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Rebecca Mosher
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Journal Articles

Abstract 1756: Antitumor effect of XMT1660, a B7H4 targeting antibody drug conjugate, in an unselected panel of patient derived xenograft models of breast cancer

Scott D. Collins, Pamela S. Shaw, Shawn P. Fessler, Jason Wang, Rebecca Mosher
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1756.
https://doi.org/10.1158/1538-7445.AM2022-1756
Published: 15 June 2022
View article titled, Abstract 1756: Antitumor effect of XMT1660, a B7H4 targeting antibody drug conjugate, in an unselected panel of patient derived xenograft models of breast cancer
Journal Articles

Abstract 907: XMT-1660, a B7-H4-targeted Dolasynthen antibody-drug conjugate for the treatment of breast cancer

Shawn P. Fessler, Jason Wang, Scott D. Collins, LiuLiang Qin, Kenneth Avocetien, Ling Xu, Ronald Eydelloth, Steven Vonderfecht, Chen-Ni Chin, Steven Bradley, Susan Clardy, Anouk Dirksen, Elizabeth Ditty, Bingfan Du, Dokyong Kim, Rebecca Mosher, Elena Ter-Ovanesyen, Kelly Slocum, Alex Uttard, Phonphimon Wongthida, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 907.
https://doi.org/10.1158/1538-7445.AM2021-907
Published: 01 July 2021
View article titled, Abstract 907: XMT-1660, a B7-H4-targeted Dolasynthen antibody-drug conjugate for the treatment of breast cancer
Journal Articles

Abstract 1738: XMT-2056, a well-tolerated, Immunosynthen-based STING-agonist antibody-drug conjugate which induces anti-tumor immune activity

Jeremy R. Duvall, Raghida A. Bukhalid, Naniye M. Cetinbas, Kalli C. Catcott, Kelly Slocum, Kenneth Avocetien, Keith W. Bentley, Stephen Bradley, Susan Clardy, Scott D. Collins, Elizabeth Ditty, Timothy Eitas, Brian D. Jones, Eugene W. Kelleher, Winnie Lee, Travis Monnell, Rebecca Mosher, Marina Protopopova, LiuLiang Qin, Pamela Shaw, Elena Ter-Ovanesyan, Joshua D. Thomas, Phonphimon Wongthida, Ling Xu, Liping Yang, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1738.
https://doi.org/10.1158/1538-7445.AM2021-1738
Published: 01 July 2021
View article titled, Abstract 1738: XMT-2056, a well-tolerated, Immunosynthen-based STING-agonist antibody-drug conjugate which induces anti-tumor immune activity
Journal Articles

Abstract 1773: Tumor cell-intrinsic STING pathway activation leads to robust induction of Type III Interferons and contributes to the anti-tumor activity elicited by STING agonism

Naniye Malli Cetinbas, Travis Monnell, Kalli Catcott, Winnie Lee, Pamela Shaw, Kelly Slocum, Kenneth Avocetien, Keith Bentley, Susan Clardy, Brian Jones, Eoin Kelleher, Rebecca Mosher, Joshua D. Thomas, Dorin Toader, Jeremy Duvall, Raghida A. Bukhalid, Marc Damelin, Timothy B. Lowinger
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1773.
https://doi.org/10.1158/1538-7445.AM2021-1773
Published: 01 July 2021
View article titled, Abstract 1773: Tumor cell-intrinsic STING pathway activation leads to robust induction of Type III Interferons and contributes to the anti-tumor activity elicited by STING agonism
Journal Articles

Abstract 2894: XMT-1592, a site-specific Dolasynthen-based NaPi2b-targeted antibody-drug conjugate for the treatment of ovarian cancer and lung adenocarcinoma

Shawn Fessler, Anouk Dirksen, Scott D. Collins, Ling Xu, Winnie Lee, Jason Wang, Ron Eydelloth, Elena Ter-Ovanesyen, Jeffrey Zurita, Elizabeth Ditty, Barrett Nehilla, Susan Clardy, Susan Clardy, Tyler Carter, Kenneth Avocetien, Mark Nazzaro, Nam Le, Kalli C. Catcott, Alex Uttard, Bingfan Du, Chen-Ni Chin, Rebecca Mosher, Kelly Slocum, Liuliang Qin, David Lee, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2894.
https://doi.org/10.1158/1538-7445.AM2020-2894
Published: 15 August 2020
View article titled, Abstract 2894: XMT-1592, a site-specific Dolasynthen-based NaPi2b-targeted antibody-drug conjugate for the treatment of ovarian cancer and lung adenocarcinoma
Journal Articles

Abstract 6706: Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines

Raghida A. Bukhalid, Jeremy R. Duvall, Naniye Malli Cetinbas, Kalli C. Catcott, Kenneth Avocetien, Keith W. Bentley, Stephen Bradley, Tyler Carter, Chen-Ni Chin, Susan Clardy, Scott D. Collins, Timothy Eitas, Brian D. Jones, Eugene W. Kelleher, Rebecca Mosher, Mark Nazzaro, Marina Protopopova, Pamela Shaw, Kelly Slocum, Elena Ter-Ovanesyan, LiuLiang Qin, Joshua D. Thomas, Ling Xu, Liping Yang, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6706.
https://doi.org/10.1158/1538-7445.AM2020-6706
Published: 15 August 2020
View article titled, Abstract 6706: Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines
Journal Articles

Abstract 2670: Combination of anti-HER2 ADC XMT-1522 and checkpoint inhibitor pembrolizumab for treatment of NSCLC in preclinical models

Natalya Bodyak, Marina Protopopova, Qingxiu Zhang, Alex Yurkovetskiy, Mao Yin, LiuLiang Qin, Laura L. Poling, Rebecca Mosher, Donald A. Bergstrom, Timothy B. Lowinger
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2670.
https://doi.org/10.1158/1538-7445.AM2017-2670
Published: 01 July 2017
View article titled, Abstract 2670: Combination of anti-HER2 ADC XMT-1522 and checkpoint inhibitor pembrolizumab for treatment of NSCLC in preclinical models
Journal Articles

Abstract 2974: Targeting cadherin-6 (CDH6) with an antibody-drug conjugate for the treatment of ovarian and renal cancer

Scott D. Collins, Parmita Saxena, Xiao Y. Li, Yeonju Shim, Lance Ostrom, Nicholas C. Yoder, Kalli C. Catcott, Molly A. McShea, Xiuxia Sun, Sanela Bilic, William R. Tschantz, Meghan Flaherty, Keith Mansfield, Tiancen Hu, Vladimir Capka, Markus Kurz, Ivana Liric Rajlic, Anne Serdakowski London, Duc Nguyen, Rebecca Mosher, Matthew J. Meyer, Aaron Bourret, Jamal Saeh, Scott Cameron, Emma Lees, Carl U. Bialucha
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2974.
https://doi.org/10.1158/1538-7445.AM2016-2974
Published: 15 July 2016
View article titled, Abstract 2974: Targeting cadherin-6 (CDH6) with an antibody-drug conjugate for the treatment of ovarian and renal cancer
Journal Articles

Abstract 872: In vivo activity of a novel CDH6 targeting antibody-drug conjugate, including population-scale ovarian PDX clinical trial

Carl U. Bialucha, Scott D. Collins, Yeonju Shim, Xiamei Zhang, Roberto Velazquez, Colleen Kowal, Caroline Bullock, Hongbo Cai, Stacy M. Rivera, Julie M. Goldovitz, Esther Kurth, Alice T. Loo, Guizhi Yang, John Green, Lance Ostrom, Matthew J. Meyer, Rebecca Mosher, Hui Gao, Juliet Williams, Emma Lees
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 872.
https://doi.org/10.1158/1538-7445.AM2016-872
Published: 15 July 2016
View article titled, Abstract 872: In vivo activity of a novel CDH6 targeting antibody-drug conjugate, including population-scale ovarian PDX clinical trial
Journal Articles

Abstract 1680: In vitro and in vivo activity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate

Matthew J. Meyer, David Jenkins, David Batt, Rebecca Mosher, Randi Isaacs, Tiancen Hu, Vladimir Capka, Xiamei Zhang, Dongshu Chen, Lujia Tang, Mike Daley, Patrycja Nowakowski, Yeonju Shim, Wei Jiang, Seth Ettenberg, Emma Lees
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1680.
https://doi.org/10.1158/1538-7445.AM2015-1680
Published: 01 August 2015
View article titled, Abstract 1680: <em>In vitro</em> and <em>in vivo</em> activity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate
Journal Articles

Abstract 1314: Evaluation of PD-L1 mRNA and protein expression in non-small cell lung and hepatocellular carcinoma

Savina Jaeger, Benjamin H. Lee, Rebecca Mosher, Olga Shebnova, Yan Wang, Yenyen Yu, David Yang, Masato Murakami, Joel Greshock, Robert Schlegel, Anthony Boral, Zhu Alexander Cao
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1314.
https://doi.org/10.1158/1538-7445.AM2015-1314
Published: 01 August 2015
View article titled, Abstract 1314: Evaluation of PD-L1 mRNA and protein expression in non-small cell lung and hepatocellular carcinoma
Journal Articles

An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin

Andrew P. Garner, Carl U. Bialucha, Elizabeth R. Sprague, Joan T. Garrett, Qing Sheng, Sharon Li, Olga Sineshchekova, Parmita Saxena, Cammie R. Sutton, Dongshu Chen, Yan Chen, Huiqin Wang, Jinsheng Liang, Rita Das, Rebecca Mosher, Jian Gu, Alan Huang, Nicole Haubst, Carolin Zehetmeier, Manuela Haberl, Winfried Elis, Christian Kunz, Analeah B. Heidt, Kara Herlihy, Joshua Murtie, Alwin Schuller, Carlos L. Arteaga, William R. Sellers, Seth A. Ettenberg
Journal: Cancer Research
Cancer Res (2013) 73 (19): 6024–6035.
https://doi.org/10.1158/0008-5472.CAN-13-1198
Published: 01 October 2013
View article titled, An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Open the PDF for An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin in another window
Includes: Supplementary data
Journal Articles

The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells

Zainab Jagani, Dmitri Wiederschain, Alice Loo, Dan He, Rebecca Mosher, Paul Fordjour, John Monahan, Michael Morrissey, Yung-Mae Yao, Christoph Lengauer, Markus Warmuth, William R. Sellers, Marion Dorsch
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5528–5538.
https://doi.org/10.1158/0008-5472.CAN-09-4229
Published: 30 June 2010
View article titled, The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells
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Includes: Supplementary data
Journal Articles

Abstract 138: Therapeutic targeting of inhibitor of apoptosis proteins

Leigh S. Zawel, Christopher Straub, Brant Firestone, John Sullivan, Kymberly Levine, Dale Porter, Colleen Conway, Guizhi Yang, Hui Gao, Dan He, Joanna Slisz, Michael Morrissey, John Monahan, Rebecca Mosher, Frank Stegmeier, Feng He, Ly Pham, Fan Yang, Julian Chen, Tim Ramsey, Megan Yao, Stephen Fawell
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 138.
https://doi.org/10.1158/1538-7445.AM10-138
Published: 15 April 2010
View article titled, Abstract 138: Therapeutic targeting of inhibitor of apoptosis proteins
Journal Articles

Abstract 4443: Molecular mechanistic study of ASA404 (vadimezan)-induced endothelial cell death

Alan Huang, Yan Chen, Xiaoyan Li, Helen He, Margaret McLaughlin, Rebecca Mosher, Colleen Conway, Brant Firestone, Frank Cook, Bailin Zhang, Bruce C. Baguley, Dean B. Evans, Robert Schlegel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4443.
https://doi.org/10.1158/1538-7445.AM10-4443
Published: 15 April 2010
View article titled, Abstract 4443: Molecular mechanistic study of ASA404 (vadimezan)-induced endothelial cell death
Journal Articles

Abstract 4290: The smoothened antagonist NVP-LDE225 targets stroma and cancer stem cells in primary human pancreatic tumor xenografts

Silvia Buonamici, Beatriz E. Ospina, Julia Xing Zhu, Jing Yuan, Kathy Hsiao, Anthony Vattay, Fang Li, James Deeds, Lance Ostrom, John Monahan, Juliet Williams, Joseph Kelleher, Stefan Peukert, Shifeng Pan, Xu Wu, Markus Warmuth, Rebecca Mosher, Yung-mae Yao, William R. Sellers, Marion Dorsch
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4290.
https://doi.org/10.1158/1538-7445.AM10-4290
Published: 15 April 2010
View article titled, Abstract 4290: The smoothened antagonist NVP-LDE225 targets stroma and cancer stem cells in primary human pancreatic tumor xenografts
Journal Articles

Potent anticancer activity of the deacetylase inhibitor panobinostat (LBH589) in colon cancer cell lines and patient-derived primary colon cancer xenografts

Youzhen Wang, Joseph Growney, Jane Cheng, Colleen Kowal, Guizhi Yang, Rebecca Mosher, Ronald Meyer, Yan Yan-Neale, Minying Pu, Wenlin Shao, Yun Feng, Paul Kwon, Peter Atadja, Stephen Fawell, Yung-mae Yao
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2442.
Published: 01 May 2008
View article titled, Potent anticancer activity of the deacetylase inhibitor panobinostat (LBH589) in colon cancer cell lines and patient-derived primary colon cancer xenografts
Journal Articles

Identification of Cervical Cancer Markers by cDNA and Tissue Microarrays

Yan Chen, Christine Miller, Rebecca Mosher, Xumei Zhao, Jim Deeds, Mike Morrissey, Barb Bryant, David Yang, Ron Meyer, Frank Cronin, Bobbie S. Gostout, Karen Smith-McCune, Robert Schlegel
Journal: Cancer Research
Cancer Res (2003) 63 (8): 1927–1935.
Published: 15 April 2003
View article titled, Identification of Cervical Cancer Markers by cDNA and Tissue Microarrays
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