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Roberto Pili
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Journal Articles

TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma

Nur P. Damayanti, Ricardo A. Cordova, Christopher Rupert, Ilaria Delle Fontane, Li Shen, Sabrina Orsi, Angela J. Klunk, W. Marston Linehan, Kirk A. Staschke, Peter C. Hollenhorst, David E. Heppner, Roberto Pili
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1286–1302.
https://doi.org/10.1158/0008-5472.CAN-23-1789
Published: 15 April 2024
View article titled, TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma
Open the PDF for TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 7584: The solute transported xCT (SLC7A11) modulates lysosome biogenesis and microRNA trafficking in drug resistant renal cell carcinoma

Abbas Jawadwala, Christopher Rupert, Remi Adelaiye-Ogala, Roberto Pili, Sreenivasulu Chintala, Ashley Orillion, May Elbanna, Nur Damayanti, Ilaria Delle Fontane
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7584.
https://doi.org/10.1158/1538-7445.AM2024-7584
Published: 22 March 2024
View article titled, Abstract 7584: The solute transported xCT (SLC7A11) modulates lysosome biogenesis and microRNA trafficking in drug resistant renal cell carcinoma
Journal Articles

Abstract 7580: The antihistamine terfenadine inhibits TFE3 dimerization, has antitumor activity and synergizes with tyrosine kinase inhibitors in translocation renal cell carcinoma

Ilaria Delle Fontane, Ricardo Cordova, Christopher Rupert, Sabrina Orsi, Abbas Jawadwala, David E. Heppener, Roberto Pili
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7580.
https://doi.org/10.1158/1538-7445.AM2024-7580
Published: 22 March 2024
View article titled, Abstract 7580: The antihistamine terfenadine inhibits TFE3 dimerization, has antitumor activity and synergizes with tyrosine kinase inhibitors in translocation renal cell carcinoma
Journal Articles

Abstract 1786: Metabolic rewiring induced by protein or calorie restriction provides unique therapeutic vulnerabilities in translocation and select clear cell renal cell carcinomas

Sabrina A. Orsi, Christopher Rupert, Sean Colligan, Musea Chang, Abbas Jawadwala, Ilaria Delle Fontane, Filomena de Nigris, Roberto Pili
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1786.
https://doi.org/10.1158/1538-7445.AM2024-1786
Published: 22 March 2024
View article titled, Abstract 1786: Metabolic rewiring induced by protein or calorie restriction provides unique therapeutic vulnerabilities in translocation and select clear cell renal cell carcinomas
Journal Articles

Abstract B020: A mechanistic study of the TFE3-splicing machinery gene fusions reveals a new druggable target for translocation renal cell carcinoma

Ilaria Delle Fontane, Nuri Damayanti, Christopher Rupert, David E. Heppner, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): B020.
https://doi.org/10.1158/1538-7445.KIDNEY23-B020
Published: 15 August 2023
View article titled, Abstract B020: A mechanistic study of the TFE3-splicing machinery gene fusions reveals a new druggable target for translocation renal cell carcinoma
Journal Articles

Abstract A009: Therapeutic targeting of P2 × 4 receptor and mitochondrial metabolism in clear cell renal carcinoma

Sabrina Orsi, Christopher Rupert, Roberto Pili, Filomena De Nigris
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): A009.
https://doi.org/10.1158/1538-7445.KIDNEY23-A009
Published: 15 August 2023
View article titled, Abstract A009: Therapeutic targeting of P2 × 4 receptor and mitochondrial metabolism in clear cell renal carcinoma
Journal Articles

Abstract 4240: Tumor PD-L1 induction associated with dietary protein restriction is modulated by PERK activation

Ricardo Cordova, Sean Colligan, Chris Rupert, Ronald Wek, Kirk Staschke, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4240.
https://doi.org/10.1158/1538-7445.AM2023-4240
Published: 04 April 2023
View article titled, Abstract 4240: Tumor PD-L1 induction associated with dietary protein restriction is modulated by PERK activation
Journal Articles

Abstract 6257: Developing HDAC inhibitors as immunomodulators

Sean Colligan, Li Shen, Christopher Rupert, Jonathan Bard, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6257.
https://doi.org/10.1158/1538-7445.AM2023-6257
Published: 04 April 2023
View article titled, Abstract 6257: Developing HDAC inhibitors as immunomodulators
Journal Articles

Abstract 4495: A mechanistic study of the TFE3-splicing machinery gene fusions reveals a new druggable target for translocation renal cell carcinoma

Nur Damayanti, Sabrina Orsi, Ricardo Cordova, Christopher Rupert, Li Shen, William Marston Linehan, Kirk Staschke, Peter Hollenhorst, David Heppner, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4495.
https://doi.org/10.1158/1538-7445.AM2023-4495
Published: 04 April 2023
View article titled, Abstract 4495: A mechanistic study of the TFE3-splicing machinery gene fusions reveals a new druggable target for translocation renal cell carcinoma
Journal Articles

Abstract 3892: EZH2 mediated kinome reprogramming drives AR phosphorylation and activation in receptor tyrosine kinase inhibitors resistant renal carcinoma models

Christopher Rupert, Stephanie Metcalf, Saranya Rajendran, Sean Colligan, Peter Hollenhorst, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3892.
https://doi.org/10.1158/1538-7445.AM2023-3892
Published: 04 April 2023
View article titled, Abstract 3892: EZH2 mediated kinome reprogramming drives AR phosphorylation and activation in receptor tyrosine kinase inhibitors resistant renal carcinoma models
Journal Articles

Abstract 4828: Therapeutic targeting of P2 × 4 receptor and mitochondrial membrane potential in renal cell carcinoma

Christopher Rupert, Roberto Pili, Filomena DeNigris
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4828.
https://doi.org/10.1158/1538-7445.AM2023-4828
Published: 04 April 2023
View article titled, Abstract 4828: Therapeutic targeting of P2 × 4 receptor and mitochondrial membrane potential in renal cell carcinoma
Journal Articles

Abstract 4818: GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis and metabolism in prostate cancer

Ricardo A. Cordova, Noah R. Sommers, Angela J. Klunk, Haroon M. Mohiuddin, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4818.
https://doi.org/10.1158/1538-7445.AM2023-4818
Published: 04 April 2023
View article titled, Abstract 4818: GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis and metabolism in prostate cancer
Journal Articles

Abstract 4816: Targeting GCN2 regulation of amino acid homeostasis sensitizes prostate cancer cells to senolytic therapies

Noah R. Sommers, Ricardo A. Cordova, Angela J. Klunk, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4816.
https://doi.org/10.1158/1538-7445.AM2023-4816
Published: 04 April 2023
View article titled, Abstract 4816: Targeting GCN2 regulation of amino acid homeostasis sensitizes prostate cancer cells to senolytic therapies
Journal Articles

Abstract 4239: Alternate-day fasting enhances the activity of anti-androgen therapy in prostate cancer models

Ricardo Cordova, May Elbanna, Angela Klunk, Christopher Rupert, Li Shen, Yanqing Wang, David Goodrich, Ron Wek, Kirk Staschke, Luigi Fontana, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4239.
https://doi.org/10.1158/1538-7445.AM2023-4239
Published: 04 April 2023
View article titled, Abstract 4239: Alternate-day fasting enhances the activity of anti-androgen therapy in prostate cancer models
Journal Articles

Abstract 3040: The eIF2 kinase GCN2 controls expression of key amino acid transporters and is critical for prostate cancer growth and progression

Ricardo Cordova, Jagannath Misra, Nur P. Damayanti, Parth H. Amin, Kenneth R. Carlson, Angela J. Klunk, Emily T. Mirek, Marcus J. Miller, Tracy G. Anthony, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3040.
https://doi.org/10.1158/1538-7445.AM2022-3040
Published: 15 June 2022
View article titled, Abstract 3040: The eIF2 kinase GCN2 controls expression of key amino acid transporters and is critical for prostate cancer growth and progression
Journal Articles

Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer

Elena Beketova, Shuyi Fang, Jake L. Owens, Sheng Liu, Xufeng Chen, Qingfu Zhang, Andrew M. Asberry, Xuehong Deng, Jonathan Malola, Jiaoti Huang, Chenglong Li, Roberto Pili, Bennett D. Elzey, Timothy L. Ratliff, Jun Wan, Chang-Deng Hu
Journal: Cancer Research
Cancer Res (2020) 80 (22): 4904–4917.
https://doi.org/10.1158/0008-5472.CAN-20-1228
Published: 13 November 2020
View article titled, Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer
Open the PDF for Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2366: HDAC inhibition improves immune checkpoint inhibitor efficacy in renal cell carcinoma

Justin Budka, Nur Damayanti, Roberto Pili
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2366.
https://doi.org/10.1158/1538-7445.AM2019-2366
Published: 01 July 2019
View article titled, Abstract 2366: HDAC inhibition improves immune checkpoint inhibitor efficacy in renal cell carcinoma
Journal Articles

Abstract 1611: Caloric restriction potentiates the therapeutic benefit of androgen deprivation therapy and alters macrophage polarization when combined with PD1 inhibition in murine models of prostate cancer

May Elbanna, Justin Budka, Paige Dausinas, Remi Adelaiye-Ogala, Nur Damayanti, Ashley Orillion, Eri Banno, Luigi Fontana, Roberto Pili
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1611.
https://doi.org/10.1158/1538-7445.AM2019-1611
Published: 01 July 2019
View article titled, Abstract 1611: Caloric restriction potentiates the therapeutic benefit of androgen deprivation therapy and alters macrophage polarization when combined with PD1 inhibition in murine models of prostate cancer
Journal Articles

Abstract 1825: PIK3CA E542K mutation in bladder cancer confers resistance to PI3K targeted therapy but synergy with BET inhibition

May Faek Elbanna, Nur Damayanti, Sreenivasulu Chintala, Roberto Pili
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1825.
https://doi.org/10.1158/1538-7445.AM2018-1825
Published: 01 July 2018
View article titled, Abstract 1825: PIK3CA E542K mutation in bladder cancer confers resistance to PI3K targeted therapy but synergy with BET inhibition
Journal Articles

Abstract 3109: Investigating the role of wild-type TFE3 in renal cell carcinoma cells harboring TFE3 fusions with spliceosome machinery associated genes

Nur P. Damayanti, Khunsha Ahmed, May Elbanna, Chinghai Kao, Roberto Pili
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3109.
https://doi.org/10.1158/1538-7445.AM2018-3109
Published: 01 July 2018
View article titled, Abstract 3109: Investigating the role of wild-type TFE3 in renal cell carcinoma cells harboring TFE3 fusions with spliceosome machinery associated genes