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Robert Z. Orlowski
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Journal Articles

Abstract 775: Integrative genomic and transcriptomic profiling of myeloma precursors in a prospective longitudinal observational study (ORIGIN)

Free
Minghao Dang, Chutima Kunacheewa, Hans C. Lee, Krina K. Patel, Sheeba K. Thomas, Melody Becnel, Donna M. Weber, Pei Lin, Zuzana Berkova, Mei Huang, David A. Berrios, Hima Bansal, Andrew Futreal, Cristhiam Rojas Hernandez, Vahid Afshar-Khargan, Michael Kroll, Peter Kuhn, Robert Z. Orlowski, Linghua Wang, Elisabet E. Manasanch
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 775.
https://doi.org/10.1158/1538-7445.AM2023-775
Published: 04 April 2023
View article titled, Abstract 775: Integrative genomic and transcriptomic profiling of myeloma precursors in a prospective longitudinal observational study (ORIGIN)
Journal Articles

Abstract 5579: Single cell characterization of circulating plasma cells and BCMA levels in patients with multiple myeloma

Free
Sonia Maryam Setayesh, Stephanie Shishido, Libere Ndacayisaba, Amin Naghdloo, Jeremy Mason, Dean Tessone, Carli Kaleta, Robert Z. Orlowski, Elisabet E. Manasanch, James Hicks, Peter Kuhn
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5579.
https://doi.org/10.1158/1538-7445.AM2023-5579
Published: 04 April 2023
View article titled, Abstract 5579: Single cell characterization of circulating plasma cells and BCMA levels in patients with multiple myeloma
Journal Articles

Abstract 921: Combination of antibody-targeted amanitin conjugates (ATAC) with immune checkpoint inhibitors shows synergistic therapeutic effect in vitro and in vivo

Free
Kristin Decker, Irina Dranova, Christian Orlik, Aniko Palfi, Christoph Mueller, Ram Kumar Singh, Robert Z. Orlowski, Torsten Hechler, Andreas Pahl, Michael Kulke
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 921.
https://doi.org/10.1158/1538-7445.AM2021-921
Published: 01 July 2021
View article titled, Abstract 921: Combination of antibody-targeted amanitin conjugates (ATAC) with immune checkpoint inhibitors shows synergistic therapeutic effect in vitro and in vivo
Journal Articles

Abstract 223: A meta-analysis of genome-wide association studies of multiple myeloma among African Americans

Free
Zhaohui Du, Chi Song, Kristin Rand, Niels Weinhold, David Van Den Berg, Amie Hwang, Xin Sheng, Victor Hom, Sikander Ailawadhi, Ajay K. Nooka, Seema Singhal, Karen Pawlish, Edward S. Peters, Cathryn Bock, Ann Mohrbacher, Alexander Stram, Sonja I. Berndt, William Blot, John David Carpten, Antoinette Stroup, Andrew Olshan, Wei Zhang, African Ancestry Breast & Prostate Consortium, Stephen Chanock, Jayesh Mehta, Graham A. Colditz, Jeffrey Wolf, Thomas G. Martin, Michael Tomasson, Mark A. Fiala, Howard Terebelo, Nalini Janakiraman, Laurence Kolonel, Loic LeMarchand, Elad Ziv, Daniel Stram, Ravi Vij, Leon Bernal-Mizrachi, Gareth J. Morgan, Jeffrey A. Zonder, Carol Ann Huff, Sagar Lonial, Robert Z. Orlowski, David V. Conti, Christopher A. Haiman, Wendy Cozen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 223.
https://doi.org/10.1158/1538-7445.AM2018-223
Published: 01 July 2018
View article titled, Abstract 223: A meta-analysis of genome-wide association studies of multiple myeloma among African Americans
Journal Articles

Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM)

Free
Tara K. Gregory, Jesus G. Berdeja, Krina K. Patel, Syed Abbas Ali, Adam D. Cohen, Caitlin Costello, Eric M. Ostertag, Nishan de Silva, Devon J. Shedlock, Michelle Resler, Matthew A. Spear, Robert Z. Orlowski
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT130.
https://doi.org/10.1158/1538-7445.AM2018-CT130
Published: 01 July 2018
View article titled, Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM)
Journal Articles

Abstract 1066: Imipridone ONC201 efficacy in refractory multiple myeloma via Erk1/2 inhibition and pro-apoptotic Bim upregulation: single agent and combinatorial approaches

Free
Yongsheng Tu, Jin He, Huan Liu, Richard Eric Davis, Robert Z. Orlowski, Varun Vijay Prabhu, Joshua Allen, Jing Yang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1066.
https://doi.org/10.1158/1538-7445.AM2017-1066
Published: 01 July 2017
View article titled, Abstract 1066: Imipridone ONC201 efficacy in refractory multiple myeloma via Erk1/2 inhibition and pro-apoptotic Bim upregulation: single agent and combinatorial approaches
Journal Articles

Abstract 4629: Multiple myeloma susceptibility loci examined in African and European ancestry populations

Free
Kristin A. Rand, Chi Song, Eric Dean, Daniel Serie, Karen Curtin, Dennis Hazelett, Amie E. Hwang, Xin Sheng, Alex Stram, David J. Van Den Berg, Carol Ann Huff, Leon Bernal-Mizrachi, Michael H. Tomasson, Sikander Ailawadhi, Anneclaire De Roos, Seema Singhal, Karen Pawlish, Edward Peters, Catherine Bock, David V. Conti, Graham Colditz, Todd Zimmerman, Scott Huntsman, John Graff, African Ancestry Prostate Cancer GWAS Consortium, African Ancestry Breast Cancer GWAS Consortium, Stephen J. Chanock, Michael Lieber, Jayesh Mehta, Eric A. Klein, Nalini Janakiraman, Richard K. Severson, Angela R. Brooks-Wilson, Vincent Rajkumar, Elizabeth E. Brown, Laurence Kolonel, Susan Slager, Brian E. Henderson, Graham G. Giles, John J. Spinelli, Brian Chiu, Kenneth C. Anderson, Jeffrey Zonder, Robert Z. Orlowski, Sagar Lonial, Nicola Camp, Celine Vachon, Elad Ziv, Dan O. Stram, Christopher A. Haiman, Wendy Cozen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4629.
https://doi.org/10.1158/1538-7445.AM2015-4629
Published: 01 August 2015
View article titled, Abstract 4629: Multiple myeloma susceptibility loci examined in African and European ancestry populations
Journal Articles

Abstract 1710: Bortezomib and lenalidomide resistant myeloma cells overexpress the hepatocyte growth factor/MET signaling axis and respond to MET kinase inhibitors

Free
Shadia Zaman, Christine M. Stellrecht, Robert Z. Orlowski, Varsha Gandhi
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1710.
https://doi.org/10.1158/1538-7445.AM2014-1710
Published: 01 October 2014
View article titled, Abstract 1710: Bortezomib and lenalidomide resistant myeloma cells overexpress the hepatocyte growth factor/MET signaling axis and respond to MET kinase inhibitors
Journal Articles

Abstract 4600: P-TEFb is a therapeutic target in human bortezomib-resistant multiple myeloma cells

Free
Yun Dai, Shuang Chen, Liang Zhou, Yu Zhang, Yun Leng, Xin-Yan Pei, Hui Lin, Robert Z. Orlowski, Steven Grant
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4600.
https://doi.org/10.1158/1538-7445.AM2014-4600
Published: 01 October 2014
View article titled, Abstract 4600: P-TEFb is a therapeutic target in human bortezomib-resistant multiple myeloma cells
Journal Articles

Abstract 3852: Obesity is associated with clinical characteristics in African American multiple myeloma patients

Free
Amie E. Hwang, Sikander Ailwadhi, Carol Ann Huff, Leon Bernal-Mizrachi, Christopher A. Haiman, Edward Peters, Seema Singhal, Karen Pawlish, Cathryn Bock, Todd Zimmerman, David J. Van Den Berg, David V. Conti, Brenda B. Birmann, Jayesh Mehta, John J. Graff, Daniel O. Stram, Niquelle Brown, Yang Yu, Moosa Azadian, Laurence Kolonel, Brian E. Henderson, Ann Mohrbacher, Graham Colditz, Brian-C Chiu, Michael Tomasson, Jeffrey Zonder, Robert Z. Orlowski, Sagar Lonial, Wendy Cozen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3852.
https://doi.org/10.1158/1538-7445.AM2014-3852
Published: 01 October 2014
View article titled, Abstract 3852: Obesity is associated with clinical characteristics in African American multiple myeloma patients
Journal Articles

Abstract 3390: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1-mediated anti-apoptotic functions and bortezomib resistance in human multiple myeloma cells.

Free
Xin-Yan Pei, Yun Dai, Jessica Felthousen, Shuang Chen, Yukie Takabatake, Leena E. Youssefian, Wesley W. Bodie, Lora B. Kramer, Robert Z. Orlowski, Steven Grant
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3390.
https://doi.org/10.1158/1538-7445.AM2013-3390
Published: 15 April 2013
View article titled, Abstract 3390: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1-mediated anti-apoptotic functions and bortezomib resistance in human multiple myeloma cells.
Journal Articles

p38 MAPK in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction

Free
Jin He, Zhiqiang Liu, Yuhuan Zheng, Jianfei Qian, Haiyan Li, Yong Lu, Jingda Xu, Bangxing Hong, Mingjun Zhang, Pei Lin, Zhen Cai, Robert Z. Orlowski, Larry W. Kwak, Qing Yi, Jing Yang
Journal: Cancer Research
Cancer Res (2012) 72 (24): 6393–6402.
https://doi.org/10.1158/0008-5472.CAN-12-2664
Published: 16 December 2012
View article titled, p38 MAPK in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction
Open the PDF for p38 MAPK in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction in another window
Includes: Supplementary data
Journal Articles

CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Free
Shuang Chen, Yun Dai, Xin-Yan Pei, Jennifer Myers, Li Wang, Lora B. Kramer, Mandy Garnett, Daniella M. Schwartz, Florence Su, Gary L. Simmons, Justin D. Richey, Dustin G. Larsen, Paul Dent, Robert Z. Orlowski, Steven Grant
Journal: Cancer Research
Cancer Res (2012) 72 (16): 4225–4237.
https://doi.org/10.1158/0008-5472.CAN-12-1118
Published: 14 August 2012
View article titled, CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Open the PDF for CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 4649: Nbk/Bik induced by flavopiridol switches GX15-070-induced autophagy to apoptosis in human multiple myeloma cells

Free
Yun Dai, Shuang Chen, Li Wang, Xin-Yan Pei, Jennifer Myers, Daniella Schwartz, Nadine Thompson, Dustin Larsen, Justin Richey, Florence Su, Robert Z. Orlowski, Steven Grant
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4649.
https://doi.org/10.1158/1538-7445.AM2012-4649
Published: 15 April 2012
View article titled, Abstract 4649: Nbk/Bik induced by flavopiridol switches GX15-070-induced autophagy to apoptosis in human multiple myeloma cells
Journal Articles

Abstract 3768: Evaluating the effects of bortezomib (Velcade®) on the pharmacokinetics (PK) of pegylated liposomal doxorubicin (Doxil®, PLD)

Free
Ninh M. La-Beck, Christine M. Walko, Lakia Scoggins, E. Claire Dees, Robert Z. Orlowski, Huali Wu, Michael Amantea, Mahsa Fardin, William Zamboni
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3768.
https://doi.org/10.1158/1538-7445.AM2012-3768
Published: 15 April 2012
View article titled, Abstract 3768: Evaluating the effects of bortezomib (Velcade®) on the pharmacokinetics (PK) of pegylated liposomal doxorubicin (Doxil®, PLD)
Journal Articles

Abstract 844: Targeting the pro-survival protein c-MET with ARQ 197 inhibits growth of multiple myeloma cells

Free
Shadia Zaman, Christine M. Stellrecht, Shujun Shentu, Deborah J. Kuhn, Chad C. Bjorklund, Robert Z. Orlowski, Varsha Gandhi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 844.
https://doi.org/10.1158/1538-7445.AM2012-844
Published: 15 April 2012
View article titled, Abstract 844: Targeting the pro-survival protein c-MET with ARQ 197 inhibits growth of multiple myeloma cells
Journal Articles

Abstract 1669: Expression of a novel zinc-finger transcription factor ZKSCAN3 in human tumors and its potential as a therapeutic target

Free
Lin Yang, Robert Z. Orlowski
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1669.
https://doi.org/10.1158/1538-7445.AM2011-1669
Published: 15 April 2011
View article titled, Abstract 1669: Expression of a novel zinc-finger transcription factor ZKSCAN3 in human tumors and its potential as a therapeutic target
Journal Articles

Abstract 2177: Long-term storage in TRIzol has little effect on microarray-based gene expression profiling in primary myeloma or acute myeloid leukemia cells

Free
Michael Wang, Zhi-Qiang Wang, Luhong Sun, Wencai Ma, David Graber, Jairo Matthews, Richard Champlin, Qing Yi, Robert Z. Orlowski, Larry Kwak, Donna M. Weber, Sheeba K. Thomas, Jatin Shah, Steven Kornblau, Richard E. Davis
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2177.
https://doi.org/10.1158/1538-7445.AM10-2177
Published: 15 April 2010
View article titled, Abstract 2177: Long-term storage in TRIzol has little effect on microarray-based gene expression profiling in primary myeloma or acute myeloid leukemia cells
Journal Articles

Mitogen-Activated Protein Kinase Phosphatase-1 Is a Mediator of Breast Cancer Chemoresistance

Free
George W. Small, Yue Y. Shi, Linda S. Higgins, Robert Z. Orlowski
Journal: Cancer Research
Cancer Res (2007) 67 (9): 4459–4466.
https://doi.org/10.1158/0008-5472.CAN-06-2644
Published: 04 May 2007
View article titled, Mitogen-Activated Protein Kinase Phosphatase-1 Is a Mediator of Breast Cancer Chemoresistance
Open the PDF for Mitogen-Activated Protein Kinase Phosphatase-1 Is a Mediator of Breast Cancer Chemoresistance in another window
Includes: Supplementary data
Journal Articles

Dietary Curcumin Inhibits Chemotherapy-induced Apoptosis in Models of Human Breast Cancer

Free
Sivagurunathan Somasundaram, Natalie A. Edmund, Dominic T. Moore, George W. Small, Yue Y. Shi, Robert Z. Orlowski
Journal: Cancer Research
Cancer Res (2002) 62 (13): 3868–3875.
Published: 01 July 2002
View article titled, Dietary Curcumin Inhibits Chemotherapy-induced Apoptosis in Models of Human Breast Cancer
Open the PDF for Dietary Curcumin Inhibits Chemotherapy-induced Apoptosis in Models of Human Breast Cancer in another window