles

Abstract LB-196: Evaluation of anti PD-1 plus nitric oxide synthase inhibition combination therapy in 12 triple-negative breast cancer patient-derived xenografts using a human-derived immune system model

Free
Daniel Davila-Gonzalez, Roberto R. Rosato, Wei Qian, Antony J. Kozielski, Wen Chen, Dong S. Choi, Bhuvanesh Dave, Dinko Kranjac, Joe E. Ensor, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-196.
https://doi.org/10.1158/1538-7445.AM2017-LB-196
Published: 01 July 2017
View articletitled, Abstract LB-196: Evaluation of anti PD-1 plus nitric oxide synthase inhibition combination therapy in 12 triple-negative breast cancer patient-derived xenografts using a human-derived immune system model
Journal Articles

Abstract 2552: Addition of repositioned-drug dexamethasone improves anti-leukemia synergy between HDAC inhibitors and nucleoside analogs

Free
Hong Zhao, Jaime Mejia, Adriana E. Rosato, Swaminathan P. Iyer, Jenny C. Chang, Roberto R. Rosato
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2552.
https://doi.org/10.1158/1538-7445.AM2015-2552
Published: 01 August 2015
View articletitled, Abstract 2552: Addition of repositioned-drug dexamethasone improves anti-leukemia synergy between HDAC inhibitors and nucleoside analogs
Journal Articles

Abstract 2960: Flavopiridol-mediated multiple modulatory effects synergistically increase sensitivity to TRAIL-induced cell death in human leukemia cells.

Free
Swaminathan P. Iyer, Jaime Mejia, Adriana E. Rosato, Steven Grant, Roberto R. Rosato
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2960.
https://doi.org/10.1158/1538-7445.AM2013-2960
Published: 15 April 2013
View articletitled, Abstract 2960: Flavopiridol-mediated multiple modulatory effects synergistically increase sensitivity to TRAIL-induced cell death in human leukemia cells.
Journal Articles

Abstract 3652: HDAC inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-dependent DNA Damage-related pathway

Free
Roberto R. Rosato, Sarah S. Kolla, Stefanie K. Hock, Jorge A. Almenara, Peter Atadja, Paul Dent, Steve Grant
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3652.
https://doi.org/10.1158/1538-7445.AM10-3652
Published: 15 April 2010
View articletitled, Abstract 3652: HDAC inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-dependent DNA Damage-related pathway
Journal Articles

The Multikinase Inhibitor Sorafenib Potentiates TRAIL Lethality in Human Leukemia Cells in Association with Mcl-1 and cFLIPL Down-regulation

Free
Roberto R. Rosato, Jorge A. Almenara, Stefanie Coe, Steven Grant
Journal: Cancer Research
Cancer Res (2007) 67 (19): 9490–9500.
https://doi.org/10.1158/0008-5472.CAN-07-0598
Published: 01 October 2007
View articletitled, The Multikinase Inhibitor Sorafenib Potentiates TRAIL Lethality in Human Leukemia Cells in Association with Mcl-1 and cFLIPL Down-regulation
Open the PDF for The Multikinase Inhibitor Sorafenib Potentiates TRAIL Lethality in Human Leukemia Cells in Association with Mcl-1 and cFLIPL Down-regulation in another window
Includes: Supplementary data
Journal Articles

Synergistic interactions between the HDAC inhibitor NVP-LAQ824 and the nucleoside analog fludarabine in human leukemia cells involve ROS generation and modulation of the NF-kB and JNK pathways

Free
Roberto R. Rosato, Sonia C. Maggio, Jorge A. Almenara, Stefanie Coe, Mohamed Rahmani, Yun Dai, Peter Atadja, Steven Grant
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1095.
Published: 15 April 2006
View articletitled, Synergistic interactions between the HDAC inhibitor NVP-LAQ824 and the nucleoside analog fludarabine in human leukemia cells involve ROS generation and modulation of the NF-kB and JNK pathways
Journal Articles

Potentiation of LAQ824-mediated lethality by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells proceeds through an XIAP- and reactive oxygen species (ROS)-dependent mechanism

Free
Roberto R. Rosato, Jorge A. Almenara, Sonia C. Maggio, Peter Atadja, Paul Dent, Steven Grant
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1259.
Published: 01 May 2005
View articletitled, Potentiation of LAQ824-mediated lethality by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells proceeds through an XIAP- and reactive oxygen species (ROS)-dependent mechanism
Journal Articles

Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol

Free
Roberto R. Rosato, Jorge A. Almenara, Chunrong Yu, Steven Grant
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1006.
Published: 01 April 2004
View articletitled, Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol
Journal Articles

The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

Free
Sonia C. Maggio, Roberto R. Rosato, Lora B. Kramer, Yun Dai, Mohamed Rahmani, David S. Paik, Ann C. Czarnik, Shawn G. Payne, Sarah Spiegel, Steven Grant
Journal: Cancer Research
Cancer Res (2004) 64 (7): 2590–2600.
https://doi.org/10.1158/0008-5472.CAN-03-2631
Published: 01 April 2004
View articletitled, The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells
Open the PDF for The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells in another window
Journal Articles

The histone deacetylase inhibitor Ms-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells

Free
Sonia C. Maggio, Roberto R. Rosato, Lora Kramer, Yun Dai, Mohamed Rahmani, David S. Paik, Ann C. Czarnik, Shawn G. Payne, Sarah Spiegel, Steven Grant
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 459.
Published: 01 April 2004
View articletitled, The histone deacetylase inhibitor Ms-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells