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Journal Articles

Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth

Marco Maruggi, Fabiana Izidro Layng, Robert Lemos, Jr, Guillermina Garcia, Brian P. James, Monica Sevilla, Ferran Soldevilla, Bas J. Baaten, Petrus R. de Jong, Mei Yee Koh, Garth Powis
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5839–5848.
https://doi.org/10.1158/0008-5472.CAN-18-2994
Published: 15 November 2019
View article titled, Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth
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Includes: Supplementary data
Journal Articles

Correction: An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors

Martin Indarte, Roisin Puentes, Marco Maruggi, Nathan T. Ihle, Geoffrey Grandjean, Michael Scott, Zamal Ahmed, Emmanuelle J. Meuillet, Shuxing Zhang, Robert Lemos, Jr, Lei Du-Cuny, Fabiana I.A.L. Layng, Ricardo G. Correa, Laurie A. Bankston, Robert C. Liddington, Lynn Kirkpatrick, Garth Powis
Journal: Cancer Research
Cancer Res (2019) 79 (20): 5457.
https://doi.org/10.1158/0008-5472.CAN-19-2586
Published: 15 October 2019
View article titled, Correction: An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors
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Journal Articles

An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors

Martin Indarte, Roisin Puentes, Marco Maruggi, Nathan T. Ihle, Geoffrey Grandjean, Michael Scott, Zamal Ahmed, Emmanuelle J. Meuillet, Shuxing Zhang, Robert Lemos, Jr, Lei Du-Cuny, Fabiana I.A.L. Layng, Ricardo G. Correa, Laurie A. Bankston, Robert C. Liddington, Lynn Kirkpatrick, Garth Powis
Journal: Cancer Research
Cancer Res (2019) 79 (12): 3100–3111.
https://doi.org/10.1158/0008-5472.CAN-18-2372
Published: 14 June 2019
View article titled, An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors
Open the PDF for An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 2916: Targeting lysophospholipid metabolism inhibits pancreatic cancer cell proliferation under nutrient-limiting conditions

Petrus R. de Jong, Marco Maruggi, Alejandro D. Campos, Morgan A. Brand, Robert Lemos, David A. Scott, Sally A. Litherland, J. Pablo Arnoletti, Brian P. James, Garth Powis
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2916.
https://doi.org/10.1158/1538-7445.AM2018-2916
Published: 01 July 2018
View article titled, Abstract 2916: Targeting lysophospholipid metabolism inhibits pancreatic cancer cell proliferation under nutrient-limiting conditions
Journal Articles

Abstract 2428: Redox regulation of β-catenin in colorectal cancer

Alejandro D. Campos, Brian James, Petrus De Jong, Robert Lemos, Nikolas Marino, Garth Powis
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2428.
https://doi.org/10.1158/1538-7445.AM2018-2428
Published: 01 July 2018
View article titled, Abstract 2428: Redox regulation of β-catenin in colorectal cancer
Journal Articles

Abstract 3015: Selective inhibition of mutant KRAS cell and tumor growth by PHT-7.3, an inhibitor of the KRas signaling nanocluster protein Cnk1

Roisin Delaney, Marco Maruggi, Martin Indarte, Robert Lemos, Geoff Grandjean, Lynn Kirkpatrick, Garth Powis
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3015.
https://doi.org/10.1158/1538-7445.AM2017-3015
Published: 01 July 2017
View article titled, Abstract 3015: Selective inhibition of mutant KRAS cell and tumor growth by PHT-7.3, an inhibitor of the KRas signaling nanocluster protein Cnk1
Journal Articles

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target

Geoffrey Grandjean, Petrus R. de Jong, Brian P. James, Mei Yee Koh, Robert Lemos, John Kingston, Alexander Aleshin, Laurie A. Bankston, Claudia P. Miller, Eun Jeong Cho, Ramakrishna Edupuganti, Ashwini Devkota, Gabriel Stancu, Robert C. Liddington, Kevin N. Dalby, Garth Powis
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (14): 4259–4269.
https://doi.org/10.1158/0008-5472.CAN-16-0401
Published: 14 July 2016
View article titled, Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target
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Includes: Supplementary data
Journal Articles

Abstract A2-29: A PDK1 inhibitors that has antitumor activity in a vemurafenib resistant BRAF(V600E)::NRAS(G12V) melanoma PDX

Brian P. James, Robert Lemos, Jr., Stacey Bagby, Steven Robinson, William Robinson, John Tentler, S. Gail Eckhardt, D. Lynn Kirkpatrick, Garth Powis
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-29.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-29
Published: 15 November 2015
View article titled, Abstract A2-29: A PDK1 inhibitors that has antitumor activity in a vemurafenib resistant BRAF(V600E)::NRAS(G12V) melanoma PDX
Journal Articles

Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma

Mei Yee Koh, Vuvi Nguyen, Robert Lemos, Jr, Bryant G. Darnay, Galina Kiriakova, Mena Abdelmelek, Thai H. Ho, Jose Karam, Federico A. Monzon, Eric Jonasch, Garth Powis
Journal: Cancer Research
Cancer Res (2015) 75 (2): 316–329.
https://doi.org/10.1158/0008-5472.CAN-13-2190
Published: 14 January 2015
View article titled, Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 5534: Metformin increases AMPKα activity by inhibition of AMPKα and cell cycle proliferation in Asian gastric cancer.

Hae Rim Jung, Hae Ryung Chang, Hye-Hyun Seo, Robert Lemos, Hee Seo Park, Han Liang, Garth Powis, Yon Hui Kim
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5534.
https://doi.org/10.1158/1538-7445.AM2013-5534
Published: 15 April 2013
View article titled, Abstract 5534: Metformin increases AMPKα activity by inhibition of AMPKα and cell cycle proliferation in Asian gastric cancer.
Journal Articles

Abstract 970: Multi-layer and integrative analysis of the whole transcriptome in Asian gastric cancer: AMPKβ modulation in cancer progression

Yon Hui Kim, Han Liang, Xiuping Liu, Julie Izzo, Robert Lemos, Ju-Seog Lee, Jae Yong Cho, Jae Ho Cheong, Hoguen Kim, Min Li, Thomas J. Downey, Matthew D. Dyer, Yongming Sun, Jingtao Sun, Ellen M. Beasley, Hyun Cheol Chung, Sung Hoon Noh, John N. Weinstein, Chang-gong Liu, Garth Powis
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 970.
https://doi.org/10.1158/1538-7445.AM2012-970
Published: 15 April 2012
View article titled, Abstract 970: Multi-layer and integrative analysis of the whole transcriptome in Asian gastric cancer: AMPKβ modulation in cancer progression
Journal Articles

Abstract 3941: HAF promotes the switch from HIF-1α to HIF-2α signaling during chronic hypoxia and promotes stem cell characteristics

Mei Yee Koh, Robert Lemos, Garth Powis
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3941.
https://doi.org/10.1158/1538-7445.AM2012-3941
Published: 15 April 2012
View article titled, Abstract 3941: HAF promotes the switch from HIF-1α to HIF-2α signaling during chronic hypoxia and promotes stem cell characteristics
Journal Articles

The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

Mei Yee Koh, Robert Lemos, Jr, Xiuping Liu, Garth Powis
Journal: Cancer Research
Cancer Res (2011) 71 (11): 4015–4027.
https://doi.org/10.1158/0008-5472.CAN-10-4142
Published: 31 May 2011
View article titled, The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
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Includes: Supplementary data
Journal Articles

Abstract 4481: Topical application of the dual PDPK1/AKT inhibitor PHT-427 inhibits signaling and growth of human breast cancer cutaneous metastases in mice

D. Lynn Kirkpatrick, Jenny L.H. Johnson, Robert Lemos, Mena Abdelemelek, Nathan Ihle, Garth Powis
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4481.
https://doi.org/10.1158/1538-7445.AM2011-4481
Published: 15 April 2011
View article titled, Abstract 4481: Topical application of the dual PDPK1/AKT inhibitor PHT-427 inhibits signaling and growth of human breast cancer cutaneous metastases in mice
Journal Articles

Abstract 1401: Evaluation of vandetanib (ZD6474) and radiation therapy in an orthotopic xenograft model of anaplastic thyroid carcinoma

Yunyun Chen, Maria Gule, Robert Lemos, Jeffrey N. Myers, David L. Schwartz, James A. Bankson, Stephen Y. Lai
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1401.
https://doi.org/10.1158/1538-7445.AM10-1401
Published: 15 April 2010
View article titled, Abstract 1401: Evaluation of vandetanib (ZD6474) and radiation therapy in an orthotopic xenograft model of anaplastic thyroid carcinoma
Journal Articles

In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT

Sylvestor A. Moses, M. Ahad Ali, Song Zuohe, Lei Du-Cuny, Li Li Zhou, Robert Lemos, Nathan Ihle, A. Geoffrey Skillman, Shuxing Zhang, Eugene A. Mash, Garth Powis, Emmanuelle J. Meuillet
Journal: Cancer Research
Cancer Res (2009) 69 (12): 5073–5081.
https://doi.org/10.1158/0008-5472.CAN-08-3839
Published: 15 June 2009
View article titled, <em>In vitro</em> and <em>In vivo</em> Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT
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Includes: Supplementary data
Journal Articles

Abstract #2012: Novel small molecule inhibitors targeting the pleckstrin homology (PH) domain of Akt

Emmanuelle Meuillet, Robert Lemos, Sylvestor Moses, Song Zuohe, Nathan Ihle, Shuxing Zhang, Lei Du-Cuny, Eugene Mash, Garth Powis
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2012.
Published: 01 May 2009
View article titled, Abstract #2012: Novel small molecule inhibitors targeting the pleckstrin homology (PH) domain of Akt
Journal Articles

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Nathan T. Ihle, Robert Lemos, Jr., Peter Wipf, Adly Yacoub, Clint Mitchell, Doris Siwak, Gordon B. Mills, Paul Dent, D. Lynn Kirkpatrick, Garth Powis
Journal: Cancer Research
Cancer Res (2009) 69 (1): 143–150.
https://doi.org/10.1158/0008-5472.CAN-07-6656
Published: 31 December 2008
View article titled, Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance
Open the PDF for Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance in another window
Journal Articles

Molecular-genetic image guided studies of the antitumor HIF-1α inhibitor PX-478 in combination with radiation

David Schwartz, Oh J, Ryan Williams, Robert Lemos, Andrei Volgin, Norihito Kuno, Suren Soghomonyan, Ryuichi Nishii, Mian Aluaddin, Uday Mukhopadhay, William Bornmann, Zheng-Hong Peng, Juri Gelovani, Garth Powis
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2566.
Published: 01 May 2008
View article titled, Molecular-genetic image guided studies of the antitumor HIF-1α inhibitor PX-478 in combination with radiation