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Robert Clarke
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Journal Articles

Abstract PO5-23-08: Adenylosuccinate lyase is essential for proliferation and mitochondrial function of endocrine therapy resistant breast cancer cells

Anil Yadav, Lu Jin, Robert Clarke, Surojeet Sengupta
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO5-23-08.
https://doi.org/10.1158/1538-7445.SABCS23-PO5-23-08
Published: 02 May 2024
View articletitled, Abstract PO5-23-08: Adenylosuccinate lyase is essential for proliferation and mitochondrial function of endocrine therapy resistant breast cancer cells
Journal Articles

Abstract 3281: Silencing of necroptosis related genes in endocrine-resistant breast cancer cells causes PFKFB3 induced arrest of necroptosis and contributes to resistance

Brandon C. Jones, Tuna Onal, Surojeet Sengupta, Catherine M. Sevigny, Lu Jin, Paula R. Pohlmann, Ayesha Shajahan-Haq, Robert Clarke
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3281.
https://doi.org/10.1158/1538-7445.AM2024-3281
Published: 22 March 2024
View articletitled, Abstract 3281: Silencing of necroptosis related genes in endocrine-resistant breast cancer cells causes PFKFB3 induced arrest of necroptosis and contributes to resistance
Journal Articles

Abstract 1985: Ablation of adenylosuccinate lyase retarded the cell proliferation and induces mitochondrial dysfunction in endocrine therapy resistant breast cancer cells

ANIL KUMAR Yadav, Lu Jin, Robert Clarke, Surojeet Sengupta
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1985.
https://doi.org/10.1158/1538-7445.AM2024-1985
Published: 22 March 2024
View articletitled, Abstract 1985: Ablation of adenylosuccinate lyase retarded the cell proliferation and induces mitochondrial dysfunction in endocrine therapy resistant breast cancer cells
Journal Articles

Abstract 4378: Identification of novel TXNIP-dependent antitumor pathways in breast cancer

Jasvinder Singh, Bindeshwar Sah, Robert Clarke, Liang Liu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4378.
https://doi.org/10.1158/1538-7445.AM2024-4378
Published: 22 March 2024
View articletitled, Abstract 4378: Identification of novel TXNIP-dependent antitumor pathways in breast cancer
Journal Articles

Abstract 391: Adenylosuccinate lyase enzyme is essential for growth of endocrine therapy resistant ER+ breast cancer cells

Anil K. Yadav, Robert Clarke, Surojeet Sengupta
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 391.
https://doi.org/10.1158/1538-7445.AM2023-391
Published: 04 April 2023
View articletitled, Abstract 391: Adenylosuccinate lyase enzyme is essential for growth of endocrine therapy resistant ER+ breast cancer cells
Journal Articles

Abstract 4677: A preclinical platform of breast cancer PDX and derived cellular models as a tool for pharmacological screening and functional studies

Delphine Nicolle, Aurore Gorce, Marie Tavernier, Elisabetta Marangoni, Didier Decaudin, Christophe Ginestier, Emmanuelle Charafe-Jaufret, Judith Passildas, Nina Robin, Robert Clarke, Erwan Corcuff, Anaïs Joachim, Bernard Malissen, Ana Zarubica, Hervé Luche, Jean-Gabriel Judde, Olivier Déas
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4677.
https://doi.org/10.1158/1538-7445.AM2023-4677
Published: 04 April 2023
View articletitled, Abstract 4677: A preclinical platform of breast cancer PDX and derived cellular models as a tool for pharmacological screening and functional studies
Journal Articles

Abstract P3-11-08: Inhibition of Sirtuin 3 Sensitizes Breast Cancer Cells to Fulvestrant

Karla Andrade de Oliveira, Surojeet Sengupta, Lu Jin, Fabia de Oliveira Andrade, Melike Ozgu-Onal, Anil Yadav, Robert Clarke
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-11-08.
https://doi.org/10.1158/1538-7445.SABCS22-P3-11-08
Published: 01 March 2023
View articletitled, Abstract P3-11-08: Inhibition of Sirtuin 3 Sensitizes Breast Cancer Cells to Fulvestrant
Journal Articles

Abstract P3-11-11: Impaired Succinate Metabolism Supports Endocrine Therapy Resistance in ER Positive Breast Cancers

Anil Yadav, Karla Andrade de Oliveira, Lu Jin, Robert Clarke, Surojeet Sengupta
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-11-11.
https://doi.org/10.1158/1538-7445.SABCS22-P3-11-11
Published: 01 March 2023
View articletitled, Abstract P3-11-11: Impaired Succinate Metabolism Supports Endocrine Therapy Resistance in ER Positive Breast Cancers
Journal Articles

Abstract 2339: Fulvestrant regulation of SIRT1 and SIRT3 expression in breast cancer cells

Karla A. De Oliveira, Surojeet Sengupta, Lu Jin, Robert Clarke
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2339.
https://doi.org/10.1158/1538-7445.AM2022-2339
Published: 15 June 2022
View articletitled, Abstract 2339: Fulvestrant regulation of SIRT1 and SIRT3 expression in breast cancer cells
Journal Articles

Abstract 12: Social isolation promotes mammary cancer recurrence, increases IL6/JAK/STAT3 signaling and causes mitochondrial dysfunction in tamoxifen treated rats, and a traditional herbal mixture reverses all these changes

Fabia de Oliveira Andrade, Lu Jin, Robert Clarke, Imani Wood, MaryAnn Dutton, Chezaray Anjorin, Grace Rubin, Audrey Gao, Surojeet Sengupta, Kevin FitzGerald, Leena Hilakivi-Clarke
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 12.
https://doi.org/10.1158/1538-7445.AM2022-12
Published: 15 June 2022
View articletitled, Abstract 12: Social isolation promotes mammary cancer recurrence, increases IL6/JAK/STAT3 signaling and causes mitochondrial dysfunction in tamoxifen treated rats, and a traditional herbal mixture reverses all these changes
Journal Articles

Abstract 2327: Dysregulated TCA cycle is associated with endocrine therapy resistance in ER+ breast cancer cells

Surojeet Sengupta, Karla Andrade de Oliviera, Lu Jin, Robert Clarke
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2327.
https://doi.org/10.1158/1538-7445.AM2022-2327
Published: 15 June 2022
View articletitled, Abstract 2327: Dysregulated TCA cycle is associated with endocrine therapy resistance in ER+ breast cancer cells
Journal Articles

Abstract P4-02-10: Pfkfb3 inhibition significantly decreases endocrine-resistant breast cancer growth and induces necroptotic cell death

Brandon C Jones, Surojeet Sengupta, Catherine M Sevigny, Lu Jin, Paula R Pohlmann, Ayesha Shajahan-Haq, Robert Clarke
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-02-10.
https://doi.org/10.1158/1538-7445.SABCS21-P4-02-10
Published: 15 February 2022
View articletitled, Abstract P4-02-10: Pfkfb3 inhibition significantly decreases endocrine-resistant breast cancer growth and induces necroptotic cell death
Journal Articles

Abstract P4-02-13: Social isolation promotes mammary cancer recurrence, increases IL6/JAK/STAT3 signaling and causes mitochondrial dysfunction in tamoxifen treated rats, and a traditional herbal mixture reverses all these changes

Fabia Andrade, Lu Jin, Robert Clarke, Imani Wood, MaryAnn Dutton, Chezaray Anjorin, Grace Rubin, Audrey Gao, Surojeet Sengupta, Kevin FitzGerald, Leena Hilakivi-Clarke
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-02-13.
https://doi.org/10.1158/1538-7445.SABCS21-P4-02-13
Published: 15 February 2022
View articletitled, Abstract P4-02-13: Social isolation promotes mammary cancer recurrence, increases IL6/JAK/STAT3 signaling and causes mitochondrial dysfunction in tamoxifen treated rats, and a traditional herbal mixture reverses all these changes
Journal Articles

Abstract P5-06-09: Rivaroxaban targets the procoagulant tumour microenvironment in vitro and thereby inhibits breast cancer progression

Emma L Blower, John Castle, Angelica Santiago-Gomez, Robert Clarke, Cliona C Kirwan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-06-09.
https://doi.org/10.1158/1538-7445.SABCS21-P5-06-09
Published: 15 February 2022
View articletitled, Abstract P5-06-09: Rivaroxaban targets the procoagulant tumour microenvironment in vitro and thereby inhibits breast cancer progression
Journal Articles

Abstract P1-10-01: Results from the breast cancer - anti progestin prevention study 1 (BC-APPS1) trial - a novel approach in breast cancer prevention

Sacha Howell, Alice Greenhalgh, Robert Pedley, Suad Alghamdi, Amanda Caruso, Mujtaba Ansari, Tiago Moreira, Sue Astlet, Anthony Maxwell, Yit Lim, Hayley Brookes, Faiza Idries, Anthony Howell, D Gareth Evans, Michael Sherratt, Andrew Gilmore, Elaine Harkness, Walid Khaled, Alecia-Jane Twigger, Matt Roberts, Robert Clarke, Bruno Simoes
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-10-01.
https://doi.org/10.1158/1538-7445.SABCS21-P1-10-01
Published: 15 February 2022
View articletitled, Abstract P1-10-01: Results from the breast cancer - anti progestin prevention study 1 (BC-APPS1) trial - a novel approach in breast cancer prevention
Journal Articles

Abstract PS17-50: Nuclear expression of acetyl-CoA producing enzymes and their roles in epigenetic reprogramming in breast cancer cells

Surojeet Sengupta, Shuait Nair, Lu Jin, Catherine M Sevigny, Brandon Jones, Robert Clarke
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS17-50.
https://doi.org/10.1158/1538-7445.SABCS20-PS17-50
Published: 15 February 2021
View articletitled, Abstract PS17-50: Nuclear expression of acetyl-CoA producing enzymes and their roles in epigenetic reprogramming in breast cancer cells
Journal Articles

Abstract B19: Role of cell-cell communication in endocrine therapy-resistant breast cancer

Surojeet Sengupta, Rong Hu, Zachary Susswein, Adeola Fagunloye, Shweta Bansal, Robert Clarke
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): B19.
https://doi.org/10.1158/1538-7445.CAMODELS2020-B19
Published: 02 June 2020
View articletitled, Abstract B19: Role of cell-cell communication in endocrine therapy-resistant breast cancer
Journal Articles

Abstract P1-18-07: Can some ER+/HER2+ patients be safely spared from treatment with chemotherapy plus herceptin?

Arran K Turnbull, Victoria Webber, Daniel McStay, Laura M Arthur, Carlos Martinez-Perez, James Meehan, Mark Gray, Charlene Kay, Lorna Renshaw, Jane Keys, Robert Clarke, Andrew H Sims, Olga Oikonomidou, J Michael Dixon
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-18-07.
https://doi.org/10.1158/1538-7445.SABCS19-P1-18-07
Published: 15 February 2020
View articletitled, Abstract P1-18-07: Can some ER+/HER2+ patients be safely spared from treatment with chemotherapy plus herceptin?
Journal Articles

Abstract P1-18-21: Neratinib reduces HER2+/luminal B breast cancer stem cell activity and inhibits resistance by blocking efflux mechanisms

Nathan Hull, Robert Clarke, Nigel Bundred
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-18-21.
https://doi.org/10.1158/1538-7445.SABCS19-P1-18-21
Published: 15 February 2020
View articletitled, Abstract P1-18-21: Neratinib reduces HER2+/luminal B breast cancer stem cell activity and inhibits resistance by blocking efflux mechanisms
Journal Articles

Abstract 2179: Population remodeling in the acquisition of endocrine resistance in breast cancer

Rong Hu, Surojeet Sengupta, Catherine Sevigny, Zhen Zhang, Yue Wang, Robert Clarke
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2179.
https://doi.org/10.1158/1538-7445.AM2018-2179
Published: 01 July 2018
View articletitled, Abstract 2179: Population remodeling in the acquisition of endocrine resistance in breast cancer