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Richard Poulsom
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Journal Articles

DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

Ji-Liang Li, Richard C.A. Sainson, Chern Ein Oon, Helen Turley, Russell Leek, Helen Sheldon, Esther Bridges, Wen Shi, Cameron Snell, Emma T. Bowden, Herren Wu, Partha S. Chowdhury, Angela J. Russell, Craig P. Montgomery, Richard Poulsom, Adrian L. Harris
Journal: Cancer Research
Cancer Res (2011) 71 (18): 6073–6083.
https://doi.org/10.1158/0008-5472.CAN-11-1704
Published: 13 September 2011
View article titled, DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy <em>In Vivo</em>
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Includes: Supplementary data
Journal Articles

PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis

Anuratha Sakthianandeswaren, Michael Christie, Carla D'Andreti, Cary Tsui, Robert N. Jorissen, Shan Li, Nicholas I. Fleming, Peter Gibbs, Lara Lipton, Jordane Malaterre, Robert G. Ramsay, Toby J. Phesse, Matthias Ernst, Rosemary E. Jeffery, Richard Poulsom, Simon J. Leedham, Stefania Segditsas, Ian P. M. Tomlinson, Oliver K. Bernhard, Richard J. Simpson, Francesca Walker, Maree C. Faux, Nicole Church, Bruno Catimel, Dustin J. Flanagan, Elizabeth Vincan, Oliver M. Sieber
Journal: Cancer Research
Cancer Res (2011) 71 (10): 3709–3719.
https://doi.org/10.1158/0008-5472.CAN-10-2342
Published: 15 May 2011
View article titled, PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis
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Includes: Supplementary data
Journal Articles

Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Houman Ashrafian, Linda O'Flaherty, Julie Adam, Violetta Steeples, Yuen-Li Chung, Phil East, Sakari Vanharanta, Heli Lehtonen, Emma Nye, Emine Hatipoglu, Melroy Miranda, Kimberley Howarth, Deepa Shukla, Helen Troy, John Griffiths, Bradley Spencer-Dene, Mohammed Yusuf, Emanuela Volpi, Patrick H. Maxwell, Gordon Stamp, Richard Poulsom, Christopher W. Pugh, Barbara Costa, Chiara Bardella, Maria Flavia Di Renzo, Michael I. Kotlikoff, Virpi Launonen, Lauri Aaltonen, Mona El-Bahrawy, Ian Tomlinson, Patrick J. Pollard
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9153–9165.
https://doi.org/10.1158/0008-5472.CAN-10-1949
Published: 14 November 2010
View article titled, Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
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Includes: Supplementary data
Journal Articles

The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo

Olivier E. Pardo, John Latigo, Rosemary E. Jeffery, Emma Nye, Richard Poulsom, Bradley Spencer-Dene, Nick R. Lemoine, Gordon W. Stamp, Eric O. Aboagye, Michael J. Seckl
Journal: Cancer Research
Cancer Res (2009) 69 (22): 8645–8651.
https://doi.org/10.1158/0008-5472.CAN-09-1576
Published: 11 November 2009
View article titled, The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth <em>In vitro</em> and <em>In vivo</em>
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Includes: Supplementary data
Journal Articles

A Role for Glial Cell–Derived Neurotrophic Factor–Induced Expression by Inflammatory Cytokines and RET/GFRα1 Receptor Up-regulation in Breast Cancer

Selma Esseghir, S. Katrina Todd, Toby Hunt, Richard Poulsom, Ivan Plaza-Menacho, Jorge S. Reis-Filho, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11732–11741.
https://doi.org/10.1158/0008-5472.CAN-07-2343
Published: 18 December 2007
View article titled, A Role for Glial Cell–Derived Neurotrophic Factor–Induced Expression by Inflammatory Cytokines and RET/GFRα1 Receptor Up-regulation in Breast Cancer
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Includes: Supplementary data
Journal Articles

Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species

Natalie C. Direkze, Rosemary Jeffery, Kairbaan Hodivala-Dilke, Toby Hunt, Raymond J. Playford, George Elia, Richard Poulsom, Nicholas A. Wright, Malcolm R. Alison
Journal: Cancer Research
Cancer Res (2006) 66 (3): 1265–1269.
https://doi.org/10.1158/0008-5472.CAN-05-3202
Published: 01 February 2006
View article titled, Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species
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Includes: Supplementary data
Journal Articles

Up-regulation of Delta-like 4 Ligand in Human Tumor Vasculature and the Role of Basal Expression in Endothelial Cell Function

Nilay S. Patel, Ji-Liang Li, Daniele Generali, Richard Poulsom, David W. Cranston, Adrian L. Harris
Journal: Cancer Research
Cancer Res (2005) 65 (19): 8690–8697.
https://doi.org/10.1158/0008-5472.CAN-05-1208
Published: 03 October 2005
View article titled, Up-regulation of Delta-like 4 Ligand in Human Tumor Vasculature and the Role of Basal Expression in Endothelial Cell Function
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Journal Articles

AZD2171, an orally active inhibitor of VEGFR tyrosine kinase activity, reduces polyp burden in a mouse model of intestinal cancer

Robert Goodlad, A. James Watkins, Richard Poulsom, Anderson J. Ryan, Stephen R. Wedge, Ian T. Pyrah, Nikki Mandir, Robert W. Wilkinson
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1374.
Published: 01 May 2005
View article titled, AZD2171, an orally active inhibitor of VEGFR tyrosine kinase activity, reduces polyp burden in a mouse model of intestinal cancer
Journal Articles

Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts

Natalie C. Direkze, Kairbaan Hodivala-Dilke, Rosemary Jeffery, Toby Hunt, Richard Poulsom, Dahmane Oukrif, Malcolm R. Alison, Nicholas A. Wright
Journal: Cancer Research
Cancer Res (2004) 64 (23): 8492–8495.
https://doi.org/10.1158/0008-5472.CAN-04-1708
Published: 01 December 2004
View article titled, Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts
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Journal Articles

c-Myc Interacts with Hypoxia to Induce Angiogenesis In vivo by a Vascular Endothelial Growth Factor-Dependent Mechanism

Ulrike E. Knies-Bamforth, Stephen B. Fox, Richard Poulsom, Gerard I. Evan, Adrian L. Harris
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6563–6570.
https://doi.org/10.1158/0008-5472.CAN-03-3176
Published: 16 September 2004
View article titled, c-Myc Interacts with Hypoxia to Induce Angiogenesis <em>In vivo</em> by a Vascular Endothelial Growth Factor-Dependent Mechanism
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Journal Articles

Bottom-up Histogenesis of Colorectal Adenomas: Origin in the Monocryptal Adenoma and Initial Expansion by Crypt Fission

Sean L. Preston, Wai-Man Wong, Annie On-On Chan, Richard Poulsom, Rosemary Jeffery, Robert A. Goodlad, Nikki Mandir, George Elia, Marco Novelli, Walter F. Bodmer, Ian P. Tomlinson, Nicholas A. Wright
Journal: Cancer Research
Cancer Res (2003) 63 (13): 3819–3825.
Published: 01 July 2003
View article titled, Bottom-up Histogenesis of Colorectal Adenomas: <subtitle>Origin in the Monocryptal Adenoma and Initial Expansion by Crypt Fission</subtitle>
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Journal Articles

Expression of the Type 1 Insulin-like Growth Factor Receptor Is Up-Regulated in Primary Prostate Cancer and Commonly Persists in Metastatic Disease

Giles O. Hellawell, Gareth D. H. Turner, David R. Davies, Richard Poulsom, Simon F. Brewster, Valentine M. Macaulay
Journal: Cancer Research
Cancer Res (2002) 62 (10): 2942–2950.
Published: 01 May 2002
View article titled, Expression of the Type 1 Insulin-like Growth Factor Receptor Is Up-Regulated in Primary Prostate Cancer and Commonly Persists in Metastatic Disease
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Journal Articles

Allelic Loss at SMAD4 in Polyps from Juvenile Polyposis Patients and Use of Fluorescence in Situ Hybridization to Demonstrate Clonal Origin of the Epithelium

Kelly Woodford-Richens, Jill Williamson, Stephen Bevan, Joanne Young, Barbara Leggett, Ian Frayling, Yi Thway, Shirley Hodgson, Jin Cheon Kim, Takeo Iwama, Marco Novelli, Denise Sheer, Richard Poulsom, Nicholas Wright, Richard Houlston, Ian Tomlinson
Journal: Cancer Research
Cancer Res (2000) 60 (9): 2477–2482.
Published: 01 May 2000
View article titled, Allelic Loss at <em>SMAD4</em> in Polyps from Juvenile Polyposis Patients and Use of Fluorescence <em>in Situ</em> Hybridization to Demonstrate Clonal Origin of the Epithelium
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