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Journal Articles

Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase

Shota Kikuchi, Piergiorgio Pettazzoni, Kristen A. Baltgalvis, Kelsey N. Lamb, Kent T. Symons, Chu-Chiao Wu, Melissa A. Hoffman, Aaron N. Snead, Xiaodan Song, Thomas Glaza, Jason C. Green, Donald C. Rogness, Betty Lam, Maria E. Rodriguez-Aguirre, David R. Woody, Christie L. Eissler, Socorro Rodiles, Seth M. Negron, Steffen M. Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N. Williams, Martha K. Pastuszka, John J. Sigler, Markus G. Rudolph, Moritz Classen, Doris Brugger, Christopher Claiborne, Jean-Marc Plancher, Isabel Cuartas, Joan Seoane, Laurence E. Burgess, Robert T. Abraham, David S. Weinstein, Gabriel M. Simon, Matthew P. Patricelli, Todd M. Kinsella
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): ND11.
https://doi.org/10.1158/1538-7445.AM2024-ND11
Published: 05 April 2024
View article titled, Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase
Journal Articles

Abstract SY34-03: Braking the cycle: Inhibition of the cyclin D-Cdk4/6 pathway in breast cancer

Robert T. Abraham, Todd VanArsdale, David V. Shields, Nathan V. Lee, Maria Koehler, Kim Arndt
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY34-03.
https://doi.org/10.1158/1538-7445.AM2014-SY34-03
Published: 01 October 2014
View article titled, Abstract SY34-03: Braking the cycle: Inhibition of the cyclin D-Cdk4/6 pathway in breast cancer
Journal Articles

Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells

Marc Damelin, Kenneth G. Geles, Maximillian T. Follettie, Ping Yuan, Michelle Baxter, Jonathon Golas, John F. DiJoseph, Maha Karnoub, Shuguang Huang, Veronica Diesl, Carmen Behrens, Sung E. Choe, Carol Rios, Janet Gruzas, Latha Sridharan, Maureen Dougher, Arthur Kunz, Philip R. Hamann, Deborah Evans, Douglas Armellino, Kiran Khandke, Kimberly Marquette, Lioudmila Tchistiakova, Erwin R. Boghaert, Robert T. Abraham, Ignacio I. Wistuba, Bin-Bing S. Zhou
Journal: Cancer Research
Cancer Res (2011) 71 (12): 4236–4246.
https://doi.org/10.1158/0008-5472.CAN-10-3919
Published: 14 June 2011
View article titled, Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells
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Includes: Supplementary data
Journal Articles

Abstract 475: Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells

Marc I. Damelin, Kenneth G. Geles, Maximillian T. Follettie, Ping Yuan, Michelle Baxter, Jonathon Golas, Shuguang Huang, John DiJoseph, Veronica Diesl, Carmen Behrens, Sung E. Choe, Carol Rios, Janet Gruzas, Latha Sridharan, Maureen Dougher, Arthur Kunz, Philip R. Hamann, Deborah Evans, Douglas Armellino, Kiran Khandke, Kimberly Marquette, Lioudmila Tchistiakova, Erwin Boghaert, Robert T. Abraham, Ignacio I. Wistuba, Bin-Bing S. Zhou
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 475.
https://doi.org/10.1158/1538-7445.AM2011-475
Published: 15 April 2011
View article titled, Abstract 475: Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells
Journal Articles

Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos, Zecheng Chen, Osvaldo Dos Santos, Semiramis Ayral-Kaloustian, Robert Mallon, Irwin Hollander, Larry Feldberg, Judy Lucas, Ker Yu, Natasja Brooijmans, Joel Bard, James Gibbons, Robert T. Abraham, Tarek S. Mansour
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 723.
https://doi.org/10.1158/1538-7445.AM10-723
Published: 15 April 2010
View article titled, Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor
Journal Articles

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral-Barza, Judy Lucas, Boris Shor, Jae Eun Kim, Wei-Guo Zhang, Robert Mahoney, Christine Gaydos, LuAnna Tardio, Sung Kyoo Kim, Roger Conant, Kevin Curran, Joshua Kaplan, Jeroen Verheijen, Semiramis Ayral-Kaloustian, Tarek S. Mansour, Robert T. Abraham, Arie Zask, James J. Gibbons
Journal: Cancer Research
Cancer Res (2010) 70 (2): 621–631.
https://doi.org/10.1158/0008-5472.CAN-09-2340
Published: 13 January 2010
View article titled, Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
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Includes: Supplementary data
Journal Articles

Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral-Barza, Celine Shi, Wei-Guo Zhang, Judy Lucas, Boris Shor, Jamie Kim, Jeroen Verheijen, Kevin Curran, David J. Malwitz, Derek C. Cole, John Ellingboe, Semiramis Ayral-Kaloustian, Tarek S. Mansour, James J. Gibbons, Robert T. Abraham, Pawel Nowak, Arie Zask
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6232–6240.
https://doi.org/10.1158/0008-5472.CAN-09-0299
Published: 29 July 2009
View article titled, Biochemical, Cellular, and <em>In vivo</em> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
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Includes: Supplementary data
Journal Articles

A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis

Boris Shor, Wei-Guo Zhang, Lourdes Toral-Barza, Jessica Lucas, Robert T. Abraham, James J. Gibbons, Ker Yu
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2934–2943.
https://doi.org/10.1158/0008-5472.CAN-07-6487
Published: 15 April 2008
View article titled, A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis
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Includes: Supplementary data
Journal Articles

A Retroinhibition Approach Reveals a Tumor Cell–Autonomous Response to Rapamycin in Head and Neck Cancer

Panomwat Amornphimoltham, Vyomesh Patel, Kantima Leelahavanichkul, Robert T. Abraham, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2008) 68 (4): 1144–1153.
https://doi.org/10.1158/0008-5472.CAN-07-1756
Published: 15 February 2008
View article titled, A Retroinhibition Approach Reveals a Tumor Cell–Autonomous Response to Rapamycin in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Tumorigenic transformation of prostate epithelial cells through defined genetic manipulation

Mei Liu, Tongyun Dang, Christoph Geisen, Elizabeth Lang, Gary G. Chiang, Jeffrey M. Arbeit, Christopher M. Counter, Robert T. Abraham
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 421.
Published: 15 April 2006
View article titled, Tumorigenic transformation of prostate epithelial cells through defined genetic manipulation
Journal Articles

Antitumor Activity of Rapamycin in a Transgenic Mouse Model of ErbB2-Dependent Human Breast Cancer

Mei Liu, Amy Howes, Jacqueline Lesperance, William B. Stallcup, Craig A. Hauser, Kuniko Kadoya, Robert G. Oshima, Robert T. Abraham
Journal: Cancer Research
Cancer Res (2005) 65 (12): 5325–5336.
https://doi.org/10.1158/0008-5472.CAN-04-4589
Published: 15 June 2005
View article titled, Antitumor Activity of Rapamycin in a Transgenic Mouse Model of ErbB2-Dependent Human Breast Cancer
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Journal Articles

Anti-tumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer

Mei Liu, Amy Howes, Jacqueline Lesperance, William Stallcup, Robert Oshima, Robert T. Abraham
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 398.
Published: 01 May 2005
View article titled, Anti-tumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer
Journal Articles

Rapamycin treatment during fractionated radiotherapy causes cell death in 3D culture

Amy L. Howes, Caroline B. Ho, Robert T. Abraham
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 540.
Published: 01 May 2005
View article titled, Rapamycin treatment during fractionated radiotherapy causes cell death in 3D culture
Journal Articles

Differential Effects of Rapamycin on Mammalian Target of Rapamycin Signaling Functions in Mammalian Cells

Aimee L. Edinger, Corinne M. Linardic, Gary G. Chiang, Craig B. Thompson, Robert T. Abraham
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8451–8460.
Published: 16 December 2003
View article titled, Differential Effects of Rapamycin on Mammalian Target of Rapamycin Signaling Functions in Mammalian Cells
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Journal Articles

A Direct Linkage between the Phosphoinositide 3-Kinase-AKT Signaling Pathway and the Mammalian Target of Rapamycin in Mitogen-stimulated and Transformed Cells

Aleksandar Sekulić, Christine C. Hudson, James L. Homme, Peng Yin, Diane M. Otterness, Larry M. Karnitz, Robert T. Abraham
Journal: Cancer Research
Cancer Res (2000) 60 (13): 3504–3513.
Published: 01 July 2000
View article titled, A Direct Linkage between the Phosphoinositide 3-Kinase-AKT Signaling Pathway and the Mammalian Target of Rapamycin in Mitogen-stimulated and Transformed Cells
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Journal Articles

The Radiosensitizing Agent 7-Hydroxystaurosporine (UCN-01) Inhibits the DNA Damage Checkpoint Kinase hChk1

Ericka C. Busby, Dru F. Leistritz, Robert T. Abraham, Larry M. Karnitz, Jann N. Sarkaria
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2108–2112.
Published: 01 April 2000
View article titled, The Radiosensitizing Agent 7-Hydroxystaurosporine (UCN-01) Inhibits the DNA Damage Checkpoint Kinase hChk1
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Journal Articles

Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine

Jann N. Sarkaria, Ericka C. Busby, Randal S. Tibbetts, Pia Roos, Yoichi Taya, Larry M. Karnitz, Robert T. Abraham
Journal: Cancer Research
Cancer Res (1999) 59 (17): 4375–4382.
Published: 01 September 1999
View article titled, Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine
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Journal Articles

Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells

Hajime Hosoi, Michael B. Dilling, Takuma Shikata, Linda N. Liu, Lili Shu, Richard A. Ashmun, Glen S. Germain, Robert T. Abraham, Peter J. Houghton
Journal: Cancer Research
Cancer Res (1999) 59 (4): 886–894.
Published: 15 February 1999
View article titled, Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells
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Journal Articles

Inhibition of Phosphoinositide 3-Kinase Related Kinases by the Radiosensitizing Agent Wortmannin

Jann N. Sarkaria, Randal S. Tibbetts, Ericka C. Busby, Amy P. Kennedy, David E. Hill, Robert T. Abraham
Journal: Cancer Research
Cancer Res (1998) 58 (19): 4375–4382.
Published: 01 October 1998
View article titled, Inhibition of Phosphoinositide 3-Kinase Related Kinases by the Radiosensitizing Agent Wortmannin
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Journal Articles

Inhibition of Protein Tyrosine Phosphatase by the Antitumor Agent Gallium Nitrate

Margareta M. Berggren, Leigh Ann Burns, Robert T. Abraham, Garth Powis
Journal: Cancer Research
Cancer Res (1993) 53 (8): 1862–1866.
Published: 01 April 1993
View article titled, Inhibition of Protein Tyrosine Phosphatase by the Antitumor Agent Gallium Nitrate
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