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Journal Articles

Abstract 5610: [¹⁸F]FluorThanatrace ([¹⁸F]FTT) PET Imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer

Cancer Res (2023) 83 (7_Supplement): 5610.

https://doi.org/10.1158/1538-7445.AM2023-5610

Published: 04 April 2023

View article titled, Abstract 5610: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer

Journal Articles

Abstract 3921: Poly(ADP-ribose) polymerase 1 (PARP-1) targeting radionuclides are highly cytotoxic across a panel of 20 neuroblastoma cell lines

Hwan Lee, Adam Mansfield, Minu Samanta, Sean W. Reilly, Kuiying Xu, Sean D. Carlin, John M. Maris, Robert H. Mach, Mehran Makvandi, Daniel A. Pryma

Cancer Res (2019) 79 (13_Supplement): 3921.

https://doi.org/10.1158/1538-7445.AM2019-3921

Published: 01 July 2019

View article titled, Abstract 3921: Poly(ADP-ribose) polymerase 1 (PARP-1) targeting radionuclides are highly cytotoxic across a panel of 20 neuroblastoma cell lines

Journal Articles

Abstract 5197: Targeting PARP-1 to deliver alpha-particles to cancer chromatin

Laura Puentes, Kuiying Xu, Catherine Hou, Robert H. Mach, John M. Maris, Daniel A. Pryma, Mehran Makvandi

Cancer Res (2017) 77 (13_Supplement): 5197.

https://doi.org/10.1158/1538-7445.AM2017-5197

Published: 01 July 2017

View article titled, Abstract 5197: Targeting PARP-1 to deliver alpha-particles to cancer chromatin

Journal Articles

Abstract 3716: Exploring the significance of PARP-1 expression for therapy and clinical PET/CT imaging of PARP-1 in ovarian cancer

Mehran Makvandi, Austin Pantel, Lauren E. Schwartz, Kuiying Xu, Chia-Ju Hsieh, Hyoung Kim, Shi-Hong Li, Robert Doot, Sharon Lee, Fiona Simpkins, Roger A. Greenberg, David A. Mankoff, Robert H. Mach, Lilie Lin

Cancer Res (2017) 77 (13_Supplement): 3716.

https://doi.org/10.1158/1538-7445.AM2017-3716

Published: 01 July 2017

View article titled, Abstract 3716: Exploring the significance of PARP-1 expression for therapy and clinical PET/CT imaging of PARP-1 in ovarian cancer

Journal Articles

Abstract 5710: PGRMC1 is a biomarker for breast cancer cell proliferation and early relapse

Elizabeth S. McDonald, Dhruv K. Pant, Tien-chi Pan, David A. Mankoff, Robert H. Mach, Lewis A. Chodosh

Cancer Res (2017) 77 (13_Supplement): 5710.

https://doi.org/10.1158/1538-7445.AM2017-5710

Published: 01 July 2017

View article titled, Abstract 5710: PGRMC1 is a biomarker for breast cancer cell proliferation and early relapse

Journal Articles

Abstract 2851: Cellular glutamine pool size change in response to glutaminase inhibition detected by kinetic analysis of [¹⁸F](2S,4R)4-fluoroglutamine PET

Austin R. Pantel, Hsiaoju Lee, Shihong Li, Robert K. Doot, Robert H. Mach, David A. Mankoff, Rong Zhou

Cancer Res (2017) 77 (13_Supplement): 2851.

https://doi.org/10.1158/1538-7445.AM2017-2851

Published: 01 July 2017

View article titled, Abstract 2851: Cellular glutamine pool size change in response to glutaminase inhibition detected by kinetic analysis of [18F](2S,4R)4-fluoroglutamine PET

Journal Articles

[¹⁸F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition

Rong Zhou, Austin R. Pantel, Shihong Li, Brian P. Lieberman, Karl Ploessl, Hoon Choi, Eric Blankemeyer, Hsiaoju Lee, Hank F. Kung, Robert H. Mach, David A. Mankoff

Cancer Res (2017) 77 (6): 1476–1484.

https://doi.org/10.1158/0008-5472.CAN-16-1945

Published: 14 March 2017

View article titled, [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition

Includes: Supplementary data

Journal Articles

A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy

Mehran Makvandi, Kuiying Xu, Brian P. Lieberman, Redmond-Craig Anderson, Samuel Sander Effron, Harrison D. Winters, Chenbo Zeng, Elizabeth S. McDonald, Daniel A. Pryma, Roger A. Greenberg, Robert H. Mach

Cancer Res (2016) 76 (15): 4516–4524.

https://doi.org/10.1158/0008-5472.CAN-16-0416

Published: 31 July 2016

View article titled, A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy

Includes: Supplementary data

Journal Articles

Abstract B42: The sigma-2 receptor as a target for therapeutic drug delivery in triple negative breast cancer

Mehran Makvandi, Estifanos D. Tilahun, Brian P. Lieberman, Kuiying Xu, Chenbo Zeng, Catherine Hou, Robert H. Mach

Cancer Res (2016) 76 (3_Supplement): B42.

https://doi.org/10.1158/1538-7445.FBCR15-B42

Published: 07 April 2016

View article titled, Abstract B42: The sigma-2 receptor as a target for therapeutic drug delivery in triple negative breast cancer

Journal Articles

Abstract 3481: Sigma-2 ligands sensitize triple negative breast cancer cells to PARP inhibitor treatment

Chenbo Zeng, Julia Mankoff, Robert H. Mach

Cancer Res (2015) 75 (15_Supplement): 3481.

https://doi.org/10.1158/1538-7445.AM2015-3481

Published: 01 August 2015

View article titled, Abstract 3481: Sigma-2 ligands sensitize triple negative breast cancer cells to PARP inhibitor treatment

Journal Articles

Abstract 3791: PGRMC1 expression is significantly up-regulated in triple negative breast cancer in vivo with associated activation of cyclin D1 target genes: Analysis of 1019 invasive breast cancers in the TCGA database

Elizabeth S. McDonald, Chenbo Zeng, David A. Mankoff, Andrew Kossenkov, Robert H. Mach

Cancer Res (2015) 75 (15_Supplement): 3791.

https://doi.org/10.1158/1538-7445.AM2015-3791

Published: 01 August 2015

View article titled, Abstract 3791: PGRMC1 expression is significantly up-regulated in triple negative breast cancer in vivo with associated activation of cyclin D1 target genes: Analysis of 1019 invasive breast cancers in the TCGA database

Journal Articles

Abstract 2131: Functional assays to define agonists and antagonists of sigma-2 receptors.

Robert H. Mach, Chenbo Zeng, Justin M. Rothfuss, Jun Zhang, Suwanna Vangveravong, Wenhua Chu, Zhude Tu, Shihong Li

Cancer Res (2013) 73 (8_Supplement): 2131.

https://doi.org/10.1158/1538-7445.AM2013-2131

Published: 15 April 2013

View article titled, Abstract 2131: Functional assays to define agonists and antagonists of sigma-2 receptors.

Journal Articles

Abstract 5690: Validating sigma-2 receptor ligand as a novel tumor-targeted drug delivery agent for treating ovarian cancer

Chenbo Zeng, Suwanna Vangveravong, Justin M. Rothfuss, Jinbin Xu, Robert H. Mach

Cancer Res (2012) 72 (8_Supplement): 5690.

https://doi.org/10.1158/1538-7445.AM2012-5690

Published: 15 April 2012

View article titled, Abstract 5690: Validating sigma-2 receptor ligand as a novel tumor-targeted drug delivery agent for treating ovarian cancer

Journal Articles

Abstract 356: Photoacoustic imaging of pancreatic cancer proliferation via sigma-2 receptor/PGRMC1-eYFP

Jinbin Xu, Xin Cai, Junjie Yao, Spitzer Dirk, Chengbo Zeng, William G. Hawkins, Lihong V. Wang, Robert H. Mach

Cancer Res (2012) 72 (8_Supplement): 356.

https://doi.org/10.1158/1538-7445.AM2012-356

Published: 15 April 2012

View article titled, Abstract 356: Photoacoustic imaging of pancreatic cancer proliferation via sigma-2 receptor/PGRMC1-eYFP

Journal Articles

Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling

Dirk Spitzer, Peter O. Simon, Jr, Hiroyuki Kashiwagi, Jinbin Xu, Chenbo Zeng, Suwanna Vangveravong, Dong Zhou, Katherine Chang, Jonathan E. McDunn, John R. Hornick, Peter Goedegebuure, Richard S. Hotchkiss, Robert H. Mach, William G. Hawkins

Cancer Res (2012) 72 (1): 201–209.

https://doi.org/10.1158/0008-5472.CAN-11-1354

Published: 02 January 2012

View article titled, Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling

Includes: Supplementary data

Journal Articles

Abstract 1054: Identification of progesterone receptor membrane component-1 as the putative sigma-2 receptor

Jinbin Xu, Chenbo Zeng, Wenhua Chu, Fenghui Pan, Robert H. Mach

Cancer Res (2010) 70 (8_Supplement): 1054.

https://doi.org/10.1158/1538-7445.AM10-1054

Published: 15 April 2010

View article titled, Abstract 1054: Identification of progesterone receptor membrane component-1 as the putative sigma-2 receptor

Journal Articles

Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy

Chenbo Zeng, Suwanna Vangveravong, Jinbin Xu, Katherine C. Chang, Richard S. Hotchkiss, Kenneth T. Wheeler, Duanwen Shen, Zhi-Ping Zhuang, Hank F. Kung, Robert H. Mach

Cancer Res (2007) 67 (14): 6708–6716.

https://doi.org/10.1158/0008-5472.CAN-06-3803

Published: 17 July 2007

View article titled, Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy

Journal Articles

[³H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe

Jinbin Xu, Zhude Tu, Lynne A. Jones, Kenneth T. Wheeler, Robert H. Mach

Cancer Res (2005) 65 (9_Supplement): 930.

Published: 01 May 2005

View article titled, [3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe

Journal Articles

Sigma-2 receptor gene expression involves in tumor cell cycles and cell proliferation

Li-Ming Wang, Qi Wu, Robert H. Mach, K. T. Wheeler, Kathryn A. Morton

Cancer Res (2005) 65 (9_Supplement): 1288–1289.

Published: 01 May 2005

View article titled, Sigma-2 receptor gene expression involves in tumor cell cycles and cell proliferation

Journal Articles

σ₂ Receptors as Potential Biomarkers of Proliferation in Breast Cancer

Robert H. Mach, Cynthia R. Smith, Isaf Al-Nabulsi, Brian R. Whirrett, Steven R. Childers, Kenneth T. Wheeler

Cancer Res (1997) 57 (1): 156–161.

Published: 01 January 1997

View article titled, σ2 Receptors as Potential Biomarkers of Proliferation in Breast Cancer

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Abstract 5610: [¹⁸F]FluorThanatrace ([¹⁸F]FTT) PET Imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer

Abstract 3921: Poly(ADP-ribose) polymerase 1 (PARP-1) targeting radionuclides are highly cytotoxic across a panel of 20 neuroblastoma cell lines

Abstract 5197: Targeting PARP-1 to deliver alpha-particles to cancer chromatin

Abstract 3716: Exploring the significance of PARP-1 expression for therapy and clinical PET/CT imaging of PARP-1 in ovarian cancer

Abstract 5710: PGRMC1 is a biomarker for breast cancer cell proliferation and early relapse

Abstract 2851: Cellular glutamine pool size change in response to glutaminase inhibition detected by kinetic analysis of [¹⁸F](2S,4R)4-fluoroglutamine PET

[¹⁸F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition

A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy

Abstract B42: The sigma-2 receptor as a target for therapeutic drug delivery in triple negative breast cancer

Abstract 3481: Sigma-2 ligands sensitize triple negative breast cancer cells to PARP inhibitor treatment

Abstract 3791: PGRMC1 expression is significantly up-regulated in triple negative breast cancer in vivo with associated activation of cyclin D1 target genes: Analysis of 1019 invasive breast cancers in the TCGA database

Abstract 2131: Functional assays to define agonists and antagonists of sigma-2 receptors.

Abstract 5690: Validating sigma-2 receptor ligand as a novel tumor-targeted drug delivery agent for treating ovarian cancer

Abstract 356: Photoacoustic imaging of pancreatic cancer proliferation via sigma-2 receptor/PGRMC1-eYFP

Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling

Abstract 1054: Identification of progesterone receptor membrane component-1 as the putative sigma-2 receptor

Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy

[³H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe

Sigma-2 receptor gene expression involves in tumor cell cycles and cell proliferation

σ₂ Receptors as Potential Biomarkers of Proliferation in Breast Cancer

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