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Robert H. Vonderheide
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Journal Articles

Abstract NG04: Agonistic anti-CD40 converts regulatory T cells in to Type 1 effector cells within the tumor microenvironment

Vivien Maltez, Charu Arora, Rina Sor, Ronald N. Germain, Robert H. Vonderheide, Katelyn T. Byrne
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): NG04.
https://doi.org/10.1158/1538-7445.AM2023-NG04
Published: 04 April 2023
View article titled, Abstract NG04: Agonistic anti-CD40 converts regulatory T cells in to Type 1 effector cells within the tumor microenvironment
Journal Articles

Abstract 6394: Immune mechanisms underlie full therapeutic efficacy of a novel inhibitor of KrasG12D in mouse models of pancreatic ductal adenocarcinoma

Noah Cheng, Samantha B. Kemp, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V. Brown, Jared B. Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P. Vostrejs, Kia Z. Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R. Donahue, Caius G. Radu, Cynthia Clendenin, James G. Christensen, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6394.
https://doi.org/10.1158/1538-7445.AM2023-6394
Published: 04 April 2023
View article titled, Abstract 6394: Immune mechanisms underlie full therapeutic efficacy of a novel inhibitor of KrasG12D in mouse models of pancreatic ductal adenocarcinoma
Journal Articles

Abstract PR019: Mutant KRAS-specific T cell receptors directed against prevalent G12D and G12V variants exhibit potent cytotoxic activity and CD8 co-receptor independence

Adham S. Bear, Rebecca B. Nadler, John Scholler, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): PR019.
https://doi.org/10.1158/1538-7445.PANCA22-PR019
Published: 15 November 2022
View article titled, Abstract PR019: Mutant KRAS-specific T cell receptors directed against prevalent G12D and G12V variants exhibit potent cytotoxic activity and CD8 co-receptor independence
Journal Articles

Abstract A016: Phase 1 study of hypofractionated radiation in combination with tremelimumab and durvalumab in refractory metastatic pancreatic adenocarcinoma

Mark H. O'Hara, Adham S. Bear, Max M. Wattenberg, Ursina R. Teitelbaum, Kim A. Reiss, Thomas B. Karasic, Charles J. Schneider, Peter J. O'Dwyer, Edgar H. Ben-Josef, Andrzej P. Wojcieszynski, Amit H. Maity, Rosemarie H. Mick, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A016.
https://doi.org/10.1158/1538-7445.PANCA22-A016
Published: 15 November 2022
View article titled, Abstract A016: Phase 1 study of hypofractionated radiation in combination with tremelimumab and durvalumab in refractory metastatic pancreatic adenocarcinoma
Journal Articles

Abstract C046: Polymorphonuclear myeloid derived suppressor cells die by ferroptosis in the tumor microenvironment

Rina Kim, Ayumi Hashimoto, Nune Markosyan, Vladimir A. Tyurin, Yulia Y. Tyurina, Shuyu Fu, Mohit Sehgal, Laura Garcia-Gerique, Gozde Kar, Andrew Kossenkov, Bereket A. Gebregziabher, John W. Tobias, Kristin Hicks, Hui Deng, Laxminarasimha Donthireddy, Andrew Greenberg, Brian Nam, Yulia Nefedova, Valerian E. Kagan, Robert H. Vonderheide, Dmitry Gabrilovich
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C046.
https://doi.org/10.1158/1538-7445.PANCA22-C046
Published: 15 November 2022
View article titled, Abstract C046: Polymorphonuclear myeloid derived suppressor cells die by ferroptosis in the tumor microenvironment
Journal Articles

Abstract C013: Response to combination immunotherapy in a mouse model of PDAC is a function of baseline T cell content

Noah C. Cheng, Nune Markosyan, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C013.
https://doi.org/10.1158/1538-7445.PANCA22-C013
Published: 15 November 2022
View article titled, Abstract C013: Response to combination immunotherapy in a mouse model of PDAC is a function of baseline T cell content
Journal Articles

Abstract C004: TCRs directed to mutant KRAS display distinct antigen recognition motifs and minimal cross-reactivity to non-cognate antigens

Rebecca B. Nadler, Adham Bear, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C004.
https://doi.org/10.1158/1538-7445.PANCA22-C004
Published: 15 November 2022
View article titled, Abstract C004: TCRs directed to mutant KRAS display distinct antigen recognition motifs and minimal cross-reactivity to non-cognate antigens
Journal Articles

Abstract 4188: CD4+ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8+ T cells

Samuel I. Kim, Charu Arora, Ioannis I. Verginadis, Christopher R. Cassella, Nune Markosyan, Constantinos Koumenis, Robert H. Vonderheide, Katelyn T. Byrne
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4188.
https://doi.org/10.1158/1538-7445.AM2022-4188
Published: 15 June 2022
View article titled, Abstract 4188: CD4+ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8+ T cells
Journal Articles

Abstract 3139: Disrupting prostaglandin E2 signaling to reverse treatment resistance in cancer

Nune Markosyan, Liz Quinones, Charu Aurora, Nikhil Joshi, Ilkyu Kim, Ben Z. Stanger, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3139.
https://doi.org/10.1158/1538-7445.AM2022-3139
Published: 15 June 2022
View article titled, Abstract 3139: Disrupting prostaglandin E<sub>2</sub> signaling to reverse treatment resistance in cancer
Journal Articles

Abstract 2723: How BRCA1/2 mutations in TNBC affect TME and subsequently immune cell functions

Dana Pueschl, Derek A. Oldrige, Jonathan Belman, Jake S. Shilan, Anupma Nayak, Bradley Wubbenhorst, John Pluta, Robert H. Vonderheide, Michael Feldman, Kara N. Maxwell, E. John Wherry, Susan M. Domchek, Katherine L. Nathanson
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2723.
https://doi.org/10.1158/1538-7445.AM2021-2723
Published: 01 July 2021
View article titled, Abstract 2723: How BRCA1/2 mutations in TNBC affect TME and subsequently immune cell functions
Journal Articles

Abstract CT005: T cell inflammation in the tumor microenvironment after agonist CD40 antibody: Clinical and translational results of a neoadjuvant clinical trial

Katelyn T. Byrne, Courtney B. Betts, Rosemarie Mick, Shamilene Sivagnanam, David L. Bajor, Daniel A. Laheru, E. Gabriela Chiorean, Mark H. O'Hara, Shannon M. Liudahl, Craig Newcomb, Cécile Alanio, Ana P. Ferreira, Byung S. Park, Takuya Ohtani, Austin P. Huffman, Sara A. Väyrynen, Andressa Dias Costa, Judith C. Kaiser, Andreanne M. Lacroix, Colleen Redlinger, Martin Stern, Jonathan A. Nowak, E. John Wherry, Martin A. Cheever, Brian M. Wolpin, Emma E. Furth, Elizabeth M. Jaffee, Lisa M. Coussens, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT005.
https://doi.org/10.1158/1538-7445.AM2021-CT005
Published: 01 July 2021
View article titled, Abstract CT005: T cell inflammation in the tumor microenvironment after agonist CD40 antibody: Clinical and translational results of a neoadjuvant clinical trial
Journal Articles

Abstract 1899: Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting

Adham S. Bear, Tatiana Blanchard, Mark H. O'Hara, John Scholler, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1899.
https://doi.org/10.1158/1538-7445.AM2021-1899
Published: 01 July 2021
View article titled, Abstract 1899: Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
Journal Articles

Abstract PR-003: Tumor-cell-intrinsic epigenetic factors underlie the heterogeneity of immune infiltration and response to immunotherapy in pancreatic cancer

Jinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Robert H. Vonderheide, Andres Blanco, Ben Z. Stanger
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PR-003.
https://doi.org/10.1158/1538-7445.PANCA20-PR-003
Published: 13 November 2020
View article titled, Abstract PR-003: Tumor-cell-intrinsic epigenetic factors underlie the heterogeneity of immune infiltration and response to immunotherapy in pancreatic cancer
Journal Articles

Abstract LB-077: Dendritic cell dysfunction precedes tumor formation during pancreatic oncogenesis

Jeffrey H. Lin, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-077.
https://doi.org/10.1158/1538-7445.AM2020-LB-077
Published: 15 August 2020
View article titled, Abstract LB-077: Dendritic cell dysfunction precedes tumor formation during pancreatic oncogenesis
Journal Articles

Abstract I12: CD40 immunotherapy for pancreatic cancer

Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): I12.
https://doi.org/10.1158/1538-7445.PANCA19-I12
Published: 13 December 2019
View article titled, Abstract I12: CD40 immunotherapy for pancreatic cancer
Journal Articles

Abstract A28: Investigation of tumor-cell-intrinsic factors regulating immune infiltration and response to immunotherapy in pancreatic cancer

Jinyang Li, Katelyn T Byrne, Nune Markosyan, Taiji Yamazoe, Fangxue Yan, Zeyu Chen, Yu H. Sun, Jeffrey Lin, Yogev Sela, Robert J. Norgard, Salina Yuan, Allyson J. Merrell, John W. Tobias, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A28.
https://doi.org/10.1158/1538-7445.PANCA19-A28
Published: 13 December 2019
View article titled, Abstract A28: Investigation of tumor-cell-intrinsic factors regulating immune infiltration and response to immunotherapy in pancreatic cancer
Journal Articles

Abstract PR04: STING and TLR-independent activation of T-cell responses against pancreatic cancer using agonistic CD40 antibody

Katelyn T. Byrne, Alexander H. Morrison, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): PR04.
https://doi.org/10.1158/1538-7445.PANCA19-PR04
Published: 13 December 2019
View article titled, Abstract PR04: STING and TLR-independent activation of T-cell responses against pancreatic cancer using agonistic CD40 antibody
Journal Articles

Abstract B31: Type 1 conventional dendritic cells are progressively and systemically dysregulated early in pancreatic carcinogenesis

Jeffrey H. Lin, Austin P. Huffman, Emma E. Furth, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B31.
https://doi.org/10.1158/1538-7445.PANCA19-B31
Published: 13 December 2019
View article titled, Abstract B31: Type 1 conventional dendritic cells are progressively and systemically dysregulated early in pancreatic carcinogenesis
Journal Articles

Abstract C13: A “mouse hospital” for preclinical testing of diagnostic and treatment modalities in pancreatic ductal adenocarcinoma (PDA)

Cynthia Clendenin, Rina Sor, Deirdre McMenamin, Ben Z. Stanger, Gregory Beatty, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C13.
https://doi.org/10.1158/1538-7445.PANCA19-C13
Published: 13 December 2019
View article titled, Abstract C13: A “mouse hospital” for preclinical testing of diagnostic and treatment modalities in pancreatic ductal adenocarcinoma (PDA)
Journal Articles

Abstract B04: Identification of T-cell receptors targeting mutant KRAS in pancreatic cancer

Adham S. Bear, Andrew J. Rech, Lee P. Richman, Mark H. O'Hara, Gerald P. Linette, Beatriz M. Carreno, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B04.
https://doi.org/10.1158/1538-7445.PANCA19-B04
Published: 13 December 2019
View article titled, Abstract B04: Identification of T-cell receptors targeting mutant KRAS in pancreatic cancer