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Journal Articles

Abstract 1215: DIRAS3 inhibits oncogenic RAS signaling and RAS-dependent cell growth driven by prevalent KRAS hot spot mutations

Gamze Bildik, Junchen Liu, Weiqun Mao, Hailing Yang, John F. Hancock, Robert C. Bast, Zhen Lu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1215.
https://doi.org/10.1158/1538-7445.AM2024-1215
Published: 22 March 2024
View article titled, Abstract 1215: DIRAS3 inhibits oncogenic RAS signaling and RAS-dependent cell growth driven by prevalent KRAS hot spot mutations
Journal Articles

Abstract 5147: Identification of pharmacodynamic biomarkers in PBMCs and cancer cells for SIK2 kinase inhibitor therapy

Hailing Yang, Weiqun Mao, Philip Rask, Markus Peter, Gayathri Swaminath, Stephan W. Morris, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5147.
https://doi.org/10.1158/1538-7445.AM2024-5147
Published: 22 March 2024
View article titled, Abstract 5147: Identification of pharmacodynamic biomarkers in PBMCs and cancer cells for SIK2 kinase inhibitor therapy
Journal Articles

Abstract 3599: Helical stapled peptides derived from DIRAS3 block KRAS dimerization and downstream MEK/ERK signaling in pancreatic and ovarian carcinomas

Joshua P. Gray, Gamze E. Bildik, Margie N. Sutton, Yong Zhou, Steven Millward, John F. Hancock, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3599.
https://doi.org/10.1158/1538-7445.AM2022-3599
Published: 15 June 2022
View article titled, Abstract 3599: Helical stapled peptides derived from DIRAS3 block KRAS dimerization and downstream MEK/ERK signaling in pancreatic and ovarian carcinomas
Journal Articles

Abstract 83: Structural and biochemical properties of DIRAS3 N-terminal extension that permit its function as a tumor suppressor of oncogenic K-RAS

Xiaowen Liang, Kwangkook Lee, Sung Y. Jung, Gamze Bildik, Weiqun Mao, Joshua P. Gray, Steven W. Millward, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 83.
https://doi.org/10.1158/1538-7445.AM2021-83
Published: 01 July 2021
View article titled, Abstract 83: Structural and biochemical properties of DIRAS3 N-terminal extension that permit its function as a tumor suppressor of oncogenic K-RAS
Journal Articles

Abstract 1999: DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas

Gamze Bildik, Joshua P. Gray, Weiqun Mao, Robert C. Bast, Zhen Lu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1999.
https://doi.org/10.1158/1538-7445.AM2021-1999
Published: 01 July 2021
View article titled, Abstract 1999: DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas
Journal Articles

Abstract 4083: Crizotinib improves the therapeutic efficacy of olaparib in ovarian cancer

Janice M. Santiago-O'Farrill, Alicia M. Blessing, Sarah E. Becker, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4083.
https://doi.org/10.1158/1538-7445.AM2020-4083
Published: 15 August 2020
View article titled, Abstract 4083: Crizotinib improves the therapeutic efficacy of olaparib in ovarian cancer
Journal Articles

Abstract 5210: Novel SIK2 inhibitors sensitize ovarian and breast cancer to PARP inhibitors

Zhen Lu, Weiqun Mso, Janice M. Santiago-O'Farrill, Hailing Yang, Lan Pang, Ahmed A. Ahmed, Hariprasad Vankayalapati, Robert C. Bast, Jr
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5210.
https://doi.org/10.1158/1538-7445.AM2020-5210
Published: 15 August 2020
View article titled, Abstract 5210: Novel SIK2 inhibitors sensitize ovarian and breast cancer to PARP inhibitors
Journal Articles

Abstract 3816: Corilagin could help to overcome PARP inhibitor resistance by inhibiting ERK signaling pathways

Baoxin Luan, Hongbo Zhao, Robert C. Bast, Jr., Zhen Lu, Yinhua Yu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3816.
https://doi.org/10.1158/1538-7445.AM2019-3816
Published: 01 July 2019
View article titled, Abstract 3816: Corilagin could help to overcome PARP inhibitor resistance by inhibiting ERK signaling pathways
Journal Articles

Abstract 4263: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to ALK inhibition

Alicia M. Blessing, Weiqun Mao, Lan Pang, Philip Rask, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4263.
https://doi.org/10.1158/1538-7445.AM2019-4263
Published: 01 July 2019
View article titled, Abstract 4263: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to ALK inhibition
Journal Articles

Abstract 4768: PARP inhibitor-induced autophagy provides an adaptive mechanism of drug resistance in preclinical models of ovarian cancer

Janice M. Santiago-O'Farrill, Saravut J. Weroha, Xiaonan Hou, Lan Pang, Philip Rask, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4768.
https://doi.org/10.1158/1538-7445.AM2019-4768
Published: 01 July 2019
View article titled, Abstract 4768: PARP inhibitor-induced autophagy provides an adaptive mechanism of drug resistance in preclinical models of ovarian cancer
Journal Articles

Abstract 912: Macrophage inhibitory factor (MIF), osteopontin (OPN) and anti-interleukin-8 (IL-8) autoantibodies (AAb) complement CA125 for detection of early-stage ovarian cancer

Jing Guo, Wei-lei Yang, Joseph Celestino, Karen Lu, Anna E. Lokshin, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 912.
https://doi.org/10.1158/1538-7445.AM2019-912
Published: 01 July 2019
View article titled, Abstract 912: Macrophage inhibitory factor (MIF), osteopontin (OPN) and anti-interleukin-8 (IL-8) autoantibodies (AAb) complement CA125 for detection of early-stage ovarian cancer
Journal Articles

Abstract LB-176: HE4 antigen-autoantibody complexes complement CA125 for detecting early stage ovarian cancer and can be elevated with CA125 in preclinical ovarian cancer

Wei-Lei Yang, Zhen Lu, Karen H. Lu, Usha Menon, Makoto Kobayashi, Samir Hanash, Steven Skates, Robert C. Bast
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-176.
https://doi.org/10.1158/1538-7445.AM2018-LB-176
Published: 01 July 2018
View article titled, Abstract LB-176: HE4 antigen-autoantibody complexes complement CA125 for detecting early stage ovarian cancer and can be elevated with CA125 in preclinical ovarian cancer
Journal Articles

Abstract 324: SIK2 inhibitors regulate DNA repair pathway and sensitize ovarian cancer to PARP1 inhibitors

Zhen Lu, Wequn Mao, Lan Pang, Janice M. Santiago-O'Farrill, Haling Yang, Ahmed Ahmed, Hariprasad Vankayalapati, Robert C. Bast
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 324.
https://doi.org/10.1158/1538-7445.AM2018-324
Published: 01 July 2018
View article titled, Abstract 324: SIK2 inhibitors regulate DNA repair pathway and sensitize ovarian cancer to PARP1 inhibitors
Journal Articles

Abstract 1325: DIRAS3 (ARHI) is required for amino acid-mediated autophagy and nutrient deprivation in dormant ovarian cancers

Margie Nicole Sutton, Gilbert Y. Huang, Jinhua Zhou, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1325.
https://doi.org/10.1158/1538-7445.AM2018-1325
Published: 01 July 2018
View article titled, Abstract 1325: DIRAS3 (ARHI) is required for amino acid-mediated autophagy and nutrient deprivation in dormant ovarian cancers
Journal Articles

Abstract 887: Magnetic relaxometry detection of stealth, antibody-targeted micellar iron oxide nanoparticles in-vivo

Rebeca Romero Aburto, Konstantin Sokolov, Adam M. Kulp, Erika C. Vreeland, Zhen Lu, Robert C. Bast, John D. Hazle, Kelsey B. Mathieu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 887.
https://doi.org/10.1158/1538-7445.AM2017-887
Published: 01 July 2017
View article titled, Abstract 887: Magnetic relaxometry detection of stealth, antibody-targeted micellar iron oxide nanoparticles in-vivo
Journal Articles

Abstract LB-296: Discovery of ARN-3261 as a potent, selective, orally available SIK2 inhibitor for treating ovarian, endometrial, primary peritoneal, fallopian tube, and triple negative breast cancers

Hariprasad Vankayalapati, Venkatakrishnareddy Yerramreddy, Jinhua Zhou, Jeffrey A. Handler, Rajendra P. Appalaneni, Ramamohan R. Kancherla, Roy J. Wu, Hiroshi Takemori, Angelique Whitehurst, Amir Anthony Jazaeri, Robert L. Coleman, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-296.
https://doi.org/10.1158/1538-7445.AM2017-LB-296
Published: 01 July 2017
View article titled, Abstract LB-296: Discovery of ARN-3261 as a potent, selective, orally available SIK2 inhibitor for treating ovarian, endometrial, primary peritoneal, fallopian tube, and triple negative breast cancers
Journal Articles

Abstract 3313: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to Crizotinib

Alicia M. Blessing, Yan Wang, Weiqun Mao, Lan Pang, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3313.
https://doi.org/10.1158/1538-7445.AM2017-3313
Published: 01 July 2017
View article titled, Abstract 3313: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to Crizotinib
Journal Articles

Abstract 1864: Feasibility of magnetic relaxometry for early ovarian cancer detection: preliminary evaluation of sensitivity and specificity in cell culture and in mice

Kelsey Mathieu, Zhen Lu, Hailing Yang, Lan Pang, Adam Kulp, John Hazle, Robert C. Bast
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1864.
https://doi.org/10.1158/1538-7445.AM2017-1864
Published: 01 July 2017
View article titled, Abstract 1864: Feasibility of magnetic relaxometry for early ovarian cancer detection: preliminary evaluation of sensitivity and specificity in cell culture and in mice
Journal Articles

Abstract 3317: Autophagy protects ovarian cancer cells from olaparib-induced toxicity

Janice M. Santiago-O'Farrill, Safia Essien, Mary Figueroa, Lan Pang, Ravi Amaravadi, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3317.
https://doi.org/10.1158/1538-7445.AM2017-3317
Published: 01 July 2017
View article titled, Abstract 3317: Autophagy protects ovarian cancer cells from olaparib-induced toxicity
Journal Articles

Abstract 3564: Silencing pfkfb2 enhances paclitaxel sensitivity by modulating metabolism of p53 wt ovarian and breast cancer cells and xenografts

Hailing Yang, Shu Zhang, Weiqun Mao, Ahmed A. Ahmed, Nicholas B. Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Anil K. Sood, Xiao-Feng Le, Zhen Lu, Robert C. Bast
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3564.
https://doi.org/10.1158/1538-7445.AM2017-3564
Published: 01 July 2017
View article titled, Abstract 3564: Silencing pfkfb2 enhances paclitaxel sensitivity by modulating metabolism of p53 wt ovarian and breast cancer cells and xenografts