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Ratna K. Vadlamudi
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Journal Articles

Abstract 628: RNA binding protein Matrin3 acts as a tumor suppressor by inhibiting microtubule nucleation

Panneerdoss Subbarayalu, Subapriya Rajamanickam, Santosh Timilsina, Saif Nirzhor, Daisy Medina, Shahad Abdulsahib, Pitta V Prabhakar, Deepika Singh, Fu-Yang Li, Pooja Yadav, Esha Reddy, Krishna Evani, Vijay Eedunuri, Trong Phat Do, Benjamin C. Onyeagucha, Tabrez A. Mohammad, Jae-Hoon Ji, Yidong Chen, Nourhan Abdelfattah, Nicholas Dybdal-Hargreaves, Li-Ju Wang, Yu-Chiao Chiu, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi, Manjeet K. Rao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 628.
https://doi.org/10.1158/1538-7445.AM2024-628
Published: 22 March 2024
View article titled, Abstract 628: RNA binding protein Matrin3 acts as a tumor suppressor by inhibiting microtubule nucleation
Journal Articles

Abstract 2100: Novel LIPA targeted therapy for treating inflammatory breast cancer

Zenaida Fuentes, Rahul Gopalam, Bianca A. Romo, Khaled Mohamed Nassar, Xue Yang, Behnam Ebrahimi, Paulina Ramirez, Chia-Yuan Chen, Scott Elmore, Harika Nagandla, Uday Pratap, Christoforos Thomas, Suryavathi Viswanadhapalli, Jung-Mo Ahn, Ganesh Raj, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2100.
https://doi.org/10.1158/1538-7445.AM2024-2100
Published: 22 March 2024
View article titled, Abstract 2100: Novel LIPA targeted therapy for treating inflammatory breast cancer
Journal Articles

Abstract 2099: PELP1 inhibition enhances the therapeutic efficacy of topoisomerase inhibitors in triple-negative breast cancer

Khaled Mohamed Nassar, John R. Sanchez, Durga Meenakshi Panneerdoss, Behnam Ebrahimi, Yang Xue, Uday P. Pratap, Salvador C. Alejo, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2099.
https://doi.org/10.1158/1538-7445.AM2024-2099
Published: 22 March 2024
View article titled, Abstract 2099: PELP1 inhibition enhances the therapeutic efficacy of topoisomerase inhibitors in triple-negative breast cancer
Journal Articles

Abstract 4422: Metabolic adaptations of glioblastoma in hypoxia is mediated by acox-1

Ayon Bhattacharya, Laura Caflisch, Henriette Balinda, Alessia Lodi, Mei Zhou, Mengxing Li, Jennifer Chiou, Renu Pandey, Gangadhara R. Sareddy, Stefano Tiziani, Yidong Chen, Ratna K. Vadlamudi, Andrew J. Brenner
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4422.
https://doi.org/10.1158/1538-7445.AM2024-4422
Published: 22 March 2024
View article titled, Abstract 4422: Metabolic adaptations of glioblastoma in hypoxia is mediated by acox-1
Journal Articles

Abstract 3237: KDM1A/LSD1 inhibition enhances chemotherapy response in ovarian cancer

Jessica D. Johnson, Yihong Chen, Sridharan Jayamohan, Yi He, Diksha Jamwal, Neetesh Pandey, Edward Kost, Ratna K. Vadlamudi, Gangadhara R. Sareddy
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3237.
https://doi.org/10.1158/1538-7445.AM2024-3237
Published: 22 March 2024
View article titled, Abstract 3237: KDM1A/LSD1 inhibition enhances chemotherapy response in ovarian cancer
Journal Articles

Abstract 4688: EC359, A new therapeutic drug for the treatment of low grade serous ovarian cancer

Yasmin Lyons, William Cole Arnold, Behnam Ebrahimi, Bindu Santhamma, Edward R. Kost, Hareesh B. Nair, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4688.
https://doi.org/10.1158/1538-7445.AM2024-4688
Published: 22 March 2024
View article titled, Abstract 4688: EC359, A new therapeutic drug for the treatment of low grade serous ovarian cancer
Journal Articles

Abstract 394: Preclinical evaluation of ERX-208, a potent inducer of ER stress for the treatment of ovarian cancer

Suryavathi Viswanadhapalli, Tae-Kyung Lee, Scott Elmore, Gaurav Sharma, Rahul Gopalam, Karla Parra, Tanner Reese, Michael Hsieh, Uday P. Pratap, Xue Yang, Behnam Ebrahimi, Henry Neal, Chia-Yuan Chen, Kara Kassees, Christian Cervantes, Zhenming Xu, Edward Kost, Gangadhara Reddy Sareddy, Rajeshwar R. Tekmal, Jung-Mo Ahn, Ganesh V. Raj, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 394.
https://doi.org/10.1158/1538-7445.AM2024-394
Published: 22 March 2024
View article titled, Abstract 394: Preclinical evaluation of ERX-208, a potent inducer of ER stress for the treatment of ovarian cancer
Journal Articles

Abstract 3172: Significance of PELP1 signaling in liver cancer progression

Uday Pratap, Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam, William C. Arnold, Timilehin Adeniran, Marian Helena Hernandez Fernandez, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Luzhe Sun, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3172.
https://doi.org/10.1158/1538-7445.AM2024-3172
Published: 22 March 2024
View article titled, Abstract 3172: Significance of PELP1 signaling in liver cancer progression
Journal Articles

Abstract 5998: Pharmacological inhibition of the LIF-LIFR autocrine loop reveals vulnerability of ovarian cancer to ferroptosis

Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Rahul Gopalam, Xue Yang, Prabhakar P. Venkata, Viktor Drel, Bindu Santhamma, Swapna Konda, Xiaonan Li, Alondra L. Rodriguez Sanchez, Hui Yan, Gangadhara R. Sareddy, Zhenming Xu, Brij B. Singh, Philip T. Valente, Yidong Chen, Zhao Lai, Manjeet Rao, Edward R. Kost, Tyler Curiel, Rajeshwar R. Tekmal, Hareesh B. Nair, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5998.
https://doi.org/10.1158/1538-7445.AM2024-5998
Published: 22 March 2024
View article titled, Abstract 5998: Pharmacological inhibition of the LIF-LIFR autocrine loop reveals vulnerability of ovarian cancer to ferroptosis
Journal Articles

Abstract 3408: The role of obesity in promoting the LIF/LIFR signaling in triple negative breast cancer

Lois Randolph, Alondra Rodriguez Sanchez, Logan Blankenship, Uday P. Pratap, Xue Yang, Durga Meenakshi Panneerdoss, Swapna Konda, Bindu Santhamma, Gangadhara R. Sareddy, Manjeet K. Rao, Edward R. Kost, Rajeshwar R. Tekmal, Hareesh B. Nair, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3408.
https://doi.org/10.1158/1538-7445.AM2023-3408
Published: 04 April 2023
View article titled, Abstract 3408: The role of obesity in promoting the LIF/LIFR signaling in triple negative breast cancer
Journal Articles

Abstract 4966: Targeting LIF/LIFR autocrine loops with EC359 in ovarian cancer: A novel LIFR targeted therapy

Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Rahul Gopalam, Xue Yang, Bindhu Santhamma, Swapna Konda, Xiaonan Li, Hui Yan, Gangadhara R. Sareddy, Zhenming Xu, Edward R. Kost, Rajeshwar R. Tekmal, Hareesh B. Nair, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4966.
https://doi.org/10.1158/1538-7445.AM2023-4966
Published: 04 April 2023
View article titled, Abstract 4966: Targeting LIF/LIFR autocrine loops with EC359 in ovarian cancer: A novel LIFR targeted therapy
Journal Articles

Abstract 1718: Development of potent estrogen receptor beta agonists for treating glioblastoma

Uday P. Pratap, Michael Tidwell, Henriette U. Balinda, Suryavathi Viswanadhapalli, Gangadhara Reddy Sareddy, Stanton McHardy, Andrew Brenner, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1718.
https://doi.org/10.1158/1538-7445.AM2023-1718
Published: 04 April 2023
View article titled, Abstract 1718: Development of potent estrogen receptor beta agonists for treating glioblastoma
Journal Articles

Abstract 4813: ERX-208 as a novel therapeutic for treating ovarian cancer by enhancing endoplasmic reticulum stress

Suryavathi Viswanadhapalli, Tae-Kyung Lee, Kara Kassees, Gaurav Sharma, Rahul Gopalam, Karla Parra, Tanner Reese, Michael Hsieh, Uday P. Pratap, Xue Yang, Behnam Ebrahimi, Chia Yuan Chen, Scott Terry Elmore, Christian Cervantes, Zhenming Xu, Edward Kost, Gangadhara Reddy Sareddy, Rajeshwar Rao Tekmal, Jung-Mo Ann, Ganesh V. Raj, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4813.
https://doi.org/10.1158/1538-7445.AM2023-4813
Published: 04 April 2023
View article titled, Abstract 4813: ERX-208 as a novel therapeutic for treating ovarian cancer by enhancing endoplasmic reticulum stress
Journal Articles

Abstract 3081: KDM1A/LSD1 inhibition enhances estrogen receptor beta mediated tumor suppression in ovarian cancer

Prabhakar P. Venkata, Sridharan Jayamohan, Yi He, Salvador Alejo, Jessica D. Johnson, Uday P. Pratap, Suryavathi Viswanadhapalli, Susan Weintraub, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Edward Kost, Gangadhara R. Sareddy
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3081.
https://doi.org/10.1158/1538-7445.AM2023-3081
Published: 04 April 2023
View article titled, Abstract 3081: KDM1A/LSD1 inhibition enhances estrogen receptor beta mediated tumor suppression in ovarian cancer
Journal Articles

Abstract 3986: Novel LIPA targeted therapy for treating ovarian cancer

Alexia B. Collier, Suryavathi Viswanadhapalli, Tae-Kyung Lee, Kara Kassees, Karla Parra, Gaurav Sharma, Tanner Reese, Michael Hsieh, Xihui Liu, Xue Yang, Behnam Ebrahimi, Uday P. Pratap, Rahul Gopalam, Chia Yuan Chen, Scott Terry Elmore, Gangadhara Reddy Sareddy, Edward R. Kost, Jung-Mo Ahn, Ganesh V. Raj, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3986.
https://doi.org/10.1158/1538-7445.AM2023-3986
Published: 04 April 2023
View article titled, Abstract 3986: Novel LIPA targeted therapy for treating ovarian cancer
Journal Articles

Abstract 6263: Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments efficacy of temozolomide in glioblastoma

Salvador Alejo, Bridgitte Palacios, Prabhakar Pitta Venkata, He Yi, Wenjing Li, Jessica Johnson, Sridharan Jayamohan, Weixing Zhao, Siyuan Zheng, Takayoshi Suzuki, Rajeshwar R. Tekmal, Andrew Brenner, Ratna K. Vadlamudi, Gangadhara R. Sareddy
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6263.
https://doi.org/10.1158/1538-7445.AM2023-6263
Published: 04 April 2023
View article titled, Abstract 6263: Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments efficacy of temozolomide in glioblastoma
Journal Articles

Abstract 440: The role of PELP1 inhibitor SMIP34 in the treatment of endometrial cancer

Xue Yang, Zexuan Liu, Weiwei Tang, Uday P. Pratap, Alexia B. Collier, Kristin A. Alwegg, Nicole Spencer, Xiaonan Li, Philip T. Valente, Edward R. Kost, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 440.
https://doi.org/10.1158/1538-7445.AM2023-440
Published: 04 April 2023
View article titled, Abstract 440: The role of PELP1 inhibitor SMIP34 in the treatment of endometrial cancer
Journal Articles

Abstract P3-07-19: Anti-depressant Amitriptyline Augments the Efficacy of Tamoxifen in ER positive breast cancer

Prabhakar Pitta Venkata, Arhan D. Rao, Santosh Timilsina, Deepika Singh, Ratna K. Vadlamudi, Virginia Kaklamani, Manjeet K. Rao
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-07-19.
https://doi.org/10.1158/1538-7445.SABCS22-P3-07-19
Published: 01 March 2023
View article titled, Abstract P3-07-19: Anti-depressant Amitriptyline Augments the Efficacy of Tamoxifen in ER positive breast cancer
Journal Articles

Abstract P6-10-14: Lysosomal acid lipase (LIPA) as a novel therapeutic vulnerability for treating TNBC

Suryavathi Viswanadhapalli, Xihui Liu, Uday Pratap, Gangadhara R. Sareddy, Susan T. Weintraub, Ganesh V. Raj, Jung-Mo Ahn, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-10-14.
https://doi.org/10.1158/1538-7445.SABCS22-P6-10-14
Published: 01 March 2023
View article titled, Abstract P6-10-14: Lysosomal acid lipase (LIPA) as a novel therapeutic vulnerability for treating TNBC
Journal Articles

A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer

Kristin A. Altwegg, Suryavathi Viswanadhapalli, Monica Mann, Dimple Chakravarty, Samaya Krishnan, Zexuan Liu, Junhao Liu, Uday P. Pratap, Behnam Ebrahimi, John R. Sanchez, Xiaonan Li, Shihong Ma, Ben H. Park, Bindu Santhamma, Yidong Chen, Zhao Lai, Ganesh V. Raj, Yaxia Yuan, Daohong Zhou, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Stan McHardy, Tim H.-M. Huang, Manjeet K. Rao, Hariprasad Vankayalapati, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2022) 82 (20): 3830–3844.
https://doi.org/10.1158/0008-5472.CAN-22-0698
Published: 17 October 2022
View article titled, A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER<sup>+</sup> Breast Cancer
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Includes: Supplementary data