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Robert M. Straubinger
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Journal Articles

Abstract PO-028: Could pharmacodynamic modelling of FOLFIRINOX lead to more therapeutically advantageous treatment of pancreatic cancer?

Taylor Allen-Coyle, Jin Niu, Eva Welsch, Fiona O'Neill, Martin Clynes, Finbarr O'Sullivan, Donald E. Mager, Robert M. Straubinger, Sandra Roche
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-028.
https://doi.org/10.1158/1538-7445.PANCA20-PO-028
Published: 13 November 2020
View articletitled, Abstract PO-028: Could pharmacodynamic modelling of FOLFIRINOX lead to more therapeutically advantageous treatment of pancreatic cancer?
Journal Articles

Abstract PO-042: FGFR1 expression correlates inversely with the in vitro and in vivo efficacy of FGFR inhibitors in pancreatic cancer

Qingxiang Lin, Andrea Serratore, Eugene Kandel, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-042.
https://doi.org/10.1158/1538-7445.PANCA20-PO-042
Published: 13 November 2020
View articletitled, Abstract PO-042: FGFR1 expression correlates inversely with the in vitro and in vivo efficacy of FGFR inhibitors in pancreatic cancer
Journal Articles

Abstract 1678: Establishment and characterization by expression microarrays of a patient-derived xenograft biobank for human pancreatic adenocarcinoma

Sandra Roche, Fiona O'Neill, Niall Swan, Ninfa L. Straubinger, Neil T. Conlon, Jean Murphy, Kevin Conlon, Ray McDermott, Justine Meiller, Justin Geoghegan, Michael Moriarty, Robert M. Straubinger, Martin Clynes
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1678.
https://doi.org/10.1158/1538-7445.AM2020-1678
Published: 15 August 2020
View articletitled, Abstract 1678: Establishment and characterization by expression microarrays of a patient-derived xenograft biobank for human pancreatic adenocarcinoma
Journal Articles

Abstract 3890: Pharmacodynamic and proteomic analysis of combined gemcitabine/nab-paclitaxel in patient-derived pancreatic cancer xenograft models

Jin Niu, Xue Wang, Shichen Shen, Ju Qu, Donald Mager, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3890.
https://doi.org/10.1158/1538-7445.AM2019-3890
Published: 01 July 2019
View articletitled, Abstract 3890: Pharmacodynamic and proteomic analysis of combined gemcitabine/nab-paclitaxel in patient-derived pancreatic cancer xenograft models
Journal Articles

Abstract 3704: Efficacy of DR5-targeted immunoliposomes in pancreatic cancer models primed with SMO inhibitors

Darren Chan, Charlene Minx, Jun Wang, Arindam Sen, Michael Johnston, Wen Wee Ma, Christopher J. Scott, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3704.
https://doi.org/10.1158/1538-7445.AM2018-3704
Published: 01 July 2018
View articletitled, Abstract 3704: Efficacy of DR5-targeted immunoliposomes in pancreatic cancer models primed with SMO inhibitors
Journal Articles

Abstract 4071: FGFR1 inhibitor reverses Smoothened inhibition-induced epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma

Tista Roy Chaudhuri, Qingxiang Lin, Ninfa L. Straubinger, Wen Wee Ma, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4071.
https://doi.org/10.1158/1538-7445.AM2017-4071
Published: 01 July 2017
View articletitled, Abstract 4071: FGFR1 inhibitor reverses Smoothened inhibition-induced epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 4072: FGFR inhibitors enhance gemcitabine sensitivity in pancreatic ductal adenocarcinoma

Qingxiang Lin, Tista Roy Chaudhuri, Ninfa L. Straubinger, Wen Wee Ma, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4072.
https://doi.org/10.1158/1538-7445.AM2017-4072
Published: 01 July 2017
View articletitled, Abstract 4072: FGFR inhibitors enhance gemcitabine sensitivity in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 2069: Activity of an EphA2-targeted docetaxel nanoliposome in pancreatic patient-derived models as monotherapy and in combination with gemcitabine

Daryl C. Drummond, Ninfa L. Straubinger, Tista Roy Chaudhuri, Michael Moser, Walid S. Kamoun, Lia Luus, Zhaohua Richard Huang, Suresh Tipparaju, Bryan Gillard, Carl Morrison, Elizabeth Repasky, Dmitri B. Kirpotin, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2069.
https://doi.org/10.1158/1538-7445.AM2016-2069
Published: 15 July 2016
View articletitled, Abstract 2069: Activity of an EphA2-targeted docetaxel nanoliposome in pancreatic patient-derived models as monotherapy and in combination with gemcitabine
Journal Articles

Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer

Daniel F. Gaddy, Helen Lee, Nancy Paz, Shannon C. Leonard, Ashish Kalra, Ninfa L. Straubinger, Robert M. Straubinger, Bryan M. Gillard, Michael T. Moser, Daryl C. Drummond, Stephan G. Klinz, Bart S. Hendriks, Jonathan B. Fitzgerald
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4830.
https://doi.org/10.1158/1538-7445.AM2016-4830
Published: 15 July 2016
View articletitled, Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer
Journal Articles

Abstract 2691: Smo-targeted sonic hedgehog signaling inhibitor enhances therapeutic antibody deposition and efficacy in a patient-derived pancreatic ductal adenocarcinoma model

Jun Wang, Yang Qu, Rose Pitoniak, Sheryl A. Trueman-Fatallah, Bonnie L. Hylander, Elizabeth A. Repasky, Wen Wee Ma, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2691.
https://doi.org/10.1158/1538-7445.AM2014-2691
Published: 01 October 2014
View articletitled, Abstract 2691: Smo-targeted sonic hedgehog signaling inhibitor enhances therapeutic antibody deposition and efficacy in a patient-derived pancreatic ductal adenocarcinoma model
Journal Articles

Abstract 3980: Computational analysis of paclitaxel-induced tumor priming that leads to enhanced deposition and efficacy nanoparticulate doxorubicin

Sihem Ait-Oudhia, Robert M. Straubinger, Donald E. Mager
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3980.
https://doi.org/10.1158/1538-7445.AM2012-3980
Published: 15 April 2012
View articletitled, Abstract 3980: Computational analysis of paclitaxel-induced tumor priming that leads to enhanced deposition and efficacy nanoparticulate doxorubicin
Journal Articles

Abstract 3681: Multi-scale analysis of everolimus and sorafenib combination in pancreatic cancer xenografts

Dipti K. Pawaskar, Robert M. Straubinger, Gerald Fetterly, Bonnie H. Hylander, Elizabeth A. Repasky, Wen W. Ma, William J. Jusko
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3681.
https://doi.org/10.1158/1538-7445.AM2012-3681
Published: 15 April 2012
View articletitled, Abstract 3681: Multi-scale analysis of everolimus and sorafenib combination in pancreatic cancer xenografts
Journal Articles

Abstract 5685: Effects of sonic Hedgehog inhibitor combined with nanoparticulate drug delivery on vascular permeability and efficacy in a pancreatic cancer model

Tista Roy Chaudhuri, Ninfa Lopez Straubinger, Rose Pitoniak, Bonnie L. Hylander, William J. Jusko, Wen W. Ma, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5685.
https://doi.org/10.1158/1538-7445.AM2012-5685
Published: 15 April 2012
View articletitled, Abstract 5685: Effects of sonic Hedgehog inhibitor combined with nanoparticulate drug delivery on vascular permeability and efficacy in a pancreatic cancer model
Journal Articles

Combinatorial Chemotherapeutic Efficacy in Non-Hodgkin Lymphoma Can Be Predicted by a Signaling Model of CD20 Pharmacodynamics

John M. Harrold, Robert M. Straubinger, Donald E. Mager
Journal: Cancer Research
Cancer Res (2012) 72 (7): 1632–1641.
https://doi.org/10.1158/0008-5472.CAN-11-2432
Published: 01 April 2012
View articletitled, Combinatorial Chemotherapeutic Efficacy in Non-Hodgkin Lymphoma Can Be Predicted by a Signaling Model of CD20 Pharmacodynamics
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Includes: Supplementary data
Journal Articles

Accurate determination of drug-responsive protein expression changes in complex tissue samples using a novel liquid chromatography/tandem mass spectroscopy (LC/MS/MS) strategy and cleavable isotope coded affinity tag (cICAT) strategy

Jun Qu, William J. Jusko, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1029.
Published: 01 May 2005
View articletitled, Accurate determination of drug-responsive protein expression changes in complex tissue samples using a novel liquid chromatography/tandem mass spectroscopy (LC/MS/MS) strategy and cleavable isotope coded affinity tag (cICAT) strategy
Journal Articles

Tumor antivascular effects of sterically-stabilized doxorubicin-containing liposomes (SSL-DXR)

Robert D. Arnold, Joseph A. Spernyak, Richard V. Mazurchuk, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 896.
Published: 01 May 2005
View articletitled, Tumor antivascular effects of sterically-stabilized doxorubicin-containing liposomes (SSL-DXR)
Journal Articles

Effect of repetitive administration of doxorubicin encapsulated in sterically stabilized liposomes on plasma kinetics, tissue/brain tumor drug deposition, and tumor vascular permeability in rats

Robert D. Arnold, Jeanine E. Slack, Donald E. Mager, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 150.
Published: 01 April 2004
View articletitled, Effect of repetitive administration of doxorubicin encapsulated in sterically stabilized liposomes on plasma kinetics, tissue/brain tumor drug deposition, and tumor vascular permeability in rats
Journal Articles

Antivasculature Effects of Doxorubicin-containing Liposomes in an Intracranial Rat Brain Tumor Model

Rong Zhou, Richard Mazurchuk, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2002) 62 (9): 2561–2566.
Published: 01 May 2002
View articletitled, Antivasculature Effects of Doxorubicin-containing Liposomes in an Intracranial Rat Brain Tumor Model
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Journal Articles

Antitumor Effect of Taxol-containing Liposomes in a Taxol-resistant Murine Tumor Model

Amarnath Sharma, Eric Mayhew, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (1993) 53 (24): 5877–5881.
Published: 01 December 1993
View articletitled, Antitumor Effect of Taxol-containing Liposomes in a Taxol-resistant Murine Tumor Model
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Journal Articles

Role of Ligand in Antibody-directed Endocytosis of Liposomes by Human T-Leukemia Cells

Katherine K. Matthay, Anna M. Abai, Suzanne Cobb, Keelung Hong, Demetrios Papahadjopoulos, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (1989) 49 (17): 4879–4886.
Published: 01 September 1989
View articletitled, Role of Ligand in Antibody-directed Endocytosis of Liposomes by Human T-Leukemia Cells
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