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Journal Articles

Abstract 5784: Structure-based drug design against caPCNA for selective cancer chemotherapy development

Jennifer Jossart, Pouya Haratipour, Long Gu, Carone M. li, Robert Lingeman, Yilun Liu, Robert J. Hickey, Linda H. Malkas, Jeff J. Perry

Cancer Res (2024) 84 (6_Supplement): 5784.

https://doi.org/10.1158/1538-7445.AM2024-5784

Published: 22 March 2024

View article titled, Abstract 5784: Structure-based drug design against caPCNA for selective cancer chemotherapy development

Journal Articles

Abstract 4481: Enhancing AOH1996 through structure activity relationship exploration for caPCNA inhibition

Pouya Haratipour, Maryam Zangi, Mahshid Yaghoubi, Long Gu, Jennifer Jossart, John J. Perry, Linda H. Malkas, Robert J. Hickey

Cancer Res (2024) 84 (6_Supplement): 4481.

https://doi.org/10.1158/1538-7445.AM2024-4481

Published: 22 March 2024

View article titled, Abstract 4481: Enhancing AOH1996 through structure activity relationship exploration for caPCNA inhibition

Journal Articles

Abstract 1875: Enhanced lung cancer treatment using AOH1996, a potent PCNA inhibitor

Robert G. Lingeman, Robert J. Hickey, Linda H. Malkas

Cancer Res (2024) 84 (6_Supplement): 1875.

https://doi.org/10.1158/1538-7445.AM2024-1875

Published: 22 March 2024

View article titled, Abstract 1875: Enhanced lung cancer treatment using AOH1996, a potent PCNA inhibitor

Journal Articles

Abstract 2112: Identification of biomarkers associated with sensitivity to a novel PCNA inhibitor (AOH1996) by CRISPRi screening

Long Gu, Ming li, Chun-Wei Chen, Robert J. Hickey, Linda H. Malkas

Cancer Res (2024) 84 (6_Supplement): 2112.

https://doi.org/10.1158/1538-7445.AM2024-2112

Published: 22 March 2024

View article titled, Abstract 2112: Identification of biomarkers associated with sensitivity to a novel PCNA inhibitor (AOH1996) by CRISPRi screening

Journal Articles

Abstract 1850: From proteomic analysis to early investigations of combining inhibitors targeting PCNA and histone deacetylase

Caroline M. Li, Krystine Garcia-Mansfield, Robert G. Lingeman, Long Gu, Robert J. Hickey, Patrick Pirrotte, Linda H. Malkas

Cancer Res (2024) 84 (6_Supplement): 1850.

https://doi.org/10.1158/1538-7445.AM2024-1850

Published: 22 March 2024

View article titled, Abstract 1850: From proteomic analysis to early investigations of combining inhibitors targeting PCNA and histone deacetylase

Journal Articles

Abstract 1269: Pharmacological targeting of transcription-replication conflict leads to anti-cancer efficacy with minimal side effects in preclinical models

Long Gu, Caroline Li, Robert Lingeman, Robert J. Hickey, Linda H. Malkas

Cancer Res (2021) 81 (13_Supplement): 1269.

https://doi.org/10.1158/1538-7445.AM2021-1269

Published: 01 July 2021

View article titled, Abstract 1269: Pharmacological targeting of transcription-replication conflict leads to anti-cancer efficacy with minimal side effects in preclinical models

Journal Articles

Abstract 2160: Targeting SMC1 in combination therapy for triple negative breast cancer

Sushma Yadav, David Berz, George Somlo, Kimlin Ashing, Yate-Ching Yuan, Robert J. Hickey, Sailee Yadav, Arthur D. Riggs

Cancer Res (2016) 76 (14_Supplement): 2160.

https://doi.org/10.1158/1538-7445.AM2016-2160

Published: 15 July 2016

View article titled, Abstract 2160: Targeting SMC1 in combination therapy for triple negative breast cancer

Journal Articles

Abstract 1258: Bin1 enhances anoikis via p38 MAPK: A potential inhibitory role in neuroblastoma metastasis

Xiaoling Zhong, Frederick J. Rescorla, Robert J. Hickey, Linda H. Malkas

Cancer Res (2010) 70 (8_Supplement): 1258.

https://doi.org/10.1158/1538-7445.AM10-1258

Published: 15 April 2010

View article titled, Abstract 1258: Bin1 enhances anoikis via p38 MAPK: A potential inhibitory role in neuroblastoma metastasis

Journal Articles

Abstract 683: Evaluating the therapeutic potential of a peptide derivative of cancer-associated PCNA in DNA repair deficient breast cancers

Elizabeth A. Phipps, Lacey E. Dobrolecki, Robert J. Hickey, George W. Sledge, Brittney-Shea Herbert, Linda H. Malkas

Cancer Res (2010) 70 (8_Supplement): 683.

https://doi.org/10.1158/1538-7445.AM10-683

Published: 15 April 2010

View article titled, Abstract 683: Evaluating the therapeutic potential of a peptide derivative of cancer-associated PCNA in DNA repair deficient breast cancers

Journal Articles

Neuroblastoma 3D cell culture: Proteomic differences between cancer spheroids and monolayers

John A. Sandoval, Derek J. Hoelz, Katharyn E. Turner, Frederick J. Rescorla, Robert J. Hickey, Linda H. Malkas

Cancer Res (2006) 66 (8_Supplement): 1019–1020.

Published: 15 April 2006

View article titled, Neuroblastoma 3D cell culture: Proteomic differences between cancer spheroids and monolayers

Journal Articles

Differences in MAP kinase signaling responses to MEK inhibition in three distinct neuroblastoma cell types

Andrew C. Eppstein, John A. Sandoval, Patrick J. Klein, Heather A. Woodruff, Jay L. Grosfeld, Robert J. Hickey, Linda H. Malkas, C. Max Schmidt

Cancer Res (2005) 65 (9_Supplement): 238.

Published: 01 May 2005

View article titled, Differences in MAP kinase signaling responses to MEK inhibition in three distinct neuroblastoma cell types

Journal Articles

The post-translational state of PCNA determines and directs its cellular function

Derek J. Hoelz, Lacey Dobrolecki, Randy Arnold, Petra Hrnicova, Yehia Mehcref, Milos Novotny, Lauren Schnaper, Robert J. Hickey, Linda H. Malkas

Cancer Res (2005) 65 (9_Supplement): 419.

Published: 01 May 2005

View article titled, The post-translational state of PCNA determines and directs its cellular function

Journal Articles

Serum proteomic profiling using SELDI-Tof MS can distinguish between androgen sensitive and androgen resistant prostate cancer patients

Lacey E. Dobrolecki, Christopher Sweeney, Tomasz Beer, Linda Battiano, Jake Vinson, Robert J. Hickey

Cancer Res (2005) 65 (9_Supplement): 1136.

Published: 01 May 2005

View article titled, Serum proteomic profiling using SELDI-Tof MS can distinguish between androgen sensitive and androgen resistant prostate cancer patients

Journal Articles

Two-dimensional (2-D) proteomic analysis of the multiprotein DNA replication complex in human neuroblastoma versus neural stem cells

John A. Sandoval, Robert J. Hickey, Linda H. Malkas

Cancer Res (2005) 65 (9_Supplement): 688–689.

Published: 01 May 2005

View article titled, Two-dimensional (2-D) proteomic analysis of the multiprotein DNA replication complex in human neuroblastoma versus neural stem cells

Journal Articles

Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis

Jin Yang, Zhiwen Chen, Yang Liu, Robert J. Hickey, Linda H. Malkas

Cancer Res (2004) 64 (16): 5597–5607.

https://doi.org/10.1158/0008-5472.CAN-04-0603

Published: 16 August 2004

View article titled, Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis

Journal Articles

Identification of a damage induced isoform of proliferating cell nuclear antigen: dPCNA

Derek J. Hoelz, Lacey Dobrolecki, Andrew Loehrer, Jianying Liu, Lauren Schnaper, Robert J. Hickey, Linda H. Malkas

Cancer Res (2004) 64 (7_Supplement): 456.

Published: 01 April 2004

View article titled, Identification of a damage induced isoform of proliferating cell nuclear antigen: dPCNA

Journal Articles

Distinct protein expression profiles in neuroblastoma.

Mauricio A. Escobar, Jr., John A. Sandoval, Robert J. Hickey, Derek J. Hoelz, Carita Lanner, Waleed Abdel-Aziz, Jianying Liu, Linda H. Malkas

Cancer Res (2004) 64 (7_Supplement): 820.

Published: 01 April 2004

View article titled, Distinct protein expression profiles in neuroblastoma.

Journal Articles

Survey of patient serum for the presence of malignancy related biomarkers.

Lacey E. Dobrolecki, Lauren Schnaper, Linda H. Malkas, Robert J. Hickey

Cancer Res (2004) 64 (7_Supplement): 818.

Published: 01 April 2004

View article titled, Survey of patient serum for the presence of malignancy related biomarkers.

Journal Articles

S-Phase targeted anticancer drug treatment of cells results in the alteration of specific components of the human cell DNA replication machinery.

Jianying Liu, Heqiao Dai, Robert J. Hickey, Derek J. Hoelz, Linda H. Malkas

Cancer Res (2004) 64 (7_Supplement): 842.

Published: 01 April 2004

View article titled, S-Phase targeted anticancer drug treatment of cells results in the alteration of specific components of the human cell DNA replication machinery.

Journal Articles

Synthesis of the primer RNA and RNA-primed nascent DNA in vitro mediated by the synthesome.

Heqiao Dai, Jianying Liu, Robert J. Hickey, Linda H. Malkas

Cancer Res (2004) 64 (7_Supplement): 885.

Published: 01 April 2004

View article titled, Synthesis of the primer RNA and RNA-primed nascent DNA in vitro mediated by the synthesome.

NARROW

Abstract 5784: Structure-based drug design against caPCNA for selective cancer chemotherapy development

Abstract 4481: Enhancing AOH1996 through structure activity relationship exploration for caPCNA inhibition

Abstract 1875: Enhanced lung cancer treatment using AOH1996, a potent PCNA inhibitor

Abstract 2112: Identification of biomarkers associated with sensitivity to a novel PCNA inhibitor (AOH1996) by CRISPRi screening

Abstract 1850: From proteomic analysis to early investigations of combining inhibitors targeting PCNA and histone deacetylase

Abstract 1269: Pharmacological targeting of transcription-replication conflict leads to anti-cancer efficacy with minimal side effects in preclinical models

Abstract 2160: Targeting SMC1 in combination therapy for triple negative breast cancer

Abstract 1258: Bin1 enhances anoikis via p38 MAPK: A potential inhibitory role in neuroblastoma metastasis

Abstract 683: Evaluating the therapeutic potential of a peptide derivative of cancer-associated PCNA in DNA repair deficient breast cancers

Neuroblastoma 3D cell culture: Proteomic differences between cancer spheroids and monolayers

Differences in MAP kinase signaling responses to MEK inhibition in three distinct neuroblastoma cell types

The post-translational state of PCNA determines and directs its cellular function

Serum proteomic profiling using SELDI-Tof MS can distinguish between androgen sensitive and androgen resistant prostate cancer patients

Two-dimensional (2-D) proteomic analysis of the multiprotein DNA replication complex in human neuroblastoma versus neural stem cells

Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis

Identification of a damage induced isoform of proliferating cell nuclear antigen: dPCNA

Distinct protein expression profiles in neuroblastoma.

Survey of patient serum for the presence of malignancy related biomarkers.

S-Phase targeted anticancer drug treatment of cells results in the alteration of specific components of the human cell DNA replication machinery.

Synthesis of the primer RNA and RNA-primed nascent DNA in vitro mediated by the synthesome.

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