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Reuben Lotan
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Journal Articles

Gprc5a Deletion Enhances the Transformed Phenotype in Normal and Malignant Lung Epithelial Cells by Eliciting Persistent Stat3 Signaling Induced by Autocrine Leukemia Inhibitory Factor

Yulong Chen, Jiong Deng, Junya Fujimoto, Humam Kadara, Taoyan Men, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8917–8926.
https://doi.org/10.1158/0008-5472.CAN-10-0518
Published: 31 October 2010
View article titled, <em>Gprc5a</em> Deletion Enhances the Transformed Phenotype in Normal and Malignant Lung Epithelial Cells by Eliciting Persistent Stat3 Signaling Induced by Autocrine Leukemia Inhibitory Factor
Open the PDF for <em>Gprc5a</em> Deletion Enhances the Transformed Phenotype in Normal and Malignant Lung Epithelial Cells by Eliciting Persistent Stat3 Signaling Induced by Autocrine Leukemia Inhibitory Factor in another window
Includes: Supplementary data
Journal Articles

Abstract 4995: Loss of the lung-specific tumor suppressor Gprc5a causes persistent activation of Stat3 leading to increased survival signaling in normal and malignant lung epithelial cells

Yulong Chen, Jiong Deng, Junya Fujimoto, Humam Kadara, Xiaofeng Ye, Taoyan Men, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4995.
https://doi.org/10.1158/1538-7445.AM10-4995
Published: 15 April 2010
View article titled, Abstract 4995: Loss of the lung-specific tumor suppressor Gprc5a causes persistent activation of Stat3 leading to increased survival signaling in normal and malignant lung epithelial cells
Journal Articles

Abstract 2466: Tobacco carcinogen-enhanced lung tumorigenesis in Gprc5a knockout mice recapitulates human lung cancer development

Junya Fujimoto, Humam N. Kadara, Qingguo Tao, Taoyan Men, Carolyn van Pelt, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2466.
https://doi.org/10.1158/1538-7445.AM10-2466
Published: 15 April 2010
View article titled, Abstract 2466: Tobacco carcinogen-enhanced lung tumorigenesis in Gprc5a knockout mice recapitulates human lung cancer development
Journal Articles

Abstract 4817: A five-gene signature predictive of survival in lung adenocarcinoma but not in squamous cell carcinoma

Humam N. Kadara, Waun K. Hong, Ignacio I. Wistuba, Reuben Lotan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4817.
https://doi.org/10.1158/1538-7445.AM10-4817
Published: 15 April 2010
View article titled, Abstract 4817: A five-gene signature predictive of survival in lung adenocarcinoma but not in squamous cell carcinoma
Journal Articles

Abstract #5347: The lung tumor suppressor GPRC5A inhibits activation of NF-\#954;B in human non-small cell lung adenocarcinoma cells

Jiong Deng, Junya Fujimoto, Xiao-Feng Ye, Tao-Yan Men, Xiao-Feng Lin, Yu-Long Chen, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5347.
Published: 01 May 2009
View article titled, Abstract #5347: The lung tumor suppressor GPRC5A inhibits activation of NF-\#954;B in human non-small cell lung adenocarcinoma cells
Journal Articles

Abstract #3453: Suppression of lung specific tumor suppressor GPRC5A expression through inhibition of retinoic acid signaling by NF-\#954;B/p65 in normal and malignant human lung cells

Xiaofeng Ye, Jiong Deng, Xiaofeng Lin, Binhua Zhou, Reuben Lotan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3453.
Published: 01 May 2009
View article titled, Abstract #3453: Suppression of lung specific tumor suppressor GPRC5A expression through inhibition of retinoic acid signaling by NF-\#954;B/p65 in normal and malignant human lung cells
Journal Articles

Abstract #1437: Gene expression signatures of tumor suppressor Gprc5a loss in murine lung cells predict poor survival in human lung adenocarcinomas

Humam Kadara, Junya Fujimoto, Taoyan Men, Dafna Lotan, Xiaofeng Ye, Ju-Seog Lee, Reuben Lotan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1437.
Published: 01 May 2009
View article titled, Abstract #1437: Gene expression signatures of tumor suppressor Gprc5a loss in murine lung cells predict poor survival in human lung adenocarcinomas
Journal Articles

Abstract #LB-265: Identification of prognostic markers by integrative gene expression analysis of an in vitro model of lung carcinogenesis and their validation in lung cancer tissue specimens

Humam Kadara, Ludovic Lacroix, Carmen Behrens, Luisa Solis, Xuemin Gu, J. Jack Lee, Eiji Tahara, Waun Hong, Ignacio Wistuba, Reuben Lotan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): LB-265.
Published: 01 May 2009
View article titled, Abstract #LB-265: Identification of prognostic markers by integrative gene expression analysis of an in vitro model of lung carcinogenesis and their validation in lung cancer tissue specimens
Journal Articles

Involvement of Rac in Fenretinide-Induced Apoptosis

Humam Kadara, Eiji Tahara, Hyun-Jung Kim, Dafna Lotan, Jeffrey Myers, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (11): 4416–4423.
https://doi.org/10.1158/0008-5472.CAN-08-0031
Published: 02 June 2008
View article titled, Involvement of Rac in Fenretinide-Induced Apoptosis
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Journal Articles

Targeting cap-dependent translation: chemoprevention potential in oral carcinogenesis

Nitin Chakravarti, Ludovic Lacroix, Do-Jun Yoon, Jerry Shay, Jeffrey Myers, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4653.
Published: 01 May 2008
View article titled, Targeting cap-dependent translation: chemoprevention potential in oral carcinogenesis
Journal Articles

Chemoprevention of NNK-induced lung carcinogenesis in the Gprc5a knockout mouse by budesonide

Junya Fujimoto, Taoyan Men, Carolyn Van Pelt, J Lee, Xuemin Gu, Levy Kopelovich, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1602.
Published: 01 May 2008
View article titled, Chemoprevention of NNK-induced lung carcinogenesis in the Gprc5a knockout mouse by budesonide
Journal Articles

The histone deacetylase inhibitor valproic acid enhances the antineoplastic activity of curcumin against head and neck squanous carcinoma cells in vitro.

Ann Gillenwater, Meiling Zhong, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 745.
Published: 01 May 2008
View article titled, The histone deacetylase inhibitor valproic acid enhances the antineoplastic activity of curcumin against head and neck squanous carcinoma cells <em>in vitro</em>.
Journal Articles

Enhancement of lung carcinogenesis in a Gprc5a knockout mouse by chronic inflammation induced by inhalation of a nontypeable Haemophilus influenzae lysate

Peter Barta, Seyed Moghaddam, Carolyn Van Pelt, Taoyan Men, Burton Dickey, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2241.
Published: 01 May 2008
View article titled, Enhancement of lung carcinogenesis in a Gprc5a knockout mouse by chronic inflammation induced by inhalation of a nontypeable Haemophilus influenzae lysate
Journal Articles

Evidence for the involvement of NF-κB and inflammation in the promotion of lung carcinogenesis in the Gprc5a knockout mouse model

Jiong Deng, Xiaofeng Ye, Junya Fujimoto, Qingguo Tao, Taoyan Men, Carolyn Van Pelt, Xiaofeng Lin, Yulong Chen, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4725.
Published: 01 May 2008
View article titled, Evidence for the involvement of NF-κB and inflammation in the promotion of lung carcinogenesis in the Gprc5a knockout mouse model
Journal Articles

Differential effects of 4HPR on gene expression and apoptosis in normal and malignant cells of the head and neck despite induction of reactive oxygen species in both cell types

Humam Kadara, Hyun Jung Kim, Eiji Tahara, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2282A.
Published: 01 May 2008
View article titled, Differential effects of 4HPR on gene expression and apoptosis in normal and malignant cells of the head and neck despite induction of reactive oxygen species in both cell types
Journal Articles

Proteomics-Based Identification of Proteins Secreted in Apical Surface Fluid of Squamous Metaplastic Human Tracheobronchial Epithelial Cells Cultured by Three-Dimensional Organotypic Air-Liquid Interface Method

Seung-Wook Kim, Kyounga Cheon, Chang-Hoon Kim, Joo-Heon Yoon, David H. Hawke, Ryuji Kobayashi, Ludmila Prudkin, Ignacio I. Wistuba, Reuben Lotan, Waun Ki Hong, Ja Seok Koo
Journal: Cancer Research
Cancer Res (2007) 67 (14): 6565–6573.
https://doi.org/10.1158/0008-5472.CAN-06-2783
Published: 17 July 2007
View article titled, Proteomics-Based Identification of Proteins Secreted in Apical Surface Fluid of Squamous Metaplastic Human Tracheobronchial Epithelial Cells Cultured by Three-Dimensional Organotypic Air-Liquid Interface Method
Open the PDF for Proteomics-Based Identification of Proteins Secreted in Apical Surface Fluid of Squamous Metaplastic Human Tracheobronchial Epithelial Cells Cultured by Three-Dimensional Organotypic Air-Liquid Interface Method in another window
Journal Articles

Identification of biomarkers for human lung carcinogenesis by analysis of transcriptomes of cell lines representing different stages of lung carcinogenesis

Ludovic Lacroix, Eiji Tahara, Carmen Behrens, Humam Kadara, Dafna Lotan, Ignacio Wistuba, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2956.
Published: 01 May 2007
View article titled, Identification of biomarkers for human lung carcinogenesis by analysis of transcriptomes of cell lines representing different stages of lung carcinogenesis
Journal Articles

Differential Rac-mediated generation of reactive oxygen species increases sensitivity of metastatic cancer cells to the proapoptotic synthetic retinoid 4HPR relative to their primary cancer cell counterparts

Humam Kadara, Eiji Tahara, Hyun-Jung Kim, Dafna Lotan, Jeffrey Myers, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4591.
Published: 01 May 2007
View article titled, Differential Rac-mediated generation of reactive oxygen species increases sensitivity of metastatic cancer cells to the proapoptotic synthetic retinoid 4HPR relative to their primary cancer cell counterparts
Journal Articles

Differential immunohistochemical expression patterns of fibroblast growth factor-2, receptors 1 and 2, and syndecan-1 in squamous cell carcinoma and adenocarcinoma of the lung

Carmen Behrens, Heather Lin, J Lee, Waun Hong, Ignacio Wistuba, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 190.
Published: 01 May 2007
View article titled, Differential immunohistochemical expression patterns of fibroblast growth factor-2, receptors 1 and 2, and syndecan-1 in squamous cell carcinoma and adenocarcinoma of the lung
Journal Articles

The expression of GPRC5A in cultured normal and malignant cells is modulated by endogenous retinoids in serum

Xiaofeng Ye, Jiong Deng, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1652.
Published: 01 May 2007
View article titled, The expression of GPRC5A in cultured normal and malignant cells is modulated by endogenous retinoids in serum