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Ricky W. Johnstone
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Journal Articles

Abstract LT02: Regulation of Exhausted CD8+ T cell Differentiation by IKZF Transcription Factors

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Sinead M. Reading, Isabelle Munoz, Maria N. de Menezes, Nicole Y. L. Saw, Krutika Ambani, Antonio Ahn, Simone Nussing, Sara Roth, Shienny Sampurno, Kelly M. Ramsbottom, Joseph A. Trapani, Kim L. Good-Jacobson, Ricky W. Johnstone, Shom Goel, Paul A. Beavis, Ian A. Parish
Journal: Cancer Research
Cancer Res (2024) 84 (8_Supplement): LT02.
https://doi.org/10.1158/1538-7445.FCS2023-LT02
Published: 15 April 2024
View articletitled, Abstract LT02: Regulation of Exhausted CD8+ T cell Differentiation by IKZF Transcription Factors
Journal Articles

Abstract 1703: Sensitizing cancer cells to TNF induced cell death by the BET-inhibitor RG6146

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Lisa C. Wellinger, Simon J. Hogg, Dane Newman, Thomas Friess, Daniela Geiss, Marina Bacac, Tanja Fauti, Astrid Ruefli-Brasse, Ricky W. Johnstone, Daniel Rohle
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1703.
https://doi.org/10.1158/1538-7445.AM2020-1703
Published: 15 August 2020
View articletitled, Abstract 1703: Sensitizing cancer cells to TNF induced cell death by the BET-inhibitor RG6146
Journal Articles

Abstract 4485: Enhancing antitumor immune responses with clinical BET bromodomain inhibitor RG6146

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Simon J. Hogg, Lisa Wellinger, Daniel Rohle, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4485.
https://doi.org/10.1158/1538-7445.AM2019-4485
Published: 01 July 2019
View articletitled, Abstract 4485: Enhancing antitumor immune responses with clinical BET bromodomain inhibitor RG6146
Journal Articles

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors

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Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R. Jenkins, Kelly M. Ramsbottom, Joseph A. Trapani, Mark J. Smyth, Phillip K. Darcy, Peter W. Atadja, Michael A. Henderson, Ricky W. Johnstone, Nicole M. Haynes
Journal: Cancer Research
Cancer Res (2017) 77 (10): 2594–2606.
https://doi.org/10.1158/0008-5472.CAN-16-2247
Published: 14 May 2017
View articletitled, HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors
Open the PDF for HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors in another window
Includes: Supplementary data
Journal Articles

CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity

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Samantha E. Boyle, Clare G. Fedele, Vincent Corbin, Elisha Wybacz, Pacman Szeto, Jeremy Lewin, Richard J. Young, Annie Wong, Robert Fuller, John Spillane, David Speakman, Simon Donahoe, Miklos Pohl, David Gyorki, Michael A. Henderson, Ricky W. Johnstone, Anthony T. Papenfuss, Mark Shackleton
Journal: Cancer Research
Cancer Res (2016) 76 (13): 3965–3977.
https://doi.org/10.1158/0008-5472.CAN-15-2377
Published: 30 June 2016
View articletitled, CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity
Open the PDF for CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity in another window
Includes: Supplementary data
Journal Articles

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

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Adele Baker, Gareth P. Gregory, Inge Verbrugge, Lev Kats, Joshua J. Hilton, Eva Vidacs, Erwin M. Lee, Richard B. Lock, Johannes Zuber, Jake Shortt, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2016) 76 (5): 1158–1169.
https://doi.org/10.1158/0008-5472.CAN-15-1070
Published: 29 February 2016
View articletitled, The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia
Open the PDF for The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

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Stephen Q. Wong, Kelly Waldeck, Ismael A. Vergara, Jan Schröder, Jason Madore, James S. Wilmott, Andrew J. Colebatch, Ricardo De Paoli-Iseppi, Jason Li, Richard Lupat, Timothy Semple, Gisela Mir Arnau, Andrew Fellowes, J. Helen Leonard, George Hruby, Graham J. Mann, John F. Thompson, Carleen Cullinane, Meredith Johnston, Mark Shackleton, Shahneen Sandhu, David D.L. Bowtell, Ricky W. Johnstone, Stephen B. Fox, Grant A. McArthur, Anthony T. Papenfuss, Richard A. Scolyer, Anthony J. Gill, Rodney J. Hicks, Richard W. Tothill
Journal: Cancer Research
Cancer Res (2015) 75 (24): 5228–5234.
https://doi.org/10.1158/0008-5472.CAN-15-1877
Published: 14 December 2015
View articletitled, UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas
Open the PDF for UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas in another window
Includes: Supplementary data
Journal Articles

Abstract PR15: Inhibition of RNA Polymerase I as a therapeutic strategy for cancer-specific activation of p53

Free
Megan J. Bywater, Kenna Anderes, Nanni Huser, Chris Proffitt, Joshua Bleisath, Mustapha Haddach, Michael Schwaebe, David Ryckman, William G. Rice, Scott W. Lowe, Ricky W. Johnstone, Gretchen Poortinga, Richard B. Pearson, Grant A. McArthur, Ross D. Hannan, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): PR15.
https://doi.org/10.1158/1538-7445.FBCR11-PR15
Published: 28 October 2014
View articletitled, Abstract PR15: Inhibition of RNA Polymerase I as a therapeutic strategy for cancer-specific activation of p53
Journal Articles

Abstract 449: Exome sequencing reveals Bcl6 co-repressor (Bcor) as a frequently mutated tumor suppressor gene in Eμ-Myc lymphoma

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Marcus P. Lefebure, Richard Tothill, Jason Li, Geoff Matthews, Jake Shortt, Edwin Hawkins, Elizabeth Kruse, Maria Doyle, Gretchen Poortinga, Ross Hannan, Vivian Bardwell, Micah Gearhart, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 449.
https://doi.org/10.1158/1538-7445.AM2014-449
Published: 01 October 2014
View articletitled, Abstract 449: Exome sequencing reveals Bcl6 co-repressor (Bcor) as a frequently mutated tumor suppressor gene in Eμ-Myc lymphoma
Journal Articles

Abstract 5533: RNAi-mediated depletion of histone deacetylases highlights the potential for isoform-specific inhibitors in B-cell lymphoma and acute myeloid leukemia

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Geoffrey M. Matthews, Leonie Cluse, Eric Wang, Mareike Roth, Chris Vakoc, Wenyan Miao, James Rusche, Johannes Zuber, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5533.
https://doi.org/10.1158/1538-7445.AM2014-5533
Published: 01 October 2014
View articletitled, Abstract 5533: RNAi-mediated depletion of histone deacetylases highlights the potential for isoform-specific inhibitors in B-cell lymphoma and acute myeloid leukemia
Journal Articles

An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors

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Alison C. West, Stephen R. Mattarollo, Jake Shortt, Leonie A. Cluse, Ailsa J. Christiansen, Mark J. Smyth, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2013) 73 (24): 7265–7276.
https://doi.org/10.1158/0008-5472.CAN-13-0890
Published: 16 December 2013
View articletitled, An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors
Open the PDF for An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract 4355: Inhibition of RNA Polymerase I as a strategy to treat cancer.

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Megan J. Bywater, Katherine M. Hannan, Gretchen Poortinga, Jennifer R. Devlin, Carleen Cullinane, Denis Drygin, William G. Rice, Daniel Von Hoff, Ricky W. Johnstone, Grant A. McArthur, Ross D. Hannan, Richard B. Pearson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4355.
https://doi.org/10.1158/1538-7445.AM2013-4355
Published: 15 April 2013
View articletitled, Abstract 4355: Inhibition of RNA Polymerase I as a strategy to treat cancer.
Journal Articles

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

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Inge Verbrugge, Jim Hagekyriakou, Leslie L. Sharp, Mara Galli, Alison West, Nicole M. McLaughlin, Hélène Duret, Hideo Yagita, Ricky W. Johnstone, Mark J. Smyth, Nicole M. Haynes
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3163–3174.
https://doi.org/10.1158/0008-5472.CAN-12-0210
Published: 01 July 2012
View articletitled, Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies
Open the PDF for Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies in another window
Includes: Supplementary data
Journal Articles

Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737

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Adrian P. Wiegmans, Amber E. Alsop, Michael Bots, Leonie A. Cluse, Steven P. Williams, Kellie-Marie Banks, Rachael Ralli, Clare L. Scott, Anna Frenzel, Andreas Villunger, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2011) 71 (10): 3603–3615.
https://doi.org/10.1158/0008-5472.CAN-10-3289
Published: 15 May 2011
View articletitled, Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737
Open the PDF for Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737 in another window
Includes: Supplementary data
Journal Articles

Abstract 2613: Histone deacetylase inhibitor induced thrombocytopenia occurs due to inhibition platelet shedding by megakaryocytes, via increased phosporylation of myosin light chain

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Mark J. Bishton, H Miles Prince, Simon J. Harrison, Ben P. Martin, Josefsson C. Emma, Chloe James, Katya J. Henley, Ben T. Kile, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2613.
https://doi.org/10.1158/1538-7445.AM2011-2613
Published: 15 April 2011
View articletitled, Abstract 2613: Histone deacetylase inhibitor induced thrombocytopenia occurs due to inhibition platelet shedding by megakaryocytes, via increased phosporylation of myosin light chain
Journal Articles

Abstract 4311: Utilising the preclinical Vk*MYC model of multiple myeloma to rapidly and effectively screen novel therapies and their combinations

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Geoffrey M. Matthews, Marta Chesi, Marcus Lefebure, Jake Shortt, Kellie Banks, Kym Stanley, David Faulkner, Peter Atadja, Leif Bergsagel, Ricky W. Johnstone
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4311.
https://doi.org/10.1158/1538-7445.AM2011-4311
Published: 15 April 2011
View articletitled, Abstract 4311: Utilising the preclinical Vk*MYC model of multiple myeloma to rapidly and effectively screen novel therapies and their combinations
Journal Articles

Abstract 4130: Genomic profiling of ovarian tumor cell lines provides a predictive signature of sensitivity to PF-4691502, a dual PI3kinase and mTOR inhibitor

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Karen E. Sheppard, Amelia Neilsen, Gwyn Ng, Joanna Chan, Richard W. Tothill, Jason Ellul, Ross D. Hannan, Ricky W. Johnstone, Grant McArthur, Wayne Phillips, Richard B. Pearson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4130.
https://doi.org/10.1158/1538-7445.AM10-4130
Published: 15 April 2010
View articletitled, Abstract 4130: Genomic profiling of ovarian tumor cell lines provides a predictive signature of sensitivity to PF-4691502, a dual PI3kinase and mTOR inhibitor
Journal Articles

Abstract 2499: Single agent activity of checkpoint kinase inhibitor PF-477736, in a MYC-driven lymphoma model

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Petranel T. Ferrão, Carleen Cullinane, Jeanette Raleigh, Sreesha Srinivasa, Wendy Levin, Ricky W. Johnstone, Grant A. McArthur
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2499.
https://doi.org/10.1158/1538-7445.AM10-2499
Published: 15 April 2010
View articletitled, Abstract 2499: Single agent activity of checkpoint kinase inhibitor PF-477736, in a MYC-driven lymphoma model
Journal Articles

Functional analysis of histone deacetylase inhibitors in vitro and in vivo using a mouse model of B cell lymphoma

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Ricky W. Johnstone, Andrea Cirnigliaro, Kate Whitecross, Andrew Wei, Clare Scott, Scott Lowe, Ralph Lindemann
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 143.
Published: 01 May 2005
View articletitled, Functional analysis of histone deacetylase inhibitors in vitro and in vivo using a mouse model of B cell lymphoma
Journal Articles

Functional analysis of histone deacetylase inhibitors in vitro and in vivo using a mouse model of B cell lymphoma.

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Ricky W. Johnstone, Andrea Cirnigliaro, Clare Scott, Scott Lowe, Andrew Wei, Marc Pellegrini, Lisa Butler, Stuart Schreiber, Ralph Lindemann
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 566.
Published: 01 April 2004
View articletitled, Functional analysis of histone deacetylase inhibitors in vitro and in vivo using a mouse model of B cell lymphoma.