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Richard B. Lock
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Journal Articles

Abstract 1905: The ROR1 antibody-drug conjugate, MK-2140, enhances the efficacy of established drugs in preclinical models of pediatric acute lymphoblastic leukemia

Richard B. Lock, Kathryn Evans, Ben Watts, Edward P. Bowman, Steven Neuhauser, Timothy Stearns, Jeffrey H. Chuang, Vivek M. Phillip, Katti A. Jessen, Emily L. Jocoy, Carol J. Bult, Beverly A. Teicher, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1905.
https://doi.org/10.1158/1538-7445.AM2024-1905
Published: 22 March 2024
View article titled, Abstract 1905: The ROR1 antibody-drug conjugate, MK-2140, enhances the efficacy of established drugs in preclinical models of pediatric acute lymphoblastic leukemia
Journal Articles

High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

Chelsea Mayoh, Jie Mao, Jinhan Xie, Gabor Tax, Shu-Oi Chow, Roxanne Cadiz, Karina Pazaky, Paulette Barahona, Pamela Ajuyah, Peter Trebilcock, Angela Malquori, Kate Gunther, Anica Avila, Doo Young Yun, Stephanie Alfred, Anjana Gopalakrishnan, Alvin Kamili, Marie Wong, Mark J. Cowley, Sophie Jessop, Loretta M.S. Lau, Toby N. Trahair, David S. Ziegler, Jamie I. Fletcher, Andrew J. Gifford, Maria Tsoli, Glenn M. Marshall, Michelle Haber, Vanessa Tyrrell, Timothy W. Failes, Greg M. Arndt, Richard B. Lock, Paul G. Ekert, M. Emmy M. Dolman
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2716–2732.
https://doi.org/10.1158/0008-5472.CAN-22-3702
Published: 15 August 2023
View article titled, High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer
Open the PDF for High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB171: The differentiated CD47 monoclonal antibody AO-176 exhibits significant in vivo activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL)

Richard B. Lock, Kathryn Evans, Narimanne El-Zein, Eric J. Earley, Stephen W. Erickson, Beverly A. Teicher, Victoria Sung, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB171.
https://doi.org/10.1158/1538-7445.AM2021-LB171
Published: 01 July 2021
View article titled, Abstract LB171: The differentiated CD47 monoclonal antibody AO-176 exhibits significant <em>in vivo</em> activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL)
Journal Articles

Abstract 3038: Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)

Richard B. Lock, Kathryn Evans, Narimanne El-Zein, Brian J. Lannutti, Katti A. Jessen, Eric J. Earley, Stephen W. Erickson, Malcolm A. Smith, Raushan Kurmasheva, Peter J. Houghton
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3038.
https://doi.org/10.1158/1538-7445.AM2021-3038
Published: 01 July 2021
View article titled, Abstract 3038: Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)
Journal Articles

Abstract 3039: Pediatric preclinical testing consortium evaluation of the dual SYK/FLT3 inhibitor TAK-659 in xenograft models of pediatric acute lymphoblastic leukemia

Richard B. Lock, Kathryn Evans, Narimanne El-Zein, Eric J. Earley, Stephen W. Erickson, Beverly A. Teicher, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3039.
https://doi.org/10.1158/1538-7445.AM2021-3039
Published: 01 July 2021
View article titled, Abstract 3039: Pediatric preclinical testing consortium evaluation of the dual SYK/FLT3 inhibitor TAK-659 in xenograft models of pediatric acute lymphoblastic leukemia
Journal Articles

Abstract 4181: The XPO1 inhibitior, eltanexor, exhibits potent in vivo activity against a broad range of pediatric acute lymphoblastic leukemia subtypes

Richard B. Lock, Kathryn Evans, Connor D. Jones, Stephen W. Erickson, Beverly A. Teicher, TJ Unger, Yosef Landesman, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4181.
https://doi.org/10.1158/1538-7445.AM2020-4181
Published: 15 August 2020
View article titled, Abstract 4181: The XPO1 inhibitior, eltanexor, exhibits potent <em>in vivo</em> activity against a broad range of pediatric acute lymphoblastic leukemia subtypes
Journal Articles

Abstract SY09-02: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia

Michelle Haber, Mark J. Cowley, Paul Ekert, Loretta Lau, Emily Mould, ZCC PRISM Omics Core, ZCC Prelinical Drug Testing Core, Andrew Gifford, Richard B. Lock, Glenn M. Marshall, Murray D. Norris, Tracey O'Brien, Dong Anh Khuong Quang, David Thomas, Toby Trahair, Katherine Tucker, David S. Ziegler, Vanessa Tyrrell
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): SY09-02.
https://doi.org/10.1158/1538-7445.AM2020-SY09-02
Published: 15 August 2020
View article titled, Abstract SY09-02: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia
Journal Articles

Abstract A52: Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with high-risk cancer

Paulette Barahona, Jamie Fletcher, Noemi Fuentes-Bolanos, Marie-Emilie Gauthier, Michelle Haber, Richard B. Lock, Glenn M. Marshall, Chelsea Mayoh, Emily Mould, Sumanth Nagabushan, Murray Norris, Tracey O’Brien, Alexandra Sherstyuk, David Thomas, Toby Trahair, Katherine Tucker, Meera Warby, Marie Wong, David S. Ziegler, Vanessa J. Tyrrell, Paul Ekert, Mark J. Cowley, Loretta Lau, Dong-Anh Khuong Quang, Zero Childhood Cancer Program National Consortium
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A52.
https://doi.org/10.1158/1538-7445.PEDCA19-A52
Published: 15 July 2020
View article titled, Abstract A52: Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with high-risk cancer
Journal Articles

Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts

Eric Earley, Richard Gorlick, Peter J. Houghton, John M. Maris, Xiao-Nan Li, Richard B. Lock, Beverly Teicher, Malcolm A. Smith, Stephen W. Erickson
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-321.
https://doi.org/10.1158/1538-7445.AM2019-LB-321
Published: 01 July 2019
View article titled, Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts
Journal Articles

Abstract 3111: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer

Emily V. Mould, Loretta Lau, Greg Arndt, Paulette Barahona, Mark J. Cowley, Paul Ekert, Tim Failes, Jamie Fletcher, Andrew Gifford, Dylan Grebert-Wade, Michelle Haber, Alvin Kamili, Amit Kumar, Richard B. Lock, Glenn M. Marshall, Chelsea Mayoh, Murray Norris, Tracey O'Brien, Dong Anh Khuong Quang, Patrick Strong, Alexandra Sherstyuk, Toby Trahair, Maria Tsoli, Katherine Tucker, Meera Warby, Marie Wong, Jinhan Xie, David S. Ziegler, Vanessa Tyrrell
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3111.
https://doi.org/10.1158/1538-7445.AM2019-3111
Published: 01 July 2019
View article titled, Abstract 3111: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer
Journal Articles

Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies

Caroline Atkinson, Carole M. Tactacan, Alvin Kamili, Federica Saletta, Christine Gana, Georgina L. Eden, Chelsea Mayoh, Richard B. Lock, Murray D. Norris, Michelle Haber, Andrew J. Gifford, Toby N. Trahair, Jamie I. Fletcher
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4741.
https://doi.org/10.1158/1538-7445.AM2019-4741
Published: 01 July 2019
View article titled, Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies
Journal Articles

Abstract 4820: Pediatric preclinical testing consortium evaluation of the CD123 antibody drug conjugate, IMGN632, against xenograft models of pediatric acute lymphoblastic leukemia

Kathryn Evans, Narimanne El-Zein, Connor Jones, Stephen W. Erickson, Yuelong Guo, Beverly A. Teicher, Sharlene Adams, Patrick A. Zweidler-McKay, Malcolm A. Smith, Richard B. Lock
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4820.
https://doi.org/10.1158/1538-7445.AM2019-4820
Published: 01 July 2019
View article titled, Abstract 4820: Pediatric preclinical testing consortium evaluation of the CD123 antibody drug conjugate, IMGN632, against xenograft models of pediatric acute lymphoblastic leukemia
Journal Articles

Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts

Beverly A. Teicher, Richard B. Lock, Kathryn Evans, Peter J. Houghton, Raushan T. Kurmasheva, Richard Gorlicki, Steve Erickson, Donn Wishka, Joel Morris, Michael Difilippantonio, Jerry E. Collins, Malcolm A. Smith, James H. Doroshow
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3839.
https://doi.org/10.1158/1538-7445.AM2019-3839
Published: 01 July 2019
View article titled, Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts
Journal Articles

Abstract 3187: Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia

Richard B. Lock, Kathryn Evans, Tara Pritchard, Stephen W. Erickson, Yuelong Guo, David A. Claremon, Gerard M. McGeehan, Beverly A. Teicher, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3187.
https://doi.org/10.1158/1538-7445.AM2018-3187
Published: 01 July 2018
View article titled, Abstract 3187: Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia
Journal Articles

Abstract 3173: Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia

Duohui Jing, Yizhou Huang, Xiaoyun Liu, Keith Sia, Rebecca C. Poulos, Miriam Span, Chao Zhang, Jianqing Mi, Jason WH Wong, Dominik Beck, John E. Pimanda, Richard B. Lock
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3173.
https://doi.org/10.1158/1538-7445.AM2018-3173
Published: 01 July 2018
View article titled, Abstract 3173: Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia
Journal Articles

Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia

Klaartje Somers, Shiloh Middlemiss, Asel Biktasova, Mawar Karsa, Leanna Cheung, Angelika Kosciolek, Kathryn Evans, Chelsea Mayoh, Ursula R. Kees, Lioubov Korotchkina, Olga B. Chernova, Richard B. Lock, Andrei V. Gudkov, Michelle Haber, Murray D. Norris, Michelle J. Henderson
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1175.
https://doi.org/10.1158/1538-7445.AM2017-1175
Published: 01 July 2017
View article titled, Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia
Journal Articles

Abstract 1942: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibits in vitro and in vivo efficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia

Kathryn Evans, Tara Pritchard, Michelle J. Henderson, Klaartje Somers, Mawar Karsa, Leanna Cheung, Raymond Yung, Stephen W. Erickson, Lioubov Korotchkina, Olga Chernova, Andrei Gudkov, Malcolm A. Smith, Richard B. Lock
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1942.
https://doi.org/10.1158/1538-7445.AM2017-1942
Published: 01 July 2017
View article titled, Abstract 1942: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibits <em>in vitro</em> and <em>in vivo</em> efficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia
Journal Articles

Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

Brendan Murphy, Han Yin, John M. Maris, E. Anders Kolb, Richard Gorlick, C. Patrick Reynolds, Min H. Kang, Stephen T. Keir, Raushan T. Kurmasheva, Igor Dvorchik, Jianrong Wu, Catherine A. Billups, Nana Boateng, Malcolm A. Smith, Richard B. Lock, Peter J. Houghton
Journal: Cancer Research
Cancer Res (2016) 76 (19): 5798–5809.
https://doi.org/10.1158/0008-5472.CAN-16-0122
Published: 02 October 2016
View article titled, Evaluation of Alternative <em>In Vivo</em> Drug Screening Methodology: A Single Mouse Analysis
Open the PDF for Evaluation of Alternative <em>In Vivo</em> Drug Screening Methodology: A Single Mouse Analysis in another window
Includes: Supplementary data
Journal Articles

Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant

Jennifer Richmond, Alissa Robbins, Kathryn Evans, Dominik Beck, Raushan T. Kurmasheva, Catherine A. Billups, Hernan Carol, Sue Heatley, Rosemary Sutton, Glenn M. Marshall, Deborah White, John Pimanda, Peter J. Houghton, Malcolm A. Smith, Richard B. Lock
Journal: Cancer Research
Cancer Res (2016) 76 (15): 4579–4591.
https://doi.org/10.1158/0008-5472.CAN-16-0523
Published: 31 July 2016
View article titled, Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant
Open the PDF for Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant in another window
Includes: Supplementary data
Journal Articles

Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia

Sibasish Dolai, Keith C.S. Sia, Alissa K. Robbins, Ling Zhong, Sue L. Heatley, Tiffaney L. Vincent, Falko Hochgräfe, Rosemary Sutton, Raushan T. Kurmasheva, Tamas Revesz, Deborah L. White, Peter J. Houghton, Malcolm A. Smith, David T. Teachey, Roger J. Daly, Mark J. Raftery, Richard B. Lock
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2766–2777.
https://doi.org/10.1158/0008-5472.CAN-15-2786
Published: 01 May 2016
View article titled, Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Open the PDF for Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia in another window
Includes: Supplementary data