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Robert D. Ladner
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Journal Articles

Abstract 3836: Imbalanced nucleotide metabolism sensitizes breast cancer cells to anthracyclines

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Craig Davison, Olivier P. Chevallier, Catherine Knowlson, Melanie McKechnie, Robbie Carson, Jaime Esteve, Richard Wilson, Robert D. Ladner, Melissa J. LaBonte (Wilson)
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3836.
https://doi.org/10.1158/1538-7445.AM2018-3836
Published: 01 July 2018
View articletitled, Abstract 3836: Imbalanced nucleotide metabolism sensitizes breast cancer cells to anthracyclines
Journal Articles

The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models

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Melissa J. LaBonte, Peter M. Wilson, Will Fazzone, Jared Russell, Stan G. Louie, Anthony El-Khoueiry, Heinz-Josef Lenz, Robert D. Ladner
Journal: Cancer Research
Cancer Res (2011) 71 (10): 3635–3648.
https://doi.org/10.1158/0008-5472.CAN-10-2430
Published: 15 May 2011
View articletitled, The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models
Open the PDF for The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models in another window
Includes: Supplementary data
Journal Articles

Abstract 1623: The nucleotide metabolizing enzyme dUTPase confers resistance to thymidylate synthase inhibition in non-small cell lung cancer cells

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Peter M. Wilson, Melissa J. LaBonte, Robert D. Ladner
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1623.
https://doi.org/10.1158/1538-7445.AM10-1623
Published: 15 April 2010
View articletitled, Abstract 1623: The nucleotide metabolizing enzyme dUTPase confers resistance to thymidylate synthase inhibition in non-small cell lung cancer cells
Journal Articles

Abstract 5438: A novel therapeutic combination with synergistic antitumor activity in colon cancer: The dual tyrosine kinase inhibitor lapatinib and the histone deacetylase inhibitor LBH589

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Melissa J. LaBonte, Peter M. Wilson, Anthony El-Khoueiry, Heinz-Josef Lenz, Robert D. Ladner
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5438.
https://doi.org/10.1158/1538-7445.AM10-5438
Published: 15 April 2010
View articletitled, Abstract 5438: A novel therapeutic combination with synergistic antitumor activity in colon cancer: The dual tyrosine kinase inhibitor lapatinib and the histone deacetylase inhibitor LBH589
Journal Articles

Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression

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S. Ram Kumar, Jeffrey S. Scehnet, Eric J. Ley, Jasbir Singh, Valery Krasnoperov, Ren Liu, Parmeet K. Manchanda, Robert D. Ladner, Debra Hawes, Fred A. Weaver, Robert W. Beart, Gagandeep Singh, Cu Nguyen, Michael Kahn, Parkash S. Gill
Journal: Cancer Research
Cancer Res (2009) 69 (9): 3736–3745.
https://doi.org/10.1158/0008-5472.CAN-08-3232
Published: 30 April 2009
View articletitled, Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression
Open the PDF for Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression in another window
Includes: Supplementary data
Journal Articles

The effect of histone deacetylease inhibitors on thymidylate synthase expression in colon cancer cell lines

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William Fazzone, Robert D. Ladner
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 507.
Published: 15 April 2006
View articletitled, The effect of histone deacetylease inhibitors on thymidylate synthase expression in colon cancer cell lines
Journal Articles

A 6 bp deletion polymorphism in the 3’UTR of the human thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

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Michael V. Mandola, Jan Stoehlmacher, Wu Zhang, Susan Groshen, Mimi C. Yu, Syma Iqbal, Heinz-Josef Lenz, Robert D. Ladner
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1096.
Published: 01 April 2004
View articletitled, A 6 bp deletion polymorphism in the 3’UTR of the human thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
Journal Articles

A Novel Single Nucleotide Polymorphism within the 5′ Tandem Repeat Polymorphism of the Thymidylate Synthase Gene Abolishes USF-1 Binding and Alters Transcriptional Activity

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Michael V. Mandola, Jan Stoehlmacher, Susan Muller-Weeks, Gregory Cesarone, Mimi C. Yu, Heinz-Josef Lenz, Robert D. Ladner
Journal: Cancer Research
Cancer Res (2003) 63 (11): 2898–2904.
Published: 01 June 2003
View articletitled, A Novel Single Nucleotide Polymorphism within the 5′ Tandem Repeat Polymorphism of the Thymidylate Synthase Gene Abolishes USF-1 Binding and Alters Transcriptional Activity
Open the PDF for A Novel Single Nucleotide Polymorphism within the 5′ Tandem Repeat Polymorphism of the Thymidylate Synthase Gene Abolishes USF-1 Binding and Alters Transcriptional Activity in another window
Journal Articles

dUTPase and Uracil-DNA Glycosylase Are Central Modulators of Antifolate Toxicity in Saccharomyces cerevisiae

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Beverly A. Tinkelenberg, Michael J. Hansbury, Robert D. Ladner
Journal: Cancer Research
Cancer Res (2002) 62 (17): 4909–4915.
Published: 01 September 2002
View articletitled, dUTPase and Uracil-DNA Glycosylase Are Central Modulators of Antifolate Toxicity in Saccharomyces cerevisiae
Open the PDF for dUTPase and Uracil-DNA Glycosylase Are Central Modulators of Antifolate Toxicity in Saccharomyces cerevisiae in another window
Journal Articles

dUTP Nucleotidohydrolase Isoform Expression in Normal and Neoplastic Tissues: Association with Survival and Response to 5-Fluorouracil in Colorectal Cancer

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Robert D. Ladner, Frank J. Lynch, Susan Groshen, Yi Ping Xiong, Andrew Sherrod, Salvatore J. Caradonna, Jan Stoehlmacher, Heinz-Josef Lenz
Journal: Cancer Research
Cancer Res (2000) 60 (13): 3493–3503.
Published: 01 July 2000
View articletitled, dUTP Nucleotidohydrolase Isoform Expression in Normal and Neoplastic Tissues: Association with Survival and Response to 5-Fluorouracil in Colorectal Cancer
Open the PDF for dUTP Nucleotidohydrolase Isoform Expression in Normal and Neoplastic Tissues: Association with Survival and Response to 5-Fluorouracil in Colorectal Cancer in another window