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Journal Articles

Abstract 2587: A novel covalent inhibitor of mutant but not wild-type (WT) epidermal growth factor receptor (EGFR) has activity in vitro and in vivo in non-small cell lung cancer (NSCLC) models

Pedro J. Beltran, Jinghui Zhan, Petia Mitchell, Ryan P. Wurz, Liping Pettus, Tian Wu, Mary Chaves, Darren L. Reid, Robert Radinsky, Keegan Cooke, Andrew Tasker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2587.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2587
Published: 01 August 2015
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Journal Articles

Abstract 728: AMG 337, a novel, potent and selective MET kinase inhibitor, has robust growth inhibitory activity in MET-dependent cancer models

Paul E. Hughes, Yajing Yang, Karen Rex, Yihong Zhang, Paula J. Kaplan-Lefko, Sean Caenepeel, Jodi Moriguchi, Martin Broome, Deborah Choquette, Robert Radinsky, Richard Kendall, Angela Coxon, Isabelle Dussault
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 728.
DOI: https://doi.org/10.1158/1538-7445.AM2014-728
Published: 01 October 2014
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Journal Articles

Abstract 5089: Combined treatment of trebananib (AMG 386) with panitumumab in preclinical tumor models.

James V. Bready, Paula Kaplan-Lefko, Jodi Moriguchi, Marc Payton, Stephen Kaufman, Jonathan Oliner, Robert Radinsky, Angela Coxon
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5089.
DOI: https://doi.org/10.1158/1538-7445.AM2013-5089
Published: 15 April 2013
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Journal Articles

Abstract 5158: Generation of a fully human Gas6 neutralizing antibody with anti-tumor activity in vivo.

Gordon E. Moody, Brian Belmontes, Chadwick King, Shuying Liu, Stephanie Masterman, Chris Murawsky, Trace Tsuruda, Wei Wang, Robert Radinsky, Pedro J. Beltran
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5158.
DOI: https://doi.org/10.1158/1538-7445.AM2013-5158
Published: 15 April 2013
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Journal Articles

Abstract 2805: In vitro characterization of AMG 511, a potent and selective class I PI3K inhibitor for the treatment of cancer

Sean Caenepeel, Nancy Zhang, Ling Wang, Mark H. Norman, Terri Burgess, Robert Radinsky, Rick Kendall, Daniel Freeman, Paul E. Hughes
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2805.
DOI: https://doi.org/10.1158/1538-7445.AM2012-2805
Published: 15 April 2012
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Journal Articles

Abstract 2797: AMG 511, a potent and selective class I PI3K inhibitor, demonstrates anti-tumor activity in multiple xenograft models

Nancy Zhang, Sean Caenepeel, Ling Wang, Mark Norman, Richard Kendall, Terri Burgess, Robert Radinsky, Paul Hughes, Daniel J. Freeman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2797.
DOI: https://doi.org/10.1158/1538-7445.AM2012-2797
Published: 15 April 2012
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Journal Articles

Abstract 3556: Antitumor activity of AMG 900, an orally available small molecule inhibitor of aurora kinases, alone and in combination with tubulin-targeting agents in human metastatic breast cancer

Tammy L. Bush, Scott Heller, Grace Chung, Deborah Guyot, Richard Kendall, Greg Friberg, Robert Radinsky, Marc Payton
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3556.
DOI: https://doi.org/10.1158/1538-7445.AM2011-3556
Published: 15 April 2011
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Journal Articles

Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines

Marc Payton, Tammy L. Bush, Grace Chung, Beth Ziegler, Patrick Eden, Patricia McElroy, Sandra Ross, Victor J. Cee, Holly L. Deak, Brian L. Hodous, Hanh Nho Nguyen, Philip R. Olivieri, Karina Romero, Laurie B. Schenkel, Annette Bak, Mary Stanton, Isabelle Dussault, Vinod F. Patel, Stephanie Geuns-Meyer, Robert Radinsky, Richard L. Kendall
Journal: Cancer Research
Cancer Res (2010) 70 (23): 9846–9854.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-3001
Published: 06 December 2010
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Includes: Supplementary data
Journal Articles

Abstract LB-306: U3-1287 (AMG 888), a fully human anti-HER3 mAb, inhibits HER3 activation and induces HER3 internalization and degradation

Thore Hettmann, Matthias Schneider, Selam Ogbagabriel, Jiansong Xie, Gloria Juan, Susanne Hartmann, Robert Radinsky, Daniel J. Freeman
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-306.
DOI: https://doi.org/10.1158/1538-7445.AM10-LB-306
Published: 15 April 2010
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Journal Articles

Abstract 5776: Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cells

Stephanie Geuns-Meyer, Victor J. Cee, Holly L. Deak, Bingfan Du, Brian L. Hodous, Hanh N. Nguyen, Philip R. Olivieri, Karina Romero, Laurie B. Schenkel, Vinod F. Patel, Xuhai Be, Tammy L. Bush, Grace Chung, Patrick Eden, Liyue Huang, Richard Kendall, Min-Hwa Jasmine Lin, Robert Radinsky, Beth Ziegler, Marc Payton
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5776.
DOI: https://doi.org/10.1158/1538-7445.AM10-5776
Published: 15 April 2010
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Journal Articles

Abstract 3600: Preclinical pharmacokinetic and biomarker analysis of AMG 900, an orally available small molecule inhibitor of aurora kinases, in human xenograft tumor and surrogate tissues

Beth Ziegler, Gloria Juan, Grace Chung, Raffi Manoukian, Liyue Huang, Min-Hwa Jasmine Lin, Connie Ma, Stephen Zoog, Stephanie Geuns-Meyer, Richard Kendall, Robert Radinsky, Greg Friberg, Marc Payton, Tammy L. Bush
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3600.
DOI: https://doi.org/10.1158/1538-7445.AM10-3600
Published: 15 April 2010
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Journal Articles

Abstract 4437: Preclinical characterization of AMG 900, an orally available small molecule inhibitor of aurora kinases in phase 1 clinical trials

Tammy L. Bush, Grace Chung, Beth Ziegler, Patrick Eden, Patricia McElroy, Min-Hwa Jasmine Lin, Robert Radinsky, Richard Kendall, Stephanie Geuns-Meyer, Marc Payton
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4437.
DOI: https://doi.org/10.1158/1538-7445.AM10-4437
Published: 15 April 2010
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Journal Articles

Abstract 21: Selective and potent inhibitors of the mutant B-Raf pathway paradoxically stimulate the MAPK pathway in wild-type B-Raf cells

Josette Carnahan, Pedro Beltran, Carol Babij, Quynh Le, Mark J. Rose, Steven Vonderfecht, Joseph L. Kim, Adrian L. Smith, Martin A. Broome, Manory Fernando, Hue Kha, Brian Belmontes, Robert Radinsky, Richard Kendall, Teresa L. Burgess
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 21.
DOI: https://doi.org/10.1158/1538-7445.AM10-21
Published: 15 April 2010
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Journal Articles

Abstract 2519: Efficacy of a potent and selective Raf inhibitor against human xenograft models displaying specific genetic mutations in the MAPK signaling pathway

Pedro J. Beltran, Josette Carnahan, Quynh Le, Manory Fernando, Mark J. Rose, Karthik Nagapudi, Adrian L. Smith, Joseph L. Kim, Brian Belmontes, Teresa L. Burgess, Richard Kendall, Robert Radinsky
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2519.
DOI: https://doi.org/10.1158/1538-7445.AM10-2519
Published: 15 April 2010
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Journal Articles

Abstract #2805: AMG 479, a fully human anti-IGF-1R monoclonal antibody, inhibits rapamycin-induced Akt activation in sarcoma cell lines

Pedro Beltran, Young-Ah Chung, Petia Mitchell, Elaina Cajulis, Gordon Moody, Robert Radinsky, Frank Calzone
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2805.
Published: 01 May 2009
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Journal Articles

Abstract #140: Assessment of angiogenesis inhibitors in the retinopathy of prematurity model in mice

Juan Estrada, Stephen Kaufman, Eunju Hurh, Daniel Freeman, Richard Kendall, Robert Radinsky, Anthony Polverino, Jonathan Oliner, Angela Coxon, James Bready
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 140.
Published: 01 May 2009
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Journal Articles

Positron emission tomography (PET) measurement of death receptor 5 (DR5) receptor occupancy (RO) using 64Cu-labeled AMG 655 in Colo205 xenografts

Dah-Ren Hwang, Raffaella Rossin, Brian Gliniak, Hiko Kohno, Thomas Arroll, Paula Kaplan-Lefko, Jeffery Wiezorek, Greg Friberg, Robert Radinsky, Jeffrey Evelhoch, Michael Welch
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3162.
Published: 01 May 2008
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Journal Articles

AMG 479, a fully human anti-IGF-1R monoclonal antibody, Inhibits IGF-1 induced phospho-Akt and enhances the antineoplastic activity of cyclophosphamide in vivo

Pedro Beltran, Elaina Cajulis, Gordon Moody, Young-Ah Chung, Petia Mitchell, Mei Mei Tsai, Robert Radinsky, Calzone Frank
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4001.
Published: 01 May 2008
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Journal Articles

AMG 458, a potent small molecule c-Met inhibitor, has significant anti-tumor activity in vivo

Paula Kaplan-Lefko, Karen Rex, Jodi Moriguchi, Yajing Yang, Yihong Zhang, April Chen, Jasmine Lin, Steve Kaufman, Tae-Seong Kim, Longbin Liu, Aaron Siegmund, Jean-Christophe Harmange, Roman Shimanovich, Teresa Burgess, Richard Kendall, Robert Radinsky, Angela Coxon, Isabelle Dussault
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4976.
Published: 01 May 2008
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Journal Articles

Modulation of radiation response by motesanib diphosphate in models of head and neck squamous cell carcinoma

Tim Kruser, Deric Wheeler, Shyhmin Huang, Eric Armstrong, Angela Coxon, Charlie Starnes, Tony Polverino, Robert Radinsky, Paul Harari
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5764.
Published: 01 May 2008
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