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Robert Langer
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Journal Articles

Abstract 2871: The Nanoprimer: a nanoparticle designed to transiently occupy the mononuclear phagocytic system in order to increase nanomedicine-based treatments efficacy

Julie Devalliere, Laurence Poul, Audrey Darmon, Oceane Jibault, Maxime Bergere, Francis Mpambani, Nell Saunders, Marion Paolini, Robert Langer, Matthieu Germain
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2871.
https://doi.org/10.1158/1538-7445.AM2020-2871
Published: 15 August 2020
View article titled, Abstract 2871: The Nanoprimer: a nanoparticle designed to transiently occupy the mononuclear phagocytic system in order to increase nanomedicine-based treatments efficacy
Journal Articles

Abstract 2848: Analytical validation of the multi-nanoparticle Proteograph platform for rapid and deep proteomic profiling

John E. Blume, William C. Manning, Gregory Troiano, Asim Siddiqui, Philip Ma, Robert Langer, Vivek Farias, Omid C. Farokhzad
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2848.
https://doi.org/10.1158/1538-7445.AM2020-2848
Published: 15 August 2020
View article titled, Abstract 2848: Analytical validation of the multi-nanoparticle Proteograph platform for rapid and deep proteomic profiling
Journal Articles

Abstract LB-147: Efficient and scalable profiling of an average of 1779 plasma proteins in 268 subjects with multi-nanoparticle (NP) Proteograph platform enables robust detection of early-stage non-small cell lung cancer (NSCLC) and classification vs. healthy and co-morbid subjects

John E. Blume, William C. Manning, Gregory Troiano, Asim Siddiqui, Philip Ma, Robert Langer, Vivek Farias, Omid C. Farokhzad
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-147.
https://doi.org/10.1158/1538-7445.AM2020-LB-147
Published: 15 August 2020
View article titled, Abstract LB-147: Efficient and scalable profiling of an average of 1779 plasma proteins in 268 subjects with multi-nanoparticle (NP) Proteograph platform enables robust detection of early-stage non-small cell lung cancer (NSCLC) and classification vs. healthy and co-morbid subjects
Journal Articles

Abstract 6571: Plasma protein-protein interactome (PPI) maps derived from the protein corona captured at the nano-bio interface of nanoparticles reveal differential networks for non-small cell lung cancer (NSCLC) and control subjects

Asim Siddiqui, John E. Blume, William C. Manning, Gregory Troiano, Philip Ma, Robert Langer, Vivek Farias, Omid C. Farokhzad
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6571.
https://doi.org/10.1158/1538-7445.AM2020-6571
Published: 15 August 2020
View article titled, Abstract 6571: Plasma protein-protein interactome (PPI) maps derived from the protein corona captured at the nano-bio interface of nanoparticles reveal differential networks for non-small cell lung cancer (NSCLC) and control subjects
Journal Articles

Abstract 2744: Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Ivy X. Chen, Vikash P. Chauhan, Jessica Posada, Mei R. Ng, Michelle Wu, Pichet Adstamongkonkul, Peigen Huang, Neal Lindeman, Robert Langer, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2744.
https://doi.org/10.1158/1538-7445.AM2019-2744
Published: 01 July 2019
View article titled, Abstract 2744: Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer
Journal Articles

Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Jatin Roper, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian, Steffen Rickelt, Mohammad Almeqdadi, Katherine Wu, Matthias Oberli, Francisco Sánchez-Rivera, Yoona Park, Xu Liang, George Eng, Martin S. Taylor, Roxana Azimi, Dmitriy Kedrin, Rachit Neupane, Semir Beyaz, Ewa T. Sicinska, Yvelisse Suarez, James Yoo, Lillian Chen, Lawrence Zukerberg, Pekka Katajisto, Vikram Deshpande, Adam Bass, Philip N. Tsichlis, Jacqueline Lees, Robert Langer, Richard O. Hynes, Jianzhu Chen, Arjun J. Bhutkar, Tyler Jacks, Ömer H. Yilmaz
Journal: Cancer Research
Cancer Res (2018) 78 (10_Supplement): B38.
https://doi.org/10.1158/1538-7445.MOUSEMODELS17-B38
Published: 14 May 2018
View article titled, Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Journal Articles

Abstract PR09: Polymeric mechanical amplifiers of tumor apoptosis

Michael John Mitchell, Robert Langer
Journal: Cancer Research
Cancer Res (2017) 77 (2_Supplement): PR09.
https://doi.org/10.1158/1538-7445.EPSO16-PR09
Published: 16 January 2017
View article titled, Abstract PR09: Polymeric mechanical amplifiers of tumor apoptosis
Journal Articles

Abstract 3901: Polymeric mechanical amplifiers of tumor cell receptor-mediated apoptosis

Michael J. Mitchell, Robert Langer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3901.
https://doi.org/10.1158/1538-7445.AM2016-3901
Published: 15 July 2016
View article titled, Abstract 3901: Polymeric mechanical amplifiers of tumor cell receptor-mediated apoptosis
Journal Articles

Abstract 2293: Vector-free engineering of immune cells for adoptive cell therapy

Armon Sharei, Jonathan Gilbert, Darrell Irvine, Klavs Jensen, Robert Langer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2293.
https://doi.org/10.1158/1538-7445.AM2016-2293
Published: 15 July 2016
View article titled, Abstract 2293: Vector-free engineering of immune cells for adoptive cell therapy
Journal Articles

Abstract B41: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis

Madeleine J. Oudin, Oliver Jonas, Tatiana Kosciuk, Liliane Broye, Jeff Wyckoff, Joelle Klazen, John Lamar, Sreeja Asokan, Charlie Whittaker, Robert Langer, Michael Cima, Kari Wisinski, Richard Hynes, Douglas Lauffenburger, Patricia Keely, James Bear, Frank Gertler
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): B41.
https://doi.org/10.1158/1538-7445.TUMMET15-B41
Published: 26 May 2016
View article titled, Abstract B41: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis
Journal Articles

Abstract PR15: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis

Madeleine J. Oudin, Oliver Jonas, Tatiana Kosciuk, Liliane Broye, Jeff Wyckoff, Joelle Klazen, John Lamar, Sreeja Asokan, Charlie Whittaker, Robert Langer, Michael Cima, Kari Wisinski, Richard Hynes, Douglas Lauffenburger, Patricia Keely, James Bear, Frank Gertler
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): PR15.
https://doi.org/10.1158/1538-7445.TUMMET15-PR15
Published: 26 May 2016
View article titled, Abstract PR15: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis
Journal Articles

Abstract B38: Developing a functional genomics platform to interrogate rare pediatric cancers

Andrew L. Hong, Glenn S. Cowley, Yuen-Yi Tseng, Jaime H. Cheah, Oliver Jonas, Mihir B. Doshi, Bryan D. Kynnap, Coyin Oh, Stephanie Meyer, Paul Clemons, Michael Burger, Francisca Vazquez, Barbara Weir, Gregory V. Kryukov, Alanna Church, Alma Imamovic, Aviad Tsherniak, Craig Bielski, Brian Crompton, Elizabeth Mullen, Charles Roberts, Carlos Rodriguez-Galindo, Katherine A. Janeway, Kimberly Stegmaier, Paul van Hummelen, Robert Langer, Levi A. Garraway, Stuart L. Schreiber, David E. Root, Jesse S. Boehm, William C. Hahn
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): B38.
https://doi.org/10.1158/1538-7445.PEDCA15-B38
Published: 04 April 2016
View article titled, Abstract B38: Developing a functional genomics platform to interrogate rare pediatric cancers
Journal Articles

Abstract 437: Mena at the nexus of chemotaxis and haptotaxis during tumor progression

Madeleine J. Oudin, Oliver Jonas, Tatiana Kosciuk, Liliane C. Broye, Jeff Wyckoff, Miles A. Miller, Alisha Lussiez, Sreeja Asokan, Robert Langer, Douglas Lauffenburger, James E. Bear, Frank B. Gertler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 437.
https://doi.org/10.1158/1538-7445.AM2015-437
Published: 01 August 2015
View article titled, Abstract 437: Mena at the nexus of chemotaxis and haptotaxis during tumor progression
Journal Articles

Abstract 5538A: Cell size-specific intracellular delivery

May Tun Saung, Armon Sharei, Viktor Adalsteinsson, Andrew Liss, Nahyun Cho, Tushar Kamath, Camilo Ruiz, Jesse Kirkpatrick, Robert Langer, Christopher Love, Klavs Jensen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5538A.
https://doi.org/10.1158/1538-7445.AM2015-5538A
Published: 01 August 2015
View article titled, Abstract 5538A: Cell size-specific intracellular delivery
Journal Articles

Abstract 4584: A novel drug-eluting platform for localized treatment of pancreatic cancer

Matteo Ligorio, Laura Indolfi, David T. Ting, Kristina Xega, Nicola Aceto, Francesca Bersani, Cristina R. Ferrone, Daniel A. Haber, Robert Langer, Elazer R. Edelman, Jeffrey W. Clark
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4584.
https://doi.org/10.1158/1538-7445.AM2014-4584
Published: 01 October 2014
View article titled, Abstract 4584: A novel drug-eluting platform for localized treatment of pancreatic cancer
Journal Articles

Abstract 5616: Enhancing tumor cell response to chemotherapy by simultaneous delivery of siRNA and cisplatin using polymeric nanoparticles.

Xiaoyang Xu, Xueqing Zhang, Kun Xie, Eric Pridgen, Robert Langer, Graham Walker, Omid Farokhzad
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5616.
https://doi.org/10.1158/1538-7445.AM2013-5616
Published: 15 April 2013
View article titled, Abstract 5616: Enhancing tumor cell response to chemotherapy by simultaneous delivery of siRNA and cisplatin using polymeric nanoparticles.
Journal Articles

Abstract 4529: Self-assembled lipid-polymer hybrid nanoparticles for the sustained delivery of siRNA and the treatment of drug-resistant cancers.

Jinjun Shi, Yingjie Xu, Xiaoyang Xu, Alexander Votruba, Xi Zhu, Eric Pridgen, Zeyu Xiao, Robert Langer, Bruce R. Zetter, Omid C. Farokhzad
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4529.
https://doi.org/10.1158/1538-7445.AM2013-4529
Published: 15 April 2013
View article titled, Abstract 4529: Self-assembled lipid-polymer hybrid nanoparticles for the sustained delivery of siRNA and the treatment of drug-resistant cancers.
Journal Articles

Abstract 2896: Nanoparticle co-delivery of RNAi and chemotherapy for the treatment of drug-resistant cancers

Jinjun Shi, Alexander R. Votruba, Xiaoyang Xu, Robert Langer, Bruce R. Zetter, Omid C. Farokhzad
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2896.
https://doi.org/10.1158/1538-7445.AM2012-2896
Published: 15 April 2012
View article titled, Abstract 2896: Nanoparticle co-delivery of RNAi and chemotherapy for the treatment of drug-resistant cancers
Journal Articles

Abstract 1955: Simultaneous delivery of siRNA and cisplatin by polymer-lipid hybrid nanoparticles sensitizes resistant cancer to chemotherapy

Xiaoyang Xu, Kun Xie, Xueqing Zhang, Eric Pridgen, Robert Langer, Graham Walker, Omid Farokhzad
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1955.
https://doi.org/10.1158/1538-7445.AM2012-1955
Published: 15 April 2012
View article titled, Abstract 1955: Simultaneous delivery of siRNA and cisplatin by polymer-lipid hybrid nanoparticles sensitizes resistant cancer to chemotherapy
Journal Articles

Abstract 367: Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection

Zeyu Xiao, Etgar Levy-Nissenbaum, Wataru Aizu, Robert Langer, Omid Farokhzad
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 367.
https://doi.org/10.1158/1538-7445.AM2011-367
Published: 15 April 2011
View article titled, Abstract 367: Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection