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Ravikumar Muthuswamy
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Journal Articles

Abstract 6789: The oncolytic virus VET3-TGI both blocks TGF-beta signaling and activates type 2 IFN responses, resulting in potent therapeutic responses in multiple mouse models

Free
Ravikumar Muthuswamy, Steve Thorne
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6789.
https://doi.org/10.1158/1538-7445.AM2023-6789
Published: 04 April 2023
View articletitled, Abstract 6789: The oncolytic virus VET3-TGI both blocks TGF-beta signaling and activates type 2 IFN responses, resulting in potent therapeutic responses in multiple mouse models
Journal Articles

Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment

Free
Marie-Nicole Theodoraki, Saigopalakrishna Yerneni, Saumendra N. Sarkar, Brian Orr, Ravikumar Muthuswamy, Jamie Voyten, Francesmary Modugno, Weijian Jiang, Melissa Grimm, Per H. Basse, David L. Bartlett, Robert P. Edwards, Pawel Kalinski
Journal: Cancer Research
Cancer Res (2018) 78 (15): 4292–4302.
https://doi.org/10.1158/0008-5472.CAN-17-3985
Published: 31 July 2018
View articletitled, Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment
Open the PDF for Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells

Free
Ravikumar Muthuswamy, Erik Berk, Beth Fallert Junecko, Herbert J. Zeh, Amer H. Zureikat, Daniel Normolle, The Minh Luong, Todd A. Reinhart, David L. Bartlett, Pawel Kalinski
Journal: Cancer Research
Cancer Res (2012) 72 (15): 3735–3743.
https://doi.org/10.1158/0008-5472.CAN-11-4136
Published: 31 July 2012
View articletitled, NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells
Open the PDF for NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells in another window
Includes: Supplementary data
Journal Articles

Defective NF-κB Signaling in Metastatic Head and Neck Cancer Cells Leads to Enhanced Apoptosis by Double-Stranded RNA

Free
Naoki Umemura, Jianzhong Zhu, Yvonne K. Mburu, Adriana Forero, Paishiun N. Hsieh, Ravikumar Muthuswamy, Pawel Kalinski, Robert L. Ferris, Saumendra N. Sarkar
Journal: Cancer Research
Cancer Res (2012) 72 (1): 45–55.
https://doi.org/10.1158/0008-5472.CAN-11-1484
Published: 02 January 2012
View articletitled, Defective NF-κB Signaling in Metastatic Head and Neck Cancer Cells Leads to Enhanced Apoptosis by Double-Stranded RNA
Open the PDF for Defective NF-κB Signaling in Metastatic Head and Neck Cancer Cells Leads to Enhanced Apoptosis by Double-Stranded RNA in another window
Includes: Supplementary data
Journal Articles

PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment

Free
Nataša Obermajer, Ravikumar Muthuswamy, Kunle Odunsi, Robert P. Edwards, Pawel Kalinski
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7463–7470.
https://doi.org/10.1158/0008-5472.CAN-11-2449
Published: 15 December 2011
View articletitled, PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment
Open the PDF for PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment in another window
Includes: Supplementary data
Journal Articles

Abstract LB-250: Establishment of a positive feedback between PGE2 and COX2 diverts DC differentiation into MDSCs and sustains their immunosuppressive functions in ovarian cancer

Free
Natasa Obermajer, Ravikumar Muthuswamy, Jamie Lesnock, Robert P. Edwards, Pawel Kalinski
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-250.
https://doi.org/10.1158/1538-7445.AM2011-LB-250
Published: 15 April 2011
View articletitled, Abstract LB-250: Establishment of a positive feedback between PGE2 and COX2 diverts DC differentiation into MDSCs and sustains their immunosuppressive functions in ovarian cancer
Journal Articles

Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells—Significant Roles of CXCL10

Free
Mitsugu Fujita, Xinmei Zhu, Ryo Ueda, Kotaro Sasaki, Gary Kohanbash, Edward R. Kastenhuber, Heather A. McDonald, Gregory A. Gibson, Simon C. Watkins, Ravikumar Muthuswamy, Pawel Kalinski, Hideho Okada
Journal: Cancer Research
Cancer Res (2009) 69 (4): 1587–1595.
https://doi.org/10.1158/0008-5472.CAN-08-2915
Published: 12 February 2009
View articletitled, Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells—Significant Roles of CXCL10
Open the PDF for Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells—Significant Roles of CXCL10 in another window
Includes: Supplementary data
Journal Articles

Ability of Mature Dendritic Cells to Interact with Regulatory T Cells Is Imprinted during Maturation

Free
Ravikumar Muthuswamy, Julie Urban, Je-Jung Lee, Todd A. Reinhart, David Bartlett, Pawel Kalinski
Journal: Cancer Research
Cancer Res (2008) 68 (14): 5972–5978.
https://doi.org/10.1158/0008-5472.CAN-07-6818
Published: 15 July 2008
View articletitled, Ability of Mature Dendritic Cells to Interact with Regulatory T Cells Is Imprinted during Maturation
Open the PDF for Ability of Mature Dendritic Cells to Interact with Regulatory T Cells Is Imprinted during Maturation in another window
Includes: Supplementary data
Journal Articles

Helper Function of Memory CD8+ T Cells: Heterologous CD8+ T Cells Support the Induction of Therapeutic Cancer Immunity

Free
Yutaro Nakamura, Payal Watchmaker, Julie Urban, Brian Sheridan, Adam Giermasz, Fumihiko Nishimura, Kotaro Sasaki, Rachel Cumberland, Ravikumar Muthuswamy, Robbie B. Mailliard, Adriana T. Larregina, Louis D. Falo, William Gooding, Walter J. Storkus, Hideho Okada, Robert L. Hendricks, Pawel Kalinski
Journal: Cancer Research
Cancer Res (2007) 67 (20): 10012–10018.
https://doi.org/10.1158/0008-5472.CAN-07-1735
Published: 17 October 2007
View articletitled, Helper Function of Memory CD8+ T Cells: Heterologous CD8+ T Cells Support the Induction of Therapeutic Cancer Immunity
Open the PDF for Helper Function of Memory CD8+ T Cells: Heterologous CD8+ T Cells Support the Induction of Therapeutic Cancer Immunity in another window
Journal Articles

Polarized DCs as therapeutic cancer vaccines

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Pawel Kalinski, Robbie Mailliard, Larissa Geskin, Adam Giermasz, Yutaro Nakamura, Payal Watchmaker, Ravikumar Muthuswamy, Walter J. Storkus, David Bartlett, Howard Edington, Louis D. Falo, Jr., John M. Kirkwood
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 739.
Published: 15 April 2006
View articletitled, Polarized DCs as therapeutic cancer vaccines