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Robert A. Casero
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Journal Articles

Abstract 6547: Ivospemin and doxorubicin cooperatively modulate polyamine metabolism and the tumor immune microenvironment to improve survival in a murine ovarian cancer model

Free
Cassandra E. Holbert, Ashley C. Nwafor, Jennifer K. Simpson, Tracy Murray Stewart, Robert A. Casero, Jr.
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6547.
https://doi.org/10.1158/1538-7445.AM2025-6547
Published: 21 April 2025
View articletitled, Abstract 6547: Ivospemin and doxorubicin cooperatively modulate polyamine metabolism and the tumor immune microenvironment to improve survival in a murine ovarian cancer model
Journal Articles

Abstract LB210: Identification of histone deacetylase 10 as a repressor of cancer cell migration

Free
Ting-Ann Liu, Ashley Nwafor, Rajendra Kumar, Laura Sena, Raphael R. Steimbach, Aubry K. Miller, Robert A. Casero, Tracy Murray Stewart
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB210.
https://doi.org/10.1158/1538-7445.AM2024-LB210
Published: 05 April 2024
View articletitled, Abstract LB210: Identification of histone deacetylase 10 as a repressor of cancer cell migration
Journal Articles

Abstract 7154: Ivospemin/doxorubicin combination modulates polyamine metabolism to improve survival in murine ovarian cancer models

Free
Cassandra E. Holbert, Jackson R. Foley, Ashley C. Nwafor, Ting-Ann Liu, Elizabeth Bruckheimer, Jennifer K. Simpson, Tracy Murray Stewart, Robert A. Casero
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7154.
https://doi.org/10.1158/1538-7445.AM2024-7154
Published: 22 March 2024
View articletitled, Abstract 7154: Ivospemin/doxorubicin combination modulates polyamine metabolism to improve survival in murine ovarian cancer models
Journal Articles

Abstract 1589: Characterization of polyaminohydroxamic acids and polyaminobenzamides as inhibitors of HDAC10

Free
Tracy Murray Stewart, Jackson R. Foley, Patrick M. Woster, Robert A. Casero
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1589.
https://doi.org/10.1158/1538-7445.AM2023-1589
Published: 04 April 2023
View articletitled, Abstract 1589: Characterization of polyaminohydroxamic acids and polyaminobenzamides as inhibitors of HDAC10
Journal Articles

Abstract 4944: Evaluating the efficacy of spermine analogue ivospemin (SBP-101) in combination with chemotherapy in ovarian cancer

Free
Cassandra E. Holbert, Jackson R. Foley, Tracy Murray Stewart, Michael J. Walker, Elizabeth Bruckheimer, Jennifer K. Simpson, Robert A. Casero
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4944.
https://doi.org/10.1158/1538-7445.AM2023-4944
Published: 04 April 2023
View articletitled, Abstract 4944: Evaluating the efficacy of spermine analogue ivospemin (SBP-101) in combination with chemotherapy in ovarian cancer
Journal Articles

Abstract 5905: Enterotoxigenic Bacteroides fragilis, a colon microbe, dysregulates polyamine catabolism to promote breast cancer progression

Free
Deeptashree Nandi, Sheetal Parida, Sowjanya Thatikonda, Jackson Foley, Tracy Stewart, Cynthia L. Sears, Robert A. Casero, Dipali Sharma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5905.
https://doi.org/10.1158/1538-7445.AM2023-5905
Published: 04 April 2023
View articletitled, Abstract 5905: Enterotoxigenic Bacteroides fragilis, a colon microbe, dysregulates polyamine catabolism to promote breast cancer progression
Journal Articles

Abstract 5812: Histone deacetylase 10 supports tumor growth under polyamine-limiting conditions

Free
Tracy Murray Stewart, Raphael R. Steimbach, Jackson R. Foley, Aubry K. Miller, Robert A. Casero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5812.
https://doi.org/10.1158/1538-7445.AM2022-5812
Published: 15 June 2022
View articletitled, Abstract 5812: Histone deacetylase 10 supports tumor growth under polyamine-limiting conditions
Journal Articles

Abstract 5488: The potential of spermine analogue SBP-101 (diethyl dihydroxyhomospermine) as a polyamine metabolism modulator in ovarian cancer

Free
Cassandra E. Holbert, Tracy Murray Stewart, Jennifer K. Simpson, Michael J. Walker, Robert A. Casero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5488.
https://doi.org/10.1158/1538-7445.AM2022-5488
Published: 15 June 2022
View articletitled, Abstract 5488: The potential of spermine analogue SBP-101 (diethyl dihydroxyhomospermine) as a polyamine metabolism modulator in ovarian cancer
Journal Articles

DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer

Free
Meghan Travers, Stephen M. Brown, Matthew Dunworth, Cassandra E. Holbert, Karla R. Wiehagen, Kurtis E. Bachman, Jackson R. Foley, Meredith L. Stone, Stephen B. Baylin, Robert A. Casero, Jr., Cynthia A. Zahnow
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3445–3454.
https://doi.org/10.1158/0008-5472.CAN-18-4018
Published: 01 July 2019
View articletitled, DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer
Open the PDF for DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B052: Leveraging the metabolic stress of polyamine biosynthesis in prostate cancer towards a novel therapeutic approach

Free
Hayley C. Affronti, Anthony J. Pellerite, Aryn Rowsam, Spencer R. Rosario, Robert A. Casero, Mikhail A. Nikiforov, James Phillips, Dominic J. Smiraglia
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B052.
https://doi.org/10.1158/1538-7445.PRCA2017-B052
Published: 14 August 2018
View articletitled, Abstract B052: Leveraging the metabolic stress of polyamine biosynthesis in prostate cancer towards a novel therapeutic approach
Journal Articles

Abstract 201: Expression of miR-124 suppresses spermine oxidase-associated H2O2 generation in human gastric adenocarcinoma cells: Implications for infection/inflammation-induced carcinogenesis

Free
Tracy Murray-Stewart, Johanna C. Sierra, Rupesh Chaturvedi, Keith T. Wilson, Robert A. Casero
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 201.
https://doi.org/10.1158/1538-7445.AM2015-201
Published: 01 August 2015
View articletitled, Abstract 201: Expression of miR-124 suppresses spermine oxidase-associated H2O2 generation in human gastric adenocarcinoma cells: Implications for infection/inflammation-induced carcinogenesis
Journal Articles

Abstract 2018: Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model

Free
Nan Li, Marcie J. Grimes, Maria A. Picchi, Hugh D. Mitchell, Christine A. Stidley, Yohannes Tesfaigzi, Meghan M. Channell, Yanbin Liu, Robert A. Casero, Stephen B. Baylin, Mathew D. Reed, Carmen S. Tellez, Thomas H. March, Steven A. Belinsky
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2018.
https://doi.org/10.1158/1538-7445.AM2011-2018
Published: 15 April 2011
View articletitled, Abstract 2018: Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model
Journal Articles

Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model

Free
Steven A. Belinsky, Marcie J. Grimes, Maria A. Picchi, Hugh D. Mitchell, Chris A. Stidley, Yohannes Tesfaigzi, Meghan M. Channell, Yanbin Liu, Robert A. Casero, Jr., Stephen B. Baylin, Mathew D. Reed, Carmen S. Tellez, Thomas H. March
Journal: Cancer Research
Cancer Res (2011) 71 (2): 454–462.
https://doi.org/10.1158/0008-5472.CAN-10-3184
Published: 13 January 2011
View articletitled, Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model
Open the PDF for Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model in another window
Includes: Supplementary data
Journal Articles

Abstract LB-97: Combination of a conformationally restricted polyamine analogue with DNA methyltransferase or histone deacetylase inhibition induces synergistic reexpression of aberrantly silenced tumor suppressor genes

Free
Tracy Murray-Stewart, Steven Belinsky, Laurence Marton, Robert A. Casero
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-97.
https://doi.org/10.1158/1538-7445.AM10-LB-97
Published: 15 April 2010
View articletitled, Abstract LB-97: Combination of a conformationally restricted polyamine analogue with DNA methyltransferase or histone deacetylase inhibition induces synergistic reexpression of aberrantly silenced tumor suppressor genes
Journal Articles

Abstract 4884: Polyamine analogues in combination with DFMO inhibits lysine-specific demethylase 1 and induces re-expression of aberrantly silenced genes

Free
Yu Wu, Laurence J. Marton, Patrick M. Woster, Robert A. Casero
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4884.
https://doi.org/10.1158/1538-7445.AM10-4884
Published: 15 April 2010
View articletitled, Abstract 4884: Polyamine analogues in combination with DFMO inhibits lysine-specific demethylase 1 and induces re-expression of aberrantly silenced genes
Journal Articles

Abstract 4877: Polyamine analogues modulate gene expression by inhibiting KDM1/LSD1 and altering chromatin structure in human breast cancer cells

Free
Qingsong Zhu, Yi Huang, Laurence J. Marton, Patrick M. Woster, Nancy E. Davidson, Robert A. Casero
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4877.
https://doi.org/10.1158/1538-7445.AM10-4877
Published: 15 April 2010
View articletitled, Abstract 4877: Polyamine analogues modulate gene expression by inhibiting KDM1/LSD1 and altering chromatin structure in human breast cancer cells
Journal Articles

The Novel Polyamine Analogue CGC-11093 Enhances the Antimyeloma Activity of Bortezomib

Free
Jennifer S. Carew, Steffan T. Nawrocki, Venudhar K. Reddy, Dorothy Bush, Jerold E. Rehg, Andrew Goodwin, Janet A. Houghton, Robert A. Casero, Jr, Laurence J. Marton, John L. Cleveland
Journal: Cancer Research
Cancer Res (2008) 68 (12): 4783–4790.
https://doi.org/10.1158/0008-5472.CAN-07-6483
Published: 16 June 2008
View articletitled, The Novel Polyamine Analogue CGC-11093 Enhances the Antimyeloma Activity of Bortezomib
Open the PDF for The Novel Polyamine Analogue CGC-11093 Enhances the Antimyeloma Activity of Bortezomib in another window
Includes: Supplementary data
Journal Articles

Tumor Necrosis Factor-α Increases Reactive Oxygen Species by Inducing Spermine Oxidase in Human Lung Epithelial Cells: A Potential Mechanism for Inflammation-Induced Carcinogenesis

Free
Naveen Babbar, Robert A. Casero, Jr.
Journal: Cancer Research
Cancer Res (2006) 66 (23): 11125–11130.
https://doi.org/10.1158/0008-5472.CAN-06-3174
Published: 04 December 2006
View articletitled, Tumor Necrosis Factor-α Increases Reactive Oxygen Species by Inducing Spermine Oxidase in Human Lung Epithelial Cells: A Potential Mechanism for Inflammation-Induced Carcinogenesis
Open the PDF for Tumor Necrosis Factor-α Increases Reactive Oxygen Species by Inducing Spermine Oxidase in Human Lung Epithelial Cells: A Potential Mechanism for Inflammation-Induced Carcinogenesis in another window
Journal Articles

Tumor Necrosis Factor α(TNFα) induces spermidine/spermine N1-acetyltrasferase (SSAT) by inducing nuclear factor κB in human non-small cell lung cancer cells

Free
Naveen Babbar, Amy Hacker, Robert A. Casero, Jr.
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 30.
Published: 15 April 2006
View articletitled, Tumor Necrosis Factor α(TNFα) induces spermidine/spermine N1-acetyltrasferase (SSAT) by inducing nuclear factor κB in human non-small cell lung cancer cells
Journal Articles

Effects of spermine oxidase (SMO/PAOh1) overexpression in NCI H157 non-small cell human lung cancer cells

Free
Alison V. Fraser, Amy Hacker, Patrick M. Woster, Robert A. Casero, Jr.
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 905–906.
Published: 15 April 2006
View articletitled, Effects of spermine oxidase (SMO/PAOh1) overexpression in NCI H157 non-small cell human lung cancer cells