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Richard A. Heyman
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Journal Articles

Abstract 5053: Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancer

James Joseph, Steven Govek, Beatrice Darimont, Daniel Brigham, Anna Aparicio, Eric Bischoff, Mehmet Kahraman, Michelle Nannini, Joshua Kaufman, Andily Lai, Kyoung-Jin Lee, Jason Oeh, Nhin Lu, Wei Zhou, Michael Moon, Jing Qian, John Sensintaffar, Gang Shao, Deepak Sampath, Lori S. Friedman, Peter Rix, Richard A. Heyman, Nicholas Smith, Jeffrey H. Hager
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5053.
https://doi.org/10.1158/1538-7445.AM2015-5053
Published: 01 August 2015
View article titled, Abstract 5053: Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancer
Journal Articles

Abstract C16: Targeting AR in castration-resistant prostate cancer: Development of ARN-509 and second-generation antiandrogen resistance models

James D. Joseph, Anna Aparicio, Josh Kaufman, Jackie Julien, Celine Bonnefous, Nicholas D. Smith, Peter Rix, Michael E. Jung, Charles L. Sawyers, Richard A. Heyman, Jeffrey H. Hager, Nicola J. Clegg, John Sensintaffar, Nhin Lu, Kate Grillot, Eric Bischoff, Gang Shao, Jing Qian, Beatrice Darimont
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): C16.
https://doi.org/10.1158/1538-7445.PRCA2012-C16
Published: 09 May 2013
View article titled, Abstract C16: Targeting AR in castration-resistant prostate cancer: Development of ARN-509 and second-generation antiandrogen resistance models
Journal Articles

ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment

Nicola J. Clegg, John Wongvipat, James D. Joseph, Chris Tran, Samedy Ouk, Anna Dilhas, Yu Chen, Kate Grillot, Eric D. Bischoff, Ling Cai, Anna Aparicio, Steven Dorow, Vivek Arora, Gang Shao, Jing Qian, Hong Zhao, Guangbin Yang, Chunyan Cao, John Sensintaffar, Teresa Wasielewska, Mark R. Herbert, Celine Bonnefous, Beatrice Darimont, Howard I. Scher, Peter Smith-Jones, Mark Klang, Nicholas D. Smith, Elisa De Stanchina, Nian Wu, Ouathek Ouerfelli, Peter J. Rix, Richard A. Heyman, Michael E. Jung, Charles L. Sawyers, Jeffrey H. Hager
Journal: Cancer Research
Cancer Res (2012) 72 (6): 1494–1503.
https://doi.org/10.1158/0008-5472.CAN-11-3948
Published: 14 March 2012
View article titled, ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
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Includes: Supplementary data
Journal Articles

The Selective Estrogen Receptor Modulator Arzoxifene and the Rexinoid LG100268 Cooperate to Promote Transforming Growth Factor β-Dependent Apoptosis in Breast Cancer

Mara H. Rendi, Nanjoo Suh, William W. Lamph, Stan Krajewski, John C. Reed, Richard A. Heyman, Andrew Berchuck, Karen Liby, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2004) 64 (10): 3566–3571.
https://doi.org/10.1158/0008-5472.CAN-04-0234
Published: 17 May 2004
View article titled, The Selective Estrogen Receptor Modulator Arzoxifene and the Rexinoid LG100268 Cooperate to Promote Transforming Growth Factor β-Dependent Apoptosis in Breast Cancer
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Journal Articles

The SERM, Arzoxifene, and the rexinoid, LG100268, synergize to promote apoptosis in colon cancer.

Mara H. Rendi, Nanjoo Suh, Karen Liby, William W. Lamph, Alan D. Palkowitz, Timothy A. Grese, Andrew L. Glasebrook, Richard A. Heyman, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 701.
Published: 01 April 2004
View article titled, The SERM, Arzoxifene, and the rexinoid, LG100268, synergize to promote apoptosis in colon cancer.
Journal Articles

Beyond Tamoxifen: The Retinoid X Receptor-selective Ligand LGD1069 (TARGRETIN) Causes Complete Regression of Mammary Carcinoma

Eric D. Bischoff, Marco M. Gottardis, Thomas E. Moon, Richard A. Heyman, William W. Lamph
Journal: Cancer Research
Cancer Res (1998) 58 (3): 479–484.
Published: 01 February 1998
View article titled, Beyond Tamoxifen: The Retinoid X Receptor-selective Ligand LGD1069 (TARGRETIN) Causes Complete Regression of Mammary Carcinoma
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Journal Articles

Differential Effects of Synthetic Nuclear Retinoid Receptor-selective Retinoids on the Growth of Human Non-Small Cell Lung Carcinoma Cells

Shi-Yong Sun, Ping Yue, Marcia I. Dawson, Braham Shroot, Serge Michel, William W. Lamph, Richard A. Heyman, Min Teng, Roshantha A. S. Chandraratna, Koichi Shudo, Waun K. Hong, Reuben Lotan
Journal: Cancer Research
Cancer Res (1997) 57 (21): 4931–4939.
Published: 01 November 1997
View article titled, Differential Effects of Synthetic Nuclear Retinoid Receptor-selective Retinoids on the Growth of Human Non-Small Cell Lung Carcinoma Cells
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Journal Articles

Retinoic Acid Receptor α Expression Correlates with Retinoid-induced Growth Inhibition of Human Breast Cancer Cells Regardless of Estrogen Receptor Status

Patrick Fitzgerald, Min Teng, Roshantha A. S. Chandraratna, Richard A. Heyman, Elizabeth A. Allegretto
Journal: Cancer Research
Cancer Res (1997) 57 (13): 2642–2650.
Published: 01 July 1997
View article titled, Retinoic Acid Receptor α Expression Correlates with Retinoid-induced Growth Inhibition of Human Breast Cancer Cells Regardless of Estrogen Receptor Status
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Journal Articles

A Novel Retinoic Acid Receptor-selective Retinoid, ALRT1550, Has Potent Antitumor Activity against Human Oral Squamous Carcinoma Xenografts in Nude Mice

David R. Shalinsky, Eric D. Bischoff, William W. Lamph, Lin Zhang, Marcus F. Boehm, Peter J. A. Davies, Alex M. Nadzan, Richard A. Heyman
Journal: Cancer Research
Cancer Res (1997) 57 (1): 162–168.
Published: 01 January 1997
View article titled, A Novel Retinoic Acid Receptor-selective Retinoid, ALRT1550, Has Potent Antitumor Activity against Human Oral Squamous Carcinoma Xenografts in Nude Mice
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Journal Articles

Chemoprevention of Mammary Carcinoma by LGD1069 (Targretin): An RXR-selective Ligand

Marco M. Gottardis, Eric D. Bischoff, Michael A. Shirley, Murriel A. Wagoner, William W. Lamph, Richard A. Heyman
Journal: Cancer Research
Cancer Res (1996) 56 (24): 5566–5570.
Published: 01 December 1996
View article titled, Chemoprevention of Mammary Carcinoma by LGD1069 (Targretin): An RXR-selective Ligand
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