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Robert S. Kerbel
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Journal Articles

Abstract 1353: Potentiating salvage radiotherapy in radiorecurrent prostate cancer through anti-CTLA4 therapy: Implications from a syngeneic model

Hanzhi Wang, Linsey Gong, Xiaoyong Huang, Stephanie D. White, Hanz T. Chung, Danny Vesprini, Tera N. Petchiny, Emmanouil Fokas, Hansen He, Robert S. Kerbel, Stanley K. Liu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1353.
https://doi.org/10.1158/1538-7445.AM2024-1353
Published: 22 March 2024
View article titled, Abstract 1353: Potentiating salvage radiotherapy in radiorecurrent prostate cancer through anti-CTLA4 therapy: Implications from a syngeneic model
Journal Articles

Abstract 3998: Metronomic gemcitabine plus neratinib effectively inhibits the growth of human Her-2 positive breast cancer cells intracranially implanted into immunodeficient mice

Serina Batson, Alejandro Sanchez, Hector M. Padilla, Diana L. Prospero, Brenda Lugo, Valeria V. Lopez, Daniella E. Estrada, Nydia De Avila, Saeedeh Darvishi, Arlene Levario, Shan Man, Ping Xu, Robert S. Kerbel, Guido Bocci, Giulio Francia
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3998.
https://doi.org/10.1158/1538-7445.AM2023-3998
Published: 04 April 2023
View article titled, Abstract 3998: Metronomic gemcitabine plus neratinib effectively inhibits the growth of human Her-2 positive breast cancer cells intracranially implanted into immunodeficient mice
Journal Articles

Abstract 10: Evaluation of metronomic chemotherapy regimens in preclinical orthotopically implanted colon cancer models, and in patient-derived xenografts

Jose Lopez, Paloma Valenzuela, Valerie Gallegos, Karla Parra, Valeria Rolih, Diana Gonzalez Garcia, Joel Martinez, Urban Emmenegger, Guido Bocci, Robert S. Kerbel, Giulio Francia
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 10.
https://doi.org/10.1158/1538-7445.AM2018-10
Published: 01 July 2018
View article titled, Abstract 10: Evaluation of metronomic chemotherapy regimens in preclinical orthotopically implanted colon cancer models, and in patient-derived xenografts
Journal Articles

Abstract 1254: Mechanistic interrogation of pre-treatment low dose aspirin effects in HER 2 positive breast cancer

Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Bruce Moran, Finbarr P. Leacy, Paul M. Loadman, Robert S. Kerbel, Darran O' Connor, Kathleen Bennett, Róisín M. Dwyer, Annette T. Byrne
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1254.
https://doi.org/10.1158/1538-7445.AM2017-1254
Published: 01 July 2017
View article titled, Abstract 1254: Mechanistic interrogation of pre-treatment low dose aspirin effects in HER 2 positive breast cancer
Journal Articles

Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers

Florence T.H. Wu, Shan Man, Ping Xu, Annabelle Chow, Marta Paez-Ribes, Christina R. Lee, Steven R. Pirie-Shepherd, Urban Emmenegger, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2016) 76 (23): 6988–7000.
https://doi.org/10.1158/0008-5472.CAN-16-0888
Published: 30 November 2016
View article titled, Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers
Open the PDF for Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers in another window
Includes: Supplementary data
Journal Articles

Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy

Yuval Shaked, Elizabeth Pham, Santosh Hariharan, Ksenia Magidey, Ofrat Beyar-Katz, Ping Xu, Shan Man, Florence T.H. Wu, Valeria Miller, David Andrews, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2016) 76 (20): 5983–5993.
https://doi.org/10.1158/0008-5472.CAN-16-0136
Published: 13 October 2016
View article titled, Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy
Open the PDF for Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy in another window
Includes: Supplementary data
Journal Articles

Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle–Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer

Elizabeth Pham, Melissa Yin, Christian G. Peters, Christina R. Lee, Donna Brown, Ping Xu, Shan Man, Lata Jayaraman, Ellen Rohde, Annabelle Chow, Douglas Lazarus, Scott Eliasof, F. Stuart Foster, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2016) 76 (15): 4493–4503.
https://doi.org/10.1158/0008-5472.CAN-15-3435
Published: 31 July 2016
View article titled, Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle–Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer
Open the PDF for Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle–Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4124: Potent anti-tumor and metastatic breast cancer efficacy of bevacizumab with CRLX101, an investigational chemotherapy nanoparticle-drug conjugate that secondarily suppresses HIF-1α

Elizabeth Pham, Christina R. Lee, Ping Xu, Shan Man, Melissa Yin, F. Stuart Foster, Christian G. Peters, Douglas Lazarus, Scott Eliasof, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4124.
https://doi.org/10.1158/1538-7445.AM2015-4124
Published: 01 August 2015
View article titled, Abstract 4124: Potent anti-tumor and metastatic breast cancer efficacy of bevacizumab with CRLX101, an investigational chemotherapy nanoparticle-drug conjugate that secondarily suppresses HIF-1α
Journal Articles

Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma

Elizabeth A. Kuczynski, Christina R. Lee, Shan Man, Eric Chen, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2015) 75 (12): 2510–2519.
https://doi.org/10.1158/0008-5472.CAN-14-3687
Published: 14 June 2015
View article titled, Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma
Open the PDF for Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3142: Derivation and analysis of preclinical models of human her-2 positive breast cancer

Paloma A. Valenzuela, Sarah N. Jallad, Karla Parra, Natzidielly Lerma, Irving Miramontes, Alejandra Gallegos, Ping Xu, William Cruz-Munoz, Shan Man, Robert S. Kerbel, Giulio Francia
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3142.
https://doi.org/10.1158/1538-7445.AM2014-3142
Published: 01 October 2014
View article titled, Abstract 3142: Derivation and analysis of preclinical models of human her-2 positive breast cancer
Journal Articles

Abstract IA29: Models of postsurgical early and late stage metastasis for improving preclinical adjuvant and metastatic therapy investigations

Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): IA29.
https://doi.org/10.1158/1538-7445.TIM2013-IA29
Published: 01 May 2014
View article titled, Abstract IA29: Models of postsurgical early and late stage metastasis for improving preclinical adjuvant and metastatic therapy investigations
Journal Articles

A Model of Postsurgical Advanced Metastatic Breast Cancer More Accurately Replicates the Clinical Efficacy of Antiangiogenic Drugs

Eric Guerin, Shan Man, Ping Xu, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2013) 73 (9): 2743–2748.
https://doi.org/10.1158/0008-5472.CAN-12-4183
Published: 30 April 2013
View article titled, A Model of Postsurgical Advanced Metastatic Breast Cancer More Accurately Replicates the Clinical Efficacy of Antiangiogenic Drugs
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Journal Articles

Abstract 863: Inhibition of breast cancer metastaticprogression by a novel uPAR targeted monoclonal antibody, ATN-658, correlateswith the uPAR expression.

Irawati Kandela, Andrey Ugolkov, Giulio Francia, Shafaat Rabbani, Robert S. Kerbel, Andrew P. Mazar
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 863.
https://doi.org/10.1158/1538-7445.AM2013-863
Published: 15 April 2013
View article titled, Abstract 863: Inhibition of breast cancer metastaticprogression by a novel uPAR targeted monoclonal antibody, ATN-658, correlateswith the uPAR expression.
Journal Articles

Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

William Cruz-Muñoz, Maria L. Jaramillo, Shan Man, Ping Xu, Myriam Banville, Catherine Collins, Andre Nantel, Giulio Francia, Sherif S. Morgan, Lee D. Cranmer, Maureen D. O'Connor-McCourt, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2012) 72 (19): 4909–4919.
https://doi.org/10.1158/0008-5472.CAN-12-2194
Published: 30 September 2012
View article titled, Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma
Open the PDF for Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1375: Contrasting effects of VEGF pathway inhibitors in primary and metastatic disease using perioperative neoadjuvant mouse models

John M.L. Ebos, Christina R. Lee, William Cruz-Munoz, Christopher Jedeszko, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1375.
https://doi.org/10.1158/1538-7445.AM2012-1375
Published: 15 April 2012
View article titled, Abstract 1375: Contrasting effects of VEGF pathway inhibitors in primary and metastatic disease using perioperative neoadjuvant mouse models
Journal Articles

Abstract 4377: Metronomic oral prodrug of gemcitabine (LY2334737) causes antitumor effects with concomitant increase in intratumoral blood flow

Giulio Francia, Yuval Shaked, Kae Hashimoto, John Sun, Ping Xu, Shan Man, Christina Hackl, Julie Stewart, Anne H. Dantzig, Mark Uhlik, Stuart Foster, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4377.
https://doi.org/10.1158/1538-7445.AM2012-4377
Published: 15 April 2012
View article titled, Abstract 4377: Metronomic oral prodrug of gemcitabine (LY2334737) causes antitumor effects with concomitant increase in intratumoral blood flow
Journal Articles

Abstract 4381: The novel direct-acting vascular targeting agent NGR-TNF exerts in vivo antitumor activity by inducing endothelial and tumor cell death in the absence of proangiogenic bone-marrow derived cell recruitment

Paola Di Matteo, Christina Hackl, Christopher Jedeszko, Simona Porcellini, Barbara Valentinis, Claudio Bordignon, Catia Traversari, Robert S. Kerbel, Gian-Paolo Rizzardi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4381.
https://doi.org/10.1158/1538-7445.AM2012-4381
Published: 15 April 2012
View article titled, Abstract 4381: The novel direct-acting vascular targeting agent NGR-TNF exerts <em>in vivo</em> antitumor activity by inducing endothelial and tumor cell death in the absence of proangiogenic bone-marrow derived cell recruitment
Journal Articles

Combined Blockade of Integrin-α4β1 Plus Cytokines SDF-1α or IL-1β Potently Inhibits Tumor Inflammation and Growth

Michael C. Schmid, Christie J. Avraamides, Philippe Foubert, Yuval Shaked, Sang Won Kang, Robert S. Kerbel, Judith A. Varner
Journal: Cancer Research
Cancer Res (2011) 71 (22): 6965–6975.
https://doi.org/10.1158/0008-5472.CAN-11-0588
Published: 13 November 2011
View article titled, Combined Blockade of Integrin-α4β1 Plus Cytokines SDF-1α or IL-1β Potently Inhibits Tumor Inflammation and Growth
Open the PDF for Combined Blockade of Integrin-α4β1 Plus Cytokines SDF-1α or IL-1β Potently Inhibits Tumor Inflammation and Growth in another window
Includes: Supplementary data
Journal Articles

Abstract 4249: NGR-TNF, a novel direct-acting vascular targeting agent, does not induce “cytokine-rebound” recruitment of pro-angiogenic bone-marrow derived cells

Paola Di Matteo, Christina Hackl, Christopher Jedeszko, Barbara Valentinis, Claudio Bordignon, Catia Traversari, Robert S. Kerbel, Gian-Paolo Rizzardi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4249.
https://doi.org/10.1158/1538-7445.AM2011-4249
Published: 15 April 2011
View article titled, Abstract 4249: NGR-TNF, a novel direct-acting vascular targeting agent, does not induce “cytokine-rebound” recruitment of pro-angiogenic bone-marrow derived cells
Journal Articles

Abstract 1452: Examination of mechanisms involved in spontaneous melanoma metastasis to CNS

William Cruz, Shan Man, Maria Jaramillo, Maureen O'Connor-McCourt, Myriam Banville, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM10-1452
Published: 15 April 2010
View article titled, Abstract 1452: Examination of mechanisms involved in spontaneous melanoma metastasis to CNS