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Reiner Siebert
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Journal Articles

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer

Owen J. Chen, Ester Castellsagué, Mohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schönberger, Dominik Schneider, Morten Hillmer, Susanne Bens, Reiner Siebert, Colin J.R. Stewart, Ziguo Zhang, William C.H. Chao, Celia M.T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3499–3515.
https://doi.org/10.1158/0008-5472.CAN-21-3956
Published: 04 October 2022
View articletitled, Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
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Includes: Supplementary data
Journal Articles

MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma

Jennifer Hüllein, Mikołaj Słabicki, Maciej Rosolowski, Alexander Jethwa, Stefan Habringer, Katarzyna Tomska, Roma Kurilov, Junyan Lu, Sebastian Scheinost, Rabea Wagener, Zhiqin Huang, Marina Lukas, Olena Yavorska, Hanne Helfrich, René Scholtysik, Kyle Bonneau, Donato Tedesco, Ralf Küppers, Wolfram Klapper, Christiane Pott, Stephan Stilgenbauer, Birgit Burkhardt, Markus Löffler, Lorenz H. Trümper, Michael Hummel, Benedikt Brors, Marc Zapatka, Reiner Siebert, Markus Kreuz, Ulrich Keller, Wolfgang Huber, Thorsten Zenz
Journal: Cancer Research
Cancer Res (2019) 79 (12): 3125–3138.
https://doi.org/10.1158/0008-5472.CAN-18-3438
Published: 14 June 2019
View articletitled, MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma
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Includes: Supplementary data
Journal Articles

Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

Barbara Rivera, Massimo Di Iorio, Jessica Frankum, Javad Nadaf, Somayyeh Fahiminiya, Suzanna L. Arcand, David L. Burk, Damien Grapton, Eva Tomiak, Valerie Hastings, Nancy Hamel, Rabea Wagener, Olga Aleynikova, Sylvie Giroux, Fadi F. Hamdan, Alexandre Dionne-Laporte, George Zogopoulos, Francois Rousseau, Albert M. Berghuis, Diane Provencher, Guy A. Rouleau, Jacques L. Michaud, Anne-Marie Mes-Masson, Jacek Majewski, Susanne Bens, Reiner Siebert, Steven A. Narod, Mohammad R. Akbari, Christopher J. Lord, Patricia N. Tonin, Alexandre Orthwein, William D. Foulkes
Journal: Cancer Research
Cancer Res (2017) 77 (16): 4517–4529.
https://doi.org/10.1158/0008-5472.CAN-17-0190
Published: 14 August 2017
View articletitled, Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 509: Genomic profiling of acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis

Manasi Ratnaparkhe, Mario Hlevnjak, Thorsten Kolb, Anna Jauch, Kendra Maass, Frauke Devens, Agata Rode, Volker Hovestadt, Andrey Korshunov, Agata Pastorczak, Wojciech Mlynarski, Stephanie Sungalee, Jan Korbel, Jessica Hoell, Ute Fischer, Till Milde, Christof Kramm, Michaela Nathrath, Krystyna Chrzanowska, Eugen Tausch, Masatoshi Takagi, Takashi Taga, Shlomi Constantini, Jan Loeffen, Jules Meijerink, Stefan Zielen, Gudrun Goehring, Brigitte Schlegelberger, Eberhard Maass, Reiner Siebert, Joachim Kunz, Andreas Kulozik, Barbara Worst, David Jones, Stefan Pfister, Marc Zapatka, Peter Lichter, Aurelie Ernst
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 509.
https://doi.org/10.1158/1538-7445.AM2017-509
Published: 01 July 2017
View articletitled, Abstract 509: Genomic profiling of acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis
Journal Articles

Abstract 2479: A functionally null RAD51D missense mutation is strongly associated with ovarian carcinoma

Barbara Rivera, Massimo R. Di Iorio, Jessica Frankum, Javad Nadaf, Somayyeh Fahiminiya, Suzanna L. Arcand, David Burk, Damien Grapton, Eva Tomiak, Valerie Hastings, Nancy Hamel, Rabea Wagener, Olga Aleynikova, Sylvie Giroux, Fadi F. Hamdan, Alexandre Orthwein, George Zogopoulos, Francois Rousseau, Albert Berghuis, Diane M. Provencher, Guy A. Rouleau, Jacques L. Michaud, Anne-Marie Mes-Masson, Jacek Majewski, Susanne Bens, Reiner Siebert, Steven Narod, Mohammad Akbari, Chris J. Lord, Patricia N. Tonin, Alexandre Dionne-Laporte, William D. Foulkes
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2479.
https://doi.org/10.1158/1538-7445.AM2017-2479
Published: 01 July 2017
View articletitled, Abstract 2479: A functionally null RAD51D missense mutation is strongly associated with ovarian carcinoma
Journal Articles

Abstract LB-019: FGFR1 abnormalities in seizure-associated familial and sporadic dysembryoplastic neuroepithelial tumors

Barbara Rivera, Tenzin Gayden, Jian Zhang, Javad Nadaf, Talia Boshari, Damien Faury, Michele Zeinieh, Romeo Blanc, David Burk, Somayyeh Fahiminiya, Eric Bareke, Ulrich Schueller, Camelia M. Monoranu, Ronald Sträter, Kornelius Kerl, Thomas Niederstadt, Gerhard Kurlemann, Benjamin Ellezam, Zuzanna Michalak, Maria Thom, Paul Lockhart, Richard Leventer, Milou Ohm, Duncan McGregor, David Jones, Jason Karamchandani, Celia Greenwood, Albert Berghuis, Susanne Bens, Reiner Siebert, Magdalena Zakrzewska, Pawel Liberski, Krzysztof Zakrzewski, Sanjay Sisodiya, Werner Paulus, Steffen Albrecht, Martin Hasselblatt, Nada Jabado, William D. Foulkes, Jacek Majewski
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-019.
https://doi.org/10.1158/1538-7445.AM2016-LB-019
Published: 15 July 2016
View articletitled, Abstract LB-019: FGFR1 abnormalities in seizure-associated familial and sporadic dysembryoplastic neuroepithelial tumors
Journal Articles

Downregulation of the TGFβ Pseudoreceptor BAMBI in Non–Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion

Sebastian Marwitz, Sofia Depner, Dmytro Dvornikov, Ruth Merkle, Magdalena Szczygieł, Karin Müller-Decker, Philippe Lucarelli, Marvin Wäsch, Heimo Mairbäurl, Klaus F. Rabe, Christian Kugler, Ekkehard Vollmer, Martin Reck, Swetlana Scheufele, Maren Kröger, Ole Ammerpohl, Reiner Siebert, Torsten Goldmann, Ursula Klingmüller
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (13): 3785–3801.
https://doi.org/10.1158/0008-5472.CAN-15-1326
Published: 30 June 2016
View articletitled, Downregulation of the TGFβ Pseudoreceptor BAMBI in Non–Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion
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Includes: Supplementary data
Journal Articles

Abstract LB-89: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

Leora Witkowski, Jian Carrot-Zhang, Steffen Albrecht, Nancy Hamel, Eva Tomiak, David Grynspan, Emmanouil Saloustros, Catherine Gilpin, Rachel Silva-Smith, François Plourde, Barbara Rivera, Ester Castellsagué, Mona Wu, Somayyeh Fahiminiya, Javad Nadaf, Avi Saskin, Madeleine Arseneault, Rouzan G. Karabakhtsian, Elizabeth A. Reilly, Frederick R. Ueland, Anna Margiolaki, Kitty Pavlakis, Sharon M. Castellino, Janez Lamovec, Lawrence M. Roth, Thomas M. Ulbright, Tracey Bender, Michel Longy, Andrew Berchuck, Marc Tischkowitz, Reiner Siebert, Inga Nagel, Vassilis Georgoulias, Colin J.r. Stewart, Glenn McCluggage, Jocelyne Arseneau, Blaise A. Clarke, Yasser Riazalhosseini, Martin Hasselblatt, Jacek Majewski, William D. Foulkes
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-89.
https://doi.org/10.1158/1538-7445.AM2014-LB-89
Published: 01 October 2014
View articletitled, Abstract LB-89: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type
Journal Articles

Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Alba Navarro, Guillem Clot, Cristina Royo, Pedro Jares, Anastasia Hadzidimitriou, Andreas Agathangelidis, Vasilis Bikos, Nikos Darzentas, Theodora Papadaki, Itziar Salaverria, Magda Pinyol, Xavier Puig, Jara Palomero, Maria Carmela Vegliante, Virgina Amador, Alejandra Martinez-Trillos, Lenka Stefancikova, Adrian Wiestner, Wyndham Wilson, Christiane Pott, Maria Jose Calasanz, Nicola Trim, Wendy Erber, Birgitta Sander, German Ott, Andreas Rosenwald, Dolors Colomer, Eva Giné, Reiner Siebert, Armando Lopez-Guillermo, Kostas Stamatopoulos, Sílvia Beà, Elías Campo
Journal: Cancer Research
Cancer Res (2012) 72 (20): 5307–5316.
https://doi.org/10.1158/0008-5472.CAN-12-1615
Published: 14 October 2012
View articletitled, Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Open the PDF for Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features in another window
Includes: Supplementary data
Journal Articles

Abstract 168: Genome-wide survey of CpG methylation across the spectrum of B-cell lymphomas

Kristen H. Taylor, Rita Shaknovich, Jose Martin-Subero, Gerald Arthur, Lynda Bennett, Ole Ammerpohl, Julia Richter, Reiner Siebert, Ari Melnick, Charles Caldwell
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 168.
https://doi.org/10.1158/1538-7445.AM10-168
Published: 15 April 2010
View articletitled, Abstract 168: Genome-wide survey of CpG methylation across the spectrum of B-cell lymphomas
Journal Articles

Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia

Xabier Agirre, Amaia Vilas-Zornoza, Antonio Jiménez-Velasco, José Ignacio Martin-Subero, Lucia Cordeu, Leire Gárate, Edurne San José-Eneriz, Gloria Abizanda, Paula Rodríguez-Otero, Puri Fortes, José Rifón, Eva Bandrés, María José Calasanz, Vanesa Martín, Anabel Heiniger, Antonio Torres, Reiner Siebert, José Román-Gomez, Felipe Prósper
Journal: Cancer Research
Cancer Res (2009) 69 (10): 4443–4453.
https://doi.org/10.1158/0008-5472.CAN-08-4025
Published: 15 May 2009
View articletitled, Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia
Open the PDF for Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

Epigenetic Inactivation of the Groucho Homologue Gene TLE1 in Hematologic Malignancies

Mario F. Fraga, Maria Berdasco, Esteban Ballestar, Santiago Ropero, Pilar Lopez-Nieva, Lidia Lopez-Serra, José I. Martín-Subero, Maria J. Calasanz, Isabel Lopez de Silanes, Fernando Setien, Sara Casado, Agustin F. Fernandez, Reiner Siebert, Stefano Stifani, Manel Esteller
Journal: Cancer Research
Cancer Res (2008) 68 (11): 4116–4122.
https://doi.org/10.1158/0008-5472.CAN-08-0085
Published: 02 June 2008
View articletitled, Epigenetic Inactivation of the Groucho Homologue Gene TLE1 in Hematologic Malignancies
Open the PDF for Epigenetic Inactivation of the Groucho Homologue Gene TLE1 in Hematologic Malignancies in another window
Includes: Supplementary data
Journal Articles

Molecular allelokaryotyping of mantle cell lymphoma

Norihiko Kawamata, Seishi Ogawa, Jose Martinez-Climent, Saskia Gueller, Reiner Siebert, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1731.
Published: 01 May 2008
View articletitled, Molecular allelokaryotyping of mantle cell lymphoma
Journal Articles

DNA methylation profiling in Hodgkin lymphomas using universal bead arrays.

Marina Bibikova, Jose Martin-Subero, Eliza Wickham-Garcia, Julia Richter, Esteban Ballestar, Lidia Lopez-Serra, Marc Seifert, Ralf Kuppers, Manel Esteller, Jian-Bing Fan, David Barker, Reiner Siebert
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): LB-210.
Published: 01 May 2007
View articletitled, DNA methylation profiling in Hodgkin lymphomas using universal bead arrays.
Journal Articles

Deletion of Chromosome 11q Predicts Response to Anthracycline-Based Chemotherapy in Early Breast Cancer

Joan Climent, Peter Dimitrow, Jane Fridlyand, Jose Palacios, Reiner Siebert, Donna G. Albertson, Joe W. Gray, Daniel Pinkel, Ana Lluch, Jose A. Martinez-Climent
Journal: Cancer Research
Cancer Res (2007) 67 (2): 818–826.
https://doi.org/10.1158/0008-5472.CAN-06-3307
Published: 18 January 2007
View articletitled, Deletion of Chromosome 11q Predicts Response to Anthracycline-Based Chemotherapy in Early Breast Cancer
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Includes: Supplementary data
Journal Articles

Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma

José I. Martín-Subero, Wolfram Klapper, Anna Sotnikova, Evelyne Callet-Bauchu, Lana Harder, Christian Bastard, Roland Schmitz, Susanne Grohmann, Jorge Höppner, Jennifer Riemke, Thomas F.E. Barth, Françoise Berger, Heinz-Wolfram Bernd, Alexander Claviez, Stefan Gesk, Georgiy A. Frank, Irina B. Kaplanskaya, Peter Möller, Reza M. Parwaresch, Thomas Rüdiger, Harald Stein, Ralf Küppers, Martin L. Hansmann, Reiner Siebert, for the Deutsche Krebshilfe Network Project “Molecular Mechanisms in Malignant Lymphomas”
Journal: Cancer Research
Cancer Res (2006) 66 (21): 10332–10338.
https://doi.org/10.1158/0008-5472.CAN-06-1992
Published: 01 November 2006
View articletitled, Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Open the PDF for Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma in another window
Includes: Supplementary data
Journal Articles

Five C/EPB gene family members are deregulated by IGH@ in B-cell precursor acute lymphoblastic leukemia.

Lisa J. Russell, Takashi Akasaka, Theo Balasas, Aneela Majid, Stephanie Struski, Isabelle Radford-Weiss, Jonathan C. Strefford, Reiner Siebert, Martin Js Dyer, Christine J. Harrison
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1337.
Published: 15 April 2006
View articletitled, Five C/EPB gene family members are deregulated by IGH@ in B-cell precursor acute lymphoblastic leukemia.
Journal Articles

CGH microarray analysis uncovers the involvement of specific oncogenes and tumor suppressor genes in multiple myeloma

David Blesa, Borja Sáez, Klaas Kok, Reiner Siebert, María J. Calasanz, Juan C. Cigudosa
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 392.
Published: 01 April 2004
View articletitled, CGH microarray analysis uncovers the involvement of specific oncogenes and tumor suppressor genes in multiple myeloma