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Abstract 2078: A multiscale map of DNA damage response in human cells

Anton Kratz, Minkyu Kim, Fan Zheng, Christopher A. Koczor, Samson Fong, Jianfeng Li, Robert W. Sobol, Nevan Krogan, Trey Ideker

Cancer Res (2021) 81 (13_Supplement): 2078.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2078

Published: 01 July 2021

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Journal Articles

Abstract 1940: Thymine DNA glycosylase (TDG) as a novel target for melanoma

Rossella Tricarico, Pietro Mancuso, Vikram Bhattacharjee, Laura Cosentino, Emmanuelle Nicolas, Margret Einarson, Neil Beeharry, Karthik Devarajan, Rich Katz, Dorjbal G. Dorjsuren, Anton Simeonov, Yuwaraj Kadariya, Guillaume Davidson, Joseph R. Testa, Irwin Davidson, Lionel Larue, Robert W. Sobol, Timothy Yen, Alfonso Bellacosa

Cancer Res (2018) 78 (13_Supplement): 1940.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1940

Published: 01 July 2018

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Journal Articles

Abstract LB-204: SON controls the oncogenic alternative splicing program in glioblastoma by regulating PTBP1/2 switch and RBFOX2 activity

Jung-Hyun Kim, Joshua K. Stone, Jianfeng Li, Alexander Richard, Lana Vukadin, G. Yancey Gillespie, Robert W. Sobol, Steve Lim, Eun-Young Erin Ahn

Cancer Res (2018) 78 (13_Supplement): LB-204.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-204

Published: 01 July 2018

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Journal Articles

Abstract 3600: Next generation high capacity DNA damage detection assay for chemotherapy and genotoxic compound screening

Peter Sykora, Sandra Woodgate, Jay George, Robert W. Sobol

Cancer Res (2016) 76 (14_Supplement): 3600.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3600

Published: 15 July 2016

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Journal Articles

Abstract 4: Hyper activation of poly(ADP-ribose) polymerase 1 initiates large-scale metabolic changes in a cellular model of glioblastoma

Anna M. Wilk, Elise Fouquerel, Bobbie Johnston, Samuel A.J. Trammell, Lindsay Schambeau, Joel F. Andrews, Lewis Pannell, Sara J. Cooper, Charles Brenner, Robert W. Sobol

Cancer Res (2016) 76 (14_Supplement): 4.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4

Published: 15 July 2016

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Journal Articles

Abstract LB-249: TDG, a dual genomic and epigenomic regulator, as a novel antimelanoma target

Rossella Tricarico, Pietro Mancuso, Vikram Bhattacharjee, Neil Beeharry, Emmanuelle Nicolas, Margret Einarson, Laura Cosentino, Irwin Davidson, Lionel Larue, Robert W. Sobol, Timothy J. Yen, Alfonso Bellacosa

Cancer Res (2015) 75 (15_Supplement): LB-249.

DOI: https://doi.org/10.1158/1538-7445.AM2015-LB-249

Published: 01 August 2015

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Journal Articles

Abstract 2379: 96-Well CometChip validation for simultaneous treatment and measurement of DNA damage in a single platform

Sandra R. Woodgate, Clare Whittaker, Jay George, Robert W. Sobol, Sandy Schamus-Haynes, Bevin P. Engelward, Jing Ge

Cancer Res (2014) 74 (19_Supplement): 2379.

DOI: https://doi.org/10.1158/1538-7445.AM2014-2379

Published: 01 October 2014

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Journal Articles

Abstract 5085: Inducing multipolarity of acentrosomal mitotic spindles as a novel tumor-specific targeting strategy revealed by the antimitotic effect of mdivi-1

Jingnan Wang, Wei Qian, Masahiro Shuda, Jianfeng Li, Lucas Santana-Santos, Robert W. Sobol, Bennett Van Houten

Cancer Res (2014) 74 (19_Supplement): 5085.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5085

Published: 01 October 2014

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Journal Articles

Abstract 4904: Activation of aldehyde dehydrogenase is essential for growth of mesenchymal glioma stem cells.

Ping Mao, Kaushal Joshi, Jian feng Li, Jakub Godlewski, Xiao kui Mo, Shi yuan Chen, Robert W. Sobol, Ichiro Nakano

Cancer Res (2013) 73 (8_Supplement): 4904.

DOI: https://doi.org/10.1158/1538-7445.AM2013-4904

Published: 15 April 2013

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Journal Articles

Abstract 2549: Chromosomal instability and DNA repair status during folic acid deficiency in breast cancer cells

Michael D. Wyatt, Katie Brady, Alexandra Litvinchuk, Virginia Noxon, Xiao-Hong Wang, Robert W. Sobol

Cancer Res (2012) 72 (8_Supplement): 2549.

DOI: https://doi.org/10.1158/1538-7445.AM2012-2549

Published: 15 April 2012

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Journal Articles

Abstract 4697: Identification, characterization and effects of inhibitors of the human Apurinic/Apyrimidinic Endonuclease 1 (APE1) protein

Ajay Srinivasan, Xiang-Qun Xie, Robert W. Sobol, Barry Gold

Cancer Res (2012) 72 (8_Supplement): 4697.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4697

Published: 15 April 2012

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Journal Articles

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8–Mediated Cleavage of Beclin 1

Hua Li, Peng Wang, Quanhong Sun, Wen-Xing Ding, Xiao-Ming Yin, Robert W. Sobol, Donna B. Stolz, Jian Yu, Lin Zhang

Cancer Res (2011) 71 (10): 3625–3634.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-4475

Published: 15 May 2011

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Includes: Supplementary data

Journal Articles

Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD⁺ Biosynthesis and Base Excision Repair

Eva M. Goellner, Bradford Grimme, Ashley R. Brown, Ying-Chih Lin, Xiao-Hong Wang, Kelsey F. Sugrue, Leah Mitchell, Ram N. Trivedi, Jiang-bo Tang, Robert W. Sobol

Cancer Res (2011) 71 (6): 2308–2317.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-3213

Published: 14 March 2011

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Includes: Supplementary data

Journal Articles

Abstract 5450: Enhanced cytotoxicity of carboplatin and paclitaxel (CP) by vorinostat (SAHA), a histone deacetylase (HDAC) inhibitor, in melanoma cell lines

Hussein Tawbi, Ying-Chih Lin, Liza Villaruz, Merrill J. Egorin, Jan H. Beumer, John M. Kirkwood, Robert W. Sobol

Cancer Res (2010) 70 (8_Supplement): 5450.

DOI: https://doi.org/10.1158/1538-7445.AM10-5450

Published: 15 April 2010

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Journal Articles

Overexpression of Dicer in Precursor Lesions of Lung Adenocarcinoma

Simion Chiosea, Elena Jelezcova, Uma Chandran, Jianhua Luo, Geeta Mantha, Robert W. Sobol, Sanja Dacic

Cancer Res (2007) 67 (5): 2345–2350.

DOI: https://doi.org/10.1158/0008-5472.CAN-06-3533

Published: 01 March 2007

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Journal Articles

The Role of Base Excision Repair in the Sensitivity and Resistance to Temozolomide-Mediated Cell Death

Ram N. Trivedi, Karen H. Almeida, Jamie L. Fornsaglio, Sandra Schamus, Robert W. Sobol

Cancer Res (2005) 65 (14): 6394–6400.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-0715

Published: 15 July 2005

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Includes: Supplementary data

Journal Articles

Base Excision Repair Deficiency Caused by Polymerase β Haploinsufficiency: Accelerated DNA Damage and Increased Mutational Response to Carcinogens

Diane C. Cabelof, ZhongMao Guo, Julian J. Raffoul, Robert W. Sobol, Samuel H. Wilson, Arlan Richardson, Ahmad R. Heydari

Cancer Res (2003) 63 (18): 5799–5807.

Published: 01 October 2003

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Journal Articles

DNA Polymerase β Mediates Protection of Mammalian Cells against Ganciclovir-induced Cytotoxicity and DNA Breakage

Maja T. Tomicic, Rudolf Thust, Robert W. Sobol, Bernd Kaina

Cancer Res (2001) 61 (20): 7399–7403.

Published: 01 October 2001

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Journal Articles

Cells Deficient in DNA Polymerase β Are Hypersensitive to Alkylating Agent-induced Apoptosis and Chromosomal Breakage

Kirsten Ochs, Robert W. Sobol, Samuel H. Wilson, Bernd Kaina

Cancer Res (1999) 59 (7): 1544–1551.

Published: 01 April 1999

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NARROW

Abstract 2078: A multiscale map of DNA damage response in human cells

Abstract 1940: Thymine DNA glycosylase (TDG) as a novel target for melanoma

Abstract LB-204: SON controls the oncogenic alternative splicing program in glioblastoma by regulating PTBP1/2 switch and RBFOX2 activity

Abstract 3600: Next generation high capacity DNA damage detection assay for chemotherapy and genotoxic compound screening

Abstract 4: Hyper activation of poly(ADP-ribose) polymerase 1 initiates large-scale metabolic changes in a cellular model of glioblastoma

Abstract LB-249: TDG, a dual genomic and epigenomic regulator, as a novel antimelanoma target

Abstract 2379: 96-Well CometChip validation for simultaneous treatment and measurement of DNA damage in a single platform

Abstract 5085: Inducing multipolarity of acentrosomal mitotic spindles as a novel tumor-specific targeting strategy revealed by the antimitotic effect of mdivi-1

Abstract 4904: Activation of aldehyde dehydrogenase is essential for growth of mesenchymal glioma stem cells.

Abstract 2549: Chromosomal instability and DNA repair status during folic acid deficiency in breast cancer cells

Abstract 4697: Identification, characterization and effects of inhibitors of the human Apurinic/Apyrimidinic Endonuclease 1 (APE1) protein

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8–Mediated Cleavage of Beclin 1

Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD⁺ Biosynthesis and Base Excision Repair

Abstract 5450: Enhanced cytotoxicity of carboplatin and paclitaxel (CP) by vorinostat (SAHA), a histone deacetylase (HDAC) inhibitor, in melanoma cell lines

Overexpression of Dicer in Precursor Lesions of Lung Adenocarcinoma

The Role of Base Excision Repair in the Sensitivity and Resistance to Temozolomide-Mediated Cell Death

Base Excision Repair Deficiency Caused by Polymerase β Haploinsufficiency: Accelerated DNA Damage and Increased Mutational Response to Carcinogens

DNA Polymerase β Mediates Protection of Mammalian Cells against Ganciclovir-induced Cytotoxicity and DNA Breakage

Cells Deficient in DNA Polymerase β Are Hypersensitive to Alkylating Agent-induced Apoptosis and Chromosomal Breakage

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