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Rima Al-Awar
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Journal Articles

The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

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Yongwei Su, Jenna L. Carter, Xinyu Li, Yu Fukuda, Ashley Gray, John Lynch, Holly Edwards, Jun Ma, Patrick Schreiner, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Steven A. Buck, Shondra M. Pruett-Miller, Katie Hege-Hurrish, Camenzind Robinson, Xinan Qiao, Shuang Liu, Shuangshuang Wu, Guan Wang, Jing Li, Joshua E. Allen, Varun V. Prabhu, Aaron D. Schimmer, Dhananjay Joshi, Shiva Kalhor-Monfared, Iain D. G. Watson, Richard Marcellus, Methvin B. Isaac, Rima Al-awar, Jeffrey W. Taub, Hai Lin, John D. Schuetz, Yubin Ge
Journal: Cancer Research
Cancer Res (2024) 84 (7): 1084–1100.
https://doi.org/10.1158/0008-5472.CAN-23-2659
Published: 01 April 2024
View articletitled, The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Open the PDF for The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 346: Synergistic antiproliferative activity of novel RAD51 inhibitor JKYN-1 and its mesylate salt with standard-of-care cancer drugs

Free
Peter J. Ferguson, Mark D. Vincent, Yousef Najajreh, Brian Shilton, Stephen Ritter, Rima Al-awar, Richard Marcellus, Mohammed Mohammed, Methvin Isaac, James Koropatnick
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 346.
https://doi.org/10.1158/1538-7445.AM2022-346
Published: 15 June 2022
View articletitled, Abstract 346: Synergistic antiproliferative activity of novel RAD51 inhibitor JKYN-1 and its mesylate salt with standard-of-care cancer drugs
Journal Articles

Abstract PO-039: Antiproliferative activity of inhibitors of RAD51, singly and in combination with chemotherapy drugs, against pancreatic cancer cell lines

Free
Peter Ferguson, Mark D. Vincent, Yousef Najajreh, Brian Shilton, Stephen Ritter, Rima Al-awar, Richard Marcellus, Mohammed Mohammed, Methvin Isaac, James Koropatnnick
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-039.
https://doi.org/10.1158/1538-7445.PANCA21-PO-039
Published: 15 November 2021
View articletitled, Abstract PO-039: Antiproliferative activity of inhibitors of RAD51, singly and in combination with chemotherapy drugs, against pancreatic cancer cell lines
Journal Articles

Abstract 1222: Validating the WD repeat protein CDC40 as a potential therapeutic target for lung cancer

Free
Die Hu, Brigitte L. Thériault, Vida Talebian, Julie Owen, Richard Marcellus, Rima Al-awar
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1222.
https://doi.org/10.1158/1538-7445.AM2021-1222
Published: 01 July 2021
View articletitled, Abstract 1222: Validating the WD repeat protein CDC40 as a potential therapeutic target for lung cancer
Journal Articles

Abstract 6321: BEND3 modulates sensitivity to the UBA1 inhibitor TAK-243 by regulating expression of the multidrug transporter BCRP

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Samir H. Barghout, Ahmed Aman, Zachary Blatman, Karen Arevalo, Geethu Thomas, Neil MacLean, Xiaoming Wang, Rose Hurren, Troy Ketela, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6321.
https://doi.org/10.1158/1538-7445.AM2020-6321
Published: 15 August 2020
View articletitled, Abstract 6321: BEND3 modulates sensitivity to the UBA1 inhibitor TAK-243 by regulating expression of the multidrug transporter BCRP
Journal Articles

Abstract 3925: A screen for epigenetic radiosensitizers in small cell lung cancer

Free
Mansi K. Aparnathi, Lifang Song, Ratheesh Subramaniam, Richard Marcellus, Rima Al-awar, Benjamin H. Lok
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3925.
https://doi.org/10.1158/1538-7445.AM2019-3925
Published: 01 July 2019
View articletitled, Abstract 3925: A screen for epigenetic radiosensitizers in small cell lung cancer
Journal Articles

Abstract 7: Discovery of OICR-10268: A potent and selective BCL6 inhibitor

Free
Iain D. Watson, Methvin Isaac, Brian Wilson, Anh Chau, Justin Morin, Pandiaraju Subramanian, Ahmed Mamai, Babu Joseph, Michael Prakesch, David Uehling, Ayome Abibi, Richard Marcellus, Craig Strathdee, Ratheesh Subramaniam, Brigitte Theriault, Jeffrey Winston, Manuel Chan, Carly Griffin, Herman Cheung, Taira Kiyota, Elijus Undzys, Ahmed Aman, Gennady Poda, Doug Kuntz, Neil C. Pomroy, Gil G. Privé, Rima Al-awar
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 7.
https://doi.org/10.1158/1538-7445.AM2019-7
Published: 01 July 2019
View articletitled, Abstract 7: Discovery of OICR-10268: A potent and selective BCL6 inhibitor
Journal Articles

Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)

Free
Mingjing Xu, Ayesh Seneviratne, Val A. Fajardo, Geethu E. Thomas, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, David Sharon, Ahmed Aman, Rima Al-awar, Steven Chan, Mark D. Minden, Paul LeBlanc, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3003.
https://doi.org/10.1158/1538-7445.AM2019-3003
Published: 01 July 2019
View articletitled, Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)
Journal Articles

Abstract 2377: Design, synthesis, and characterization of 4-aminopyrazole quinazolines as potent inhibitors of G protein-coupled receptor kinase GRK6 for the potential treatment of multiple myeloma

Free
David Uehling, Babu Joseph, Carly Griffin, Ratheesh Subramaniam, Ayome Abibi, Richard Marcellus, Michael Prakesch, Gennadiy Poda, Methvin Isaac, Chungyee Leung-Hagesteijn, Rodger Tiedemann, Rima Al-awar
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2377.
https://doi.org/10.1158/1538-7445.AM2018-2377
Published: 01 July 2018
View articletitled, Abstract 2377: Design, synthesis, and characterization of 4-aminopyrazole quinazolines as potent inhibitors of G protein-coupled receptor kinase GRK6 for the potential treatment of multiple myeloma
Journal Articles

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

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Yuting Sun, Jessica L. Bell, Daniel Carter, Samuele Gherardi, Rebecca C. Poulos, Giorgio Milazzo, Jason W.H. Wong, Rima Al-Awar, Andrew E. Tee, Pei Y. Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M. Shohet, Ygal Haupt, Johannes H. Schulte, Peter J. Brown, Cheryl H. Arrowsmith, Masoud Vedadi, Karen L. MacKenzie, Stefan Hüttelmaier, Giovanni Perini, Glenn M. Marshall, Antony Braithwaite, Tao Liu
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5143–5154.
https://doi.org/10.1158/0008-5472.CAN-15-0423
Published: 30 November 2015
View articletitled, WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Open the PDF for WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer

Free
Tao Deng, Jeff C. Liu, Philip E.D. Chung, David Uehling, Ahmed Aman, Babu Joseph, Troy Ketela, Zhe Jiang, Nathan F. Schachter, Robert Rottapel, Sean E. Egan, Rima Al-awar, Jason Moffat, Eldad Zacksenhaus
Journal: Cancer Research
Cancer Res (2014) 74 (7): 2119–2130.
https://doi.org/10.1158/0008-5472.CAN-13-2138
Published: 31 March 2014
View articletitled, shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Open the PDF for shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2590: A novel use of E2f and Cdk inhibitors to prevent RB-null tumours in genetically engineered models of retinoblastoma

Free
Sean R. McCurdy, Ahmed Aman, Izhar Livne-Bar, Monika Sangwan, Danian Chen, Rima Al-awar, Rod Bremner
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2590.
https://doi.org/10.1158/1538-7445.AM2012-2590
Published: 15 April 2012
View articletitled, Abstract 2590: A novel use of E2f and Cdk inhibitors to prevent RB-null tumours in genetically engineered models of retinoblastoma
Journal Articles

Abstract 4989: Selective inhibitors of the inositol-requiring enzyme 1 kinase domain

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Carly Griffin, Ayome Abibi, Ratheesh Subramaniam, Hassan S. Zaidi, Richard Marcellus, Gennadiy Poda, Michael Prakesch, David Uehling, Marella Canny, David Chiovitti, Dan Durocher, Frank Sicheri, Rima Al-awar
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4989.
https://doi.org/10.1158/1538-7445.AM2012-4989
Published: 15 April 2012
View articletitled, Abstract 4989: Selective inhibitors of the inositol-requiring enzyme 1 kinase domain
Journal Articles

Abstract 156: Screening and characterization of inhibitors of G-protein coupled receptor kinase GRK6 as potential therapeutics for multiple myeloma

Free
Carly Griffin, Ratheesh Subramanian, Hassan S. Zaidi, Richard Marcellus, Babu Joseph, Methvin Isaac, David Uehling, Chungyee Leung-Hagesteijn, Rodger Tiedemann, Rima Al-awar
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 156.
https://doi.org/10.1158/1538-7445.AM2012-156
Published: 15 April 2012
View articletitled, Abstract 156: Screening and characterization of inhibitors of G-protein coupled receptor kinase GRK6 as potential therapeutics for multiple myeloma
Journal Articles

Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

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Siyuan Song, Tania Christova, Stephen Perusini, Solmaz Alizadeh, Ren-Yue Bao, Bryan W. Miller, Rose Hurren, Yulia Jitkova, Marcela Gronda, Methvin Isaac, Babu Joseph, Ratheesh Subramaniam, Ahmed Aman, Anh Chau, Donna E. Hogge, Scott J. Weir, James Kasper, Aaron D. Schimmer, Rima Al-awar, Jeff L. Wrana, Liliana Attisano
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7628–7639.
https://doi.org/10.1158/0008-5472.CAN-11-2745
Published: 15 December 2011
View articletitled, Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers
Open the PDF for Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers in another window
Includes: Supplementary data
Journal Articles

Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

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Natalie Grinshtein, Alessandro Datti, Mayumi Fujitani, David Uehling, Michael Prakesch, Methvin Isaac, Meredith S. Irwin, Jeffrey L. Wrana, Rima Al-awar, David R. Kaplan
Journal: Cancer Research
Cancer Res (2011) 71 (4): 1385–1395.
https://doi.org/10.1158/0008-5472.CAN-10-2484
Published: 14 February 2011
View articletitled, Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells
Open the PDF for Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells in another window
Includes: Supplementary data