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Rinath Jeselsohn
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Journal Articles

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

Agostina Nardone, Xintao Qiu, Sandor Spisak, Zsuzsanna Nagy, Ariel Feiglin, Avery Feit, Gabriela Cohen Feit, Yingtian Xie, Alba Font-Tello, Cristina Guarducci, Francisco Hermida-Prado, Sudeepa Syamala, Klothilda Lim, Miguel Munoz Gomez, Matthew Pun, MacIntosh Cornwell, Weihan Liu, Aysegul Ors, Hisham Mohammed, Paloma Cejas, Jane B. Brock, Matthew L. Freedman, Eric P. Winer, Xiaoyong Fu, Rachel Schiff, Henry W. Long, Otto Metzger Filho, Rinath Jeselsohn
Journal: Cancer Research
Cancer Res CAN-21-3186.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3186
Published: 11 August 2022
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Abstract 5802: Isotopic tracing reveals distinct metabolic changes with palbociclib or abemaciclib treatment & resistance in breast cancer cell lines

Chandrashekhar Honrao, Kanchan Sonkar, Cristina Guarducci, Agostina Nardone, Wen Ma, Srihari Raghavendra Rao, Chen Dong, Leo Rodrigues, Rinath Jeselsohn, Elizabeth O'Day
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5802.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5802
Published: 15 June 2022
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Abstract PD1-05: Targeting the FRA1-dependent transcriptional nexus in high FOXA1-driven endocrine-resistant and metastatic breast cancer

Chia Chia Liu, Lanfang Qin, Carmine De Angelis, Sarmistha Nanda, Resel Pereira, Martin J. Shea, Agostina Nardone, Rinath Jeselsohn, Ofir Cohen, Nikhil Wagle, Zhijie Liu, Mothaffar F. Rimawi, C. Kent Osborne, Rachel Schiff, Xiaoyong Fu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD1-05
Published: 15 February 2022
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Abstract P1-04-13: Generation and validation of an estrogen receptor signaling (ERS) gene panel that inversely correlates with antigen presentation and T cell infiltration and activity in hormone receptor positive (HR+) breast cancer

Jonathan S Goldberg, Xiaoyong Cui, Kenichi Shimada, Sandra McAllister, Sara Tolaney, Adrienne Waks, Rinath Jeselsohn, Jennifer Guerriero, Judith Agudo, Elizabeth Mittendorf
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-04-13.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-04-13
Published: 15 February 2022
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Abstract GS3-10: Study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in combination with fulvestrant in patients with advanced hormone receptor positive HER2 negative breast cancer (HR+BC)

Charles Coombes, Sasha J Howell, Matthew G Krebs, Simon Lord, Laura M Kenny, Ash Bahl, Glen Clack, Edward Ainscow, Paul A Dickinson, Raluca Fostea, Janine Mansi, Carlo Palmieri, Gianflippo Bertelli, Rinath Jeselsohn, Zahi Mitri, William J Gradishar, Sagar Sardesai, Joyce O'Shaughnessy, Patrick Ward, Pavani Chalasani, Manfred Lehnert, Simak Ali, Stuart McIntosh
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS3-10.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS3-10
Published: 15 February 2022
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Abstract GS2-09: Tamoxifen instigates uterine cancer development by activating PI3K signaling and supersedes PIK3CA driver mutations

Kirsten Kubler, Agostina Nardone, Shankara Anand, Daniel Gorvich, Marjolein Droog, Francisco Hermida-Prado, Tara Akshi, Avery S Feit, Gabriella Cohen, Gwen Dackus, Matthew Pun, Yanan Kuang, Justin Cha, Mendy Miller, William J Gibson, Cloud P Paweletz, Eliezer M Van Allen, Flora E van Leeuwen, Petra Nederlof, Harry Hollema, Quang-Dé Nguyen, Marian JE Mourits, Ignaty Leshchiner, Chip Stewart, Ursula A Matulonis, Wilbert Zwart, Yosef E Maruvka, Gad Getz, Rinath Jeselsohn
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS2-09.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS2-09
Published: 15 February 2022
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Abstract PD8-03: A FOXA1/FRA1-centered transcriptional axis regulates interferon signaling in high FOXA1-associated endocrine-resistant and metastatic breast cancer

Xiaoyong Fu, Resel Pereira, Lanfang Qin, Carmine De Angelis, Sarmistha Nanda, Martin Shea, Agostina Nardone, Rinath Jeselsohn, Ofir Cohen, Nikhil Wagle, Mothaffar Rimawi, C Kent Osborne, Rachel Schiff
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD8-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD8-03
Published: 15 February 2021
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Abstract GS1-07: Treatment persistence of residual breast tumors through an embryonic diapause-like cancer cell state with suppressed myc activity

Eugen Dhimolea, Ricardo De Matos Simoes, Dhvanir Kansara, Juliette Bouyssou, Jennifer Roth, Michal Sheffer, Rinath Jeselsohn, Nathanael Gray, Ulrich Steidl, Boris Bartholdy, Myles Brown, Aedin Culhane, Constantine Mitsiades
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS1-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-GS1-07
Published: 15 February 2021
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Journal Articles

The ESR1 Mutations: From Bedside to Bench to Bedside

Francisco Hermida-Prado, Rinath Jeselsohn
Journal: Cancer Research
Cancer Res (2021) 81 (3): 537–538.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-4037
Published: 01 February 2021
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Pleiotropic Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment

Eugen Dhimolea, Ricardo de Matos Simoes, Dhvanir Kansara, Xiang Weng, Shruti Sharma, Pallavi Awate, Zhiyi Liu, Dong Gao, Nicholas Mitsiades, Joseph H. Schwab, Yu Chen, Rinath Jeselsohn, Aedín C. Culhane, Myles Brown, Irene Georgakoudi, Constantine S. Mitsiades
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (2): 371–383.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-0571
Published: 15 January 2021
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Includes: Supplementary data
Journal Articles

Abstract B16: Mathematical modeling identifies optimum palbociclib dosing schedules for the treatment of estrogen receptor-positive (ER+) breast cancer patients

Shayna Stein, Agostina Nardone, Weihan Liu, Gabriella Cohen, Cristina Guarducci, Myles Brown, Rinath Jeselsohn, Franziska Michor
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): B16.
DOI: https://doi.org/10.1158/1538-7445.CAMODELS2020-B16
Published: 02 June 2020
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Abstract PD2-02: Activation of the EGFR/RAS/p42,44 MAPK axis as a convergent mechanism of resistance to CDK4/6 inhibitors in ER+ breast cancer

Carmine De Angelis, Maria Letizia Cataldo, Agostina Nardone, Jamunarani Veeraraghavan, Xiaoyong Fu, Sarmistha Nanda, Lanfang Qin, Vidyalakshmi Sethunath, Resel Pereira, Britta Weigelt, Jorge S. Reis-Filho, Mothaffar F. Rimawi, Rinath Jeselsohn, Kent Osborne, Rachel Schiff
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD2-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-PD2-02
Published: 15 February 2020
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Journal Articles

Abstract PD7-01: Identification of a high FOXA1-induced pro-metastatic enhancer signature in endocrine-resistant and metastatic breast cancer

Xiaoyong Fu, Resel Pereira, Carmine De Angelis, Sarmistha Nanda, Lanfang Qin, Jamunarani Veeraraghavan, Pier Selenica, Britta Weigelt, Jorge S Reis-Filho, Agostina Nardone, Rinath Jeselsohn, Myles Brown, Mothaffar F Rimawi, C Kent Osborne, Rachel Schiff
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD7-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-PD7-01
Published: 15 February 2020
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Journal Articles

Abstract P6-04-02: Integrative cistromic/transcriptomic profiling identifies a high FOXA1/ER-activated pro-metastatic secretome in endocrine-resistant breast cancer

Xiaoyong Fu, Resel Pereira, Carmine De Angelis, Sarmistha Nanda, Lanfang Qin, Martin J Shea, Tamika Mitchell, Jamunarani Veeraraghavan, Vidyalakshmi Sethunath, Carolina Gutierrez, Balázs Győrffy, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Myles Brown, Mothaffar F Rimawi, C Kent Osborne, Rachel Schiff
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-04-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P6-04-02
Published: 15 February 2020
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Abstract GS2-01: High levels of interferon-response gene signatures are associated with de novo and acquired resistance to CDK4/6 inhibitors in ER+ breast cancer

Carmine De Angelis, Xiaoyong Fu, Maria Letizia Cataldo, Agostina Nardone, Valerie M. Jansen, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Vidyalakshmi Sethunath, Resel Pereira, Matteo Benelli, Ilenia Migliaccio, Luca Malorni, Joshua Donaldson, Pier Selenica, David N. Brown, Britta Weigelt, Jorge S. Reis-Filho, Ben H. Park, Sara A. Hurvitz, Dennis J. Slamon, Mothaffar F. Rimawi, Rinath Jeselsohn, Kent Osborne, Rachel Schiff
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): GS2-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-GS2-01
Published: 15 February 2020
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Journal Articles

Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis

Yanming Wu, Zhao Zhang, Mauro E. Cenciarini, Cecilia J. Proietti, Matias Amasino, Tao Hong, Mei Yang, Yiji Liao, Huai-Chin Chiang, Virginia G. Kaklamani, Rinath Jeselsohn, Ratna K. Vadlamudi, Tim Hui-Ming Huang, Rong Li, Carmine De Angelis, Xiaoyong Fu, Patricia V. Elizalde, Rachel Schiff, Myles Brown, Kexin Xu
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (3): 671–684.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-1327
Published: 31 January 2018
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Journal Articles

Abstract 4950: The emergence of ESR1 mutations is associated with aromatase inhibitor and fulvestrant therapy

Yanan Kuang, Bilal Siddiqui, Jiani Hu, William T. Barry, Nancy U. Lin, Nikhil Wagle, Paul Kirschmeier, Pasi A. Jänne, Cloud Paweletz, Ian Krop, Eric P. Winer, Myles Brown, Rinath Jeselsohn
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4950.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4950
Published: 01 July 2017
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Journal Articles

Abstract PD6-2: FoxA1 gene amplification in ER+ breast cancer mediates endocrine resistance by increasing IL-8

Xiaoyong Fu, Rinath Jeselsohn, Emporia F Hollingsworth, Dolores Lopez-Terrada, Chad J Creighton, Agostina Nardone, Martin Shea, Laura M Heiser, Pavana Anur, Nicholas Wang, Catie Grasso, Paul Spellman, Carolina Gutierrez, Mothaffar F Rimawi, Susan G Hilsenbeck, Joe W Gray, Myles Brown, C K Osborne, Rachel Schiff
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): PD6-2.
DOI: https://doi.org/10.1158/1538-7445.SABCS14-PD6-2
Published: 01 May 2015
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Abstract P4-01-06: Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis

Mario Giuliano, Sabrina Herrera, Pavel Christiny, Chad Shaw, Chad J Creighton, Tamika Mitchell, Raksha Bhat, Xiaomei Zhang, Sufeng Mao, Lacey Dobrolecki, Ahmed Al-rawi, Fengju Chen, Bianca M Veneziani, Xiang H Zhang, Susan G Hilsenbeck, Alejandro Contreras, Carolina Gutierrez, Rinath Jeselsohn, Mothaffar F Rimawi, C Kent Osborne, Michael T Lewis, Rachel Schiff, Meghana V Trivedi
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P4-01-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS14-P4-01-06
Published: 01 May 2015
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Journal Articles

D538G Mutation in Estrogen Receptor-α: A Novel Mechanism for Acquired Endocrine Resistance in Breast Cancer

Keren Merenbakh-Lamin, Noa Ben-Baruch, Adva Yeheskel, Addie Dvir, Lior Soussan-Gutman, Rinath Jeselsohn, Roman Yelensky, Myles Brown, Vincent A. Miller, David Sarid, Shulamith Rizel, Baruch Klein, Tami Rubinek, Ido Wolf
Journal: Cancer Research
Cancer Res (2013) 73 (23): 6856–6864.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-1197
Published: 01 December 2013
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