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Richard L. Klemke
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Journal Articles

Abstract LB-067: Cargocytes: A novel cell therapy platform to drive anti-tumor immunity

Richard L. Klemke, Huawei Wang, Bei Liu, Christina Alarcon, Felicia Watson
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-067.
https://doi.org/10.1158/1538-7445.AM2019-LB-067
Published: 01 July 2019
View article titled, Abstract LB-067: Cargocytes: A novel cell therapy platform to drive anti-tumor immunity
Journal Articles

KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop

Ken Fujimura, Huawei Wang, Felicia Watson, Richard L. Klemke
Journal: Cancer Research
Cancer Res (2018) 78 (6): 1444–1456.
https://doi.org/10.1158/0008-5472.CAN-17-2873
Published: 14 March 2018
View article titled, KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop
Open the PDF for KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop in another window
Includes: Supplementary data
Journal Articles

Abstract 1811: A PEAK1/GATA2 signaling axis controls VEGFR2 expression to mediate angiogenesis

Richard L. Klemke
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1811.
https://doi.org/10.1158/1538-7445.AM2017-1811
Published: 01 July 2017
View article titled, Abstract 1811: A PEAK1/GATA2 signaling axis controls VEGFR2 expression to mediate angiogenesis
Journal Articles

eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth

Jan Strnadel, Sunkyu Choi, Ken Fujimura, Huawei Wang, Wei Zhang, Meghan Wyse, Tracy Wright, Emilie Gross, Carlos Peinado, Hyun Woo Park, Jack Bui, Jonathan Kelber, Michael Bouvet, Kun-Liang Guan, Richard L. Klemke
Journal: Cancer Research
Cancer Res (2017) 77 (8): 1997–2007.
https://doi.org/10.1158/0008-5472.CAN-16-2594
Published: 13 April 2017
View article titled, eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth
Open the PDF for eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth in another window
Includes: Supplementary data
Journal Articles

A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer

Ken Fujimura, Tracy Wright, Jan Strnadel, Sharmeela Kaushal, Cristina Metildi, Andrew M. Lowy, Michael Bouvet, Jonathan A. Kelber, Richard L. Klemke
Journal: Cancer Research
Cancer Res (2014) 74 (22): 6671–6681.
https://doi.org/10.1158/0008-5472.CAN-14-1031
Published: 13 November 2014
View article titled, A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Open the PDF for A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4911: Aggressive variants isolated from human pancreatic cancer passaging in mice are enriched in stem cell markers and PEAK1 expression.

Cristina A. Metildi, Sharmeela Kaushal, Jan Strnadel, Tracy Wright, Jonathan A. Kelber, Richard L. Klemke, Robert M. Hoffman, Michael Bouvet
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4911.
https://doi.org/10.1158/1538-7445.AM2013-4911
Published: 15 April 2013
View article titled, Abstract 4911: Aggressive variants isolated from human pancreatic cancer passaging in mice are enriched in stem cell markers and PEAK1 expression.
Journal Articles

KRas Induces a Src/PEAK1/ErbB2 Kinase Amplification Loop That Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer

Jonathan A. Kelber, Theresa Reno, Sharmeela Kaushal, Cristina Metildi, Tracy Wright, Konstantin Stoletov, Jessica M. Weems, Frederick D. Park, Evangeline Mose, Yingchun Wang, Robert M. Hoffman, Andrew M. Lowy, Michael Bouvet, Richard L. Klemke
Journal: Cancer Research
Cancer Res (2012) 72 (10): 2554–2564.
https://doi.org/10.1158/0008-5472.CAN-11-3552
Published: 14 May 2012
View article titled, KRas Induces a Src/PEAK1/ErbB2 Kinase Amplification Loop That Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer
Open the PDF for KRas Induces a Src/PEAK1/ErbB2 Kinase Amplification Loop That Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4167: KRas induces a Src/PEAK1/ErbB2 kinase amplification loop to drive pancreatic cancer growth, metastasis and therapy resistance

Jonathan A. Kelber, Theresa Reno, Sharmeela Kaushal, Cristina Metildi, Konstantin Stoletov, Jessica Weems, Fred D. Park, Tracy Wright, Evangeline Mose, Robert M. Hoffman, Andrew M. Lowy, Michael M. Bouvet, Richard L. Klemke
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4167.
https://doi.org/10.1158/1538-7445.AM2012-4167
Published: 15 April 2012
View article titled, Abstract 4167: KRas induces a Src/PEAK1/ErbB2 kinase amplification loop to drive pancreatic cancer growth, metastasis and therapy resistance
Journal Articles

Abstract 914: Ciclopirox olamine (CPX) inhibits breast cancer cell proliferation by blocking the formation of a PEAK1-Src-eIF5a protein complex

Jessica M. Weems, Theresa A. Reno, Richard L. Klemke
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 914.
https://doi.org/10.1158/1538-7445.AM2012-914
Published: 15 April 2012
View article titled, Abstract 914: Ciclopirox olamine (CPX) inhibits breast cancer cell proliferation by blocking the formation of a PEAK1-Src-eIF5a protein complex
Journal Articles

Abstract 4464: Ciclopirox Olamine alters PEAK-1-mediated cytoskeleton organization and invasion of metastatic cancer cells

Jessica M. Weems, Richard L. Klemke
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4464.
https://doi.org/10.1158/1538-7445.AM2011-4464
Published: 15 April 2011
View article titled, Abstract 4464: Ciclopirox Olamine alters PEAK-1-mediated cytoskeleton organization and invasion of metastatic cancer cells
Journal Articles

Abstract 4006: Soluble ALK4 extracellular domain antagonizes oncogenic Cripto signaling and inhibits tumor growth

Benjamin T. Spike, Jonathan A. Kelber, Evan C. Booker, Richard L. Klemke, Geoffrey M. Wahl, Wylie W. Vale, Peter C. Gray
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4006.
https://doi.org/10.1158/1538-7445.AM10-4006
Published: 15 April 2010
View article titled, Abstract 4006: Soluble ALK4 extracellular domain antagonizes oncogenic Cripto signaling and inhibits tumor growth