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Journal Articles

Abstract 3823: Viral transcript and tumor immune microenvironment-based transcriptomic profiling of HPV-associated head and neck cancer identifies subtypes associated with prognosis

Daria Kiriy, Dmitry Tychinin, Nikita Kotlov, Olga Kudryashova, Anastasia Nikitina, Andrey Tyshevich, Naira Samarina, Ksenia Demina, Sandrine Degryse, Susan Raju Paul, Mark Poznansky, Krystle Lang Kuhs, James S. Lewis, Robert L. Ferris, Xiaowei Wang, Alexander Bagaev, Nathan Fowler, Lori Wirth, Daniel Faden

Cancer Res (2022) 82 (12_Supplement): 3823.

https://doi.org/10.1158/1538-7445.AM2022-3823

Published: 15 June 2022

View article titled, Abstract 3823: Viral transcript and tumor immune microenvironment-based transcriptomic profiling of HPV-associated head and neck cancer identifies subtypes associated with prognosis

Journal Articles

Abstract CT236: INTERLINK-1: A phase 3, randomized, double-blind, placebo-controlled, multicenter, global study of monalizumab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma previously treated with an immune checkpoint inhibitor

Jérôme Fayette, Tanguy Seiwert, Robert L. Ferris, Kevin Harrington, Robert Haddad, Makoto Tahara, Lisa Licitra, Lillian L. Siu, Jean-Pascal Machiels, Malgorzata Dominiewska, Julia Xiong, Paramjit Kaur, Dario Ruscica, Roger B. Cohen

Cancer Res (2022) 82 (12_Supplement): CT236.

https://doi.org/10.1158/1538-7445.AM2022-CT236

Published: 15 June 2022

View article titled, Abstract CT236: INTERLINK-1: A phase 3, randomized, double-blind, placebo-controlled, multicenter, global study of monalizumab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma previously treated with an immune checkpoint inhibitor

Journal Articles

Abstract PO-083: Utilizing spatial transcriptomics to elucidate tertiary lymphoid structure heterogeneity in human cancer

Dongyan Liu, Xiang Li, Rajesh Acharya, Ernest M. Meyer, Shelley Reynolds, Ayana Ruffin, Robert L. Ferris, Dario A.A. Vignali, Riyue Bao, Tullia C. Bruno

Cancer Res (2020) 80 (21_Supplement): PO-083.

https://doi.org/10.1158/1538-7445.TUMHET2020-PO-083

Published: 03 November 2020

View article titled, Abstract PO-083: Utilizing spatial transcriptomics to elucidate tertiary lymphoid structure heterogeneity in human cancer

Journal Articles

Abstract 4893: Multi-modality sequencing of multiple HPV mediated oropharyngeal squamous cell carcinomas from single patients reveals synchrony in viral genomes yet discordant mutational profiles and signatures

Daniel L. Faden, Adam Langenbucher, Krystle Kuhs, James S. Lewis, Michael S. Lawrence, Lisa Mirabello, Robert L. Ferris

Cancer Res (2020) 80 (16_Supplement): 4893.

https://doi.org/10.1158/1538-7445.AM2020-4893

Published: 15 August 2020

View article titled, Abstract 4893: Multi-modality sequencing of multiple HPV mediated oropharyngeal squamous cell carcinomas from single patients reveals synchrony in viral genomes yet discordant mutational profiles and signatures

Journal Articles

Abstract CT170: A phase II, multicenter study to evaluate the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-145) for the treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck

Rom Leidner, Ammar Sukari, Christine Chung, James Ohr, Missak Haigentz, Ezra Cohen, Robert Brown, Sam Suzuki, Igor Gorbatchevsky, Maria Fardis, Robert L. Ferris

Cancer Res (2018) 78 (13_Supplement): CT170.

https://doi.org/10.1158/1538-7445.AM2018-CT170

Published: 01 July 2018

View article titled, Abstract CT170: A phase II, multicenter study to evaluate the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-145) for the treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck

Journal Articles

Abstract CT116: Nivolumab (Nivo) vs investigator's choice (IC) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): 2-yr outcomes in the overall population and PD-L1 subgroups of CheckMate 141

Cancer Res (2018) 78 (13_Supplement): CT116.

https://doi.org/10.1158/1538-7445.AM2018-CT116

Published: 01 July 2018

View article titled, Abstract CT116: Nivolumab (Nivo) vs investigator's choice (IC) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): 2-yr outcomes in the overall population and PD-L1 subgroups of CheckMate 141

Journal Articles

Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis

Hui Cheng, Xinping Yang, Han Si, Anthony Saleh, Wenming Xiao, Jamie Coupar, Susanne M. Gollin, Robert L. Ferris, Natalia Issaeva, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2018) 78 (13_Supplement): 5346.

https://doi.org/10.1158/1538-7445.AM2018-5346

Published: 01 July 2018

View article titled, Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis

Journal Articles

PD-1 Status in CD8⁺ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer

Benjamin A. Kansy, Fernando Concha-Benavente, Raghvendra M. Srivastava, Hyun-Bae Jie, Gulidanna Shayan, Yu Lei, Jessica Moskovitz, Jennifer Moy, Jing Li, Sven Brandau, Stephan Lang, Nicole C. Schmitt, Gordon J. Freeman, William E. Gooding, David A. Clump, Robert L. Ferris

Cancer Res (2017) 77 (22): 6353–6364.

https://doi.org/10.1158/0008-5472.CAN-16-3167

Published: 14 November 2017

View article titled, PD-1 Status in CD8<sup>+</sup> T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer

Includes: Supplementary data

Journal Articles

Abstract CT157: Treatment beyond progression with nivolumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck in the phase 3 Checkmate 141 study

Robert Haddad, Robert L. Ferris, George Blumenschein, Jerome Fayette, Joel Guigay, Alexander D. Colevas, Lisa Licitra, Stefan Kasper, Everett E. Vokes, Francis Worden, Nabil F. Saba, Makoto Tahara, Manish Monga, Mark Lynch, Jin Zhu, James W. Shaw, Maura L. Gillison, Kevin Harrington

Cancer Res (2017) 77 (13_Supplement): CT157.

https://doi.org/10.1158/1538-7445.AM2017-CT157

Published: 01 July 2017

View article titled, Abstract CT157: Treatment beyond progression with nivolumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck in the phase 3 Checkmate 141 study

Journal Articles

Abstract 4374: Chromosome 3q22-29 amplification is linked to increased expression of multiple genes in key pathways deregulated in head and neck cancer tumors and cell lines

Hui Cheng, Xinping Yang, Han Si, Anthony Saleh, Jamie Coupar, Robert L. Ferris, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2017) 77 (13_Supplement): 4374.

https://doi.org/10.1158/1538-7445.AM2017-4374

Published: 01 July 2017

View article titled, Abstract 4374: Chromosome 3q22-29 amplification is linked to increased expression of multiple genes in key pathways deregulated in head and neck cancer tumors and cell lines

Journal Articles

Abstract CT022: Evaluation of oral microbiome profiling as a response biomarker in squamous cell carcinoma of the head and neck: Analyses from CheckMate 141

Robert L. Ferris, George Blumenschein, Kevin Harrington, Jérôme Fayette, Joël Guigay, A. Dimitrios Colevas, Lisa Licitra, Everett Vokes, Maura Gillison, Caroline Even, Cheryl Ho, Makoto Tahara, Robert Haddad, Mark Lynch, Manish Monga, Somnath Bandyopadhyay, Omar Jabado, Henry Kao

Cancer Res (2017) 77 (13_Supplement): CT022.

https://doi.org/10.1158/1538-7445.AM2017-CT022

Published: 01 July 2017

View article titled, Abstract CT022: Evaluation of oral microbiome profiling as a response biomarker in squamous cell carcinoma of the head and neck: Analyses from CheckMate 141

Journal Articles

Abstract CT021: Tumor-associated immune cell PD-L1 expression and peripheral immune profiling: Analyses from CheckMate 141

Cancer Res (2017) 77 (13_Supplement): CT021.

https://doi.org/10.1158/1538-7445.AM2017-CT021

Published: 01 July 2017

View article titled, Abstract CT021: Tumor-associated immune cell PD-L1 expression and peripheral immune profiling: Analyses from CheckMate 141

Journal Articles

Abstract 870: Radiation-induced PD-L1 upregulation can be detected by Zr-89-PD-L1 PET/CT in the tumor micro-environment of murine HPV positive HNSCC model and melanoma model

Masahiro Kikuchi, Raghvendra M Srivastava, David A Clump, Julio A Diaz-Perez, Lingyi Sun, Dexing Zeng, W. Barry Edwards, Carolyn J Anderson, Robert L Ferris

Cancer Res (2017) 77 (13_Supplement): 870.

https://doi.org/10.1158/1538-7445.AM2017-870

Published: 01 July 2017

View article titled, Abstract 870: Radiation-induced PD-L1 upregulation can be detected by Zr-89-PD-L1 PET/CT in the tumor micro-environment of murine HPV positive HNSCC model and melanoma model

Journal Articles

Abstract 5138: The PD-1/PD-L1 axis and clinical outcomes in head and neck squamous cell carcinomas

Sumita Trivedi, Raja R. Seethala, Robert L. Ferris

Cancer Res (2016) 76 (14_Supplement): 5138.

https://doi.org/10.1158/1538-7445.AM2016-5138

Published: 15 July 2016

View article titled, Abstract 5138: The PD-1/PD-L1 axis and clinical outcomes in head and neck squamous cell carcinomas

Journal Articles

Abstract CT099: Nivolumab (nivo) vs investigator's choice (IC) for recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): CheckMate-141

Cancer Res (2016) 76 (14_Supplement): CT099.

https://doi.org/10.1158/1538-7445.AM2016-CT099

Published: 15 July 2016

View article titled, Abstract CT099: Nivolumab (nivo) vs investigator's choice (IC) for recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): CheckMate-141

Journal Articles

Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer

Fernando Concha-Benavente, Raghvendra M. Srivastava, Sumita Trivedi, Yu Lei, Uma Chandran, Raja R. Seethala, Gordon J. Freeman, Robert L. Ferris

Cancer Res (2016) 76 (5): 1031–1043.

https://doi.org/10.1158/0008-5472.CAN-15-2001

Published: 29 February 2016

View article titled, Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer

Includes: Supplementary data

Journal Articles

Abstract 4804: High throughput whole exome DNA and transcriptome RNA sequencing to identify genetic drivers and alterations in HPV-negative and HPV-positive HNSCC cell lines

Hui Cheng, Xinping Yang, Han Si, Anthony Saleh, Jamie Coupar, Robert L. Ferris, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2015) 75 (15_Supplement): 4804.

https://doi.org/10.1158/1538-7445.AM2015-4804

Published: 01 August 2015

View article titled, Abstract 4804: High throughput whole exome DNA and transcriptome RNA sequencing to identify genetic drivers and alterations in HPV-negative and HPV-positive HNSCC cell lines

Journal Articles

Abstract 3340: Intraoral administration of mitochondrial targeted GS-nitroxide (JP4-039) radioprotects the oral mucosa but not orthotopic tumors in Fancd2-/- mice

Michael W. Epperly, Ashwin Shinde, Hebist Berhane, Byung Han Rhieu, Ronny Kalash, Karen Xu, Darcy Franicola, Xichen Zhang, Tracy Dixon, Donna Shields, Hong Wang, Peter Wipf, Kalindi Parmar, Eva Guinan, Valerian Kagan, Yulia Tyurina, Robert L. Ferris, Song Li, Joel S. Greenberger

Cancer Res (2015) 75 (15_Supplement): 3340.

https://doi.org/10.1158/1538-7445.AM2015-3340

Published: 01 August 2015

View article titled, Abstract 3340: Intraoral administration of mitochondrial targeted GS-nitroxide (JP4-039) radioprotects the oral mucosa but not orthotopic tumors in Fancd2-/- mice

Journal Articles

CTLA-4⁺ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis

Hyun-Bae Jie, Patrick J. Schuler, Steve C. Lee, Raghvendra M. Srivastava, Athanassios Argiris, Soldano Ferrone, Theresa L. Whiteside, Robert L. Ferris

Cancer Res (2015) 75 (11): 2200–2210.

https://doi.org/10.1158/0008-5472.CAN-14-2788

Published: 31 May 2015

View article titled, CTLA-4<sup>+</sup> Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis

Journal Articles

PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment

Jing Li, Hyun-Bae Jie, Yu Lei, Neil Gildener-Leapman, Sumita Trivedi, Tony Green, Lawrence P. Kane, Robert L. Ferris

Cancer Res (2015) 75 (3): 508–518.

https://doi.org/10.1158/0008-5472.CAN-14-1215

Published: 01 February 2015

View article titled, PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment

Includes: Supplementary data

NARROW

Abstract 3823: Viral transcript and tumor immune microenvironment-based transcriptomic profiling of HPV-associated head and neck cancer identifies subtypes associated with prognosis

Abstract CT236: INTERLINK-1: A phase 3, randomized, double-blind, placebo-controlled, multicenter, global study of monalizumab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma previously treated with an immune checkpoint inhibitor

Abstract PO-083: Utilizing spatial transcriptomics to elucidate tertiary lymphoid structure heterogeneity in human cancer

Abstract 4893: Multi-modality sequencing of multiple HPV mediated oropharyngeal squamous cell carcinomas from single patients reveals synchrony in viral genomes yet discordant mutational profiles and signatures

Abstract CT170: A phase II, multicenter study to evaluate the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-145) for the treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck

Abstract CT116: Nivolumab (Nivo) vs investigator's choice (IC) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): 2-yr outcomes in the overall population and PD-L1 subgroups of CheckMate 141

Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis

PD-1 Status in CD8⁺ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer

Abstract CT157: Treatment beyond progression with nivolumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck in the phase 3 Checkmate 141 study

Abstract 4374: Chromosome 3q22-29 amplification is linked to increased expression of multiple genes in key pathways deregulated in head and neck cancer tumors and cell lines

Abstract CT022: Evaluation of oral microbiome profiling as a response biomarker in squamous cell carcinoma of the head and neck: Analyses from CheckMate 141

Abstract CT021: Tumor-associated immune cell PD-L1 expression and peripheral immune profiling: Analyses from CheckMate 141

Abstract 870: Radiation-induced PD-L1 upregulation can be detected by Zr-89-PD-L1 PET/CT in the tumor micro-environment of murine HPV positive HNSCC model and melanoma model

Abstract 5138: The PD-1/PD-L1 axis and clinical outcomes in head and neck squamous cell carcinomas

Abstract CT099: Nivolumab (nivo) vs investigator's choice (IC) for recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): CheckMate-141

Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer

Abstract 4804: High throughput whole exome DNA and transcriptome RNA sequencing to identify genetic drivers and alterations in HPV-negative and HPV-positive HNSCC cell lines

Abstract 3340: Intraoral administration of mitochondrial targeted GS-nitroxide (JP4-039) radioprotects the oral mucosa but not orthotopic tumors in Fancd2-/- mice

CTLA-4⁺ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis

PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment

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