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Robert W. Robey
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Journal Articles

Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein

Tobie D. Lee, Olivia W. Lee, Kyle R. Brimacombe, Min Shen, Lu Chen, Rajarshi Guha, Bethelihem Tebase, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Matthew D. Hall
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-066.
https://doi.org/10.1158/1538-7445.AM2018-LB-066
Published: 01 July 2018
View article titled, Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein
Journal Articles

Abstract 4040: Short-term romidepsin treatment combined with clotrimazole or bifonazole leads to decreased mitochondrial hexokinase 2 and apoptosis in cancer cells

Robert W. Robey, Andrew J. McDonald, Hanna Kozlowski, Michael M. Gottesman, Susan E. Bates
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4040.
https://doi.org/10.1158/1538-7445.AM2017-4040
Published: 01 July 2017
View article titled, Abstract 4040: Short-term romidepsin treatment combined with clotrimazole or bifonazole leads to decreased mitochondrial hexokinase 2 and apoptosis in cancer cells
Journal Articles

Abstract 1771: Metabolic reprogramming in KRAS mutant cancer cells may cause sensitivity to the histone deacetylase (HDAC) inhibitor romidepsin

Agnes Basseville, Carole Sourbier, Robert W. Robey, Dan L. Sackett, W. Marston Linehan, Susan E. Bates
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1771.
https://doi.org/10.1158/1538-7445.AM2015-1771
Published: 01 August 2015
View article titled, Abstract 1771: Metabolic reprogramming in KRAS mutant cancer cells may cause sensitivity to the histone deacetylase (HDAC) inhibitor romidepsin
Journal Articles

Abstract 5536: Short-term romidepsin treatment combined with MAPK pathway inhibition results in decreased mitochondrial hexokinase 2, increased mitochondrial Bim and apoptosis in BRAF mutant cancers

Susan E. Bates, Victoria Luchenko, Agnes Basseville, Julian Bahr, Arup R. Chakraborty, Andrew McDonald, Alexandra Zimmer, Richard L. Piekarz, Robert W. Robey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5536.
https://doi.org/10.1158/1538-7445.AM2014-5536
Published: 01 October 2014
View article titled, Abstract 5536: Short-term romidepsin treatment combined with MAPK pathway inhibition results in decreased mitochondrial hexokinase 2, increased mitochondrial Bim and apoptosis in BRAF mutant cancers
Journal Articles

HG-829 Is a Potent Noncompetitive Inhibitor of the ATP-Binding Cassette Multidrug Resistance Transporter ABCB1

Gisela Caceres, Robert W. Robey, Lubomir Sokol, Kathy L. McGraw, Justine Clark, Nicholas J. Lawrence, Said M. Sebti, Michael Wiese, Alan F. List
Journal: Cancer Research
Cancer Res (2012) 72 (16): 4204–4213.
https://doi.org/10.1158/0008-5472.CAN-12-0743
Published: 14 August 2012
View article titled, HG-829 Is a Potent Noncompetitive Inhibitor of the ATP-Binding Cassette Multidrug Resistance Transporter <em>ABCB1</em>
Open the PDF for HG-829 Is a Potent Noncompetitive Inhibitor of the ATP-Binding Cassette Multidrug Resistance Transporter <em>ABCB1</em> in another window
Includes: Supplementary data
Journal Articles

Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter

Agnes Basseville, Akina Tamaki, Caterina Ierano, Shana Trostel, Yvona Ward, Robert W. Robey, Ramanujan S. Hegde, Susan E. Bates
Journal: Cancer Research
Cancer Res (2012) 72 (14): 3642–3651.
https://doi.org/10.1158/0008-5472.CAN-11-2008
Published: 15 July 2012
View article titled, Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Open the PDF for Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter in another window
Includes: Supplementary data
Journal Articles

Abstract 4709: Combined mitogen-activated protein kinase pathway inhibition with short-term romidepsin treatment induces proapoptotic Bim and cell death in BRAF mutant cancers

Robert W. Robey, Victoria L. Luchenko, Julian Bahr, Arup R. Chakraborty, Alexandra S. Zimmer, Richard L. Piekarz, Susan E. Bates
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4709.
https://doi.org/10.1158/1538-7445.AM2012-4709
Published: 15 April 2012
View article titled, Abstract 4709: Combined mitogen-activated protein kinase pathway inhibition with short-term romidepsin treatment induces proapoptotic Bim and cell death in BRAF mutant cancers
Journal Articles

Abstract 1739: Reversal of ABCB1- and ABCG2-mediated drug resistance by sildenafil

Amit K. Tiwari, Zhi Shi, Suneet Shukla, Robert W. Robey, Satyakam Singh, In-Wha Kim, Susan E. Bates, Xing-xiang Peng, Ioana Abraham, Suresh V. Ambudkar, Tanaji T. Talele, Li-wu Fu, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1739.
https://doi.org/10.1158/1538-7445.AM2011-1739
Published: 15 April 2011
View article titled, Abstract 1739: Reversal of ABCB1- and ABCG2-mediated drug resistance by sildenafil
Journal Articles

Abstract 2610: Histone deacetylase inhibitors mediate pharmacological rescue of the ABCG2 Q141K variant: Potential for therapeutics in cancer and gout

Agnes Basseville, Akina Tamaki, Caterina Ierano, Yvona Ward, Robert W. Robey, Ramanujan Hegde, Susan E. Bates
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2610.
https://doi.org/10.1158/1538-7445.AM2011-2610
Published: 15 April 2011
View article titled, Abstract 2610: Histone deacetylase inhibitors mediate pharmacological rescue of the ABCG2 Q141K variant: Potential for therapeutics in cancer and gout
Journal Articles

Abstract 2633: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration

Caterina Ierano, Kin Wah To, Robert W. Robey, Susan E. Bates, Stefania Scala
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2633.
https://doi.org/10.1158/1538-7445.AM2011-2633
Published: 15 April 2011
View article titled, Abstract 2633: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration
Journal Articles

Abstract 2624: Elevated expression of phosphorylated mitogen activated protein kinase kinase (MEK) as a mechanism of resistance to the histone deacetylase inhibitor romidepsin in HUT 78 cutaneous T-cell lymphoma cells

Arup R. Chakraborty, Robert W. Robey, Nathan Collie, Jean-Pierre Gillet, Richard L. Piekarz, Michael M. Gottesman, Susan E. Bates
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2624.
https://doi.org/10.1158/1538-7445.AM2011-2624
Published: 15 April 2011
View article titled, Abstract 2624: Elevated expression of phosphorylated mitogen activated protein kinase kinase (MEK) as a mechanism of resistance to the histone deacetylase inhibitor romidepsin in HUT 78 cutaneous T-cell lymphoma cells
Journal Articles

Abstract 2620: Identification of cell context specific and pleiotropic effects of the histone deacetylase inhibitors romidepsin (depsipeptide) and vorinostat (SAHA)

Victoria L. Luchenko, Thomas Litman, Christopher Devor, Aaron Heffner, Robert W. Robey, Julia Wilkerson, Arup R. Chakraborty, Lois Bangiolo, David Levens, Susan E. Bates
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2620.
https://doi.org/10.1158/1538-7445.AM2011-2620
Published: 15 April 2011
View article titled, Abstract 2620: Identification of cell context specific and pleiotropic effects of the histone deacetylase inhibitors romidepsin (depsipeptide) and vorinostat (SAHA)
Journal Articles

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

Zhi Shi, Amit K. Tiwari, Suneet Shukla, Robert W. Robey, Satyakam Singh, In-Wha Kim, Susan E. Bates, Xingxiang Peng, Ioana Abraham, Suresh V. Ambudkar, Tanaji T. Talele, Li-Wu Fu, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8): 3029–3041.
https://doi.org/10.1158/0008-5472.CAN-10-3820
Published: 13 April 2011
View article titled, Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance
Open the PDF for Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract 3541: Pharmacological chaperones increase membrane expression of ABCG2 harboring the Q141K single nucleotide polymorphism

Akina Tamaki, Ierano Caterina, Suneet Shukla, Robert W. Robey, Suresh V. Ambudkar, Susan E. Bates
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3541.
https://doi.org/10.1158/1538-7445.AM10-3541
Published: 15 April 2010
View article titled, Abstract 3541: Pharmacological chaperones increase membrane expression of ABCG2 harboring the Q141K single nucleotide polymorphism
Journal Articles

Abstract 3528: Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in TM1 of ABCG2

Caterina Ierano, Orsolya Polgar, Akina Tamaki, Bradford Stanley, Yvona Ward, Di Xia, Nadya Tarasova, Robert W. Robey, Susan E, Bates
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3528.
https://doi.org/10.1158/1538-7445.AM10-3528
Published: 15 April 2010
View article titled, Abstract 3528: Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in TM1 of ABCG2
Journal Articles

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

Chun-ling Dai, Amit K. Tiwari, Chung-Pu Wu, Xiao-dong Su, Si-Rong Wang, Dong-geng Liu, Charles R. Ashby, Jr., Yan Huang, Robert W. Robey, Yong-ju Liang, Li-ming Chen, Cheng-Jun Shi, Suresh V. Ambudkar, Zhe-Sheng Chen, Li-wu Fu
Journal: Cancer Research
Cancer Res (2008) 68 (19): 7905–7914.
https://doi.org/10.1158/0008-5472.CAN-08-0499
Published: 30 September 2008
View article titled, Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2
Open the PDF for Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2 in another window
Includes: Supplementary data
Journal Articles

Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance

Zhi Shi, Xing-Xiang Peng, In-Wha Kim, Suneet Shukla, Qiu-Sheng Si, Robert W. Robey, Susan E. Bates, Tong Shen, Charles R. Ashby, Jr., Li-Wu Fu, Suresh V. Ambudkar, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2007) 67 (22): 11012–11020.
https://doi.org/10.1158/0008-5472.CAN-07-2686
Published: 15 November 2007
View article titled, Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance
Open the PDF for Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance in another window
Journal Articles

Bisindolylmaleimide and indolocarbazole protein kinase (PK) inhibitors reverse ABCG2-mediated drug transport and resistance

Robert W. Robey, Suneet Shukla, Kenneth Steadman, Suresh V. Ambudkar, Susan E. Bates
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 146.
Published: 15 April 2006
View article titled, Bisindolylmaleimide and indolocarbazole protein kinase (PK) inhibitors reverse ABCG2-mediated drug transport and resistance
Journal Articles

ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates

Assaf Shafran, Ilan Ifergan, Eran Bram, Gerrit Jansen, Ietje Kathmann, Godefridus J. Peters, Robert W. Robey, Susan E. Bates, Yehuda G. Assaraf
Journal: Cancer Research
Cancer Res (2005) 65 (18): 8414–8422.
https://doi.org/10.1158/0008-5472.CAN-04-4547
Published: 15 September 2005
View article titled, ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates
Open the PDF for ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates in another window
Journal Articles

Phase II trial of depsipeptide in patients with T-cell lymphoma: Review of responses and surrogate marker analysis

Richard L. Piekarz, Robin Frye, Zhirong Zhan, Robert W. Robey, Kenneth Steadman, Alex Sparreboom, Tito Fojo, John Wright, William D. Figg, Susan E. Bates
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 937.
Published: 01 May 2005
View article titled, Phase II trial of depsipeptide in patients with T-cell lymphoma: Review of responses and surrogate marker analysis