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Richard O. Hynes
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Journal Articles

Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases

Noor Jailkhani, Karl R. Clauser, Howard H. Mak, Steffen Rickelt, Chenxi Tian, Charles A. Whittaker, Kenneth K. Tanabe, Stephen R. Purdy, Steven A. Carr, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2023) 83 (12): 2052–2065.
https://doi.org/10.1158/0008-5472.CAN-22-1532
Published: 15 June 2023
View articletitled, Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases
Open the PDF for Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases in another window
Includes: Supplementary data
Journal Articles

YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation

David C. Benjamin, Joon Ho Kang, Bashar Hamza, Emily M. King, John M. Lamar, Scott R. Manalis, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3867–3879.
https://doi.org/10.1158/0008-5472.CAN-20-0212
Published: 15 September 2020
View articletitled, YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation
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Includes: Multimedia, Supplementary data
Journal Articles

Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

Chenxi Tian, Daniel Öhlund, Steffen Rickelt, Tommy Lidström, Ying Huang, Liangliang Hao, Renee T. Zhao, Oskar Franklin, Sangeeta N. Bhatia, David A. Tuveson, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1461–1474.
https://doi.org/10.1158/0008-5472.CAN-19-2578
Published: 02 April 2020
View articletitled, Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma
Open the PDF for Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches

Jess D. Hebert, Samuel A. Myers, Alexandra Naba, Genevieve Abbruzzese, John M. Lamar, Steven A. Carr, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1475–1485.
https://doi.org/10.1158/0008-5472.CAN-19-2961
Published: 02 April 2020
View articletitled, Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches
Open the PDF for Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches in another window
Includes: Supplementary data
Journal Articles

Abstract 5004: Profiling the extracellular matrix landscape of tumor microenvironments using proteomics

Alexandra Naba, Karl R. Clauser, Steven A. Carr, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5004.
https://doi.org/10.1158/1538-7445.AM2018-5004
Published: 01 July 2018
View articletitled, Abstract 5004: Profiling the extracellular matrix landscape of tumor microenvironments using proteomics
Journal Articles

Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Jatin Roper, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian, Steffen Rickelt, Mohammad Almeqdadi, Katherine Wu, Matthias Oberli, Francisco Sánchez-Rivera, Yoona Park, Xu Liang, George Eng, Martin S. Taylor, Roxana Azimi, Dmitriy Kedrin, Rachit Neupane, Semir Beyaz, Ewa T. Sicinska, Yvelisse Suarez, James Yoo, Lillian Chen, Lawrence Zukerberg, Pekka Katajisto, Vikram Deshpande, Adam Bass, Philip N. Tsichlis, Jacqueline Lees, Robert Langer, Richard O. Hynes, Jianzhu Chen, Arjun J. Bhutkar, Tyler Jacks, Ömer H. Yilmaz
Journal: Cancer Research
Cancer Res (2018) 78 (10_Supplement): B38.
https://doi.org/10.1158/1538-7445.MOUSEMODELS17-B38
Published: 14 May 2018
View articletitled, Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Journal Articles

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

Ran Li, Jess D. Hebert, Tara A. Lee, Hao Xing, Alexandra Boussommier-Calleja, Richard O. Hynes, Douglas A. Lauffenburger, Roger D. Kamm
Journal: Cancer Research
Cancer Res (2017) 77 (2): 279–290.
https://doi.org/10.1158/0008-5472.CAN-16-0442
Published: 16 January 2017
View articletitled, Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
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Includes: Supplementary data
Journal Articles

Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade

Michelle B. Chen, John M. Lamar, Ran Li, Richard O. Hynes, Roger D. Kamm
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2513–2524.
https://doi.org/10.1158/0008-5472.CAN-15-1325
Published: 01 May 2016
View articletitled, Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade
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Includes: Multimedia, Supplementary data
Journal Articles

A Quantitative System for Studying Metastasis Using Transparent Zebrafish

Silja Heilmann, Kajan Ratnakumar, Erin M. Langdon, Emily R. Kansler, Isabella S. Kim, Nathaniel R. Campbell, Elizabeth B. Perry, Amy J. McMahon, Charles K. Kaufman, Ellen van Rooijen, William Lee, Christine A. Iacobuzio-Donahue, Richard O. Hynes, Leonard I. Zon, Joao B. Xavier, Richard M. White
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (20): 4272–4282.
https://doi.org/10.1158/0008-5472.CAN-14-3319
Published: 14 October 2015
View articletitled, A Quantitative System for Studying Metastasis Using Transparent Zebrafish
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1819: Profiling of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis

Chenxi Tian, Daniel Ohlund, Karl Clauser, Steven A. Carr, David A. Tuveson, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1819.
https://doi.org/10.1158/1538-7445.AM2015-1819
Published: 01 August 2015
View articletitled, Abstract 1819: Profiling of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis
Journal Articles

Abstract 306: Role of tumor beta-1 integrin in the tumor cell extravasation cascade

Michelle B. Chen, John M. Lamar, Roger D. Kamm, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 306.
https://doi.org/10.1158/1538-7445.AM2015-306
Published: 01 August 2015
View articletitled, Abstract 306: Role of tumor beta-1 integrin in the tumor cell extravasation cascade
Journal Articles

Abstract A45: Understanding the roles of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis

Chenxi Tian, Daniel Olund, David Tuveson, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A45.
https://doi.org/10.1158/1538-7445.PANCA2014-A45
Published: 30 June 2015
View articletitled, Abstract A45: Understanding the roles of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis
Journal Articles

Abstract PR1: Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis

Mvriam Labelle, Shahinoor Begum, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): PR1.
https://doi.org/10.1158/1538-7445.FBCR11-PR1
Published: 28 October 2014
View articletitled, Abstract PR1: Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
Journal Articles

Abstract 4855: Proteomic characterization of the extracellular matrix in multiple myeloma

Siobhan V. Glavey, Alexandra Naba, Manuela Gambella, Alberto Rocci, Antonio Sacco, John Asara, Antonio Palumbo, Richard O. Hynes, Aldo M. Roccaro, Irene M. Ghobrial
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4855.
https://doi.org/10.1158/1538-7445.AM2014-4855
Published: 01 October 2014
View articletitled, Abstract 4855: Proteomic characterization of the extracellular matrix in multiple myeloma
Journal Articles

Abstract 2973: Adhesion of tumor cells to ECM microarrays identifies novel ECM interactions in metastasis

Nathan E. Reticker-Flynn, David F. Braga Malta, Monte M. Winslow, Mary J. Xu, John M. Lamar, Richard O. Hynes, Tyler E. Jacks, Sangeeta N. Bhatia
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2973.
https://doi.org/10.1158/1538-7445.AM2012-2973
Published: 15 April 2012
View articletitled, Abstract 2973: Adhesion of tumor cells to ECM microarrays identifies novel ECM interactions in metastasis
Journal Articles

Abstract SY28-01: Multiple changes in tumor extracellular matrices

Richard O. Hynes, Alexandra Naba, Sebastian Hoersch, Karl Clauser, Steven A. Carr
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): SY28-01.
https://doi.org/10.1158/1538-7445.AM2012-SY28-01
Published: 15 April 2012
View articletitled, Abstract SY28-01: Multiple changes in tumor extracellular matrices
Journal Articles

GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression

Liquan Yang, Guangchun Chen, Sonali Mohanty, Glynis Scott, Fabeha Fazal, Arshad Rahman, Shahinoor Begum, Richard O. Hynes, Lei Xu
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5558–5568.
https://doi.org/10.1158/0008-5472.CAN-10-4543
Published: 11 August 2011
View articletitled, GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression
Open the PDF for GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression in another window
Includes: Supplementary data
Journal Articles

Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors

Olga Sobolev, Patrick Stern, Adam Lacy-Hulbert, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2531–2539.
https://doi.org/10.1158/0008-5472.CAN-08-3126
Published: 17 March 2009
View articletitled, Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors
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Includes: Supplementary data
Journal Articles

A Direct Test of Potential Roles for β3 and β5 Integrins in Growth and Metastasis of Murine Mammary Carcinomas

Daniela Taverna, Denise Crowley, Mary Connolly, Roderick T. Bronson, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2005) 65 (22): 10324–10329.
https://doi.org/10.1158/0008-5472.CAN-04-4098
Published: 15 November 2005
View articletitled, A Direct Test of Potential Roles for β3 and β5 Integrins in Growth and Metastasis of Murine Mammary Carcinomas
Open the PDF for A Direct Test of Potential Roles for β3 and β5 Integrins in Growth and Metastasis of Murine Mammary Carcinomas in another window
Includes: Supplementary data
Journal Articles

Tumor-Secreted Vascular Endothelial Growth Factor-C Is Necessary for Prostate Cancer Lymphangiogenesis, but Lymphangiogenesis Is Unnecessary for Lymph Node Metastasis

Sunny Y. Wong, Herbert Haack, Denise Crowley, Marc Barry, Roderick T. Bronson, Richard O. Hynes
Journal: Cancer Research
Cancer Res (2005) 65 (21): 9789–9798.
https://doi.org/10.1158/0008-5472.CAN-05-0901
Published: 01 November 2005
View articletitled, Tumor-Secreted Vascular Endothelial Growth Factor-C Is Necessary for Prostate Cancer Lymphangiogenesis, but Lymphangiogenesis Is Unnecessary for Lymph Node Metastasis
Open the PDF for Tumor-Secreted Vascular Endothelial Growth Factor-C Is Necessary for Prostate Cancer Lymphangiogenesis, but Lymphangiogenesis Is Unnecessary for Lymph Node Metastasis in another window
Includes: Supplementary data