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Abstract LB252: Evaluation of the pan-class I phosphoinositide 3-kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium osteosarcoma in vivo models

Douglas Harrison, Jonathan Gill, Pooja Hingorani, Michael Roth, Wendong Zhang, Beverly Teicher, Eric J. Earley, Stephen W. Erickson, Gregory Gatto, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Edward A. Kolb, Richard Gorlick

Cancer Res (2021) 81 (13_Supplement): LB252.

DOI: https://doi.org/10.1158/1538-7445.AM2021-LB252

Published: 01 July 2021

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Journal Articles

A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan T. Kurmasheva, Morgan Diolaiti, Alan Ashworth, Cody J. Peer, Ryan Nguyen, William D. Figg, Sr., Denis R. Beckford-Vera, Daniel V. Santi

Cancer Res (2021) 81 (4): 1076–1086.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-1741

Published: 15 February 2021

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Includes: Supplementary data

Journal Articles

Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts

Beverly A. Teicher, Richard B. Lock, Kathryn Evans, Peter J. Houghton, Raushan T. Kurmasheva, Richard Gorlicki, Steve Erickson, Donn Wishka, Joel Morris, Michael Difilippantonio, Jerry E. Collins, Malcolm A. Smith, James H. Doroshow

Cancer Res (2019) 79 (13_Supplement): 3839.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3839

Published: 01 July 2019

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Journal Articles

Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

Brendan Murphy, Han Yin, John M. Maris, E. Anders Kolb, Richard Gorlick, C. Patrick Reynolds, Min H. Kang, Stephen T. Keir, Raushan T. Kurmasheva, Igor Dvorchik, Jianrong Wu, Catherine A. Billups, Nana Boateng, Malcolm A. Smith, Richard B. Lock, Peter J. Houghton

Cancer Res (2016) 76 (19): 5798–5809.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-0122

Published: 02 October 2016

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Includes: Supplementary data

Journal Articles

Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant

Jennifer Richmond, Alissa Robbins, Kathryn Evans, Dominik Beck, Raushan T. Kurmasheva, Catherine A. Billups, Hernan Carol, Sue Heatley, Rosemary Sutton, Glenn M. Marshall, Deborah White, John Pimanda, Peter J. Houghton, Malcolm A. Smith, Richard B. Lock

Cancer Res (2016) 76 (15): 4579–4591.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-0523

Published: 31 July 2016

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Includes: Supplementary data

Journal Articles

Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia

Sibasish Dolai, Keith C.S. Sia, Alissa K. Robbins, Ling Zhong, Sue L. Heatley, Tiffaney L. Vincent, Falko Hochgräfe, Rosemary Sutton, Raushan T. Kurmasheva, Tamas Revesz, Deborah L. White, Peter J. Houghton, Malcolm A. Smith, David T. Teachey, Roger J. Daly, Mark J. Raftery, Richard B. Lock

Cancer Res (2016) 76 (9): 2766–2777.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-2786

Published: 01 May 2016

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Includes: Supplementary data

Journal Articles

Abstract 1620: In vivo and in vitro efficacy of birinapant in preclinical models of Ph-like pediatric acute lymphoblastic leukemia

Jennifer Richmond, Kathryn Evans, Alissa Robbins, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Richard B. Lock

Cancer Res (2015) 75 (15_Supplement): 1620.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1620

Published: 01 August 2015

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Journal Articles

Abstract 1614: Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma

Peter J. Houghton, Doris A. Phelps, Kathryn Bondra, Star Seum, Christopher Chronowski, Justin Leasure, Raushan T. Kurmasheva, Stephen Middleton, Dian Wang, Xiaokui Mo

Cancer Res (2015) 75 (15_Supplement): 1614.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1614

Published: 01 August 2015

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Journal Articles

Abstract 1616: Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): a report from the Pediatric Preclinical Testing Program

Malcolm A. Smith, Richard Lock, Hernan Carol, John M. Maris, Richard Gorlick, E. Anders Kolb, Stephen T. Keir, Jianrong Wu, Yosef Landesman, Sharon Shacham, Dmitry Lyalin, Raushan T. Kurmasheva, Peter J. Houghton

Cancer Res (2015) 75 (15_Supplement): 1616.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1616

Published: 01 August 2015

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Journal Articles

Abstract 477: Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma

Adam W. Studebaker, Kathryn Bondra, Star Seum, Justin Leasure, Christopher Chronowski, Changxian Shen, Doris Phelps, Paul D. Smith, Raushan T. Kurmasheva, Xiaokui Mo, Peter J. Houghton

Cancer Res (2015) 75 (15_Supplement): 477.

DOI: https://doi.org/10.1158/1538-7445.AM2015-477

Published: 01 August 2015

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Journal Articles

ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis

Hemant K. Bid, Ryan D. Roberts, Maren Cam, Anthony Audino, Raushan T. Kurmasheva, Jiayuh Lin, Peter J. Houghton, Hakan Cam

Cancer Res (2014) 74 (1): 320–329.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-0894

Published: 05 January 2014

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Includes: Supplementary data

Journal Articles

Abstract 2754: Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of the antimicrotubule agents cabazitaxel and docetaxel.

Peter J. Houghton, Min Kang, C Patrick Reynolds, Richard B. Lock, Hernan Carol, Richard Gorlick, E Anders Kolb, John M. Maris, Stephen T. Keir, Catherine A. Billups, Raushan T. Kurmasheva, Malcolm Anders Smith

Cancer Res (2013) 73 (8_Supplement): 2754.

DOI: https://doi.org/10.1158/1538-7445.AM2013-2754

Published: 15 April 2013

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Journal Articles

Abstract 2481: Exploiting BRAF mutation for therapy of childhood low-grade astrocytoma

Aaron Kibler, Sagymbek Manap, Hemant K. Bid, Doris A. Phelps, Raushan T. Kurmasheva, Christopher E. Pelloski, Peter J. Houghton

Cancer Res (2012) 72 (8_Supplement): 2481.

DOI: https://doi.org/10.1158/1538-7445.AM2012-2481

Published: 15 April 2012

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Journal Articles

Abstract 5291: A novel gain of function of deltaNp63 in tumor angiogenesis

Maren Cam, Hemant K. Bid, Antony Audino, Raushan T. Kurmasheva, Jiayuh Lin, Hakan Cam

Cancer Res (2012) 72 (8_Supplement): 5291.

DOI: https://doi.org/10.1158/1538-7445.AM2012-5291

Published: 15 April 2012

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Journal Articles

The Insulin-like Growth Factor-1 Receptor–Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of Childhood Sarcoma

Raushan T. Kurmasheva, Lorina Dudkin, Catherine Billups, Larisa V. Debelenko, Christopher L. Morton, Peter J. Houghton

Cancer Res (2009) 69 (19): 7662–7671.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-1693

Published: 01 October 2009

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Includes: Supplementary data

Journal Articles

Regulation of VEGF in most neuroblastoma cell lines is dependent on Akt but not mTOR signaling.

Raushan T. Kurmasheva, Franklin C. Harwood, Lili Shu, Peter J. Houghton

Cancer Res (2006) 66 (8_Supplement): 1324.

Published: 15 April 2006

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Journal Articles

Dysregulation of hypoxia-inducible factor 1α (HIF-1α) in neuroblastoma and rhabdomyosarcoma cells

Raushan T. Kurmasheva, Franklin C. Harwood, Maryam Fouladi, Peter J. Houghton

Cancer Res (2005) 65 (9_Supplement): 688.

Published: 01 May 2005

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NARROW

Abstract LB252: Evaluation of the pan-class I phosphoinositide 3-kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium osteosarcoma in vivo models

A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models

Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts

Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant

Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia

Abstract 1620: In vivo and in vitro efficacy of birinapant in preclinical models of Ph-like pediatric acute lymphoblastic leukemia

Abstract 1614: Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma

Abstract 1616: Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): a report from the Pediatric Preclinical Testing Program

Abstract 477: Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma

ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis

Abstract 2754: Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of the antimicrotubule agents cabazitaxel and docetaxel.

Abstract 2481: Exploiting BRAF mutation for therapy of childhood low-grade astrocytoma

Abstract 5291: A novel gain of function of deltaNp63 in tumor angiogenesis

The Insulin-like Growth Factor-1 Receptor–Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of Childhood Sarcoma

Regulation of VEGF in most neuroblastoma cell lines is dependent on Akt but not mTOR signaling.

Dysregulation of hypoxia-inducible factor 1α (HIF-1α) in neuroblastoma and rhabdomyosarcoma cells

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